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- Antibody Data
- Antigen structure
- References [34]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15851-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15851-1-AP, RRID:AB_2175014
- Product name
- PYGL antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PYGL antibody (Cat. #15851-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Si-Ni-San promotes liver regeneration by maintaining hepatic oxidative equilibrium and glucose/lipid metabolism homeostasis.
Radix Astragali decoction improves liver regeneration by upregulating hepatic expression of aquaporin-9.
PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer.
The effect of hormones insulin and glucagon on ubiquitin modifications elucidated by proteomics in liver cells.
Depressed Proximal Glycolysis in Myocardium Of Human Heart Failure with Preserved Ejection Fraction.
Identification of Exosome-Related Genes Associated with Prognosis and Immune Infiltration Features in Head-Neck Squamous Cell Carcinoma.
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Metabolic alterations and mitochondrial dysfunction underlie hepatocellular carcinoma cell death induced by a glycogen metabolic inhibitor.
Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers.
MYCT1 alters the glycogen shunt by regulating selective translation of RACK1-mediated enzymes.
Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes.
Liver fibrosis alters the molecular structures of hepatic glycogen.
Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis.
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
Brain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice.
Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase.
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis.
Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders.
The different expression of glycogen phosphorylases in renal clear cell renal carcinoma and chromophobe renal carcinoma.
Chronic liver disease and impaired hepatic glycogen metabolism in argininosuccinate lyase deficiency.
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.
Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis.
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice.
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Induction of protective immunity against Chlamydia muridarum intravaginal infection with a chlamydial glycogen phosphorylase.
20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.
Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice.
Yang X, Zhang J, Li Y, Hu H, Li X, Ma T, Zhang B
Journal of ethnopharmacology 2024 May 23;326:117918
Journal of ethnopharmacology 2024 May 23;326:117918
Radix Astragali decoction improves liver regeneration by upregulating hepatic expression of aquaporin-9.
Li Y, Yang X, Bao T, Sun X, Li X, Zhu H, Zhang B, Ma T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155166
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155166
PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer.
Ji Q, Li H, Cai Z, Yuan X, Pu X, Huang Y, Fu S, Chu L, Jiang C, Xue J, Zhang X, Li R
International journal of biological sciences 2023;19(6):1894-1909
International journal of biological sciences 2023;19(6):1894-1909
The effect of hormones insulin and glucagon on ubiquitin modifications elucidated by proteomics in liver cells.
Vemana HP, Dukhande VV
Life sciences 2023 Sep 15;329:121935
Life sciences 2023 Sep 15;329:121935
Depressed Proximal Glycolysis in Myocardium Of Human Heart Failure with Preserved Ejection Fraction.
Koleini N, Meddeb M, Keykhaei M, Kwon S, Zhao L, Hahn V, Sharma K, Pearce EL, Kass DA
medRxiv : the preprint server for health sciences 2023 Oct 2;
medRxiv : the preprint server for health sciences 2023 Oct 2;
Identification of Exosome-Related Genes Associated with Prognosis and Immune Infiltration Features in Head-Neck Squamous Cell Carcinoma.
You Y, Du Z, Xu G, Tian Z, Xiao M, Wang Y
Biomolecules 2023 Jun 7;13(6)
Biomolecules 2023 Jun 7;13(6)
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Rome FI, Shobert GL, Voigt WC, Stagg DB, Puchalska P, Burgess SC, Crawford PA, Hughey CC
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
Metabolic alterations and mitochondrial dysfunction underlie hepatocellular carcinoma cell death induced by a glycogen metabolic inhibitor.
Barot S, Stephenson OJ, Priya Vemana H, Yadav A, Bhutkar S, Trombetta LD, Dukhande VV
Biochemical pharmacology 2022 Sep;203:115201
Biochemical pharmacology 2022 Sep;203:115201
Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism or systemic lipolysis in rat.
Liu Z, Zhang L, Qian C, Zhou Y, Yu Q, Yuan J, Lv Y, Zhang L, Chang X, Li Y, Liu Y
Metabolism: clinical and experimental 2022 Nov;136:155310
Metabolism: clinical and experimental 2022 Nov;136:155310
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Glycogen Storage Disease Phenotypes Accompanying the Perturbation of the Methionine Cycle in NDRG3-Deficient Mouse Livers.
Sohn HA, Lee DC, Park A, Kang M, Yoon BH, Lee CH, Kim YH, Oh KJ, Kim CY, Park SH, Koo H, Kim HC, Yoon WK, Lim DS, Kim D, Park KC, Yeom YI
Cells 2022 May 4;11(9)
Cells 2022 May 4;11(9)
MYCT1 alters the glycogen shunt by regulating selective translation of RACK1-mediated enzymes.
Ding DX, Wang Y, Yan W, Fu WN
iScience 2022 Mar 18;25(3):103955
iScience 2022 Mar 18;25(3):103955
Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes.
Maschalidi S, Mehrotra P, Keçeli BN, De Cleene HKL, Lecomte K, Van der Cruyssen R, Janssen P, Pinney J, van Loo G, Elewaut D, Massie A, Hoste E, Ravichandran KS
Nature 2022 Jun;606(7915):776-784
Nature 2022 Jun;606(7915):776-784
Liver fibrosis alters the molecular structures of hepatic glycogen.
Wan Y, Hu Z, Liu Q, Wang L, Sullivan MA, Gilbert RG
Carbohydrate polymers 2022 Feb 15;278:118991
Carbohydrate polymers 2022 Feb 15;278:118991
Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis.
Zhang Z, Chen Y, Yin Y, Chen Y, Chen Q, Bing Z, Zheng Y, Hou Y, Shen S, Chen Y, Wang T
International immunopharmacology 2022 Dec;113(Pt B):109430
International immunopharmacology 2022 Dec;113(Pt B):109430
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
Rome FI, Hughey CC
Molecular metabolism 2022 Apr;58:101452
Molecular metabolism 2022 Apr;58:101452
Brain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice.
