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- Antibody Data
- Antigen structure
- References [45]
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- Immunohistochemistry [1]
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- Product number
- 13533-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- HMGCR antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HMGCR antibody (Cat. #13533-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Pitavastatin induces autophagy-dependent ferroptosis in MDA-MB-231 cells via the mevalonate pathway.
Atorvastatin causes developmental and behavioral toxicity in yellowstripe goby (Mugilogobius chulae) embryos/larvae via disrupting lipid metabolism and autophagy processes.
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.
L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer.
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non-small cell lung cancer.
Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.
Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction.
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.
Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation.
L-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway.
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells.
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes.
Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer.
Novel Metabolic Regulation of Bile Acid Responses to Low Cholesterol in Whole-Grain-Diet-Fed Mice.
Cholesterol was identified as a biomarker in human melanocytic nevi using DESI and DESI/PI mass spectrometry imaging.
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Circulating miR-27a-3p as a candidate for a biomarker of whole grain diets for lipid metabolism.
miR-144 Mediates High Fat-Induced Changes of Cholesterol Metabolism via Direct Regulation of C/EBPα in the Liver and Isolated Hepatocytes of Yellow Catfish.
Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids.
l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.
Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival.
Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells.
Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?
Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain.
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
The antihypercholesterolemic effect of columbamine from Rhizoma Coptidis in HFHC-diet induced hamsters through HNF-4α/FTF-mediated CYP7A1 activation.
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
Potent effects of dioscin against obesity in mice.
Tang WJ, Xu D, Liang MX, Wo GQ, Chen WQ, Tang JH, Zhang W
Heliyon 2024 Mar 15;10(5):e27084
Heliyon 2024 Mar 15;10(5):e27084
Atorvastatin causes developmental and behavioral toxicity in yellowstripe goby (Mugilogobius chulae) embryos/larvae via disrupting lipid metabolism and autophagy processes.
Zhao Y, Wang Y, Ren J, Gong W, Nie X, Peng Y, Li J, Duan C
Aquatic toxicology (Amsterdam, Netherlands) 2024 Jun;271:106909
Aquatic toxicology (Amsterdam, Netherlands) 2024 Jun;271:106909
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
Xing K, Bian X, Shi D, Dong S, Zhou H, Xiao S, Bai J, Wu W
Journal of hepatocellular carcinoma 2023;10:2173-2185
Journal of hepatocellular carcinoma 2023;10:2173-2185
MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism.
Xu X, Yu C, He H, Pan X, Hou A, Feng J, Tan R, Gong L, Chen J, Ren J
iScience 2023 Nov 17;26(11):108352
iScience 2023 Nov 17;26(11):108352
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA.
Zhang W, Pan X, Xu Y, Guo H, Zheng M, Chen X, Wu H, Luan F, He Q, Ding L, Yang B
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Acta pharmaceutica Sinica. B 2023 Jun;13(6):2585-2600
Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.
Yang QC, Wang S, Liu YT, Song A, Wu ZZ, Wan SC, Li HM, Sun ZJ
iScience 2023 Jun 16;26(6):106916
iScience 2023 Jun 16;26(6):106916
L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.
Xu W, Kong Y, Zhang T, Gong Z, Xiao W
Journal of the science of food and agriculture 2023 Feb;103(3):1283-1293
Journal of the science of food and agriculture 2023 Feb;103(3):1283-1293
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Yuan Y, Zhu Y, Li Y, Li X, Jiao R, Bai W
International journal of molecular sciences 2023 Feb 7;24(4)
International journal of molecular sciences 2023 Feb 7;24(4)
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer.
Tang W, Li G, Lin Q, Zhu Z, Wang Z, Wang Z
Journal of translational medicine 2023 Dec 7;21(1):887
Journal of translational medicine 2023 Dec 7;21(1):887
Decreased Imiquimod-Induced Psoriasis-Like Skin Inflammation in a Novel Mvd(F250S/+) Knock-In Mouse Model.
La Y, Wong W, Peng K, Tian Z, Pan J, Sun R, Luan J, Yan K, Zhang Q, Zhang Z
Inflammation 2023 Aug;46(4):1575-1586
Inflammation 2023 Aug;46(4):1575-1586
Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non-small cell lung cancer.
Mao W, Cai Y, Chen D, Jiang G, Xu Y, Chen R, Wang F, Wang X, Zheng M, Zhao X, Mei J
JCI insight 2022 Sep 22;7(18)
JCI insight 2022 Sep 22;7(18)
Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.
