Tissue expression
Cell line expression

HMGCR

gene product
 
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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364 antibodies from 35 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
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1 antibody
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5 antibodies
Atlas Antibodies
3 antibodies
antibodies-online
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GeneTex
3 antibodies
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Wuhan Fine Biotech Co., Ltd.
2 antibodies
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3 antibodies
Affinity Biosciences
1 antibody
Bioworld Technology, Inc
1 antibody
Boster Biological Technology
2 antibodies
HUABIO Research
1 antibody
Creative Biolabs
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RabMAbs
1 antibody
Abnova Corporation
3 antibodies
OriGene
2 antibodies
NSJ Bioreagents
1 antibody
Abbexa
8 antibodies
Aviva Systems Biology
3 antibodies
MyBioSource
5 antibodies
Creative Diagnostics
4 antibodies
Abiocode, Inc.
1 antibody
United States Biological
24 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
EMD Millipore
2 antibodies
Abgent
2 antibodies
Leading Biology
2 antibodies
Everest Biotech
1 antibody
RayBiotech, Inc.
1 antibody
ProSci
1 antibody