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- Antigen structure
- References [12]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 16229-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16229-1-AP, RRID:AB_2264075
- Product name
- HEXB antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HEXB antibody (Cat. #16229-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi.
Combined single-cell RNA-seq and bulk RNA-seq construction of M2 TAMs signature for predicting HNSCC prognosis and immunotherapy.
The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.
Globotriaosylceramide Gb3 Influences Wound Healing and Scar Formation by Orchestrating Fibroblast Heterogeneity.
Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson's disease model mice.
Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumour growth in experimental hepatocellular carcinoma.
Characteristics of activation of monocyte-derived macrophages versus microglia after mouse experimental intracerebral hemorrhage.
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Identification and Validation of a Nine-Gene Amino Acid Metabolism-Related Risk Signature in HCC.
Microglia-Specific Expression of HEXA and HEXB Leads to Poor Prognosis in Glioblastoma Patients.
The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain.
Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.
Nüchel J, Omidi M, Fernandes SA, Tauber M, Pohl S, Plomann M, Demetriades C
EMBO reports 2026 Apr 16;
EMBO reports 2026 Apr 16;
Combined single-cell RNA-seq and bulk RNA-seq construction of M2 TAMs signature for predicting HNSCC prognosis and immunotherapy.
Wang J, Li H, Shi M, Ren C, Wei W, Zhao Q, He X, Yang Z, Wei J, Yang X
Frontiers in immunology 2025;16:1620931
Frontiers in immunology 2025;16:1620931
The mTORC2 subunit RICTOR drives breast cancer progression by promoting ganglioside biosynthesis through transcriptional and epigenetic mechanisms.
Ansari MN, Jha SK, Khan A, Rajput K, Pandey N, Jain D, Tripathi R, Medatwal N, Sharma P, Datta S, Kar A, Pani T, Ali SA, Cholke K, Rana K, Snijesh VP, Mukherjee G, Deo SVS, Basak S, Mishra A, Prabhu JS, Mukhopadhyay A, Bajaj A, Dasgupta U
PLoS biology 2025 Sep;23(9):e3003362
PLoS biology 2025 Sep;23(9):e3003362
Globotriaosylceramide Gb3 Influences Wound Healing and Scar Formation by Orchestrating Fibroblast Heterogeneity.
Xie S, Huang R, Qian W, Ding X, Zhang W, Li Y, Lu J, Sun H, Liu Y, Yao Y, Lu B, Wu M, Xia Z, Ji S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e09733
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e09733
Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson's disease model mice.
Song W, Zhou ZM, Zhang LL, Shu HF, Xia JR, Qin X, Hua R, Zhang YM
Cell death & disease 2025 Jan 14;16(1):18
Cell death & disease 2025 Jan 14;16(1):18
Oxidative stress induces extracellular vesicle release by upregulation of HEXB to facilitate tumour growth in experimental hepatocellular carcinoma.
Duan J, Huang Z, Qin S, Li B, Zhang Z, Liu R, Wang K, Nice EC, Jiang J, Huang C
Journal of extracellular vesicles 2024 Jul;13(7):e12468
Journal of extracellular vesicles 2024 Jul;13(7):e12468
Characteristics of activation of monocyte-derived macrophages versus microglia after mouse experimental intracerebral hemorrhage.
Ye F, Yang J, Holste KG, Koduri S, Hua Y, Keep RF, Garton HJ, Xi G
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2023 Sep;43(9):1475-1489
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2023 Sep;43(9):1475-1489
Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis.
Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr
Nature communications 2022 Oct 7;13(1):5924
Nature communications 2022 Oct 7;13(1):5924
Identification and Validation of a Nine-Gene Amino Acid Metabolism-Related Risk Signature in HCC.
Zhao Y, Zhang J, Wang S, Jiang Q, Xu K
Frontiers in cell and developmental biology 2021;9:731790
Frontiers in cell and developmental biology 2021;9:731790
Microglia-Specific Expression of HEXA and HEXB Leads to Poor Prognosis in Glioblastoma Patients.
Jia M, Zhang W, Zhu J, Huang C, Zhou J, Lian J, Wang Y, Teng H, Huang Z
Frontiers in oncology 2021;11:685893
Frontiers in oncology 2021;11:685893
The Role of Oxidized Cholesterol in Diabetes-Induced Lysosomal Dysfunction in the Brain.
Sims-Robinson C, Bakeman A, Rosko A, Glasser R, Feldman EL
Molecular neurobiology 2016 May;53(4):2287-96
Molecular neurobiology 2016 May;53(4):2287-96
Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo.
Bastow ER, Last K, Golub S, Stow JL, Stanley AC, Fosang AJ
Biology open 2012 Apr 15;1(4):318-28
Biology open 2012 Apr 15;1(4):318-28
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 16229-1-AP(HEXB antibody) at dilution of 1:200
- Sample type
- cell line
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HEXB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HEXB. This antibody recognizes human,mouse,rat antigen. The HEXB antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 16229-1-AP(HEXB antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
