ADAM17

gene product
CD156B, cSVP, TACE
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
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894 antibodies from 43 providers.

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Novus Biologicals
62 antibodies
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13 antibodies
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antibodies-online
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GeneTex
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LifeSpan BioSciences, Inc.
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OriGene
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Affinity Biosciences
2 antibodies
NSJ Bioreagents
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Antibodies.com
1 antibody
Arigo
2 antibodies
ProSci
5 antibodies
St John's Laboratory
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Proteintech Group
2 antibodies
RabMAbs
3 antibodies
Everest Biotech
1 antibody
Creative Biolabs
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MyBioSource
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RayBiotech, Inc.
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Bioworld Technology, Inc
1 antibody
Signalway Antibody LLC
1 antibody
Abbkine Scientific Co.Ltd.
3 antibodies
Creative Diagnostics
7 antibodies
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Sigma-Aldrich
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Rockland Immunochemicals, Inc.
1 antibody
Absolute Antibody
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GenWay
4 antibodies
eBioscience, An Affymetrix Company
2 antibodies
EMD Millipore
2 antibodies
Exalpha Biologicals, Inc.
1 antibody