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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [81]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- 15240-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15240-1-AP, RRID:AB_1557426
- Product name
- HLA class I ABC antibody
- Antibody type
- Polyclonal
- Description
- HLA class I ABC antibody (Cat. #15240-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrative Multi-Omics and Experimental Analyses Identify TAPBP as a Key Mediator Linking Genetic Susceptibility to Melanocyte Dysfunction in Vitiligo.
Targeting IL27RA Enhances Immunotherapy in Triple-Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment.
CD20(+)FCRL4(+) B Cells Activate CD8(+) T Cells via MHC-I Restriction in Nasopharyngeal Carcinoma Anti-Tumor Immunity.
Loss of Ribosomal Protein L22 (RPL22) Expression Identifies a Transcriptional Subset of MLH1-Deficient Endometrial Cancers With Lower Numbers of Tumor-Associated Lymphocytes.
Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer.
Low expression of ALOX15B modulates immunosuppressive tumor microenvironment in diffuse large B-cell lymphoma via the TAP1/MHC-I axis.
CUL5 E3 ubiquitin ligase regulates the evasion of bladder cancer cells to CD8+ T cell-mediated killing by inhibiting autophagy.
Multifunctional extracellular vesicles inhibiting autophagy ameliorate immunotherapy in non-small cell lung cancer.
Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes.
TAPBPR promotes editing of the HLA-B44 peptide repertoire, increasing the presentation of peptides containing a C-terminal tryptophan.
ZNF180 modulates tumor intrinsic immunotherapy resistance in melanoma through driving plasticity.
CDK4/6 Inhibition Induces CD8(+) T Cell Antitumor Immunity via MIF-Induced Functional Orchestration of Tumor-Associated Macrophages.
Corilagin regulates antigen processing and presentation by directly binding to inhibit ERAP1.
Radiation regulates the expression of HLA-I in esophageal squamous cell carcinoma through interferon-γ.
Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment.
Ferrostatin-1 reduces the inflammatory response of rheumatoid arthritis by decreasing the antigen presenting function of fibroblast-like synoviocytes.
Allogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial.
Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis.
IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC.
Application of Human Epineural Patch (hEP) as a Novel Strategy for Nerve Protection and Enhancement of Regeneration After Nerve Crush Injury.
Analysis of the ubiquitin-modified proteome identifies novel host factors in Kaposi's sarcoma herpesvirus lytic reactivation.
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.
Protective Effect of the Human Epineural Patch Application after Sciatic Nerve Crush Injury Followed by Nerve Transection and End-to-End Repair.
Low-dose SAHA enhances CD8(+) T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer.
Human induced pluripotent stem cell-derived myotubes to model inclusion body myositis.
HSP90 inhibitor AUY922 suppresses tumor growth and modulates immune response through YAP1-TEAD pathway inhibition in gastric cancer.
Clinically Relevant Humanized Mouse Models of Metastatic Prostate Cancer Facilitate Therapeutic Evaluation.
Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response.
Mechanisms of neural infiltration-mediated tumor metabolic reprogramming impacting immunotherapy efficacy in non-small cell lung cancer.
MHC-I in the hippocampus promotes comorbid depressive symptoms in bone cancer pain via the upregulation of microglial TREM2/DAP12 signaling.
Proteogenomic analysis identifies neoantigens and bacterial peptides as immunotherapy targets in colorectal cancer.
Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice.
Genetic alteration of SJ293TS cells and modification of serum-free media enhances lentiviral vector production.
Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma.
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer.
SARS-CoV-2 ORF7a Mutation Found in BF.5 and BF.7 Sublineages Impacts Its Functions.
Platycodin D reduces PD-L1 levels by inhibiting LXR-β activity and combines with nintedanib to enhance the tumor-killing effect of T cells.
Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis.
Claudin 7 suppresses invasion and metastasis through repression of a smooth muscle actin program.
IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion.
Shifts in receptors during submergence of an encephalitic arbovirus.
Carnosic Acid: A Novel Selective Inhibitor of ERAP1 by Direct Binding and Its Modulation of Antigen Processing and Presentation.
Combining single-cell spatial transcriptomics and molecular simulation to develop in vivo probes targeting the perineural invasion region of adenoid cystic carcinoma.
Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.
Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity.
Clinically relevant humanized mouse models of metastatic prostate cancer to evaluate cancer therapies.
Genome-wide DNA methylation sequencing reveals epigenetic features and potential biomarkers of Sjögren syndrome.
The Toll-like Receptor 7-Mediated Ro52 Antigen-Presenting Pathway in the Salivary Gland Epithelial Cells of Sjögren's Syndrome.
Inhibition of FGFR3 upregulates MHC-I and PD-L1 via TLR3/NF-kB pathway in muscle-invasive bladder cancer.
