AF930

antibody from Novus Biologicals

Targeting: ADAM17 CD156B, cSVP, TACE

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

AF930

Provider

Novus Biologicals

Product name

Chicken Polyclonal TACE/ADAM17 Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. Detects human TACE/ADAM17 Ectodomain in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) BACE, rhADAM8, rhADAM10, and recombinant mouse ADAM10 is observed.

Reactivity

Human

Host

Chicken/Avian

Conjugate

Unconjugated

Isotype

IgY

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

References

Submitted references

The shedding activity of ADAM17 is sequestered in lipid rafts.

Tellier E, Canault M, Rebsomen L, Bonardo B, Juhan-Vague I, Nalbone G, Peiretti F
Experimental cell research 2006 Dec 10;312(20):3969-80

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FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity.

Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan-Vague I, Nalbone G, Peiretti F
Journal of cellular physiology 2006 Aug;208(2):363-72

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ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase.

Ito N, Nomura S, Iwase A, Ito T, Kikkawa F, Tsujimoto M, Ishiura S, Mizutani S
Biochemical and biophysical research communications 2004 Feb 20;314(4):1008-13

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ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase.

Ito N, Nomura S, Iwase A, Ito T, Kikkawa F, Tsujimoto M, Ishiura S, Mizutani S
Biochemical and biophysical research communications 2004 Feb 20;314(4):1008-13