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- References [79]
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- Product number
- 21698-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21698-1-AP, RRID:AB_10858626
- Product name
- NEDD4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NEDD4 antibody (Cat. #21698-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, monkey and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Triptonide-mediated PTGS2 Inhibition Induces Autophagic Cell Death to Suppress the Progression of Triple-negative Breast Cancer and Epithelial Ovarian Cancer.
NEDD4 promotes reactive astrogliosis by enhancing K63-linked ubiquitination and inhibiting chaperone-mediated autophagy degradation of YAP1.
TMEM207-mediated the impairment of skin regeneration through YAP sequestration in an allergic contact dermatitis model.
Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin.
Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism.
K63-linked ubiquitylation of S2P-RNAPII regulates transcription in a DNAPK inter-dependent manner in response to double-strand breaks.
E3 ubiquitin ligase NEDD4 inhibits PEDV infection through ubiquitination and degradation of the viral primase NSP8.
Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss.
Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin-Mediated Regulation of ENO1.
Inhibiting NEDD4 in triple-negative breast cancer cells reprograms tumor immune microenvironment via the β-TrCP/YAP/ECM axis.
Loss of CFIm activates YAP/TAZ and connects mRNA cleavage and polyadenylation inhibition to BRCAness.
Hypoxia-induced degradation of FTO promotes apoptosis by unmasking RACK1-mediated activation of MTK1-JNK1/2 pathway.
GDNF signaling modulation by Akkermansia muciniphila ameliorates constipation-depression comorbidity in Parkinson's disease.
Ferroptosis-Related Genes Are Effective Markers for Diagnostic Targets of Crohn's Disease.
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
NEDD4 facilitates the progression of endometrial carcinoma by enhancing PAMR1 protein degradation through ubiquitination.
Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR.
OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model.
K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity.
HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells.
Lack of intestinal Mucin-1 impairs intestinal epithelial barrier and promotes metabolic dysfunction-associated steatotic liver disease in male mice.
Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway.
NEDD4 suppresses ferroptosis in lung ischemia-reperfusion injury by ubiquitinating and degrading SLC1A5.
The E3 ubiquitin ligase FBXL18 stabilizes BST2 to promote inflammation in RABV-infected astrocytes.
Artesunate attenuates cerebral injury after cardiac arrest via inhibiting caspase-11-mediated pyroptosis through NEDD4.
UBE2C promotes pancreatic tumorigenesis by KRAS stabilization via APC/C(CDH1)-mediated WDR76 degradation.
µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.
NEDD4-Mediated Endothelial-Mesenchymal Transition Participates in Radiation-Induced Lung Injury Through the ATM Signaling Pathway.
FAT10 mediates the sorafenib-resistance of hepatocellular carcinoma cells by stabilizing E3 ligase NEDD4 to enhance PTEN/AKT pathway-induced autophagy.
Ceftriaxone Modulates Ubiquitination of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid Receptors to Improve Long-Term Potentiation Impairment Induced by Exogenous β-Amyloid in a Glutamate Transporter-1 Dependent Manner.
Gentiopicroside ameliorates glucose and lipid metabolism in T2DM via targeting FGFR1.
Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1.
N4BP3 facilitates NOD2-MAPK/NF-κB pathway in inflammatory bowel disease through mediating K63-linked RIPK2 ubiquitination.
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis.
Mecp2 fine-tunes quiescence exit by targeting nuclear receptors.
Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.
DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice.
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Inhibition of RIPK1 alleviating vascular smooth muscle cells osteogenic transdifferentiation via Runx2.
Downregulation of CD86 in HCMV-infected THP-1 cells.
Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids.
Fish Snx27 promotes viral products by modulating the innate immune response and exosomal machinery.
The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif.
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma.
Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells.
Hepatocytic lipocalin-2 controls HDL metabolism and atherosclerosis via Nedd4-1-SR-BI axis in mice.
FGF21 protects against doxorubicin-induced cardiotoxicity by inhibiting connexin 43 ubiquitination.
