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- Antibody Data
- Antigen structure
- References [117]
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- Western blot [4]
- Immunohistochemistry [6]
- Flow cytometry [3]
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- Product number
- NB100-106 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-106, RRID:AB_10104097
- Product name
- Rabbit Polyclonal OGG1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Rabbit, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references High glucose induced endothelial cell reactive oxygen species via OGG1/PKC/NADPH oxidase pathway.
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis.
Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy.
Altered expression of DNA damage repair genes in the brain tissue of mice conceived by in vitro fertilization.
The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization.
High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes.
CEES-induced ROS accumulation regulates mitochondrial complications and inflammatory response in keratinocytes.
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.
Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis.
Critical Role of Oxidatively Damaged DNA in Selective Noradrenergic Vulnerability.
Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.
CFTR Deletion Confers Mitochondrial Dysfunction and Disrupts Lipid Homeostasis in Intestinal Epithelial Cells.
Levels of oxidative DNA damage are low in ex vivo engineered human limbal epithelial tissue.
Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis.
The Paradoxical Effects of Different Hepatitis C Viral Loads on Host DNA Damage and Repair Abilities.
Treatment with antioxidants ameliorates oxidative damage in a mouse model of propionic acidemia.
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
Enforced DNA repair enzymes rescue neurons from apoptosis induced by target deprivation and axotomy in mouse models of neurodegeneration.
Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1.
A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal.
Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response.
Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats.
Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET).
Reduced MUTYH, MTH1, and OGG1 expression and TP53 mutation in diffuse-type adenocarcinoma of gastric cardia.
8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.
Long-term High Fat Ketogenic Diet Promotes Renal Tumor Growth in a Rat Model of Tuberous Sclerosis.
Corrigendum: 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.
Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells.
BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication.
PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.
Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing.
HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10.
8-Oxo-7,8-dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients.
Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells.
Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.
Effects of CEES and LPS synergistically stimulate oxidative stress inactivates OGG1 signaling in macrophage cells.
Oxidative DNA damage in human esophageal cancer: clinicopathological analysis of 8-hydroxydeoxyguanosine and its repair enzyme.
Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice.
The significance of the alteration of 8-OHdG in serous ovarian carcinoma.
Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin.
The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1.
Decreased mitochondrial OGG1 expression is linked to mitochondrial defects and delayed hepatoma cell growth.
Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs.
Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons.
Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1.
Human 8-oxoguanine-DNA glycosylase-1 is downregulated in human basal cell carcinoma.
Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders.
Protection from palmitate-induced mitochondrial DNA damage prevents from mitochondrial oxidative stress, mitochondrial dysfunction, apoptosis, and impaired insulin signaling in rat L6 skeletal muscle cells.
Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype.
Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility.
Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice.
Functional polymorphisms of the hOGG1 gene confer risk to type 2 epithelial ovarian cancer in Chinese.
Dynamics of the primate ovarian surface epithelium during the ovulatory menstrual cycle.
Two functional variations in 5'-UTR of hoGG1 gene associated with the risk of breast cancer in Chinese.
Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice.
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity.
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.
Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats.
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Base excision repair of reactive oxygen species-initiated 7,8-dihydro-8-oxo-2'-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs.
Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA.
The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells.
Human 8-oxoguanine-DNA glycosylase 1 protein and gene are expressed more abundantly in the superficial than basal layer of human epidermis.
Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase.
Translesion synthesis of 7,8-dihydro-8-oxo-2'-deoxyguanosine by DNA polymerase eta in vivo.
Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene.
beta(2)-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy.
The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord.
The effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity.
Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria.
Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria.
The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells.
In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage through MAP kinase signaling.
Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells.
Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria.
Induction of OGG1 gene expression by HIV-1 Tat.
DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA.
The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity.
Cadmium exposure down-regulates 8-oxoguanine DNA glycosylase expression in rat lung and alveolar epithelial cells.
Cadmium exposure down-regulates 8-oxoguanine DNA glycosylase expression in rat lung and alveolar epithelial cells.
Concomitant loss of mitochondria and the DNA repair protein hOGG1 in clear cell carcinoma of the kidney.
Concomitant loss of mitochondria and the DNA repair protein hOGG1 in clear cell carcinoma of the kidney.
Malgun (clear) cell change in Helicobacter pylori gastritis reflects epithelial genomic damage and repair.
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein.
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein.
Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria.
Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines.
Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death.
Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells.
Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells.
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.
Frequent allelic imbalance and loss of protein expression of the DNA repair gene hOGG1 in head and neck squamous cell carcinoma.
Frequent allelic imbalance and loss of protein expression of the DNA repair gene hOGG1 in head and neck squamous cell carcinoma.
Up-regulation of base excision repair activity for 8-hydroxy-2'-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion.
Up-regulation of base excision repair activity for 8-hydroxy-2'-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion.
hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population.
hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population.
Human MMH (OGG1) type 1a protein is a major enzyme for repair of 8-hydroxyguanine lesions in human cells.
Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles.
Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles.
Binding of circulating antibodies to reactive oxygen species modified-DNA and detecting DNA damage by a monoclonal antibody probe.
Binding of circulating antibodies to reactive oxygen species modified-DNA and detecting DNA damage by a monoclonal antibody probe.
Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III.
Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III.
A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.
A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.
Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
Anti-ROS-DNA monoclonal antibody as molecular probe for oxidative DNA damage.
Anti-ROS-DNA monoclonal antibody as molecular probe for oxidative DNA damage.
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.
Zinc(II) inhibits the release of thyroid and glucocorticoid receptors from chromatin of cultured GC cells.
