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Learn12462-1-AP
antibody from Proteintech Group
Targeting: SPAG6
CFAP194, CT141, FAP194, PF16, Repro-SA-1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [13]
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- Validations
- Western blot [1]
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- Product number
- 12462-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12462-1-AP, RRID:AB_2194798
- Product name
- SPAG6 antibody
- Antibody type
- Polyclonal
- Description
- SPAG6 antibody (Cat. #12462-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Novel mutations in FSIP2 cause male infertility through multiple morphological abnormalities of the sperm flagella.
Novel biallelic DNHD1 variants associated with male infertility with severe MMAF phenotype.
A novel frameshift variant in AXDND1 may cause multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family.
Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets.
High Expression of SPAG6 Acts as a Pro-Tumor Factor and Associated With Poor Prognosis in Acute Myeloid Leukemia.
SPAG6 overexpression decreases the pro-apoptotic effect of daunorubicin in acute myeloid leukemia cells through the ROS/JNK MAPK axis in a GSTP1-dependent manner.
CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.
A homozygous ARMC3 splicing variant causes asthenozoospermia and flagellar disorganization in a consanguineous family.
Microcystin leucine arginine induces human sperm damage: Involvement of the Ca(2+)/CaMKKβ/AMPK pathway.
CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men.
Identification of novel biallelic LRRC6 variants in male Chinese patients with primary ciliary dyskinesia and infertility.
Novel Loss-of-Function Mutations in DNAH1 Displayed Different Phenotypic Spectrum in Humans and Mice.
Spag6 Negatively Regulates Neuronal Migration During Mouse Brain Development.
Hussain M, Mansoor A, Zhang H, Uddin M, Mustafa G, Abbas M, Shafiq U, Shoaib M, Rahim F, Ahmed N, Zeb A, Abbas T, Shah W, Shi QH
Asian journal of andrology 2026 Mar 1;28(2):205-212
Asian journal of andrology 2026 Mar 1;28(2):205-212
Novel biallelic DNHD1 variants associated with male infertility with severe MMAF phenotype.
Uddin I, Zafar I, Xu CL, Xing XM, Li WQ, Zou JQ, Tahmasebi H, Khan MI, Wu LM, Bao JQ
Asian journal of andrology 2026 Mar 1;28(2):179-186
Asian journal of andrology 2026 Mar 1;28(2):179-186
A novel frameshift variant in AXDND1 may cause multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family.
Ali I, Yang ML, Rahim F, Ali H, Zeb A, Ahmad N, Raza Y, Yue W, Shoaib M, Abbas T, Shah W, Ma H, Zhang H, Yin H, Shi QH
Asian journal of andrology 2025 Nov 1;27(6):691-696
Asian journal of andrology 2025 Nov 1;27(6):691-696
Novel homozygous SPAG17 variants cause human male infertility through multiple morphological abnormalities of spermatozoal flagella related to axonemal microtubule doublets.
Liu T, Rahim F, Yang ML, Uddin M, Ye JW, Ali I, Raza Y, Mansoor A, Shoaib M, Hussain M, Khan I, Shah B, Khan A, Nisar A, Ma H, Xu B, Shah W, Shi QH
Asian journal of andrology 2025 Mar 1;27(2):245-253
Asian journal of andrology 2025 Mar 1;27(2):245-253
High Expression of SPAG6 Acts as a Pro-Tumor Factor and Associated With Poor Prognosis in Acute Myeloid Leukemia.
Luo J, Zhao H, Zang X, Liu L
International journal of laboratory hematology 2025 Aug;47(4):680-689
International journal of laboratory hematology 2025 Aug;47(4):680-689
SPAG6 overexpression decreases the pro-apoptotic effect of daunorubicin in acute myeloid leukemia cells through the ROS/JNK MAPK axis in a GSTP1-dependent manner.
Luo J, Ding L, Pan S, Luo J, Zhao H, Yin J, Su R, Zhang J, Liu L
Frontiers in pharmacology 2024;15:1390456
Frontiers in pharmacology 2024;15:1390456
CCDC181 is required for sperm flagellum biogenesis and male fertility in mice.
Zhang XJ, Hou XN, Zhou JT, Shi BL, Ye JW, Yang ML, Jiang XH, Xu B, Wu LM, Shi QH
Zoological research 2024 Sep 18;45(5):1061-1072
Zoological research 2024 Sep 18;45(5):1061-1072
A homozygous ARMC3 splicing variant causes asthenozoospermia and flagellar disorganization in a consanguineous family.
Rahim F, Tao L, Khan K, Ali I, Zeb A, Khan I, Dil S, Abbas T, Hussain A, Zubair M, Zhang H, Hui M, Khan MA, Shah W, Shi Q
Clinical genetics 2024 Oct;106(4):437-447
Clinical genetics 2024 Oct;106(4):437-447
Microcystin leucine arginine induces human sperm damage: Involvement of the Ca(2+)/CaMKKβ/AMPK pathway.
Guo X, Meng R, Liu J, Zhang S, Liu H, Du X, Zhang H, Li Y
Ecotoxicology and environmental safety 2023 May;256:114845
Ecotoxicology and environmental safety 2023 May;256:114845
CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile men.
Jin HJ, Wang JL, Geng XY, Wang CY, Wang BB, Chen SR
EBioMedicine 2023 Jul;93:104675
EBioMedicine 2023 Jul;93:104675
Identification of novel biallelic LRRC6 variants in male Chinese patients with primary ciliary dyskinesia and infertility.
Li Y, Li Y, Wang Y, Meng L, Tan C, Du J, Tan YQ, Nie H, Zhang Q, Lu G, Lin G, Li H, Zhang H, Tu C
Journal of assisted reproduction and genetics 2023 Jan;40(1):41-51
Journal of assisted reproduction and genetics 2023 Jan;40(1):41-51
Novel Loss-of-Function Mutations in DNAH1 Displayed Different Phenotypic Spectrum in Humans and Mice.
Khan R, Zaman Q, Chen J, Khan M, Ma A, Zhou J, Zhang B, Ali A, Naeem M, Zubair M, Zhao D, Shah W, Khan M, Zhang Y, Xu B, Zhang H, Shi Q
Frontiers in endocrinology 2021;12:765639
Frontiers in endocrinology 2021;12:765639
Spag6 Negatively Regulates Neuronal Migration During Mouse Brain Development.
Yan R, Hu X, Zhang Q, Song L, Zhang M, Zhang Y, Zhao S
Journal of molecular neuroscience : MN 2015 Dec;57(4):463-9
Journal of molecular neuroscience : MN 2015 Dec;57(4):463-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SPAG6 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SPAG6. This antibody recognizes human, mouse, rat antigen. The SPAG6 antibody has been validated for the following applications: ELISA, WB analysis.