Wang Y, Wang Y, Ding L, Ren X, Wang B, Wang L, Zhao S, Yue X, Wu Z, Li C, Liang X, Ma C, Gao L
Cell reports 2022 Nov 29;41(9):111738
Cell reports 2022 Nov 29;41(9):111738
Probiotic-fermented rice buckwheat alleviates high-fat diet-induced hyperlipidemia in mice by suppressing lipid accumulation and modulating gut microbiota.
Yan J, Xue Q, Chen W, Wang K, Peng D, Jiang J, Li P, Du B
Food research international (Ottawa, Ont.) 2022 May;155:111125
Food research international (Ottawa, Ont.) 2022 May;155:111125
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Wang Q, Wang L, Abdullah, Tian W, Song M, Cao Y, Xiao J
Food & function 2022 Mar 21;13(6):3419-3430
Food & function 2022 Mar 21;13(6):3419-3430
Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction.
Wang HY, Yu P, Chen XS, Wei H, Cao SJ, Zhang M, Zhang Y, Tao YG, Cao DS, Qiu F, Cheng Y
Acta pharmacologica Sinica 2022 Jun;43(6):1594-1604
Acta pharmacologica Sinica 2022 Jun;43(6):1594-1604
Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.
Wang Y, Peng X, Zhou Z, Tang C, Liu W
Pharmaceutical biology 2022 Dec;60(1):1670-1678
Pharmaceutical biology 2022 Dec;60(1):1670-1678
Loss of Mature Lamin A/C Triggers a Shift in Intracellular Metabolic Homeostasis via AMPKα Activation.
Zhou Y, Yang JJ, Cheng Y, Feng GX, Yang RH, Yuan Y, Wang LY, Wang M, Kong L
Cells 2022 Dec 9;11(24)
Cells 2022 Dec 9;11(24)
L-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice.
Wang Y, Zhao J, Li Q, Liu J, Sun Y, Zhang K, Fan M, Qian H, Li Y, Wang L
Nutrition & metabolism 2022 Apr 15;19(1):30
Nutrition & metabolism 2022 Apr 15;19(1):30
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway.
Chen Z, Chen L, Sun B, Liu D, He Y, Qi L, Li G, Han Z, Zhan L, Zhang S, Zhu K, Luo Y, Chen L, Zhang N, Guo H
Molecular metabolism 2021 Sep;51:101230
Molecular metabolism 2021 Sep;51:101230
TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
Ho WY, Chang JC, Lim K, Cazenave-Gassiot A, Nguyen AT, Foo JC, Muralidharan S, Viera-Ortiz A, Ong SJM, Hor JH, Agrawal I, Hoon S, Arogundade OA, Rodriguez MJ, Lim SM, Kim SH, Ravits J, Ng SY, Wenk MR, Lee EB, Tucker-Kellogg G, Ling SC
The Journal of cell biology 2021 Sep 6;220(9)
The Journal of cell biology 2021 Sep 6;220(9)
Defining the Cholesterol Lowering Mechanism of Bergamot (Citrus bergamia) Extract in HepG2 and Caco-2 Cells.
Huang Y, Tocmo R, Nauman MC, Haughan MA, Johnson JJ
Nutrients 2021 Sep 10;13(9)
Nutrients 2021 Sep 10;13(9)
Role of Epigallocatechin Gallate in Glucose, Lipid, and Protein Metabolism and L-Theanine in the Metabolism-Regulatory Effects of Epigallocatechin Gallate.
Lin L, Zeng L, Liu A, Yuan D, Peng Y, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Nutrients 2021 Nov 17;13(11)
Nutrients 2021 Nov 17;13(11)
Localisation and regulation of cholesterol transporters in the human hair follicle: mapping changes across the hair cycle.
Palmer MA, Smart E, Haslam IS
Histochemistry and cell biology 2021 May;155(5):529-545
Histochemistry and cell biology 2021 May;155(5):529-545
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
Improvement of hyperlipidemia by aerobic exercise in mice through a regulatory effect of miR-21a-5p on its target genes.
Zhao J, Song Y, Zeng Y, Chen L, Yan F, Chen A, Wu B, Wang Y
Scientific reports 2021 Jun 7;11(1):11966
Scientific reports 2021 Jun 7;11(1):11966
Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer.
Xu H, Xia H, Zhou S, Tang Q, Bi F
Cell death discovery 2021 Feb 26;7(1):38
Cell death discovery 2021 Feb 26;7(1):38
Novel Metabolic Regulation of Bile Acid Responses to Low Cholesterol in Whole-Grain-Diet-Fed Mice.
Liu J, Wang Y, Xue L, Nie C, Sun J, Fan M, Qian H, Wang L, Li Y
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8440-8447
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8440-8447
Cholesterol was identified as a biomarker in human melanocytic nevi using DESI and DESI/PI mass spectrometry imaging.