Multi-Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins.
Xinbao Pill attenuated chronic heart failure by suppressing the ubiquitination of β-adrenergic receptors.
CFDP1 promotes hepatocellular carcinoma progression through activating NEDD4/PTEN/PI3K/AKT signaling pathway.
hCINAP regulates the differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase-separation-mediated YAP1 activation.
NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis.
High glucose environment induces NEDD4 deficiency that impairs angiogenesis and diabetic wound healing.
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer.
PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex.
Identification of Marek's disease virus pUL56 homologue and analysis of critical amino acid stretches indispensable for its intracellular localization.
NEDD4 attenuates phosgene-induced acute lung injury through the inhibition of Notch1 activation.
Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination.
Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4.
Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4.
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis.
Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway.
Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases.
HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity.
Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway.
JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling.
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.
Multivesicular body sorting and the exosomal pathway are required for the release of rat hepatitis E virus from infected cells.
Promotion of liver growth by CAR is accompanied by Akt pathway activation and FoxM1-Nedd4-mediated repression of PTEN.
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.
N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21.
Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.
Inhibition of ubiquitin proteasome function prevents monocrotaline-induced pulmonary arterial remodeling.
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.
O-GlcNAc regulates NEDD4-1 stability via caspase-mediated pathway.
Gong K, Song K, Wang H, Li L, Sun X, Sun L, Hao W, Chen ZS, Huang Y
International journal of biological sciences 2026;22(5):2215-2232
International journal of biological sciences 2026;22(5):2215-2232
NEDD4 promotes reactive astrogliosis by enhancing K63-linked ubiquitination and inhibiting chaperone-mediated autophagy degradation of YAP1.
Ye W, Li Y, Wang W, Pan D, Wang X, Gu Y, Zhu Y, Wang H, Lu X, Jiang D, Tang P, Shu H, Ma J, Cai W
International journal of biological sciences 2026;22(2):858-875
International journal of biological sciences 2026;22(2):858-875
TMEM207-mediated the impairment of skin regeneration through YAP sequestration in an allergic contact dermatitis model.
Nomura S, Kito Y, Saigo C, Takeuchi T
Biochemistry and biophysics reports 2026 Mar;45:102409
Biochemistry and biophysics reports 2026 Mar;45:102409
Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin.
Jeong H, Qin Y, Xu F, Trajkovic K, Kim MJ, Marotta N, Hamada K, Allada R, Yang S, Krainc D
JCI insight 2026 Feb 23;11(4)
JCI insight 2026 Feb 23;11(4)
Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism.
Byrd A, Marmorale LJ, Marcinowski S, Dykstra MM, Addison V, Barmada SJ, Buchan JR
The Journal of cell biology 2026 Feb 2;225(2)
The Journal of cell biology 2026 Feb 2;225(2)
K63-linked ubiquitylation of S2P-RNAPII regulates transcription in a DNAPK inter-dependent manner in response to double-strand breaks.
Pantazi V, Smith P, Pahi ZG, Katona M, Pap A, Darula Z, Fischer R, Vendrell I, Kessler BM, van Vugt MATM, D'Angiolella V, Pankotai T
Nucleic acids research 2026 Apr 23;54(8)
Nucleic acids research 2026 Apr 23;54(8)
E3 ubiquitin ligase NEDD4 inhibits PEDV infection through ubiquitination and degradation of the viral primase NSP8.
Guo X, Zhao X, He J, Lu Y, Jin S, Ma Z, Li Z, Zheng Z, Li Y, Feng Y, Xu L, Liu X, Zhang J, Wei Z, Zheng H, Xiao S
Journal of virology 2026 Apr 21;100(4):e0215625
Journal of virology 2026 Apr 21;100(4):e0215625
Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss.
Yuan C, Ma T, Liu M, Jiang L, Tang G, Hu Q, Zhang T
Frontiers in aging neuroscience 2025;17:1526519
Frontiers in aging neuroscience 2025;17:1526519
Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin-Mediated Regulation of ENO1.