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression.
HIV-1 Nef Changes the Proteome of T Cells Extracellular Vesicles Depleting IFITMs and Other Antiviral Factors.
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
Increased response to TPF chemotherapy promotes immune escape in hypopharyngeal squamous cell carcinoma.
Chemotherapy- and Immune-Related Gene Panel in Prognosis Prediction and Immune Microenvironment of SCLC.
Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes.
Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and Pcsk9 siRNA Potentiate Immune Checkpoint Therapy for Colorectal Cancer.
Sequential modulation of the Wnt/β-catenin signaling pathway enhances tumor-intrinsic MHC I expression and tumor clearance.
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Peripheral Injection of Tim-3 Antibody Attenuates VSV Encephalitis by Enhancing MHC-I Presentation.
Immune infiltration profiling in gastric cancer and their clinical implications.
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression.
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.
MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer.
Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity.
THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.
Long Non-coding RNA LINC02195 as a Regulator of MHC I Molecules and Favorable Prognostic Marker for Head and Neck Squamous Cell Carcinoma.
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
Noncoding RNA 886 alleviates tumor cellular immunological rejection in host C57BL/C mice.
Pancreatic beta cells persistently infected with coxsackievirus B4 are targets of NK cell-mediated cytolytic activity.
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress.
An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
Activation of Toll-like receptor 7 signaling in labial salivary glands of primary Sjögren's syndrome patients.
Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis.
Loss of Fas expression and high expression of HLA-E promoting the immune escape of early colorectal cancer cells.
HIV-1 Nef: Taking Control of Protein Trafficking.
Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer.
The prognostic impact of human leukocyte antigen (HLA) class I antigen abnormalities in salivary gland cancer. A clinicopathological study of 288 cases.
Shi J, Guo M, Fu L, He J, Hu Y
Clinical, cosmetic and investigational dermatology 2026;19:577486
Clinical, cosmetic and investigational dermatology 2026;19:577486
Targeting IL27RA Enhances Immunotherapy in Triple-Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment.
Xu J, Long Q, Zhou M, Chen Q, Peng J, Liang Q, Zhang D, Zhou H, Yi W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e16703
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(14):e16703
CD20(+)FCRL4(+) B Cells Activate CD8(+) T Cells via MHC-I Restriction in Nasopharyngeal Carcinoma Anti-Tumor Immunity.
Zhang B, Yuan X, Gao K, You B, Wang Y, Meng L, Chen Z, Xie S, Liu Y, Dong Z, Xie S, Fan R, Wang F, Zhang J, Xie Z, Mo Y, Zhang H, Jiang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(13):e14982
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(13):e14982
Loss of Ribosomal Protein L22 (RPL22) Expression Identifies a Transcriptional Subset of MLH1-Deficient Endometrial Cancers With Lower Numbers of Tumor-Associated Lymphocytes.
Osborne-Frazier ML, LaBuda SE, Parrish ML, Atkins HM, Broaddus RR, Gladden AB
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2026 Jan;39(1):100899
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2026 Jan;39(1):100899
Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer.
Zhan W, Fu Y, Liu Y, Cai R, Bai F, Guo C, Cheng Y, Wu Z, Qin G, Xie Y, Zhang J, Deng Y
Cell reports. Medicine 2026 Jan 20;7(1):102534
Cell reports. Medicine 2026 Jan 20;7(1):102534
Low expression of ALOX15B modulates immunosuppressive tumor microenvironment in diffuse large B-cell lymphoma via the TAP1/MHC-I axis.
Wang L, Liu J, Shang Y, Zhang L, Zhang M, Fu D, Cheng S, Xu P, Anegeli E, Bousquet G, Fang Y, Liu Y, Zhao WL
Journal of experimental & clinical cancer research : CR 2026 Jan 12;45(1):43
Journal of experimental & clinical cancer research : CR 2026 Jan 12;45(1):43
CUL5 E3 ubiquitin ligase regulates the evasion of bladder cancer cells to CD8+ T cell-mediated killing by inhibiting autophagy.
Gao X, Yu Y, Sun J, Zhao H, You Y, Shi X, Wang K, Hong S, Xiong X, Huang C, Zhang H, Jiang G
PLoS biology 2026 Feb;24(2):e3003647
PLoS biology 2026 Feb;24(2):e3003647
Multifunctional extracellular vesicles inhibiting autophagy ameliorate immunotherapy in non-small cell lung cancer.
Wang S, Chen J, Cui Y, Xing J, Liu J, Jiang H, Yang H, Zhang H, Sun M, Li J, Liu W, Chen Z, Sun W, Wang X, Yang Z
Acta pharmaceutica Sinica. B 2026 Feb;16(2):1022-1045
Acta pharmaceutica Sinica. B 2026 Feb;16(2):1022-1045
Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes.
Zhang Z, Du N, He G, Zhang M, Zhang G, Gao J, Liu Y, Deng Y, Sun L, Li M
International journal of biological sciences 2025;21(14):6501-6521
International journal of biological sciences 2025;21(14):6501-6521
TAPBPR promotes editing of the HLA-B44 peptide repertoire, increasing the presentation of peptides containing a C-terminal tryptophan.
Aflalo A, Altenburg AF, Wacker M, Khanfar E, Bauer J, Walz JS, Boyle LH
Frontiers in immunology 2025;16:1685705
Frontiers in immunology 2025;16:1685705
ZNF180 modulates tumor intrinsic immunotherapy resistance in melanoma through driving plasticity.
Song WM, Kondapuram SK, Zhou X, Chen SH, Agrawal P
bioRxiv : the preprint server for biology 2025 Sep 18;
bioRxiv : the preprint server for biology 2025 Sep 18;
CDK4/6 Inhibition Induces CD8(+) T Cell Antitumor Immunity via MIF-Induced Functional Orchestration of Tumor-Associated Macrophages.
He L, Peng Y, Leong LL, Zhou J, Tang D, Wang W, Wu X, Haipeng Lei J, Ye Y, Feng Y, Qiao Y, Chu X, Mu D, Zhao Q, Liu T, Chen Y, Tam PK, Deng CX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct 13;:e11330
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct 13;:e11330
Corilagin regulates antigen processing and presentation by directly binding to inhibit ERAP1.
Sun X, Zhou Y, Yu S, Liu X, Wu J, Zhou Y, Bai J, Li D, Xu H, Cao H
International immunopharmacology 2025 Oct 10;163:115180
International immunopharmacology 2025 Oct 10;163:115180
Radiation regulates the expression of HLA-I in esophageal squamous cell carcinoma through interferon-γ.
Shao S, Pan C, Ni Q, Huang J
Scientific reports 2025 Nov 18;15(1):40577
Scientific reports 2025 Nov 18;15(1):40577
Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment.
Lv W, Zeng Y, Li C, Liang Y, Tao H, Zhu Y, Sui X, Li Y, Jiang S, Gao Q, Rodriguez-Fos E, Prasad G, Wang Y, Zhou R, Xu Z, Pan X, Chen L, Xiang X, Teng H, Sun C, Qin T, Dong W, Li Y, Lan X, Li X, Lin L, Bolund L, Yang H, Verhaak RGW, Faltas BM, Hansen JB, Wu S, Mischel PS, Henssen AG, Bafna V, Luebeck J, Regenberg B, Luo Y, Lin C, Han P
Cancer discovery 2025 May 7;:OF1-OF22
Cancer discovery 2025 May 7;:OF1-OF22
Ferrostatin-1 reduces the inflammatory response of rheumatoid arthritis by decreasing the antigen presenting function of fibroblast-like synoviocytes.
Zhu X, Lu H, Jia H, Wei X, Xue J, Li W, Zhang J, Wang Y, Yan J, Sun H, Ge Y, Zhang Z
Journal of translational medicine 2025 Mar 6;23(1):280
Journal of translational medicine 2025 Mar 6;23(1):280
Allogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial.
Nieto Y, Banerjee P, Kaur I, Basar R, Li Y, Daher M, Rafei H, Kerbauy LN, Kaplan M, Marin D, Griffin L, Barnett M, Bassett R, Uprety N, Shrestha R, Silva FR, Islam S, Ganesh C, Borneo Z, Ramdial J, Ramirez A, Hosing C, Alousi A, Popat U, Qazilbash M, Ahmed S, Iyer S, Sainz TP, Vega F, Fowlkes NW, Alexis K, Emig M, Harstrick A, Overesch A, Shpall EJ, Rezvani K
Nature medicine 2025 Jun;31(6):1987-1993
Nature medicine 2025 Jun;31(6):1987-1993
Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis.
Promila L, Sarkar K, Guleria S, Rakshit A, Rathore M, Singh NC, Khan S, Tomar MS, Ammanathan V, Barthwal MK, Kumaravelu J, Shrivastava A, Mitra K, Guha R, Aggarwal A, Lahiri A
Free radical biology & medicine 2025 Jul;234:55-71
Free radical biology & medicine 2025 Jul;234:55-71
IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC.
Cui Y, Qiu T, Wang J, Liu X, Luo L, Yin J, Zhi X, Wang W, Feng G, Wu C, Zhao Z, Zhang H, Li F, Wu F, Ren S
Molecular cancer 2025 Jul 3;24(1):187
Molecular cancer 2025 Jul 3;24(1):187
Application of Human Epineural Patch (hEP) as a Novel Strategy for Nerve Protection and Enhancement of Regeneration After Nerve Crush Injury.
