MAB9301

antibody from R&D Systems

Targeting: ADAM17 CD156B, cSVP, TACE

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

MAB9301

Provider

R&D Systems

Product name

Anti-Human TACE/ADAM17 Ectodomain Monoclonal Antibody (Clone 111633)

Antibody type

Monoclonal

Antigen

Insect ovarian cell line T. ni-derived recombinant human TACE/ADAM17, Pro18-Asn671

Description

Protein A or G purified from ascites

Reactivity

Human

Host

Mouse

Antigen sequence

P78536


Isotype

IgG

Vial size

500 µg

References

Submitted references

Increasing TIMP3 expression by hypomethylating agents diminishes soluble MICA, MICB and ULBP2 shedding in acute myeloid leukemia, facilitating NK cell-mediated immune recognition.

Raneros AB, Minguela A, Rodriguez RM, Colado E, Bernal T, Anguita E, Mogorron AV, Gil AC, Vidal-Castiñeira JR, Márquez-Kisinousky L, Bulnes PD, Marin AM, Garay MCG, Suarez-Alvarez B, Lopez-Larrea C
Oncotarget 2017 May 9;8(19):31959-31976

---

Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17.

Buchanan PC, Boylan KLM, Walcheck B, Heinze R, Geller MA, Argenta PA, Skubitz APN
The Journal of biological chemistry 2017 Apr 14;292(15):6339-6351

---

Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells.

Jing Y, Ni Z, Wu J, Higgins L, Markowski TW, Kaufman DS, Walcheck B
PloS one 2015;10(3):e0121788

---

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.

Zingoni A, Cecere F, Vulpis E, Fionda C, Molfetta R, Soriani A, Petrucci MT, Ricciardi MR, Fuerst D, Amendola MG, Mytilineos J, Cerboni C, Paolini R, Cippitelli M, Santoni A
Journal of immunology (Baltimore, Md. : 1950) 2015 Jul 15;195(2):736-48

---

Expansion of necrotic core and shedding of Mertk receptor in human carotid plaques: a role for oxidized polyunsaturated fatty acids?

Garbin U, Baggio E, Stranieri C, Pasini A, Manfro S, Mozzini C, Vallerio P, Lipari G, Merigo F, Guidi G, Cominacini L, Fratta Pasini A
Cardiovascular research 2013 Jan 1;97(1):125-33

---

A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1).

Breshears LM, Schlievert PM, Peterson ML
The Journal of biological chemistry 2012 Sep 21;287(39):32578-87

---

The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9.

Gutiérrez-López MD, Gilsanz A, Yáñez-Mó M, Ovalle S, Lafuente EM, Domínguez C, Monk PN, González-Alvaro I, Sánchez-Madrid F, Cabañas C
Cellular and molecular life sciences : CMLS 2011 Oct;68(19):3275-92

---

Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases.

Koenen RR, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, Reiss K, Sarabi A, Lindbom L, Hackeng TM, Weber C, Ludwig A
Blood 2009 May 7;113(19):4799-809

---

Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment.

Hurst LA, Bunning RA, Couraud PO, Romero IA, Weksler BB, Sharrack B, Woodroofe MN
Journal of neuroimmunology 2009 May 29;210(1-2):108-12

---

Tissue inhibitors of matrix metalloproteinases in platelets and megakaryocytes: a novel organization for these secreted proteins.

Villeneuve J, Block A, Le Bousse-Kerdilès MC, Lepreux S, Nurden P, Ripoche J, Nurden AT
Experimental hematology 2009 Jul;37(7):849-56