Sun N, Wang YB, Huang J, Deng RW, He HY, Gao L, Gao X, Fan YL, Cong Y, Guo YL, Chen YQ, Wang GJ, Fang SH, Gu X, Yu B, Wu BX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e00096
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(35):e00096
Inhibiting NEDD4 in triple-negative breast cancer cells reprograms tumor immune microenvironment via the β-TrCP/YAP/ECM axis.
Su N, Lian W, Zhang B, Tian Y, Li L, Chen Y, Zhi X, Zeng T, Wu Q, Chen L, Zhou D, Wang HR, Cheng SC, Li L, Deng X
Cell reports. Medicine 2025 Oct 21;6(10):102420
Cell reports. Medicine 2025 Oct 21;6(10):102420
Loss of CFIm activates YAP/TAZ and connects mRNA cleavage and polyadenylation inhibition to BRCAness.
Goldthorpe M, Hou J, Nadendla A, Osmanbeyoglu HU, Hwang HW
bioRxiv : the preprint server for biology 2025 Oct 21;
bioRxiv : the preprint server for biology 2025 Oct 21;
Hypoxia-induced degradation of FTO promotes apoptosis by unmasking RACK1-mediated activation of MTK1-JNK1/2 pathway.
Li C, Liu Z, Fu C, Li H, He T, Wu G, Sheng Y, Shen M, Liu H
Journal of advanced research 2025 Nov;77:137-153
Journal of advanced research 2025 Nov;77:137-153
GDNF signaling modulation by Akkermansia muciniphila ameliorates constipation-depression comorbidity in Parkinson's disease.
Mu C, Zhou Z, Li J, Su M, Xue K, Zhang J, Shi S, Li Y, Yao X, Wang M, Zhang W, Wang Z, Zhu J, Fang S, Wang W, Tang C, Qin X
NPJ Parkinson's disease 2025 Nov 28;11(1):342
NPJ Parkinson's disease 2025 Nov 28;11(1):342
Ferroptosis-Related Genes Are Effective Markers for Diagnostic Targets of Crohn's Disease.
Liu P, Liu Q, Tian Y, Cai P, Bai J
Immunity, inflammation and disease 2025 Mar;13(3):e70170
Immunity, inflammation and disease 2025 Mar;13(3):e70170
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
NEDD4 facilitates the progression of endometrial carcinoma by enhancing PAMR1 protein degradation through ubiquitination.
Guo H, Tang H, Yang Y, Xu H, Fan J, Chen S, Hou L, Yuan Y, Zhang G
Functional & integrative genomics 2025 Mar 15;25(1):65
Functional & integrative genomics 2025 Mar 15;25(1):65
Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR.
Wu Z, Ye Q, Zhang S, Hu LP, Wang XQ, Yao LL, Zhu L, Xiao SY, Duan ZH, Zhang XL, Jiang SH, Zhang ZG, Liu DJ, Li DX, Yang XM
Clinical and translational medicine 2025 Jan;15(1):e70191
Clinical and translational medicine 2025 Jan;15(1):e70191
OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model.
Song X, Liu T, Yu L, Ji Q, Guo X, Zong R, Li Y, Huang G, Xue Q, Fu Q, Liu B, Zheng Y, Chen L, Gao C, Liu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2406700
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2406700
K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity.
Zeng Q, Guo H, Tang N, Renavikar PS, Karandikar NJ, Lovett-Racke AE, Racke MK, Yan C, Tang R, Sinha S, Ghosh K, Ryal JP, Ouyang S, Chen M, Amari F, Vincenzo C, Pope RM, Li Y, Yang H, Langdon WY, Zhang J
Journal of biomedical science 2025 Feb 19;32(1):26
Journal of biomedical science 2025 Feb 19;32(1):26
HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells.
