Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 12926-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12926-1-AP, RRID:AB_2189317
- Product name
- SKAP2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SKAP2 antibody (Cat. #12926-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells.
The mechanism of acentrosomal spindle assembly in human oocytes.
SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation.
SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients.
Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation.
Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR signalling pathway.
SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst.
Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer.
SKAP2 regulates Arp2/3 complex for actin-mediated asymmetric cytokinesis by interacting with WAVE2 in mouse oocytes.
Skap2 is required for β(2) integrin-mediated neutrophil recruitment and functions.
Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.
SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression.
Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer.
Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.
Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.
The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.
Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.
SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell.
Wang X, Yu S, Jian Y, Pan H, Guo J, Wu J, Guo W
Frontiers in cardiovascular medicine 2022;9:1023982
Frontiers in cardiovascular medicine 2022;9:1023982
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation.
Ghelman J, Grewing L, Windener F, Albrecht S, Zarbock A, Kuhlmann T
Glia 2021 Nov;69(11):2699-2716
Glia 2021 Nov;69(11):2699-2716
SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients.
Fløyel T, Meyerovich K, Prause MC, Kaur S, Frørup C, Mortensen HB, Nielsen LB, Pociot F, Cardozo AK, Størling J
Diabetes 2021 Feb;70(2):464-476
Diabetes 2021 Feb;70(2):464-476
Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation.
Nguyen GT, Xu S, Adams W, Leong JM, Bunnell SC, Mansour MK, Sykes DB, Mecsas J
iScience 2021 Aug 20;24(8):102871
iScience 2021 Aug 20;24(8):102871
Levobupivacaine inhibits proliferation and promotes apoptosis of breast cancer cells by suppressing the PI3K/Akt/mTOR signalling pathway.
Kwakye AK, Kampo S, Lv J, Ramzan MN, Richard SA, Falagán AA, Agudogo J, Atito-Narh E, Yan Q, Wen QP
BMC research notes 2020 Aug 17;13(1):386
BMC research notes 2020 Aug 17;13(1):386
SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst.
Nguyen GT, Shaban L, Mack M, Swanson KD, Bunnell SC, Sykes DB, Mecsas J
eLife 2020 Apr 30;9
eLife 2020 Apr 30;9
Scorpion Venom Analgesic Peptide, BmK AGAP Inhibits Stemness, and Epithelial-Mesenchymal Transition by Down-Regulating PTX3 in Breast Cancer.
Kampo S, Ahmmed B, Zhou T, Owusu L, Anabah TW, Doudou NR, Kuugbee ED, Cui Y, Lu Z, Yan Q, Wen QP
Frontiers in oncology 2019;9:21
Frontiers in oncology 2019;9:21
SKAP2 regulates Arp2/3 complex for actin-mediated asymmetric cytokinesis by interacting with WAVE2 in mouse oocytes.
He SW, Xu BH, Liu Y, Wang YL, Chen MH, Xu L, Liao BQ, Lui R, Li FP, Lin YH, Fu XP, Fu BB, Hong ZW, Liu YX, Qi ZQ, Wang HL
Cell cycle (Georgetown, Tex.) 2017;16(23):2272-2281
Cell cycle (Georgetown, Tex.) 2017;16(23):2272-2281
Skap2 is required for β(2) integrin-mediated neutrophil recruitment and functions.
Boras M, Volmering S, Bokemeyer A, Rossaint J, Block H, Bardel B, Van Marck V, Heitplatz B, Kliche S, Reinhold A, Lowell C, Zarbock A
The Journal of experimental medicine 2017 Mar 6;214(3):851-874
The Journal of experimental medicine 2017 Mar 6;214(3):851-874
Ethylacetate extract from Tetrastigma hemsleyanum induces apoptosis via the mitochondrial caspase-dependent intrinsic pathway in HepG2 cells.
Peng X, Zhang YY, Wang J, Ji Q
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jan;37(1):865-76
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jan;37(1):865-76
SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression.
Tanaka M, Shimamura S, Kuriyama S, Maeda D, Goto A, Aiba N
Cancer research 2016 Jan 15;76(2):358-69
Cancer research 2016 Jan 15;76(2):358-69
Src kinase-associated phosphoprotein2 expression is associated with poor prognosis in non-small cell lung cancer.
Kuranami S, Yokobori T, Mogi A, Altan B, Yajima T, Onozato R, Azuma Y, Iijima M, Kosaka T, Kuwano H
Anticancer research 2015 Apr;35(4):2411-5
Anticancer research 2015 Apr;35(4):2411-5
Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.
Ayoub E, Hall A, Scott AM, Chagnon MJ, Miquel G, Hallé M, Noda M, Bikfalvi A, Tremblay ML
The Journal of biological chemistry 2013 Sep 6;288(36):25739-25748
The Journal of biological chemistry 2013 Sep 6;288(36):25739-25748
Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.
Rolán HG, Durand EA, Mecsas J
Cell host & microbe 2013 Sep 11;14(3):306-17
Cell host & microbe 2013 Sep 11;14(3):306-17
The Src substrate SKAP2 regulates actin assembly by interacting with WAVE2 and cortactin proteins.
Shimamura S, Sasaki K, Tanaka M
The Journal of biological chemistry 2013 Jan 11;288(2):1171-83
The Journal of biological chemistry 2013 Jan 11;288(2):1171-83
Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.
Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD
Journal of cell science 2012 Nov 15;125(Pt 22):5535-45
Journal of cell science 2012 Nov 15;125(Pt 22):5535-45
SKAP2, a novel target of HSF4b, associates with NCK2/F-actin at membrane ruffles and regulates actin reorganization in lens cell.
Zhou L, Zhang Z, Zheng Y, Zhu Y, Wei Z, Xu H, Tang Q, Kong X, Hu L
Journal of cellular and molecular medicine 2011 Apr;15(4):783-95
Journal of cellular and molecular medicine 2011 Apr;15(4):783-95
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human liver tissue were subjected to SDS PAGE followed by western blot with 12926-1-AP(SKAP2 antibody) at dilution of 1:1500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 12926-1-AP(SKAP2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SKAP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SKAP2. This antibody recognizes human,mouse,rat antigen. The SKAP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.