LDLR

gene product
LDLCQ2
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
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antibodies-online
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Aviva Systems Biology
3 antibodies
ProSci
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Atlas Antibodies
2 antibodies
RabMAbs
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GenWay
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Abbkine Scientific Co.Ltd.
1 antibody
Affinity Biosciences
1 antibody
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Sino Biological Inc.
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MyBioSource
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BioLegend
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St John's Laboratory
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Abbiotec
1 antibody
Abiocode, Inc.
1 antibody
Bethyl Laboratories
1 antibody
Sigma-Aldrich
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3 antibodies
United States Biological
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Abbexa
3 antibodies
EMD Millipore
1 antibody