Xie Z, Shao J, Shen Z, Ye Z, Okada Y, Okuzaki D, Okada N, Tachibana M
Cancer immunology, immunotherapy : CII 2025 Feb 1;74(3):81
Cancer immunology, immunotherapy : CII 2025 Feb 1;74(3):81
Lack of intestinal Mucin-1 impairs intestinal epithelial barrier and promotes metabolic dysfunction-associated steatotic liver disease in male mice.
Li Z, Gu R, Liu D, Zhang Y, Qin Y, Li X, Qiao Y, Li Z, Guo J, Wang J, Meng H, Peng L
Nature communications 2025 Dec 5;17(1):321
Nature communications 2025 Dec 5;17(1):321
Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway.
Zeng Q, Liao ML, Luo YY, Li S, You G, Huang CM, Liu MH, Liu W, Tang SY
International journal of molecular sciences 2025 Dec 30;27(1)
International journal of molecular sciences 2025 Dec 30;27(1)
NEDD4 suppresses ferroptosis in lung ischemia-reperfusion injury by ubiquitinating and degrading SLC1A5.
Li J, Meng F, Qian X, Chen S
Scientific reports 2025 Dec 23;16(1):2568
Scientific reports 2025 Dec 23;16(1):2568
The E3 ubiquitin ligase FBXL18 stabilizes BST2 to promote inflammation in RABV-infected astrocytes.
Wang J, Guo J, Li N, Tu Z, Liu S, Ma J, Zhang X, Cheng H, Hao Z, Feng Y, Lv S, Tai G, Zhou Y, Fu J, Tu C, Liu Y
Nature communications 2025 Dec 13;16(1):11324
Nature communications 2025 Dec 13;16(1):11324
Artesunate attenuates cerebral injury after cardiac arrest via inhibiting caspase-11-mediated pyroptosis through NEDD4.
He L, Zhang W, Hu Y, Zhu J, Liang L, Yang H, Chen Q, Xu J, Zhang M
Life sciences 2025 Dec 1;382:124019
Life sciences 2025 Dec 1;382:124019
UBE2C promotes pancreatic tumorigenesis by KRAS stabilization via APC/C(CDH1)-mediated WDR76 degradation.
Wang L, Chen X, Qu R, Shao S, Gong L, Li T, Jiang S, Lu Y, Ma Y, Sun Y, Cui D, Xiong X, Zhao Y
Cancer letters 2025 Aug 30;633:218013
Cancer letters 2025 Aug 30;633:218013
µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.
Pan CR, Knutson SD, Huth SW, MacMillan DWC
Nature chemical biology 2025 Apr;21(4):490-500
Nature chemical biology 2025 Apr;21(4):490-500
NEDD4-Mediated Endothelial-Mesenchymal Transition Participates in Radiation-Induced Lung Injury Through the ATM Signaling Pathway.
Feng Y, Zhang L, Zhang Y, Xu Y, Zhou K, Yang Z, Zhu W, Zhang Q, Cao J, Wang L, Jiao Y
Dose-response : a publication of International Hormesis Society 2025 Apr-Jun;23(2):15593258251352726
Dose-response : a publication of International Hormesis Society 2025 Apr-Jun;23(2):15593258251352726
FAT10 mediates the sorafenib-resistance of hepatocellular carcinoma cells by stabilizing E3 ligase NEDD4 to enhance PTEN/AKT pathway-induced autophagy.
Zhang W, Du D, Lu H, Zhang D, Liu L, Li J, Chen Z, Yu X, Ye M, Wang W, Chen L, Shao J
American journal of cancer research 2024;14(4):1523-1544
American journal of cancer research 2024;14(4):1523-1544
Ceftriaxone Modulates Ubiquitination of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid Receptors to Improve Long-Term Potentiation Impairment Induced by Exogenous β-Amyloid in a Glutamate Transporter-1 Dependent Manner.
Jiang R, Li L, Wang B, Liu L, Liu L, Xian X, Li W
Molecular neurobiology 2024 Sep;61(9):7181-7194
Molecular neurobiology 2024 Sep;61(9):7181-7194
Gentiopicroside ameliorates glucose and lipid metabolism in T2DM via targeting FGFR1.
Xu Z, Huang J, Wen M, Zhang X, Lyu D, Li S, Xiao H, Li M, Shen C, Huang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155780
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155780
Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1.
Wu Y, Chen Z, Zheng Z, Li X, Shu J, Mao R, An J, Fan S, Luo R, Guo Y, Xu W, Liang M, Huang K, Wang C
Journal of biomedical science 2024 Sep 5;31(1):88
Journal of biomedical science 2024 Sep 5;31(1):88
N4BP3 facilitates NOD2-MAPK/NF-κB pathway in inflammatory bowel disease through mediating K63-linked RIPK2 ubiquitination.
Jiang W, Zhao Y, Han M, Xu J, Chen K, Liang Y, Yin J, Hu J, Shen Y
Cell death discovery 2024 Oct 17;10(1):440
Cell death discovery 2024 Oct 17;10(1):440
ECHDC2 inhibits the proliferation of gastric cancer cells by binding with NEDD4 to degrade MCCC2 and reduce aerobic glycolysis.
He J, Yi J, Ji L, Dai L, Chen Y, Xue W
Molecular medicine (Cambridge, Mass.) 2024 May 23;30(1):69
Molecular medicine (Cambridge, Mass.) 2024 May 23;30(1):69
Mecp2 fine-tunes quiescence exit by targeting nuclear receptors.
Yang J, Zou S, Qiu Z, Lai M, Long Q, Chen H, Lai PL, Zhang S, Rao Z, Xie X, Gong Y, Liu A, Li M, Bai X
eLife 2024 May 15;12
eLife 2024 May 15;12
Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy.
Huang YK, Cheng WC, Kuo TT, Yang JC, Wu YC, Wu HH, Lo CC, Hsieh CY, Wong SC, Lu CH, Wu WL, Liu SJ, Li YC, Lin CC, Shen CN, Hung MC, Lin JT, Yeh CC, Sher YP
Nature cancer 2024 Mar;5(3):400-419
Nature cancer 2024 Mar;5(3):400-419
Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.
Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L, Chen X
Cell metabolism 2024 Jun 4;36(6):1351-1370.e8
Cell metabolism 2024 Jun 4;36(6):1351-1370.e8
DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice.
Zou D, Li K, Su L, Liu J, Lu Y, Huang R, Li M, Mang X, Geng Q, Li P, Tang J, Yu Z, Zhang Z, Chen D, Miao S, Yu J, Yan W, Song W
Developmental cell 2024 Jul 8;59(13):1707-1723.e8
Developmental cell 2024 Jul 8;59(13):1707-1723.e8
PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.
Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y
Journal of experimental & clinical cancer research : CR 2024 Jan 11;43(1):17
Journal of experimental & clinical cancer research : CR 2024 Jan 11;43(1):17
Inhibition of RIPK1 alleviating vascular smooth muscle cells osteogenic transdifferentiation via Runx2.
Li Y, Jie W, Qi Y, Mo M, Lian Y, Yin L, Huang H
iScience 2024 Feb 16;27(2):108766
iScience 2024 Feb 16;27(2):108766
Downregulation of CD86 in HCMV-infected THP-1 cells.
Koshizuka T, Sasaki Y, Kondo H, Koizumi J, Takahashi K
Microbiology and immunology 2024 Dec;68(12):406-413
Microbiology and immunology 2024 Dec;68(12):406-413
Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids.
Chen D, Li G, Luo L, Lin T, Chu X, Liu K, Lai T, Liao Y, Lin X, Chen J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156155
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156155
Fish Snx27 promotes viral products by modulating the innate immune response and exosomal machinery.
Yu Y, Liu J, Zhao Z, Lan X, Li L, Hu J, Zang Y-a, Zhang X, Chen J
Journal of virology 2024 Dec 17;98(12):e0097424
Journal of virology 2024 Dec 17;98(12):e0097424
The matrix protein of lyssavirus hijacks autophagosome for efficient egress by recruiting NEDD4 through its PPxY motif.
