NBP1-06709

antibody from Novus Biologicals

Targeting: LDLR LDLCQ2

Western blot (Supportive data in Antibodypedia)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

NBP1-06709

Provider

Novus Biologicals

Proper citation

Novus Cat#NBP1-06709, RRID:AB_1625769

Product name

Rabbit Polyclonal LDLR Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. This is specific for both the unglycosylated and glycosylated forms of the LDL Receptor.

Reactivity

Human, Mouse

Host

Rabbit

Isotype

IgG

Vial size

0.1 ml

Concentration

1.5 mg/ml

Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

References

Submitted references

Gypenosides mediate cholesterol efflux and suppress oxidized LDL induced inflammation in retinal pigment epithelium cells.

Biswas L, Zeng Z, Graham A, Shu X
Experimental eye research 2020 Feb;191:107931

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Hepatocyte-Specific Expression of Human Carboxylesterase 1 Attenuates Diet-Induced Steatohepatitis and Hyperlipidemia in Mice.

Xu Y, Zhu Y, Bawa FC, Hu S, Pan X, Yin L, Zhang Y
Hepatology communications 2020 Apr;4(4):527-539

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Clinical relevance of cholesterol homeostasis genes in colorectal cancer.

Sharma B, Gupta V, Dahiya D, Kumar H, Vaiphei K, Agnihotri N
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 Oct;1864(10):1314-1327

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Angiotensin II induces cholesterol accumulation and injury in podocytes.

Yang Y, Yang Q, Yang J, Ma Y, Ding G
Scientific reports 2017 Sep 6;7(1):10672

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Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr (-/-) mice.

Xu J, Xu Y, Xu Y, Yin L, Zhang Y
Scientific reports 2017 Dec 19;7(1):17845

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Adipose tissue deficiency results in severe hyperlipidemia and atherosclerosis in the low-density lipoprotein receptor knockout mice.

Wang M, Gao M, Liao J, Qi Y, Du X, Wang Y, Li L, Liu G, Yang H
Biochimica et biophysica acta 2016 May;1861(5):410-8

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Lipocalin 2 deficiency alters estradiol production and estrogen receptor signaling in female mice.

Guo H, Zhang Y, Brockman DA, Hahn W, Bernlohr DA, Chen X
Endocrinology 2012 Mar;153(3):1183-93

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Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression.

Duan Y, Chen Y, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J
The Journal of biological chemistry 2012 Jul 6;287(28):23667-77

Western blot

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Simple Western: LDL R Antibody [NBP1-06709] - Simple Western lane view shows a specific band for LDL R in 0.05 mg/ml of HepG2 lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Western Blot: LDL R Antibody [NBP1-06709] - Western Blot on HepG2 whole cell lysate.

Immunohistochemistry

Supportive validation

Submitted by

Novus Biologicals (provider)

Main image

Experimental details

Immunohistochemistry-Paraffin: LDL R Antibody [NBP1-06709] - LDL Receptor was detected in immersion fixed paraffin-embedded sections of human liver cancer using rabbit anti-human antibody (Catalog # NBP1-06709) at 1:3000 dilution overnight at 4C. Tissue was stained using the VisuCyte anti-rabbit HRP polymer detection reagent (Catalog # VC003) with DAB chromogen (brown) and counterstained with hematoxylin (blue).Images may not be copied, printed or otherwise disseminated without express written permission of Novus Biologicals a bio-techne brand.