Xie X, Chen Y, Liu J, Zhang W, Zhang X, Zha L, Liu W, Ling Y, Li S, Tang S
Life sciences 2020 Sep 1;256:117886
Life sciences 2020 Sep 1;256:117886
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease.
Pao PC, Patnaik D, Watson LA, Gao F, Pan L, Wang J, Adaikkan C, Penney J, Cam HP, Huang WC, Pantano L, Lee A, Nott A, Phan TX, Gjoneska E, Elmsaouri S, Haggarty SJ, Tsai LH
Nature communications 2020 May 18;11(1):2484
Nature communications 2020 May 18;11(1):2484
Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis.
Kim SJ, Cheresh P, Jablonski RP, Rachek L, Yeldandi A, Piseaux-Aillon R, Ciesielski MJ, Ridge K, Gottardi C, Lam AP, Pardo A, Selman M, Natarajan V, Kamp DW
American journal of physiology. Lung cellular and molecular physiology 2020 May 1;318(5):L1084-L1096
American journal of physiology. Lung cellular and molecular physiology 2020 May 1;318(5):L1084-L1096
Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy.
Zheng J, Akbari M, Schirmer C, Reynaert ML, Loyens A, Lefebvre B, Buée L, Croteau DL, Galas MC, Bohr VA
Acta neuropathologica communications 2020 Mar 4;8(1):25
Acta neuropathologica communications 2020 Mar 4;8(1):25
Altered expression of DNA damage repair genes in the brain tissue of mice conceived by in vitro fertilization.
Hu M, Lou Y, Liu S, Mao Y, Le F, Wang L, Li L, Wang Q, Li H, Lou H, Wang N, Jin F
Molecular human reproduction 2020 Mar 26;26(3):141-153
Molecular human reproduction 2020 Mar 26;26(3):141-153
The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization.
Wang J, Nagy N, Masucci MG
Oncogene 2020 Jan;39(3):603-616
Oncogene 2020 Jan;39(3):603-616
High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes.
Rizwan H, Pal S, Sabnam S, Pal A
Life sciences 2020 Jan 15;241:117148
Life sciences 2020 Jan 15;241:117148
CEES-induced ROS accumulation regulates mitochondrial complications and inflammatory response in keratinocytes.
Sabnam S, Rizwan H, Pal S, Pal A
Chemico-biological interactions 2020 Apr 25;321:109031
Chemico-biological interactions 2020 Apr 25;321:109031
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE
The Journal of physiology 2019 May;597(9):2391-2401
The Journal of physiology 2019 May;597(9):2391-2401
Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7758-7766
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jun;33(6):7758-7766
Targeted and Persistent 8-Oxoguanine Base Damage at Telomeres Promotes Telomere Loss and Crisis.
Fouquerel E, Barnes RP, Uttam S, Watkins SC, Bruchez MP, Opresko PL
Molecular cell 2019 Jul 11;75(1):117-130.e6
Molecular cell 2019 Jul 11;75(1):117-130.e6
Critical Role of Oxidatively Damaged DNA in Selective Noradrenergic Vulnerability.
Zhan Y, Raza MU, Yuan L, Zhu MY
Neuroscience 2019 Dec 1;422:184-201
Neuroscience 2019 Dec 1;422:184-201
Knockout of Mpv17-Like Protein (M-LPH) Gene in Human Hepatoma Cells Results in Impairment of mtDNA Integrity through Reduction of TFAM, OGG1, and LIG3 at the Protein Levels.
Iida R, Ueki M, Yasuda T
Oxidative medicine and cellular longevity 2018;2018:6956414
Oxidative medicine and cellular longevity 2018;2018:6956414
CFTR Deletion Confers Mitochondrial Dysfunction and Disrupts Lipid Homeostasis in Intestinal Epithelial Cells.
Kleme ML, Sané A, Garofalo C, Seidman E, Brochiero E, Berthiaume Y, Levy E
Nutrients 2018 Jun 27;10(7)
Nutrients 2018 Jun 27;10(7)
Levels of oxidative DNA damage are low in ex vivo engineered human limbal epithelial tissue.
Lorenzo Y, Haug Berg K, Ringvold A, Petrovski G, Moe MC, Collins A, Nicolaissen B
Acta ophthalmologica 2018 Dec;96(8):834-840
Acta ophthalmologica 2018 Dec;96(8):834-840
Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis.
Kumagae Y, Hirahashi M, Takizawa K, Yamamoto H, Gushima M, Esaki M, Matsumoto T, Nakamura M, Kitazono T, Oda Y
Oncology letters 2018 Aug;16(2):1765-1776
Oncology letters 2018 Aug;16(2):1765-1776
The Paradoxical Effects of Different Hepatitis C Viral Loads on Host DNA Damage and Repair Abilities.
Wang SC, Lai KR, Li CY, Chiang CS, Yu GY, Sakamoto N, Tu WY, Hsieh MH, Huang JF, Chuang WL, Dai CY, Yu ML
PloS one 2017;12(1):e0164281
PloS one 2017;12(1):e0164281
Treatment with antioxidants ameliorates oxidative damage in a mouse model of propionic acidemia.
Rivera-Barahona A, Alonso-Barroso E, Pérez B, Murphy MP, Richard E, Desviat LR
Molecular genetics and metabolism 2017 Sep;122(1-2):43-50
Molecular genetics and metabolism 2017 Sep;122(1-2):43-50
Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
Pillai VB, Kanwal A, Fang YH, Sharp WW, Samant S, Arbiser J, Gupta MP
Oncotarget 2017 May 23;8(21):34082-34098
Oncotarget 2017 May 23;8(21):34082-34098
Enforced DNA repair enzymes rescue neurons from apoptosis induced by target deprivation and axotomy in mouse models of neurodegeneration.
