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- Antigen structure
- References [16]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15851-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15851-1-AP, RRID:AB_2175014
- Product name
- PYGL antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PYGL antibody (Cat. #15851-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase.
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis.
Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders.
Chronic liver disease and impaired hepatic glycogen metabolism in argininosuccinate lyase deficiency.
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.
Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis.
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice.
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Induction of protective immunity against Chlamydia muridarum intravaginal infection with a chlamydial glycogen phosphorylase.
20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.
Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice.
Figlak K, Williams G, Bertolini M, Paus R, Philpott MP
Scientific reports 2021 Oct 21;11(1):20761
Scientific reports 2021 Oct 21;11(1):20761
Fgf15 Neurons of the Dorsomedial Hypothalamus Control Glucagon Secretion and Hepatic Gluconeogenesis.
Picard A, Metref S, Tarussio D, Dolci W, Berney X, Croizier S, Labouebe G, Thorens B
Diabetes 2021 Jul;70(7):1443-1457
Diabetes 2021 Jul;70(7):1443-1457
Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders.
Soria LR, Gurung S, De Sabbata G, Perocheau DP, De Angelis A, Bruno G, Polishchuk E, Paris D, Cuomo P, Motta A, Orford M, Khalil Y, Eaton S, Mills PB, Waddington SN, Settembre C, Muro AF, Baruteau J, Brunetti-Pierri N
EMBO molecular medicine 2021 Feb 5;13(2):e13158
EMBO molecular medicine 2021 Feb 5;13(2):e13158
Chronic liver disease and impaired hepatic glycogen metabolism in argininosuccinate lyase deficiency.
Burrage LC, Madan S, Li X, Ali S, Mohammad M, Stroup BM, Jiang MM, Cela R, Bertin T, Jin Z, Dai J, Guffey D, Finegold M, Members of the Urea Cycle Disorders Consortium (UCDC)., Nagamani S, Minard CG, Marini J, Masand P, Schady D, Shneider BL, Leung DH, Bali D, Lee B
JCI insight 2020 Feb 27;5(4)
JCI insight 2020 Feb 27;5(4)
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Gu Z, Zhang H, Guo X, Cao Y
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5
Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
Curtis M, Kenny HA, Ashcroft B, Mukherjee A, Johnson A, Zhang Y, Helou Y, Batlle R, Liu X, Gutierrez N, Gao X, Yamada SD, Lastra R, Montag A, Ahsan N, Locasale JW, Salomon AR, Nebreda AR, Lengyel E
Cell metabolism 2019 Jan 8;29(1):141-155.e9
Cell metabolism 2019 Jan 8;29(1):141-155.e9
Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen.
Wang Z, Jiang SF, Cao J, Liu K, Xu SH, Arfat Y, Guo QL, Chang H, Goswami N, Hinghofer-Szalkay H, Gao YF
Journal of cellular physiology 2019 Aug;234(8):13318-13331
Journal of cellular physiology 2019 Aug;234(8):13318-13331
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase.
Hunter RW, Hughey CC, Lantier L, Sundelin EI, Peggie M, Zeqiraj E, Sicheri F, Jessen N, Wasserman DH, Sakamoto K
Nature medicine 2018 Sep;24(9):1395-1406
Nature medicine 2018 Sep;24(9):1395-1406
Ketohexokinase C blockade ameliorates fructose-induced metabolic dysfunction in fructose-sensitive mice.
Lanaspa MA, Andres-Hernando A, Orlicky DJ, Cicerchi C, Jang C, Li N, Milagres T, Kuwabara M, Wempe MF, Rabinowitz JD, Johnson RJ, Tolan DR
The Journal of clinical investigation 2018 Jun 1;128(6):2226-2238
The Journal of clinical investigation 2018 Jun 1;128(6):2226-2238
Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis.
Han Q, Ma Y, Wang H, Dai Y, Chen C, Liu Y, Jing L, Sun X
Journal of translational medicine 2018 Jul 20;16(1):201
Journal of translational medicine 2018 Jul 20;16(1):201
Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses.
Thwe PM, Pelgrom LR, Cooper R, Beauchamp S, Reisz JA, D'Alessandro A, Everts B, Amiel E
Cell metabolism 2017 Sep 5;26(3):558-567.e5
Cell metabolism 2017 Sep 5;26(3):558-567.e5
1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice.
Wang T, Xu D, Fan Q, Rong W, Zheng J, Gao C, Li G, Zeng N, Guo T, Zeng L, Wang F, Xiao C, Cai L, Tang S, Deng X, Yin X, Huang M, Lu F, Hu Q, Chen W, Huang Z, Wang Q
Toxicology 2017 Apr 1;380:38-49
Toxicology 2017 Apr 1;380:38-49
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Yang R, Zhang M, Gustafson AR, Wang E, Cole MP, Tooley CE, Cheng A
Bioscience reports 2015 May 1;35(3)
Bioscience reports 2015 May 1;35(3)
Induction of protective immunity against Chlamydia muridarum intravaginal infection with a chlamydial glycogen phosphorylase.
Li Z, Lu C, Peng B, Zeng H, Zhou Z, Wu Y, Zhong G
PloS one 2012;7(3):e32997
PloS one 2012;7(3):e32997
20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.
Lai G, Wu J, Liu X, Zhao Y
Molecular endocrinology (Baltimore, Md.) 2012 Nov;26(11):1907-16
Molecular endocrinology (Baltimore, Md.) 2012 Nov;26(11):1907-16
Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice.
Shinozaki S, Choi CS, Shimizu N, Yamada M, Kim M, Zhang T, Shiota G, Dong HH, Kim YB, Kaneki M
The Journal of biological chemistry 2011 Oct 7;286(40):34959-75
The Journal of biological chemistry 2011 Oct 7;286(40):34959-75
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 15851-1-AP(PYGL antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 15851-1-AP(PYGL antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PYGL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PYGL. This antibody recognizes human, mouse, rat antigen. The PYGL antibody has been validated for the following applications: ELISA, WB, IHC analysis.