Kozlowska K, Radecka W, Brodowska S, Chambily L, Kuc D, Lopez A, Siemionow M
Biomedicines 2025 Jul 3;13(7)
Biomedicines 2025 Jul 3;13(7)
Analysis of the ubiquitin-modified proteome identifies novel host factors in Kaposi's sarcoma herpesvirus lytic reactivation.
Causey A, Constantine M, Oswald J, Dellomo A, Masters B, Omorogbe E, Admon A, Garzino-Demo A, Ehrlich E
Journal of virology 2025 Jan 31;99(1):e0122424
Journal of virology 2025 Jan 31;99(1):e0122424
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.
Wang H, Fan S, Zhan Y, Xu Y, Du Y, Luo J, Zang H, Peng S, Wang W
Cell death & disease 2025 Jan 16;16(1):21
Cell death & disease 2025 Jan 16;16(1):21
Protective Effect of the Human Epineural Patch Application after Sciatic Nerve Crush Injury Followed by Nerve Transection and End-to-End Repair.
Siemionow M, Radecka W, Kozlowska K, Chambily L, Brodowska S, Kuc D, Filipek G, Budzynska K
Archivum immunologiae et therapiae experimentalis 2025 Jan 1;73(1)
Archivum immunologiae et therapiae experimentalis 2025 Jan 1;73(1)
Low-dose SAHA enhances CD8(+) T cell-mediated antitumor immunity by boosting MHC I expression in non-small cell lung cancer.
Dong W, He B, Cao Y, Yang R, Zhang S, Kong Y, Lu D, Zheng X, Hou Y, Zhu M, Wang C, Yu S, Cui D, Wang H, Wang B
Cellular oncology (Dordrecht, Netherlands) 2025 Feb;48(1):249-264
Cellular oncology (Dordrecht, Netherlands) 2025 Feb;48(1):249-264
Human induced pluripotent stem cell-derived myotubes to model inclusion body myositis.
Cantó-Santos J, Valls-Roca L, Tobías E, García-García FJ, Guitart-Mampel M, Andújar-Sánchez F, Vilaseca-Capel A, Esteve-Codina A, Martín-Mur B, Padrosa J, Peruga E, Madrigal I, Segalés P, García-Ruiz C, Fernández-Checa JC, Moreno-Lozano PJ, O'Callaghan AS, Sevilla A, Milisenda JC, Garrabou G
Acta neuropathologica communications 2025 Feb 21;13(1):38
Acta neuropathologica communications 2025 Feb 21;13(1):38
HSP90 inhibitor AUY922 suppresses tumor growth and modulates immune response through YAP1-TEAD pathway inhibition in gastric cancer.
Yoshimura K, Zou G, Fan Y, Yamashita K, Wang L, Wu J, Wang R, Shao S, Scott AW, Jin J, Pizzi MP, Yao X, Brown CA, Wang L, Gan Q, Waters RE, Yin F, Song S, Dhar SS, Ajani JA
Cancer letters 2025 Feb 1;610:217354
Cancer letters 2025 Feb 1;610:217354
Clinically Relevant Humanized Mouse Models of Metastatic Prostate Cancer Facilitate Therapeutic Evaluation.
Kostlan RJ, Phoenix JT, Budreika A, Ferrari MG, Khurana N, Choi JE, Juckette K, Mahapatra S, McCollum BL, Moskal R, Mannan R, Qiao Y, Vander Griend DJ, Chinnaiyan AM, Kregel S
Molecular cancer research : MCR 2024 Sep 4;22(9):826-839
Molecular cancer research : MCR 2024 Sep 4;22(9):826-839
Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response.
Tan L, Yin T, Xiang H, Wang L, Mudgal P, Chen J, Ding Y, Wang G, Lim BJW, Huang Y, Huang D, Liang Y, Alexander PB, Xiang K, Wang E, Yan C, Ma Z, Tan M, Li QJ, Wang XF
Nature communications 2024 Oct 3;15(1):8569
Nature communications 2024 Oct 3;15(1):8569
Mechanisms of neural infiltration-mediated tumor metabolic reprogramming impacting immunotherapy efficacy in non-small cell lung cancer.
Zheng Y, Li L, Shen Z, Wang L, Niu X, Wei Y, Sun S, Zhao J
Journal of experimental & clinical cancer research : CR 2024 Oct 10;43(1):284
Journal of experimental & clinical cancer research : CR 2024 Oct 10;43(1):284
MHC-I in the hippocampus promotes comorbid depressive symptoms in bone cancer pain via the upregulation of microglial TREM2/DAP12 signaling.
Li X, Jia Y, Xiong M, Gao Y, Xu X, Ke C
Behavioural brain research 2024 Mar 12;461:114843
Behavioural brain research 2024 Mar 12;461:114843
Proteogenomic analysis identifies neoantigens and bacterial peptides as immunotherapy targets in colorectal cancer.