Zhu Y, Fan Z, Zhao Q, Li J, Cai G, Wang R, Liang Y, Lu N, Kang J, Luo D, Tao H, Li Y, Huang J, Wu S
Frontiers in molecular neuroscience 2021;14:819440
Frontiers in molecular neuroscience 2021;14:819440
Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase.
Figlak K, Williams G, Bertolini M, Paus R, Philpott MP
Scientific reports 2021 Oct 21;11(1):20761
Scientific reports 2021 Oct 21;11(1):20761
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis.
Picard A, Metref S, Tarussio D, Dolci W, Berney X, Croizier S, Labouebe G, Thorens B
Diabetes 2021 Jul;70(7):1443-1457
Diabetes 2021 Jul;70(7):1443-1457
Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders.
Soria LR, Gurung S, De Sabbata G, Perocheau DP, De Angelis A, Bruno G, Polishchuk E, Paris D, Cuomo P, Motta A, Orford M, Khalil Y, Eaton S, Mills PB, Waddington SN, Settembre C, Muro AF, Baruteau J, Brunetti-Pierri N
EMBO molecular medicine 2021 Feb 5;13(2):e13158
EMBO molecular medicine 2021 Feb 5;13(2):e13158
The different expression of glycogen phosphorylases in renal clear cell renal carcinoma and chromophobe renal carcinoma.
Lu Y, Luo G, Zhu S, Wang X, Chen Y, Dong Z, Wang S, Ma J, Deng H, Wu D, Dong J
Clinical proteomics 2020;17:7
Clinical proteomics 2020;17:7
Chronic liver disease and impaired hepatic glycogen metabolism in argininosuccinate lyase deficiency.
Burrage LC, Madan S, Li X, Ali S, Mohammad M, Stroup BM, Jiang MM, Cela R, Bertin T, Jin Z, Dai J, Guffey D, Finegold M, Members of the Urea Cycle Disorders Consortium (UCDC), Nagamani S, Minard CG, Marini J, Masand P, Schady D, Shneider BL, Leung DH, Bali D, Lee B
JCI insight 2020 Feb 27;5(4)
JCI insight 2020 Feb 27;5(4)
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Gu Z, Zhang H, Guo X, Cao Y
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
Curtis M, Kenny HA, Ashcroft B, Mukherjee A, Johnson A, Zhang Y, Helou Y, Batlle R, Liu X, Gutierrez N, Gao X, Yamada SD, Lastra R, Montag A, Ahsan N, Locasale JW, Salomon AR, Nebreda AR, Lengyel E
Cell metabolism 2019 Jan 8;29(1):141-155.e9
Cell metabolism 2019 Jan 8;29(1):141-155.e9
Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.
Wang Z, Jiang SF, Cao J, Liu K, Xu SH, Arfat Y, Guo QL, Chang H, Goswami N, Hinghofer-Szalkay H, Gao YF
Journal of cellular physiology 2019 Aug;234(8):13318-13331
Journal of cellular physiology 2019 Aug;234(8):13318-13331
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K
Nature medicine 2018 Sep;24(9):1395-1406
Nature medicine 2018 Sep;24(9):1395-1406
Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.
Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR
The Journal of clinical investigation 2018 Jun 1;128(6):2226-2238
The Journal of clinical investigation 2018 Jun 1;128(6):2226-2238
Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis.
Han Q, Ma Y, Wang H, Dai Y, Chen C, Liu Y, Jing L, Sun X
Journal of translational medicine 2018 Jul 20;16(1):201
Journal of translational medicine 2018 Jul 20;16(1):201
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
Thwe PM, Pelgrom LR, Cooper R, Beauchamp S, Reisz JA, D'Alessandro A, Everts B, Amiel E
Cell metabolism 2017 Sep 5;26(3):558-567.e5
Cell metabolism 2017 Sep 5;26(3):558-567.e5
1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice.
Wang T, Xu D, Fan Q, Rong W, Zheng J, Gao C, Li G, Zeng N, Guo T, Zeng L, Wang F, Xiao C, Cai L, Tang S, Deng X, Yin X, Huang M, Lu F, Hu Q, Chen W, Huang Z, Wang Q
Toxicology 2017 Apr 1;380:38-49
Toxicology 2017 Apr 1;380:38-49
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Yang R, Zhang M, Gustafson AR, Wang E, Cole MP, Tooley CE, Cheng A
Bioscience reports 2015 May 1;35(3)
Bioscience reports 2015 May 1;35(3)
Induction of protective immunity against Chlamydia muridarum intravaginal infection with a chlamydial glycogen phosphorylase.
Li Z, Lu C, Peng B, Zeng H, Zhou Z, Wu Y, Zhong G
PloS one 2012;7(3):e32997
PloS one 2012;7(3):e32997
20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.
Lai G, Wu J, Liu X, Zhao Y
Molecular endocrinology (Baltimore, Md.) 2012 Nov;26(11):1907-16
Molecular endocrinology (Baltimore, Md.) 2012 Nov;26(11):1907-16
Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice.
Shinozaki S, Choi CS, Shimizu N, Yamada M, Kim M, Zhang T, Shiota G, Dong HH, Kim YB, Kaneki M
The Journal of biological chemistry 2011 Oct 7;286(40):34959-75
The Journal of biological chemistry 2011 Oct 7;286(40):34959-75
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15851-1-AP(PYGL antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15851-1-AP(PYGL antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PYGL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PYGL. This antibody recognizes human, mouse, rat antigen. The PYGL antibody has been validated for the following applications: ELISA, WB, IHC analysis.
