NEDD4

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

Description

NEDD4 E3 ubiquitin protein ligase

Tissue specificity

Tissue enhanced (skeletal muscle, tongue)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

15 (55826922 - 55993660)

Ensembl ID

ENSG00000069869  (ver. 103.38)

Orthologs

Mouse Nedd4: ENSMUSG00000032216

UniProt

P46934

neXtProt

NX_P46934

Human splice variants
Mouse splice variants

Protein structure