Yao P, Gao M, Hu W, Wang J, Wang Y, Wang Q, Ji J
Pharmacological research 2024 Jun;204:107209
Pharmacological research 2024 Jun;204:107209
Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice.
Muralidharan C, Huang F, Enriquez JR, Wang JE, Nelson JB, Nargis T, May SC, Chakraborty A, Figatner KT, Navitskaya S, Anderson CM, Calvo V, Surguladze D, Mulvihill MJ, Yi X, Sarkar S, Oakes SA, Webb-Robertson BM, Sims EK, Staschke KA, Eizirik DL, Nakayasu ES, Stokes ME, Tersey SA, Mirmira RG
bioRxiv : the preprint server for biology 2024 Jun 3;
bioRxiv : the preprint server for biology 2024 Jun 3;
Genetic alteration of SJ293TS cells and modification of serum-free media enhances lentiviral vector production.
Bauler M, Ferrara F, Lowe B, Beard JA, Wincek C, Wielgosz MM, Park JJ, Shang N, Nandy S, Li C, Langfitt DM, Zhou S, Throm RE
Molecular therapy. Methods & clinical development 2024 Jun 13;32(2):101270
Molecular therapy. Methods & clinical development 2024 Jun 13;32(2):101270
Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma.
Chen W, Liao Y, Sun P, Tu J, Zou Y, Fang J, Chen Z, Li H, Chen J, Peng Y, Wen L, Xie X
Journal of translational medicine 2024 Jan 16;22(1):66
Journal of translational medicine 2024 Jan 16;22(1):66
G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer.
Zheng X, Chen J, Deng M, Ning K, Peng Y, Liu Z, Li X, Zhou Z, Tang H, Li Y, Kang T, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305922
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2305922
SARS-CoV-2 ORF7a Mutation Found in BF.5 and BF.7 Sublineages Impacts Its Functions.
Timilsina U, Ivey EB, Duffy S, Plianchaisuk A, The Genotype To Phenotype Japan G P-Japan Consortium, Ito J, Sato K, Stavrou S
International journal of molecular sciences 2024 Feb 16;25(4)
International journal of molecular sciences 2024 Feb 16;25(4)
Platycodin D reduces PD-L1 levels by inhibiting LXR-β activity and combines with nintedanib to enhance the tumor-killing effect of T cells.
Lei J, Cao XW, Li PF, Zhao J, Wang FJ
FEBS letters 2024 Dec;598(24):3053-3070
FEBS letters 2024 Dec;598(24):3053-3070
Oxytocin attenuates cardiac hypertrophy by improving cardiac glucose metabolism and regulating OXTR/JAK2/STAT3 axis.
Yang Y, Liu J, Wang L, Wu W, Wang Q, Zhao Y, Qian X, Wang Z, Fu N, Wang Y, Qian J
Peptides 2024 Dec;182:171323
Peptides 2024 Dec;182:171323
Claudin 7 suppresses invasion and metastasis through repression of a smooth muscle actin program.
West JJ, Golloshi R, Cho CY, Wang Y, Stevenson P, Stein-O'Brien G, Fertig EJ, Ewald AJ
The Journal of cell biology 2024 Dec 2;223(12)
The Journal of cell biology 2024 Dec 2;223(12)
IRGQ-mediated autophagy in MHC class I quality control promotes tumor immune evasion.
Herhaus L, Gestal-Mato U, Eapen VV, Mačinković I, Bailey HJ, Prieto-Garcia C, Misra M, Jacomin AC, Ammanath AV, Bagarić I, Michaelis J, Vollrath J, Bhaskara RM, Bündgen G, Covarrubias-Pinto A, Husnjak K, Zöller J, Gikandi A, Ribičić S, Bopp T, van der Heden van Noort GJ, Langer JD, Weigert A, Harper JW, Mancias JD, Dikic I
Cell 2024 Dec 12;187(25):7285-7302.e29
Cell 2024 Dec 12;187(25):7285-7302.e29
Shifts in receptors during submergence of an encephalitic arbovirus.
Li W, Plante JA, Lin C, Basu H, Plung JS, Fan X, Boeckers JM, Oros J, Buck TK, Anekal PV, Hanson WA, Varnum H, Wells A, Mann CJ, Tjang LV, Yang P, Reyna RA, Mitchell BM, Shinde DP, Walker JL, Choi SY, Brusic V, Llopis PM, Weaver SC, Umemori H, Chiu IM, Plante KS, Abraham J
Nature 2024 Aug;632(8025):614-621
Nature 2024 Aug;632(8025):614-621
Carnosic Acid: A Novel Selective Inhibitor of ERAP1 by Direct Binding and Its Modulation of Antigen Processing and Presentation.
