WWP1

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

Description

WW domain containing E3 ubiquitin protein ligase 1

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Golgi apparatus, Plasma membrane, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

8 (86342547 - 86478420)

Ensembl ID

ENSG00000123124  (ver. 103.38)

Orthologs

Mouse Wwp1: ENSMUSG00000041058

UniProt

Q9H0M0

neXtProt

NX_Q9H0M0

Human splice variants
Mouse splice variants

Protein structure