MAB2148

antibody from R&D Systems

Targeting: LDLR LDLCQ2

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

MAB2148

Provider

R&D Systems

Product name

Anti-Human LDL R Monoclonal Antibody (Clone 472413)

Antibody type

Monoclonal

Antigen

Chinese hamster ovary cell line CHO-derived recombinant human LDL R, Ala22-Arg788

Description

Protein A or G purified from hybridoma culture supernatant

Reactivity

Human

Host

Mouse

Antigen sequence

P01130


Isotype

IgG

Vial size

500 µg

References

Submitted references

The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA.

Susan-Resiga D, Girard E, Kiss RS, Essalmani R, Hamelin J, Asselin MC, Awan Z, Butkinaree C, Fleury A, Soldera A, Dory YL, Baass A, Seidah NG
The Journal of biological chemistry 2017 Feb 3;292(5):1573-1590

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Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation.

Weider E, Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Nimesh S, Ashraf Y, Wycoff KL, Zhang J, Prat A, Seidah NG
The Journal of biological chemistry 2016 Aug 5;291(32):16659-71

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Endophilin marks and controls a clathrin-independent endocytic pathway.

Boucrot E, Ferreira AP, Almeida-Souza L, Debard S, Vallis Y, Howard G, Bertot L, Sauvonnet N, McMahon HT
Nature 2015 Jan 22;517(7535):460-5

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Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor.

Amirache F, Lévy C, Costa C, Mangeot PE, Torbett BE, Wang CX, Nègre D, Cosset FL, Verhoeyen E
Blood 2014 Feb 27;123(9):1422-4

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Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages.

Karta MR, Wickert LE, Curran CS, Gavala ML, Denlinger LC, Gern JE, Bertics PJ
The Journal of allergy and clinical immunology 2014 Apr;133(4):1227-1230.e4

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Characterization of proprotein convertase subtilisin/kexin type 9 (PCSK9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (APLP2).

DeVay RM, Shelton DL, Liang H
The Journal of biological chemistry 2013 Apr 12;288(15):10805-18

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Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route.

Poirier S, Mayer G, Poupon V, McPherson PS, Desjardins R, Ly K, Asselin MC, Day R, Duclos FJ, Witmer M, Parker R, Prat A, Seidah NG
The Journal of biological chemistry 2009 Oct 16;284(42):28856-64