Tissue expression
Cell line expression
Protein structure
OGG1
8-oxoguanine DNA glycosylaseHMMH, HOGG1, MUTM, OGH1
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]
Top validated antibodies |
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Novus Biologicals | NB100-106 | 117 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
antibodies-online | ABIN151034 | 85 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
Proteintech Group | 15125-1-AP | 28 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
|
GeneTex | GTX20204 | 3 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
Invitrogen Antibodies | PA1-31402 | 4 references | Polyclonal |
WB
ICC
IP
IHC
FC
OA |
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Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider