PFKL

This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Description

phosphofructokinase, liver type

Protein family

Enzymes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas)

Chromosome

21:q22.3 (44300051 - 44327376)

Ensembl ID

ENSG00000141959  (ver. 99.38)

Orthologs

Mouse Pfkl: ENSMUSG00000020277

UniProt

P17858

neXtProt

NX_P17858

Human splice variants
Mouse splice variants