Yuan Y, Fang A, Wang Z, Chen H, Fu ZF, Zhou M, Zhao L
Autophagy 2024 Aug;20(8):1723-1740
Autophagy 2024 Aug;20(8):1723-1740
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Zhong C, Xiong G, Yang H, Du X, Du J, Yao F, Fang W, Deng Y
International journal of biological sciences 2023;19(4):1110-1122
International journal of biological sciences 2023;19(4):1110-1122
Oncogenic Role of the NFATC2/NEDD4/FBP1 Axis in Cholangiocarcinoma.
Zhao W, Zhao J, Li K, Hu Y, Yang D, Tan B, Shi J
Laboratory investigation; a journal of technical methods and pathology 2023 Sep;103(9):100193
Laboratory investigation; a journal of technical methods and pathology 2023 Sep;103(9):100193
Nedd4-1 regulates human sodium-dependent vitamin C transporter-2 functional expression in neuronal and epithelial cells.
Teafatiller T, Perez O, Kitazawa M, Agrawal A, Subramanian VS
The Journal of nutritional biochemistry 2023 Oct;120:109413
The Journal of nutritional biochemistry 2023 Oct;120:109413
Hepatocytic lipocalin-2 controls HDL metabolism and atherosclerosis via Nedd4-1-SR-BI axis in mice.
Hu S, Zhu Y, Zhao X, Li R, Shao G, Gong D, Hu C, Liu H, Xu K, Liu C, Xu M, Zhao Z, Li T, Hu Z, Shao M, Liu J, Li X, Wu H, Li J, Xu Y
Developmental cell 2023 Nov 6;58(21):2326-2337.e5
Developmental cell 2023 Nov 6;58(21):2326-2337.e5
FGF21 protects against doxorubicin-induced cardiotoxicity by inhibiting connexin 43 ubiquitination.
Huang Y, Wei C, Li P, Shao Y, Wang M, Wang F, Niu G, Sun K, Zhang Q, Gou Z, Yan X
Free radical biology & medicine 2023 Nov 1;208:748-758
Free radical biology & medicine 2023 Nov 1;208:748-758
Multi-Cell Line Analysis of Lysosomal Proteomes Reveals Unique Features and Novel Lysosomal Proteins.
Akter F, Bonini S, Ponnaiyan S, Kögler-Mohrbacher B, Bleibaum F, Damme M, Renard BY, Winter D
Molecular & cellular proteomics : MCP 2023 Mar;22(3):100509
Molecular & cellular proteomics : MCP 2023 Mar;22(3):100509
Xinbao Pill attenuated chronic heart failure by suppressing the ubiquitination of β-adrenergic receptors.
Tian X, Huang Z, Wang Y, Qi X, Wang D, Liu Z, Cheng Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154830
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154830
CFDP1 promotes hepatocellular carcinoma progression through activating NEDD4/PTEN/PI3K/AKT signaling pathway.
Zhou Y, Qiu J, Liu S, Wang P, Ma D, Zhang G, Cao Y, Hu L, Wang Z, Wu J, Jiang C
Cancer medicine 2023 Jan;12(1):425-444
Cancer medicine 2023 Jan;12(1):425-444
hCINAP regulates the differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase-separation-mediated YAP1 activation.
Zhuge R, Wang C, Wang J, Yu S, Liao L, Zheng X
Cell reports 2023 Jan 31;42(1):111935
Cell reports 2023 Jan 31;42(1):111935
NEDD4 ameliorates myocardial reperfusion injury by preventing macrophages pyroptosis.
Sun W, Lu H, Cui S, Zhao S, Yu H, Song H, Ruan Q, Zhang Y, Chu Y, Dong S
Cell communication and signaling : CCS 2023 Feb 2;21(1):29
Cell communication and signaling : CCS 2023 Feb 2;21(1):29
High glucose environment induces NEDD4 deficiency that impairs angiogenesis and diabetic wound healing.
