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RAPGEF5
Rap guanine nucleotide exchange factor 5GFR, KIAA0277, MR-GEF
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]). [supplied by OMIM, Mar 2008]
Top validated antibodies |
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| LSBio |  LS-B11458 |
Polyclonal |
WB
EL
IHC
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| Proteintech Group | 12556-1-AP |
1 references | Polyclonal |
WB
EL
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| NovoPro Bioscience Inc. | 132786 |
Polyclonal |
WB
EL
IHC
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| Affinity Biosciences | DF4382 |
Polyclonal |
WB
EL
ICC
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| Novus Biologicals | H00009771-B01P |
Polyclonal |
WB
ICC
|
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