Wu J, Li Z, Liu X, Feng D, Liang R, Su X, Li D, Hua H, Cao H
Journal of agricultural and food chemistry 2024 Aug 7;72(31):17343-17355
Journal of agricultural and food chemistry 2024 Aug 7;72(31):17343-17355
Combining single-cell spatial transcriptomics and molecular simulation to develop in vivo probes targeting the perineural invasion region of adenoid cystic carcinoma.
Yuan X, Dong Z, Zhang B, Li Q, Jiang W
Heliyon 2024 Aug 15;10(15):e34628
Heliyon 2024 Aug 15;10(15):e34628
Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.
Yang C, Wang X, To KKW, Cui C, Luo M, Wu S, Huang L, Fu K, Pan C, Liu Z, Fan T, Yang C, Wang F, Fu L
Signal transduction and targeted therapy 2024 Apr 5;9(1):84
Signal transduction and targeted therapy 2024 Apr 5;9(1):84
Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity.
Peng L, Zhou L, Li H, Zhang X, Li S, Wang K, Yang M, Ma X, Zhang D, Xiang S, Duan Y, Wang T, Sun C, Wang C, Lu D, Qian M, Wang Z
Cell reports 2024 Apr 23;43(4):114003
Cell reports 2024 Apr 23;43(4):114003
Clinically relevant humanized mouse models of metastatic prostate cancer to evaluate cancer therapies.
Kostlan RJ, Phoenix JT, Budreika A, Ferrari MG, Khurana N, Cho JE, Juckette K, McCollum BL, Moskal R, Mannan R, Qiao Y, Griend DJV, Chinnaiyan AM, Kregel S
bioRxiv : the preprint server for biology 2023 Oct 17;
bioRxiv : the preprint server for biology 2023 Oct 17;
Genome-wide DNA methylation sequencing reveals epigenetic features and potential biomarkers of Sjögren syndrome.
Lu DQ, Yao XY, Ren YT, Zhang KY, Zhu XC, Hong T, Yu X, Xie ZM, Chen LY, Wang XC
International journal of rheumatic diseases 2023 Nov;26(11):2223-2232
International journal of rheumatic diseases 2023 Nov;26(11):2223-2232
The Toll-like Receptor 7-Mediated Ro52 Antigen-Presenting Pathway in the Salivary Gland Epithelial Cells of Sjögren's Syndrome.
Nishihata SY, Shimizu T, Umeda M, Furukawa K, Ohyama K, Kawakami A, Nakamura H
Journal of clinical medicine 2023 Jun 30;12(13)
Journal of clinical medicine 2023 Jun 30;12(13)
Inhibition of FGFR3 upregulates MHC-I and PD-L1 via TLR3/NF-kB pathway in muscle-invasive bladder cancer.
Wu W, Chen L, Jia G, Tang Q, Han B, Xia S, Jiang Q, Liu H
Cancer medicine 2023 Jul;12(14):15676-15690
Cancer medicine 2023 Jul;12(14):15676-15690
SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression.
Arshad N, Laurent-Rolle M, Ahmed WS, Hsu JC, Mitchell SM, Pawlak J, Sengupta D, Biswas KH, Cresswell P
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 3;120(1):e2208525120
Proceedings of the National Academy of Sciences of the United States of America 2023 Jan 3;120(1):e2208525120
HIV-1 Nef Changes the Proteome of T Cells Extracellular Vesicles Depleting IFITMs and Other Antiviral Factors.
da Silva-Januário ME, da Costa CS, Tavares LA, Oliveira AK, Januário YC, de Carvalho AN, Cassiano MHA, Rodrigues RL, Miller ME, Palameta S, Arns CW, Arruda E, Paes Leme AF, daSilva LLP
Molecular & cellular proteomics : MCP 2023 Dec;22(12):100676
Molecular & cellular proteomics : MCP 2023 Dec;22(12):100676
E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC.
Tang F, Lu C, He X, Lin W, Xie B, Gao X, Peng Y, Yang D, Sun L, Weng L
Cell reports 2023 Dec 26;42(12):113477
Cell reports 2023 Dec 26;42(12):113477
Increased response to TPF chemotherapy promotes immune escape in hypopharyngeal squamous cell carcinoma.
Li R, Yan L, Tian S, Zhao Y, Zhu Y, Wang X
Frontiers in pharmacology 2022;13:1097197
Frontiers in pharmacology 2022;13:1097197
Chemotherapy- and Immune-Related Gene Panel in Prognosis Prediction and Immune Microenvironment of SCLC.
Chen MY, Zeng YC, Zhao XH
Frontiers in cell and developmental biology 2022;10:893490
Frontiers in cell and developmental biology 2022;10:893490
Immunopeptidomics-based design of mRNA vaccine formulations against Listeria monocytogenes.