Guo Y, Wang Y, Liu H, Jiang X, Lei S
Journal of dermatological science 2023 Dec;112(3):148-157
Journal of dermatological science 2023 Dec;112(3):148-157
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer.
Liu S, Guo R, Xu H, Yang J, Luo H, Yeung SJ, Li K, Lee MH, Yang R
Cell reports 2023 Aug 29;42(8):112870
Cell reports 2023 Aug 29;42(8):112870
PINCH-1 promotes IGF-1 receptor expression and skin cancer progression through inhibition of the GRB10-NEDD4 complex.
Wang X, Wang R, Jiang K, Zhu M, Guo L, Wu C
Theranostics 2022;12(6):2613-2630
Theranostics 2022;12(6):2613-2630
Identification of Marek's disease virus pUL56 homologue and analysis of critical amino acid stretches indispensable for its intracellular localization.
Zhang J, Xu B, Ma D, Song J, Liu X, Wei P, Huang T
Virus research 2022 May;313:198741
Virus research 2022 May;313:198741
NEDD4 attenuates phosgene-induced acute lung injury through the inhibition of Notch1 activation.
Shao Y, Jiang Z, He D, Shen J
Journal of cellular and molecular medicine 2022 May;26(10):2831-2840
Journal of cellular and molecular medicine 2022 May;26(10):2831-2840
Hepatokine ERAP1 Disturbs Skeletal Muscle Insulin Sensitivity Via Inhibiting USP33-Mediated ADRB2 Deubiquitination.
Niu Y, Jiang H, Yin H, Wang F, Hu R, Hu X, Peng B, Shu Y, Li Z, Chen S, Guo F
Diabetes 2022 May 1;71(5):921-933
Diabetes 2022 May 1;71(5):921-933
Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4.
Sun F, Sun Y, Zhu J, Wang X, Ji C, Zhang J, Chen S, Yu Y, Xu W, Qian H
Stem cell research & therapy 2022 Jul 15;13(1):293
Stem cell research & therapy 2022 Jul 15;13(1):293
Samotolisib Attenuates Acute Liver Injury Through Inhibiting Caspase-11-Mediated Pyroptosis Via Regulating E3 Ubiquitin Ligase Nedd4.
Zhao YY, Wu DM, He M, Zhang F, Zhang T, Liu T, Li J, Li L, Xu Y
Frontiers in pharmacology 2021;12:726198
Frontiers in pharmacology 2021;12:726198
Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis.
Wang H, Wang J, Zhang S, Jia J, Liu X, Zhang J, Wang P, Song X, Che L, Liu K, Ribback S, Cigliano A, Evert M, Wu H, Calvisi DF, Zeng Y, Chen X
Cellular and molecular gastroenterology and hepatology 2021;11(4):1095-1117
Cellular and molecular gastroenterology and hepatology 2021;11(4):1095-1117
Tumor-derived exosomal miR-19b-3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway.
Chen J, Zhang K, Zhi Y, Wu Y, Chen B, Bai J, Wang X
Clinical and translational medicine 2021 Sep;11(9):e478
Clinical and translational medicine 2021 Sep;11(9):e478
Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases.
Koshizuka T, Kondo H, Kato H, Takahashi K
Microbiology and immunology 2021 Nov;65(11):472-480
Microbiology and immunology 2021 Nov;65(11):472-480
HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity.
Nuro-Gyina PK, Tang N, Guo H, Yan C, Zeng Q, Waldschmidt TJ, Zhang J
Journal of immunology (Baltimore, Md. : 1950) 2021 Aug 1;207(3):868-877
Journal of immunology (Baltimore, Md. : 1950) 2021 Aug 1;207(3):868-877
Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway.
Xie Y, Zhou X, Li J, Yao XC, Liu WL, Kang FH, Zou ZX, Xu KP, Xu PS, Tan GS
Bioorganic chemistry 2021 Apr;109:104744
Bioorganic chemistry 2021 Apr;109:104744
JAC1 suppresses proliferation of breast cancer through the JWA/p38/SMURF1/HER2 signaling.
Ren Y, Chen D, Zhai Z, Chen J, Li A, Liang Y, Zhou J
Cell death discovery 2021 Apr 19;7(1):85
Cell death discovery 2021 Apr 19;7(1):85
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.
Zhang P, Li C, Li H, Yuan L, Dai H, Peng Z, Deng Z, Chang Z, Cui CP, Zhang L
Cell death and differentiation 2020 Nov;27(11):3177-3195
Cell death and differentiation 2020 Nov;27(11):3177-3195
Multivesicular body sorting and the exosomal pathway are required for the release of rat hepatitis E virus from infected cells.
Primadharsini PP, Nagashima S, Takahashi M, Kobayashi T, Nishiyama T, Nishizawa T, Yasuda J, Mulyanto, Okamoto H
Virus research 2020 Mar;278:197868
Virus research 2020 Mar;278:197868
Promotion of liver growth by CAR is accompanied by Akt pathway activation and FoxM1-Nedd4-mediated repression of PTEN.
Yarushkin AA, Mazin ME, Pustylnyak YA, Prokopyeva EA, Pustylnyak VO
Archives of biochemistry and biophysics 2019 Sep 15;672:108065
Archives of biochemistry and biophysics 2019 Sep 15;672:108065
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Xu J, Sheng Z, Li F, Wang S, Yuan Y, Wang M, Yu Z
Experimental cell research 2019 Oct 1;383(1):111505
Experimental cell research 2019 Oct 1;383(1):111505
YY1-regulated LINC00152 promotes triple negative breast cancer progression by affecting on stability of PTEN protein.
Shen X, Zhong J, Yu P, Zhao Q, Huang T
Biochemical and biophysical research communications 2019 Feb 5;509(2):448-454
Biochemical and biophysical research communications 2019 Feb 5;509(2):448-454
N-myc downstream-regulated gene 1 inhibits the proliferation of colorectal cancer through emulative antagonizing NEDD4-mediated ubiquitylation of p21.
Zhang S, Yu C, Yang X, Hong H, Lu J, Hu W, Hao X, Li S, Aikemu B, Yang G, He Z, Zhang L, Xue P, Cai Z, Ma J, Zang L, Feng B, Yuan F, Sun J, Zheng M
Journal of experimental & clinical cancer research : CR 2019 Dec 12;38(1):490
Journal of experimental & clinical cancer research : CR 2019 Dec 12;38(1):490
Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies.
Juenemann K, Jansen AHP, van Riel L, Merkx R, Mulder MPC, An H, Statsyuk A, Kirstein J, Ovaa H, Reits EA
Scientific reports 2018 Jan 23;8(1):1405
Scientific reports 2018 Jan 23;8(1):1405
Inhibition of ubiquitin proteasome function prevents monocrotaline-induced pulmonary arterial remodeling.
Zhu Y, Wu Y, Shi W, Wang J, Yan X, Wang Q, Liu Y, Yang L, Gao L, Li M
Life sciences 2017 Mar 15;173:36-42
Life sciences 2017 Mar 15;173:36-42
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Sun H, Ma H, Wang J, Xia L, Zhu G, Wang Z, Sun J, Chen Z
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317709639
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317709639
Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.
Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX, Zhao XY, Wu J, Lin JD
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 22;114(34):E7111-E7120
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 22;114(34):E7111-E7120
O-GlcNAc regulates NEDD4-1 stability via caspase-mediated pathway.
Jiang K, Bai B, Ta Y, Zhang T, Xiao Z, Wang PG, Zhang L
Biochemical and biophysical research communications 2016 Mar 18;471(4):539-44
Biochemical and biophysical research communications 2016 Mar 18;471(4):539-44
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- C6 cells were subjected to SDS PAGE followed by western blot with 21698-1-AP(NEDD4 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NEDD4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human NEDD4. This antibody recognizes human,mouse,rat, monkey antigen. The NEDD4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
