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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [6]
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- Validations
- Flow cytometry [1]
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- Product number
- FAB9301P - Provider product page
- Provider
- R&D Systems
- Product name
- Human TACE/ADAM17 Ectodomain PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects the ectodomain of human TACE/ADAM17 in direct ELISAs. In direct ELISAs, less than 5% cross-reactivity with the ectodomain of recombinant human ADAM8, 9, 15 and recombinant mouse ADAM10 is observed.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P78536- Isotype
- IgG
- Antibody clone number
- 111633
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Metalloproteinases TACE and MMP-9 Differentially Regulate Death Factors on Adult and Neonatal Monocytes After Infection with Escherichia coli.
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.
Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE.
Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway.
Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.
FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity.
Dreschers S, Platen C, Ludwig A, Gille C, Köstlin N, Orlikowsky TW
International journal of molecular sciences 2019 Mar 20;20(6)
International journal of molecular sciences 2019 Mar 20;20(6)
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.
Lécuyer H, Virion Z, Barnier JP, Matczak S, Bourdoulous S, Bianchini E, Saller F, Borgel D, Nassif X, Coureuil M
PLoS pathogens 2018 Apr;14(4):e1006981
PLoS pathogens 2018 Apr;14(4):e1006981
Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE.
Moreira-Tabaka H, Peluso J, Vonesch JL, Hentsch D, Kessler P, Reimund JM, Dumont S, Muller CD
PloS one 2012;7(3):e34184
PloS one 2012;7(3):e34184
Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway.
Wang CH, Huang CD, Lin HC, Huang TT, Lee KY, Lo YL, Lin SM, Chung KF, Kuo HP
The Journal of allergy and clinical immunology 2012 May;129(5):1367-76
The Journal of allergy and clinical immunology 2012 May;129(5):1367-76
Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.
Canault M, Leroyer AS, Peiretti F, Lesèche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G
The American journal of pathology 2007 Nov;171(5):1713-23
The American journal of pathology 2007 Nov;171(5):1713-23
FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity.
Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan-Vague I, Nalbone G, Peiretti F
Journal of cellular physiology 2006 Aug;208(2):363-72
Journal of cellular physiology 2006 Aug;208(2):363-72
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Supportive validation
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- R&D Systems (provider)
- Main image
- Experimental details
- Detection of TACE/ADAM17 in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line was stained with Mouse Anti-Human TACE/ADAM17 Ectodomain PE-conjugated Monoclonal Antibody (Catalog # FAB9301P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
