CABT-B11800

antibody from Creative Diagnostics

Targeting: WRAP53 FLJ10385, TCAB1, WDR79

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B11800

Provider

Creative Diagnostics

Product name

Mouse anti-Human WRAP53 monoclonal antibody, clone 2G23

Antibody type

Monoclonal

Description

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5 untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5 UTR have been found for this gene. [provided by RefSeq, Mar 2011]

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2G23

Vial size

100 _g

Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.