Martin LJ, Wong M
Mechanisms of ageing and development 2017 Jan;161(Pt A):149-162
Mechanisms of ageing and development 2017 Jan;161(Pt A):149-162
Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1.
Yang JL, Chen WY, Chen YP, Kuo CY, Chen SD
Theranostics 2016;6(12):2015-2027
Theranostics 2016;6(12):2015-2027
A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal.
Chaisiriwong L, Wanitphakdeedecha R, Sitthinamsuwan P, Sampattavanich S, Chatsiricharoenkul S, Manuskiatti W, Panich U
Oxidative medicine and cellular longevity 2016;2016:5934024
Oxidative medicine and cellular longevity 2016;2016:5934024
Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response.
Moreli JB, Santos JH, Lorenzon-Ojea AR, Corrêa-Silva S, Fortunato RS, Rocha CR, Rudge MV, Damasceno DC, Bevilacqua E, Calderon IM
International journal of biological sciences 2016;12(4):466-77
International journal of biological sciences 2016;12(4):466-77
Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats.
Tarry-Adkins JL, Fernandez-Twinn DS, Chen JH, Hargreaves IP, Neergheen V, Aiken CE, Ozanne SE
Disease models & mechanisms 2016 Oct 1;9(10):1221-1229
Disease models & mechanisms 2016 Oct 1;9(10):1221-1229
Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET).
Nikitaki Z, Nikolov V, Mavragani IV, Mladenov E, Mangelis A, Laskaratou DA, Fragkoulis GI, Hellweg CE, Martin OA, Emfietzoglou D, Hatzi VI, Terzoudi GI, Iliakis G, Georgakilas AG
Free radical research 2016 Nov;50(sup1):S64-S78
Free radical research 2016 Nov;50(sup1):S64-S78
Reduced MUTYH, MTH1, and OGG1 expression and TP53 mutation in diffuse-type adenocarcinoma of gastric cardia.
Kohno Y, Yamamoto H, Hirahashi M, Kumagae Y, Nakamura M, Oki E, Oda Y
Human pathology 2016 Jun;52:145-52
Human pathology 2016 Jun;52:145-52
8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.
Leon J, Sakumi K, Castillo E, Sheng Z, Oka S, Nakabeppu Y
Scientific reports 2016 Feb 25;6:22086
Scientific reports 2016 Feb 25;6:22086
Long-term High Fat Ketogenic Diet Promotes Renal Tumor Growth in a Rat Model of Tuberous Sclerosis.
Liśkiewicz AD, Kasprowska D, Wojakowska A, Polański K, Lewin-Kowalik J, Kotulska K, Jędrzejowska-Szypułka H
Scientific reports 2016 Feb 19;6:21807
Scientific reports 2016 Feb 19;6:21807
Corrigendum: 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.
Leon J, Sakumi K, Castillo E, Sheng Z, Oka S, Nakabeppu Y
Scientific reports 2016 Apr 29;6:24696
Scientific reports 2016 Apr 29;6:24696
Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells.
Zijno A, De Angelis I, De Berardis B, Andreoli C, Russo MT, Pietraforte D, Scorza G, Degan P, Ponti J, Rossi F, Barone F
Toxicology in vitro : an international journal published in association with BIBRA 2015 Oct;29(7):1503-12
Toxicology in vitro : an international journal published in association with BIBRA 2015 Oct;29(7):1503-12
BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication.
Fridlich R, Annamalai D, Roy R, Bernheim G, Powell SN
DNA repair 2015 Jun;30:11-20
DNA repair 2015 Jun;30:11-20
PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.
Dziaman T, Ludwiczak H, Ciesla JM, Banaszkiewicz Z, Winczura A, Chmielarczyk M, Wisniewska E, Marszalek A, Tudek B, Olinski R
PloS one 2014;9(12):e115558
PloS one 2014;9(12):e115558
Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing.
Wang H, Wang X, Chen G, Zhang X, Tang X, Park D, Cucinotta FA, Yu DS, Deng X, Dynan WS, Doetsch PW, Wang Y
The Journal of biological chemistry 2014 Oct 31;289(44):30635-30644
The Journal of biological chemistry 2014 Oct 31;289(44):30635-30644
HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β.
Fang Q, Inanc B, Schamus S, Wang XH, Wei L, Brown AR, Svilar D, Sugrue KF, Goellner EM, Zeng X, Yates NA, Lan L, Vens C, Sobol RW
Nature communications 2014 Nov 26;5:5513
Nature communications 2014 Nov 26;5:5513
NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10.
Cordero MD, Alcocer-Gómez E, Culic O, Carrión AM, de Miguel M, Díaz-Parrado E, Pérez-Villegas EM, Bullón P, Battino M, Sánchez-Alcazar JA
Antioxidants & redox signaling 2014 Mar 10;20(8):1169-80
Antioxidants & redox signaling 2014 Mar 10;20(8):1169-80
8-Oxo-7,8-dihydroguanine and uric acid as efficient predictors of survival in colon cancer patients.
Dziaman T, Banaszkiewicz Z, Roszkowski K, Gackowski D, Wisniewska E, Rozalski R, Foksinski M, Siomek A, Speina E, Winczura A, Marszalek A, Tudek B, Olinski R
International journal of cancer 2014 Jan 15;134(2):376-83
International journal of cancer 2014 Jan 15;134(2):376-83
Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells.
