Tissue expression
Cell line expression
Protein structure
ADAM15
ADAM metallopeptidase domain 15MDC15
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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R&D Systems | ![]() |
2 references | Monoclonal |
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Invitrogen Antibodies | ![]() |
Monoclonal |
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Novus Biologicals | ![]() |
Monoclonal |
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NovoPro Bioscience Inc. | ![]() |
Monoclonal |
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GeneTex | ![]() |
1 references | Polyclonal |
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