Qi K, Lv Y, Ren Y, Wang X, Wu L, Wang J, Zhang X, He Y, Zhang C, Liu C, Pan Y
Talanta 2021 Aug 15;231:122380
Talanta 2021 Aug 15;231:122380
L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding.
Xu W, Lin L, Liu A, Zhang T, Zhang S, Li Y, Chen J, Gong Z, Liu Z, Xiao W
Food & function 2020 Sep 23;11(9):8369-8379
Food & function 2020 Sep 23;11(9):8369-8379
Circulating miR-27a-3p as a candidate for a biomarker of whole grain diets for lipid metabolism.
Liu J, Li Y, Xue L, Fan M, Nie C, Wang Y, Zhang H, Qian H, Wang L
Food & function 2020 Oct 21;11(10):8852-8865
Food & function 2020 Oct 21;11(10):8852-8865
miR-144 Mediates High Fat-Induced Changes of Cholesterol Metabolism via Direct Regulation of C/EBPα in the Liver and Isolated Hepatocytes of Yellow Catfish.
Chen G, Wu K, Zhao T, Ling S, Liu W, Luo Z
The Journal of nutrition 2020 Mar 1;150(3):464-474
The Journal of nutrition 2020 Mar 1;150(3):464-474
Geniposide reduces cholesterol accumulation and increases its excretion by regulating the FXR-mediated liver-gut crosstalk of bile acids.
Liu J, Li Y, Sun C, Liu S, Yan Y, Pan H, Fan M, Xue L, Nie C, Zhang H, Qian H, Ying H, Wang L
Pharmacological research 2020 Feb;152:104631
Pharmacological research 2020 Feb;152:104631
l-Theanine regulates glucose, lipid, and protein metabolism via insulin and AMP-activated protein kinase signaling pathways.
Lin L, Zeng L, Liu A, Peng Y, Yuan D, Zhang S, Li Y, Chen J, Xiao W, Gong Z
Food & function 2020 Feb 26;11(2):1798-1809
Food & function 2020 Feb 26;11(2):1798-1809
Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival.
Wang LW, Wang Z, Ersing I, Nobre L, Guo R, Jiang S, Trudeau S, Zhao B, Weekes MP, Gewurz BE
PLoS pathogens 2019 Sep;15(9):e1008030
PLoS pathogens 2019 Sep;15(9):e1008030
Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells.
Lu J, Meng Z, Cheng B, Liu M, Tao S, Guan S
Experimental and therapeutic medicine 2019 Oct;18(4):2965-2971
Experimental and therapeutic medicine 2019 Oct;18(4):2965-2971
Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?
Wu G, Wang Q, Xu Y, Li J, Zhang H, Qi G, Xia Q
Cell death & disease 2019 May 28;10(6):416
Cell death & disease 2019 May 28;10(6):416
Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.
Yang D, Hu C, Deng X, Bai Y, Cao H, Guo J, Su Z
Molecules (Basel, Switzerland) 2019 Jan 31;24(3)
Molecules (Basel, Switzerland) 2019 Jan 31;24(3)
Cholesterol-lowering effects and potential mechanisms of chitooligosaccharide capsules in hyperlipidemic rats.
Jiang Y, Fu C, Liu G, Guo J, Su Z
Food & nutrition research 2018;62
Food & nutrition research 2018;62
Lead exposure induces Alzheimers's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain.
Zhou CC, Gao ZY, Wang J, Wu MQ, Hu S, Chen F, Liu JX, Pan H, Yan CH
Toxicology letters 2018 Oct 15;296:173-183
Toxicology letters 2018 Oct 15;296:173-183
Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.
He K, Hu Y, Ma H, Zou Z, Xiao Y, Yang Y, Feng M, Li X, Ye X
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
Biochimica et biophysica acta 2016 Sep;1862(9):1696-709
The antihypercholesterolemic effect of columbamine from Rhizoma Coptidis in HFHC-diet induced hamsters through HNF-4α/FTF-mediated CYP7A1 activation.
Wang Y, Han Y, Chai F, Xiang H, Huang T, Kou S, Han B, Gong X, Ye X
Fitoterapia 2016 Dec;115:111-121
Fitoterapia 2016 Dec;115:111-121
Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.
He K, Li X, Xiao Y, Yong Y, Zhang Z, Li S, Zhou T, Yang D, Gao P, Xin X
Food & function 2016 Aug 10;7(8):3505-15
Food & function 2016 Aug 10;7(8):3505-15
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HMGCR antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HMGCR. This antibody recognizes human,mouse,rat antigen. The HMGCR antibody has been validated for the following applications: ELISA, IHC analysis.