Kim SJ, Cheresh P, Williams D, Cheng Y, Ridge K, Schumacker PT, Weitzman S, Bohr VA, Kamp DW
The Journal of biological chemistry 2014 Feb 28;289(9):6165-76
The Journal of biological chemistry 2014 Feb 28;289(9):6165-76
Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells.
Kumar P, Rao GN, Pal BB, Pal A
The international journal of biochemistry & cell biology 2014 Aug;53:302-19
The international journal of biochemistry & cell biology 2014 Aug;53:302-19
Effects of CEES and LPS synergistically stimulate oxidative stress inactivates OGG1 signaling in macrophage cells.
Sagar S, Kumar P, Behera RR, Pal A
Journal of hazardous materials 2014 Aug 15;278:236-49
Journal of hazardous materials 2014 Aug 15;278:236-49
Oxidative DNA damage in human esophageal cancer: clinicopathological analysis of 8-hydroxydeoxyguanosine and its repair enzyme.
Kubo N, Morita M, Nakashima Y, Kitao H, Egashira A, Saeki H, Oki E, Kakeji Y, Oda Y, Maehara Y
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2014 Apr;27(3):285-93
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 2014 Apr;27(3):285-93
Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice.
Yuzefovych LV, Musiyenko SI, Wilson GL, Rachek LI
PloS one 2013;8(1):e54059
PloS one 2013;8(1):e54059
The significance of the alteration of 8-OHdG in serous ovarian carcinoma.
Xu X, Wang Y, Guo W, Zhou Y, Lv C, Chen X, Liu K
Journal of ovarian research 2013 Oct 29;6(1):74
Journal of ovarian research 2013 Oct 29;6(1):74
Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin.
Surjana D, Halliday GM, Damian DL
Carcinogenesis 2013 May;34(5):1144-9
Carcinogenesis 2013 May;34(5):1144-9
The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1.
Smith TB, Dun MD, Smith ND, Curry BJ, Connaughton HS, Aitken RJ
Journal of cell science 2013 Mar 15;126(Pt 6):1488-97
Journal of cell science 2013 Mar 15;126(Pt 6):1488-97
Decreased mitochondrial OGG1 expression is linked to mitochondrial defects and delayed hepatoma cell growth.
Lee YK, Youn HG, Wang HJ, Yoon G
Molecules and cells 2013 Jun;35(6):489-97
Molecules and cells 2013 Jun;35(6):489-97
Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs.
Rittinghausen S, Bellmann B, Creutzenberg O, Ernst H, Kolling A, Mangelsdorf I, Kellner R, Beneke S, Ziemann C
Toxicology 2013 Jan 7;303:177-86
Toxicology 2013 Jan 7;303:177-86
Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons.
Hill JW, Poddar R, Thompson JF, Rosenberg GA, Yang Y
Neuroscience 2012 Sep 18;220:277-90
Neuroscience 2012 Sep 18;220:277-90
Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1.
Siggens L, Figg N, Bennett M, Foo R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):2117-24
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 May;26(5):2117-24
Human 8-oxoguanine-DNA glycosylase-1 is downregulated in human basal cell carcinoma.
Huang XX, Scolyer RA, Abubakar A, Halliday GM
Molecular genetics and metabolism 2012 May;106(1):127-30
Molecular genetics and metabolism 2012 May;106(1):127-30
Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
Kadekaro AL, Chen J, Yang J, Chen S, Jameson J, Swope VB, Cheng T, Kadakia M, Abdel-Malek Z
Molecular cancer research : MCR 2012 Jun;10(6):778-86
Molecular cancer research : MCR 2012 Jun;10(6):778-86
Accumulation of nuclear and mitochondrial DNA damage in the frontal cortex cells of patients with HIV-associated neurocognitive disorders.
Zhang Y, Wang M, Li H, Zhang H, Shi Y, Wei F, Liu D, Liu K, Chen D
Brain research 2012 Jun 6;1458:1-11
Brain research 2012 Jun 6;1458:1-11
Protection from palmitate-induced mitochondrial DNA damage prevents from mitochondrial oxidative stress, mitochondrial dysfunction, apoptosis, and impaired insulin signaling in rat L6 skeletal muscle cells.
Yuzefovych LV, Solodushko VA, Wilson GL, Rachek LI
Endocrinology 2012 Jan;153(1):92-100
Endocrinology 2012 Jan;153(1):92-100
Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype.
Karihtala P, Kauppila S, Puistola U, Jukkola-Vuorinen A
British journal of cancer 2012 Jan 17;106(2):344-7
British journal of cancer 2012 Jan 17;106(2):344-7
Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility.
Wang HT, Hu Y, Tong D, Huang J, Gu L, Wu XR, Chung FL, Li GM, Tang MS
The Journal of biological chemistry 2012 Apr 6;287(15):12379-86
The Journal of biological chemistry 2012 Apr 6;287(15):12379-86
Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice.
La Maestra S, Kisby GE, Micale RT, Johnson J, Kow YW, Bao G, Sheppard C, Stanfield S, Tran H, Woltjer RL, D'Agostini F, Steele VE, De Flora S
Toxicological sciences : an official journal of the Society of Toxicology 2011 Oct;123(2):471-9
Toxicological sciences : an official journal of the Society of Toxicology 2011 Oct;123(2):471-9
Functional polymorphisms of the hOGG1 gene confer risk to type 2 epithelial ovarian cancer in Chinese.
Chen X, Liu X, Wang J, Guo W, Sun C, Cai Z, Wu Q, Xu X, Wang Y
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2011 Nov;21(8):1407-13
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2011 Nov;21(8):1407-13
Dynamics of the primate ovarian surface epithelium during the ovulatory menstrual cycle.
