Tissue expression
Cell line expression
Protein structure
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductaseHMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Top validated antibodies |
|||||
Invitrogen Antibodies | PA5-37367 | 9 references | Polyclonal |
WB
ICC
IHC
OA |
|
NSJ Bioreagents | RQ7289 | Polyclonal |
WB
EL
ICC
IHC
FC
|
||
Proteintech Group | 13533-1-AP | 45 references | Polyclonal |
EL
IHC |
|
LSBio | LS-C331599 | Polyclonal |
WB
ICC
IHC
|
||
Biorbyt | orb1290009 | Polyclonal |
WB
EL
ICC
IHC
FC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider