Tissue expression
Cell line expression
Protein structure
IMPA1
Inositol monophosphatase 1IMPA
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Top validated antibodies |
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LSBio | LS-C482587 | Polyclonal |
WB
ICC
IHC
|
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Proteintech Group | 16593-1-AP | Polyclonal |
WB
EL
ICC
IHC |
||
Invitrogen Antibodies | PA5-118009 | Polyclonal |
WB
IP
IHC
OA |
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Novus Biologicals | NBP2-59416-100ul | Monoclonal |
WB
EL
ICC
FC |
||
NovoPro Bioscience Inc. | 111761 | Polyclonal |
WB
EL
ICC
IHC |
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Supportive data in Antibodypedia
Data presented on provider website
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Recommended by provider