Wright JW, Jurevic L, Stouffer RL
Human reproduction (Oxford, England) 2011 Jun;26(6):1408-21
Human reproduction (Oxford, England) 2011 Jun;26(6):1408-21
Two functional variations in 5'-UTR of hoGG1 gene associated with the risk of breast cancer in Chinese.
Chen X, Wang J, Guo W, Liu X, Sun C, Cai Z, Fan Y, Wang Y
Breast cancer research and treatment 2011 Jun;127(3):795-803
Breast cancer research and treatment 2011 Jun;127(3):795-803
Host DNA repair proteins in response to Pseudomonas aeruginosa in lung epithelial cells and in mice.
Wu M, Huang H, Zhang W, Kannan S, Weaver A, McKibben M, Herington D, Zeng H, Gao H
Infection and immunity 2011 Jan;79(1):75-87
Infection and immunity 2011 Jan;79(1):75-87
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity.
Zhang L, Gavin T, Barber DS, LoPachin RM
Toxicology letters 2011 Aug 10;205(1):1-7
Toxicology letters 2011 Aug 10;205(1):1-7
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.
Huang E, Qu D, Zhang Y, Venderova K, Haque ME, Rousseaux MW, Slack RS, Woulfe JM, Park DS
Nature cell biology 2010 Jun;12(6):563-71
Nature cell biology 2010 Jun;12(6):563-71
Zinc deficiency affects DNA damage, oxidative stress, antioxidant defenses, and DNA repair in rats.
Song Y, Leonard SW, Traber MG, Ho E
The Journal of nutrition 2009 Sep;139(9):1626-31
The Journal of nutrition 2009 Sep;139(9):1626-31
Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells.
Yan T, Seo Y, Kinsella TJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 Nov 15;15(22):6912-20
Base excision repair of reactive oxygen species-initiated 7,8-dihydro-8-oxo-2'-deoxyguanosine inhibits the cytotoxicity of platinum anticancer drugs.
Preston TJ, Henderson JT, McCallum GP, Wells PG
Molecular cancer therapeutics 2009 Jul;8(7):2015-26
Molecular cancer therapeutics 2009 Jul;8(7):2015-26
Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA.
Salas TR, Petruseva I, Lavrik O, Saintomé C
Nucleic acids research 2009 Jan;37(1):38-46
Nucleic acids research 2009 Jan;37(1):38-46
The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells.
de Souza-Pinto NC, Maynard S, Hashiguchi K, Hu J, Muftuoglu M, Bohr VA
Molecular and cellular biology 2009 Aug;29(16):4441-54
Molecular and cellular biology 2009 Aug;29(16):4441-54
Human 8-oxoguanine-DNA glycosylase 1 protein and gene are expressed more abundantly in the superficial than basal layer of human epidermis.
Javeri A, Huang XX, Bernerd F, Mason RS, Halliday GM
DNA repair 2008 Sep 1;7(9):1542-50
DNA repair 2008 Sep 1;7(9):1542-50
Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase.
Simone S, Gorin Y, Velagapudi C, Abboud HE, Habib SL
Diabetes 2008 Oct;57(10):2626-36
Diabetes 2008 Oct;57(10):2626-36
Translesion synthesis of 7,8-dihydro-8-oxo-2'-deoxyguanosine by DNA polymerase eta in vivo.
Lee DH, Pfeifer GP
Mutation research 2008 May 10;641(1-2):19-26
Mutation research 2008 May 10;641(1-2):19-26
Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene.
Murakami T, Nagai M, Miyazaki K, Morimoto N, Ohta Y, Kurata T, Takehisa Y, Kamiya T, Abe K
Brain research 2007 May 30;1150:182-9
Brain research 2007 May 30;1150:182-9
beta(2)-Adrenergic stimulation attenuates left ventricular remodeling, decreases apoptosis, and improves calcium homeostasis in a rodent model of ischemic cardiomyopathy.
Xydas S, Kherani AR, Chang JS, Klotz S, Hay I, Mutrie CJ, Moss GW, Gu A, Schulman AR, Gao D, Hu D, Wu EX, Wei C, Oz MC, Wang J
The Journal of pharmacology and experimental therapeutics 2006 May;317(2):553-61
The Journal of pharmacology and experimental therapeutics 2006 May;317(2):553-61
The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord.
Roseborough G, Gao D, Chen L, Trush MA, Zhou S, Williams GM, Wei C
The American journal of pathology 2006 May;168(5):1443-51
The American journal of pathology 2006 May;168(5):1443-51
The effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity.
Chatterjee A, Mambo E, Osada M, Upadhyay S, Sidransky D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jan;20(1):112-4
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jan;20(1):112-4
Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria.
Rachek LI, Thornley NP, Grishko VI, LeDoux SP, Wilson GL
Diabetes 2006 Apr;55(4):1022-8
Diabetes 2006 Apr;55(4):1022-8
Protection of INS-1 cells from free fatty acid-induced apoptosis by targeting hOGG1 to mitochondria.
Rachek LI, Thornley NP, Grishko VI, LeDoux SP, Wilson GL
Diabetes 2006 Apr;55(4):1022-8
Diabetes 2006 Apr;55(4):1022-8
The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells.
Chen D, Yu Z, Zhu Z, Lopez CD
Cancer research 2006 Apr 1;66(7):3485-94
Cancer research 2006 Apr 1;66(7):3485-94
In vivo inosine protects alveolar epithelial type 2 cells against hyperoxia-induced DNA damage through MAP kinase signaling.
