IMPA1

gene product
IMPA
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
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Invitrogen Antibodies
5 antibodies
Proteintech Group
1 antibody
Novus Biologicals
8 antibodies
Biorbyt
7 antibodies
Atlas Antibodies
1 antibody
NovoPro Bioscience Inc.
1 antibody
antibodies-online
45 antibodies
LifeSpan BioSciences, Inc.
25 antibodies
GeneTex
3 antibodies
St John's Laboratory
1 antibody
Abnova Corporation
6 antibodies
R&D Systems
2 antibodies
Bioworld Technology, Inc
1 antibody
Bethyl Laboratories
2 antibodies
Acris Antibodies GmbH
3 antibodies
Creative Biolabs
7 antibodies
Creative Diagnostics
4 antibodies
MyBioSource
2 antibodies
Aviva Systems Biology
1 antibody
OriGene
1 antibody
Boster Biological Technology
1 antibody
United States Biological
12 antibodies
Sigma-Aldrich
2 antibodies
Sino Biological Inc.
1 antibody