SCRG1

Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]

Description

Stimulator of chondrogenesis 1

Tissue specificity

Tissue enhanced (brain, choroid plexus)

Predicted location

Secreted in brain

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

4:q34.1 (173384701 - 173406380)

Ensembl ID

ENSG00000164106  (ver. 103.38)

Orthologs

Mouse Scrg1: ENSMUSG00000031610

UniProt

O75711

neXtProt

NX_O75711

Human splice variants
Mouse splice variants