Buckley S, Barsky L, Weinberg K, Warburton D
American journal of physiology. Lung cellular and molecular physiology 2005 Mar;288(3):L569-75
American journal of physiology. Lung cellular and molecular physiology 2005 Mar;288(3):L569-75
Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells.
Ruchko M, Gorodnya O, LeDoux SP, Alexeyev MF, Al-Mehdi AB, Gillespie MN
American journal of physiology. Lung cellular and molecular physiology 2005 Mar;288(3):L530-5
American journal of physiology. Lung cellular and molecular physiology 2005 Mar;288(3):L530-5
Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes. Protective role of targeting 8-oxoguanine glycosylase to mitochondria.
Druzhyna NM, Musiyenko SI, Wilson GL, LeDoux SP
The Journal of biological chemistry 2005 Jun 3;280(22):21673-9
The Journal of biological chemistry 2005 Jun 3;280(22):21673-9
Induction of OGG1 gene expression by HIV-1 Tat.
Imai K, Nakata K, Kawai K, Hamano T, Mei N, Kasai H, Okamoto T
The Journal of biological chemistry 2005 Jul 22;280(29):26701-13
The Journal of biological chemistry 2005 Jul 22;280(29):26701-13
DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA.
Stuart JA, Hashiguchi K, Wilson DM 3rd, Copeland WC, Souza-Pinto NC, Bohr VA
Nucleic acids research 2004;32(7):2181-92
Nucleic acids research 2004;32(7):2181-92
The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity.
Hashiguchi K, Stuart JA, de Souza-Pinto NC, Bohr VA
Nucleic acids research 2004;32(18):5596-608
Nucleic acids research 2004;32(18):5596-608
Cadmium exposure down-regulates 8-oxoguanine DNA glycosylase expression in rat lung and alveolar epithelial cells.
Potts RJ, Watkin RD, Hart BA
Toxicology 2003 Mar 3;184(2-3):189-202
Toxicology 2003 Mar 3;184(2-3):189-202
Cadmium exposure down-regulates 8-oxoguanine DNA glycosylase expression in rat lung and alveolar epithelial cells.
Potts RJ, Watkin RD, Hart BA
Toxicology 2003 Mar 3;184(2-3):189-202
Toxicology 2003 Mar 3;184(2-3):189-202
Concomitant loss of mitochondria and the DNA repair protein hOGG1 in clear cell carcinoma of the kidney.
Mukunyadzi P, Huang H, Liu K, Fan CY
Applied immunohistochemistry & molecular morphology : AIMM 2003 Dec;11(4):334-8
Applied immunohistochemistry & molecular morphology : AIMM 2003 Dec;11(4):334-8
Concomitant loss of mitochondria and the DNA repair protein hOGG1 in clear cell carcinoma of the kidney.
Mukunyadzi P, Huang H, Liu K, Fan CY
Applied immunohistochemistry & molecular morphology : AIMM 2003 Dec;11(4):334-8
Applied immunohistochemistry & molecular morphology : AIMM 2003 Dec;11(4):334-8
Malgun (clear) cell change in Helicobacter pylori gastritis reflects epithelial genomic damage and repair.
Jang J, Lee S, Jung Y, Song K, Fukumoto M, Gould VE, Lee I
The American journal of pathology 2003 Apr;162(4):1203-11
The American journal of pathology 2003 Apr;162(4):1203-11
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein.
Tuo J, Chen C, Zeng X, Christiansen M, Bohr VA
DNA repair 2002 Nov 3;1(11):913-27
DNA repair 2002 Nov 3;1(11):913-27
Functional crosstalk between hOgg1 and the helicase domain of Cockayne syndrome group B protein.
Tuo J, Chen C, Zeng X, Christiansen M, Bohr VA
DNA repair 2002 Nov 3;1(11):913-27
DNA repair 2002 Nov 3;1(11):913-27
Conditional targeting of the DNA repair enzyme hOGG1 into mitochondria.
Rachek LI, Grishko VI, Musiyenko SI, Kelley MR, LeDoux SP, Wilson GL
The Journal of biological chemistry 2002 Nov 22;277(47):44932-7
The Journal of biological chemistry 2002 Nov 22;277(47):44932-7
Defective repair of 8-hydroxyguanine in mitochondria of MCF-7 and MDA-MB-468 human breast cancer cell lines.
Mambo E, Nyaga SG, Bohr VA, Evans MK
Cancer research 2002 Mar 1;62(5):1349-55
Cancer research 2002 Mar 1;62(5):1349-55
Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death.
Dobson AW, Grishko V, LeDoux SP, Kelley MR, Wilson GL, Gillespie MN
American journal of physiology. Lung cellular and molecular physiology 2002 Jul;283(1):L205-10
American journal of physiology. Lung cellular and molecular physiology 2002 Jul;283(1):L205-10
Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells.
Hodges NJ, Chipman JK
Carcinogenesis 2002 Jan;23(1):55-60
Carcinogenesis 2002 Jan;23(1):55-60
Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells.
Hodges NJ, Chipman JK
Carcinogenesis 2002 Jan;23(1):55-60
Carcinogenesis 2002 Jan;23(1):55-60
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.
Tyrberg B, Anachkov KA, Dib SA, Wang-Rodriguez J, Yoon KH, Levine F
BMC endocrine disorders 2002 Apr 25;2(1):2
BMC endocrine disorders 2002 Apr 25;2(1):2
Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes.
Tyrberg B, Anachkov KA, Dib SA, Wang-Rodriguez J, Yoon KH, Levine F
BMC endocrine disorders 2002 Apr 25;2(1):2
BMC endocrine disorders 2002 Apr 25;2(1):2
Frequent allelic imbalance and loss of protein expression of the DNA repair gene hOGG1 in head and neck squamous cell carcinoma.
Fan CY, Liu KL, Huang HY, Barnes EL, Swalsky PA, Bakker A, Woods J, Finkelstein SD
Laboratory investigation; a journal of technical methods and pathology 2001 Oct;81(10):1429-38
Laboratory investigation; a journal of technical methods and pathology 2001 Oct;81(10):1429-38
Frequent allelic imbalance and loss of protein expression of the DNA repair gene hOGG1 in head and neck squamous cell carcinoma.
Fan CY, Liu KL, Huang HY, Barnes EL, Swalsky PA, Bakker A, Woods J, Finkelstein SD
Laboratory investigation; a journal of technical methods and pathology 2001 Oct;81(10):1429-38
Laboratory investigation; a journal of technical methods and pathology 2001 Oct;81(10):1429-38
Up-regulation of base excision repair activity for 8-hydroxy-2'-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion.
Lin LH, Cao S, Yu L, Cui J, Hamilton WJ, Liu PK
Journal of neurochemistry 2000 Mar;74(3):1098-105
Journal of neurochemistry 2000 Mar;74(3):1098-105
Up-regulation of base excision repair activity for 8-hydroxy-2'-deoxyguanosine in the mouse brain after forebrain ischemia-reperfusion.
Lin LH, Cao S, Yu L, Cui J, Hamilton WJ, Liu PK
Journal of neurochemistry 2000 Mar;74(3):1098-105
Journal of neurochemistry 2000 Mar;74(3):1098-105
hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population.
Wikman H, Risch A, Klimek F, Schmezer P, Spiegelhalder B, Dienemann H, Kayser K, Schulz V, Drings P, Bartsch H
International journal of cancer 2000 Dec 15;88(6):932-7
International journal of cancer 2000 Dec 15;88(6):932-7
hOGG1 polymorphism and loss of heterozygosity (LOH): significance for lung cancer susceptibility in a caucasian population.
Wikman H, Risch A, Klimek F, Schmezer P, Spiegelhalder B, Dienemann H, Kayser K, Schulz V, Drings P, Bartsch H
International journal of cancer 2000 Dec 15;88(6):932-7
International journal of cancer 2000 Dec 15;88(6):932-7
Human MMH (OGG1) type 1a protein is a major enzyme for repair of 8-hydroxyguanine lesions in human cells.
Monden Y, Arai T, Asano M, Ohtsuka E, Aburatani H, Nishimura S
Biochemical and biophysical research communications 1999 May 19;258(3):605-10
Biochemical and biophysical research communications 1999 May 19;258(3):605-10
Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles.
Tsurudome Y, Hirano T, Yamato H, Tanaka I, Sagai M, Hirano H, Nagata N, Itoh H, Kasai H
Carcinogenesis 1999 Aug;20(8):1573-6
Carcinogenesis 1999 Aug;20(8):1573-6
Changes in levels of 8-hydroxyguanine in DNA, its repair and OGG1 mRNA in rat lungs after intratracheal administration of diesel exhaust particles.
Tsurudome Y, Hirano T, Yamato H, Tanaka I, Sagai M, Hirano H, Nagata N, Itoh H, Kasai H
Carcinogenesis 1999 Aug;20(8):1573-6
Carcinogenesis 1999 Aug;20(8):1573-6
Binding of circulating antibodies to reactive oxygen species modified-DNA and detecting DNA damage by a monoclonal antibody probe.
Ashok BT, Ali R
Mechanisms of ageing and development 1998 Jun 1;103(1):69-80
Mechanisms of ageing and development 1998 Jun 1;103(1):69-80
Binding of circulating antibodies to reactive oxygen species modified-DNA and detecting DNA damage by a monoclonal antibody probe.
Ashok BT, Ali R
Mechanisms of ageing and development 1998 Jun 1;103(1):69-80
Mechanisms of ageing and development 1998 Jun 1;103(1):69-80
Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III.
Hilbert TP, Chaung W, Boorstein RJ, Cunningham RP, Teebor GW
The Journal of biological chemistry 1997 Mar 7;272(10):6733-40
The Journal of biological chemistry 1997 Mar 7;272(10):6733-40
Cloning and expression of the cDNA encoding the human homologue of the DNA repair enzyme, Escherichia coli endonuclease III.
Hilbert TP, Chaung W, Boorstein RJ, Cunningham RP, Teebor GW
The Journal of biological chemistry 1997 Mar 7;272(10):6733-40
The Journal of biological chemistry 1997 Mar 7;272(10):6733-40
A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.
Lu R, Nash HM, Verdine GL
Current biology : CB 1997 Jun 1;7(6):397-407
Current biology : CB 1997 Jun 1;7(6):397-407
A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.
Lu R, Nash HM, Verdine GL
Current biology : CB 1997 Jun 1;7(6):397-407
Current biology : CB 1997 Jun 1;7(6):397-407
Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
Radicella JP, Dherin C, Desmaze C, Fox MS, Boiteux S
Proceedings of the National Academy of Sciences of the United States of America 1997 Jul 22;94(15):8010-5
Proceedings of the National Academy of Sciences of the United States of America 1997 Jul 22;94(15):8010-5
Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.
Radicella JP, Dherin C, Desmaze C, Fox MS, Boiteux S
Proceedings of the National Academy of Sciences of the United States of America 1997 Jul 22;94(15):8010-5
Proceedings of the National Academy of Sciences of the United States of America 1997 Jul 22;94(15):8010-5
Anti-ROS-DNA monoclonal antibody as molecular probe for oxidative DNA damage.
Ashok BT, Ahmad J, Qadri A, Ali R
Biochemistry and molecular biology international 1997 Dec;43(6):1219-29
Biochemistry and molecular biology international 1997 Dec;43(6):1219-29
Anti-ROS-DNA monoclonal antibody as molecular probe for oxidative DNA damage.
Ashok BT, Ahmad J, Qadri A, Ali R
Biochemistry and molecular biology international 1997 Dec;43(6):1219-29
Biochemistry and molecular biology international 1997 Dec;43(6):1219-29
Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.
Sakumi K, Furuichi M, Tsuzuki T, Kakuma T, Kawabata S, Maki H, Sekiguchi M
The Journal of biological chemistry 1993 Nov 5;268(31):23524-30
The Journal of biological chemistry 1993 Nov 5;268(31):23524-30
Zinc(II) inhibits the release of thyroid and glucocorticoid receptors from chromatin of cultured GC cells.
Ramirez IJ, Halwer M, Shapiro LE, Surks MI
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 1991 Apr;23(4):155-61
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 1991 Apr;23(4):155-61
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Supportive validation
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- Western Blot: OGG1 Antibody [NB100-106] - 1, 5, 10 and 20 ng titration of human recombinant Ogg1 protein, detected by NB 100-106.
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- Western Blot: OGG1 Antibody [NB100-106] - Analysis of Ogg1 recombinant protein using Ogg1 antibody at 1 ug/mL.
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- Western Blot: OGG1 Antibody [NB100-106] - - Analysis of Ogg1 expression in Jurkat whole cell lysate.
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- Western Blot: OGG1 Antibody [NB100-106] - The protein expression levels of HVL and LVL sorted cells by western blotting. The ATM, phospho-ATM, GPX2, MRE11, OGG1, and XPC levels were measured by western blot analysis. The figure is representative of three independent experiments. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0164281), licensed under a CC-BY licence.
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- Immunohistochemistry-Frozen: OGG1 Antibody [NB100-106] - Detection of OGG1 in formaldehyde-fixed frozen sections of the substantia nigra from a Rhesus macaque (Macaca mulatta) using NB100-106 at 10 ug/mL. Photo courtesy of Glen Kisby, Oregon Health Sciences University.
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- Immunohistochemistry-Paraffin: OGG1 Antibody [NB100-106] - Analysis of OGG1 in human skin tissues. Image courtesy of product review by Arash Javeri.
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- Immunohistochemistry: OGG1 Antibody [NB100-106] - Staining of human tonsil, germinal center and mantle zone.
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- Immunohistochemistry: OGG1 Antibody [NB100-106] - Figure 5 IHC-P analysis of hOGG1 protein expression in serous ovarian cancer: (A) Normal ovarian tissue treated with anti-hOGG1 antibody, biotinylated anti-rabbit IgG secondary antibody, and avidin-biotin-peroxidase complex, and counterstained with p-dimethylaminobenzaldehyde reagent (magnification 100 x); (B) serous cystadenoma with positive staining (magnification 200 x); (C) LG-SOC tissue with moderate positive staining (magnification 200 x); and (D) HG-SOC with negative staining (magnification 200 x). Black arrow pointed at the immunostained epithelial cells. Image collected and cropped by CiteAb from the following publication (http://ovarianresearch.biomedcentral.com/articles/10.1186/1757-2215-6-74), licensed under a CC-BY licence.
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- Immunohistochemistry: OGG1 Antibody [NB100-106] - The H&E staining ((a)-(c)) and IHC staining for oxidative DNA damage, 8-oxo-dGuo ((d)-(g)), and DNA repair enzyme hOGG1 ((h)-(j)) in control subjects and tumor and nontumor lesions of BCC patients. Values given are mean +/- SD. The statistical significance of differences between the control and case and between adjacent epidermis and tumor lesions of BCC patients was evaluated by nonparametric variables with Kruskal-Wallis test followed by Dunnett's post hoc test. * P < 0.05, *P < 0.01, *P < 0.001 compared to control; ##P < 0.01, ###P < 0.001 compared to tumor lesions of BCC patients. Image collected and cropped by CiteAb from the following publication (http://www.hindawi.com/journals/omcl/2016/5934024/), licensed under a CC-BY licence.
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- Immunohistochemistry-Paraffin: OGG1 Antibody [NB100-106] - Comparison of the expression of OGG1 protein in normal colon tissue, polyp and cancer tissue of adenoma (AD, n = 68) and carcinoma (CRC, n = 103) patients. Immunohistochemical detection in paraffin embedded sections stained with hematoxylin and eosin. Center mark in the box indicates the medians of the samples. The length of each box (IQR, interquartile range) represents the range within which the central 50% of the values fell, with the vertical edges placed at the first and third quartiles. Whiskers show variability outside the upper and lower quartiles. P was obtained with the Mann-Whitney test. Image collected and cropped by CiteAb from the following publication (http://dx.plos.org/10.1371/journal.pone.0115558), licensed under a CC-BY licence.
Supportive validation
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- Flow Cytometry: OGG1 Antibody [NB100-106] - Baseline Ogg1 expression in human PBMC from a healthy donor. Image from verified.customer review.
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- Flow (Intracellular): OGG1 Antibody [NB100-106] - An intracellular stain was performed on HeLa cells with NB100-106C (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Dylight 650.
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- Flow Cytometry: OGG1 Antibody [NB100-106] - An intracellular stain was performed on Jurkat Cells with NB100-106 and a matched isotype control. Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 2.5 ug/mL for 30 minutes at room temperature, followed by Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Dylight 550.