Mayer RL, Verbeke R, Asselman C, Aernout I, Gul A, Eggermont D, Boucher K, Thery F, Maia TM, Demol H, Gabriels R, Martens L, Bécavin C, De Smedt SC, Vandekerckhove B, Lentacker I, Impens F
Nature communications 2022 Oct 14;13(1):6075
Nature communications 2022 Oct 14;13(1):6075
Self-Assembly of a Multifunction DNA Tetrahedron for Effective Delivery of Aptamer PL1 and Pcsk9 siRNA Potentiate Immune Checkpoint Therapy for Colorectal Cancer.
Guo W, Gao H, Li H, Ge S, Zhang F, Wang L, Shi H, Han A
ACS applied materials & interfaces 2022 Jul 20;14(28):31634-31644
ACS applied materials & interfaces 2022 Jul 20;14(28):31634-31644
Sequential modulation of the Wnt/β-catenin signaling pathway enhances tumor-intrinsic MHC I expression and tumor clearance.
Dholakia J, Scalise CB, Katre AA, Goldsberry WN, Meza-Perez S, Randall TD, Norian LA, Novak L, Arend RC
Gynecologic oncology 2022 Jan;164(1):170-180
Gynecologic oncology 2022 Jan;164(1):170-180
EZH2 Inhibitor Enhances the STING Agonist‒Induced Antitumor Immunity in Melanoma.
Xu T, Dai J, Tang L, Yang L, Si L, Sheng X, Cui C, Chi Z, Kong Y, Guo J
The Journal of investigative dermatology 2022 Apr;142(4):1158-1170.e8
The Journal of investigative dermatology 2022 Apr;142(4):1158-1170.e8
Peripheral Injection of Tim-3 Antibody Attenuates VSV Encephalitis by Enhancing MHC-I Presentation.
Li G, Tang L, Hou C, Wang Z, Gao Y, Dou S, Mo R, Hao Y, Gao Z, Li Y, Dong J, Zhang J, Shen B, Wang R, Han G
Frontiers in immunology 2021;12:667478
Frontiers in immunology 2021;12:667478
Immune infiltration profiling in gastric cancer and their clinical implications.
Ren F, Zhao Q, Zhao M, Zhu S, Liu B, Bukhari I, Zhang K, Wu W, Fu Y, Yu Y, Tang Y, Zheng P, Mi Y
Cancer science 2021 Sep;112(9):3569-3584
Cancer science 2021 Sep;112(9):3569-3584
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.
Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz TD, Pinch BJ, Akshinthala D, Verma A, Gaglia G, Nezu Y, Ke S, Qiu C, Ohuchida K, Oda Y, Lee TH, Wegiel B, Clohessy JG, London N, Santagata S, Wulf GM, Hidalgo M, Muthuswamy SK, Nakamura M, Gray NS, Zhou XZ, Lu KP
Cell 2021 Sep 2;184(18):4753-4771.e27
Cell 2021 Sep 2;184(18):4753-4771.e27
Arecoline induces epithelial-mesenchymal transformation and promotes metastasis of oral cancer by SAA1 expression.
Ren H, He G, Lu Z, He Q, Li S, Huang Z, Chen Z, Cao C, Wang A
Cancer science 2021 Jun;112(6):2173-2184
Cancer science 2021 Jun;112(6):2173-2184
Cisplatin remodels the tumor immune microenvironment via the transcription factor EB in ovarian cancer.
Liu W, Wang Y, Xie Y, Dai T, Fan M, Li C, Zou Y
Cell death discovery 2021 Jun 5;7(1):136
Cell death discovery 2021 Jun 5;7(1):136
Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.
Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 1;118(22)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jun 1;118(22)
MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer.
Wu SY, Xiao Y, Wei JL, Xu XE, Jin X, Hu X, Li DQ, Jiang YZ, Shao ZM
Journal for immunotherapy of cancer 2021 Jul;9(7)
Journal for immunotherapy of cancer 2021 Jul;9(7)
Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity.
Li C, Yao H, Wang H, Fang JY, Xu J
Oncogene 2021 Feb;40(6):1128-1146
Oncogene 2021 Feb;40(6):1128-1146
THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy.
Li C, Chi H, Deng S, Wang H, Yao H, Wang Y, Chen D, Guo X, Fang JY, He F, Xu J
Journal for immunotherapy of cancer 2021 Aug;9(8)
Journal for immunotherapy of cancer 2021 Aug;9(8)
Long Non-coding RNA LINC02195 as a Regulator of MHC I Molecules and Favorable Prognostic Marker for Head and Neck Squamous Cell Carcinoma.
Li H, Xiong HG, Xiao Y, Yang QC, Yang SC, Tang HC, Zhang WF, Sun ZJ
Frontiers in oncology 2020;10:615
Frontiers in oncology 2020;10:615
Herpes Simplex Virus Type 2 Inhibits Type I IFN Signaling Mediated by the Novel E3 Ubiquitin Protein Ligase Activity of Viral Protein ICP22.
Zhang M, Fu M, Li M, Hu H, Gong S, Hu Q
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292
Journal of immunology (Baltimore, Md. : 1950) 2020 Sep 1;205(5):1281-1292
Noncoding RNA 886 alleviates tumor cellular immunological rejection in host C57BL/C mice.
Ma H, Wang M, Zhou Y, Yang JJ, Wang LY, Yang RH, Wen MJ, Kong L
Cancer medicine 2020 Jul;9(14):5258-5271
Cancer medicine 2020 Jul;9(14):5258-5271
Pancreatic beta cells persistently infected with coxsackievirus B4 are targets of NK cell-mediated cytolytic activity.
Nekoua MP, Bertin A, Sane F, Alidjinou EK, Lobert D, Trauet J, Hober C, Engelmann I, Moutairou K, Yessoufou A, Hober D
Cellular and molecular life sciences : CMLS 2020 Jan;77(1):179-194
Cellular and molecular life sciences : CMLS 2020 Jan;77(1):179-194
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Liu X, Bao X, Hu M, Chang H, Jiao M, Cheng J, Xie L, Huang Q, Li F, Li CY
Nature 2020 Dec;588(7839):693-698
Nature 2020 Dec;588(7839):693-698
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress.
Merriman C, Fu D
The Journal of biological chemistry 2019 Nov 8;294(45):16992-17006
The Journal of biological chemistry 2019 Nov 8;294(45):16992-17006
An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles.
Clancy JW, Zhang Y, Sheehan C, D'Souza-Schorey C
Nature cell biology 2019 Jul;21(7):856-866
Nature cell biology 2019 Jul;21(7):856-866
Activation of Toll-like receptor 7 signaling in labial salivary glands of primary Sjögren's syndrome patients.
Shimizu T, Nakamura H, Takatani A, Umeda M, Horai Y, Kurushima S, Michitsuji T, Nakashima Y, Kawakami A
Clinical and experimental immunology 2019 Apr;196(1):39-51
Clinical and experimental immunology 2019 Apr;196(1):39-51
Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis.
Guo Y, Zhang Z, Wei H, Wang J, Lv J, Zhang K, Keller ET, Yao Z, Wang Q
The Journal of pathology 2017 Oct;243(2):208-219
The Journal of pathology 2017 Oct;243(2):208-219
Loss of Fas expression and high expression of HLA-E promoting the immune escape of early colorectal cancer cells.
Huang R, Zhang D, Li F, Xiao Z, Wu M, Shi D, Xiang P, Bao Z
Oncology letters 2017 May;13(5):3379-3386
Oncology letters 2017 May;13(5):3379-3386
HIV-1 Nef: Taking Control of Protein Trafficking.
Pereira EA, daSilva LL
Traffic (Copenhagen, Denmark) 2016 Sep;17(9):976-96
Traffic (Copenhagen, Denmark) 2016 Sep;17(9):976-96
Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
de Carvalho JV, de Castro RO, da Silva EZ, Silveira PP, da Silva-Januário ME, Arruda E, Jamur MC, Oliver C, Aguiar RS, daSilva LL
PloS one 2014;9(11):e113691
PloS one 2014;9(11):e113691
Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer.
Dobbin ZC, Katre AA, Steg AD, Erickson BK, Shah MM, Alvarez RD, Conner MG, Schneider D, Chen D, Landen CN
Oncotarget 2014 Sep 30;5(18):8750-64
Oncotarget 2014 Sep 30;5(18):8750-64
The prognostic impact of human leukocyte antigen (HLA) class I antigen abnormalities in salivary gland cancer. A clinicopathological study of 288 cases.
Müller M, Agaimy A, Zenk J, Ettl T, Iro H, Hartmann A, Seliger B, Schwarz S
Histopathology 2013 May;62(6):847-59
Histopathology 2013 May;62(6):847-59
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 15240-1-AP(HLA class I (HLA-A) antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells using 15240-1-AP( HLA class I (HLA-A) Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HLA class I (HLA-A) (IP:15240-1-AP, 3ug; Detection:15240-1-AP 1:500) with HepG2 cells lysate 1720ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human stomach cancer using 15240-1-AP(HLA class I (HLA-A) antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human stomach cancer using 15240-1-AP(HLA class I (HLA-A) antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HLA class I (HLA-A) antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HLA class I (HLA-A). This antibody recognizes human antigen. The HLA class I (HLA-A) antibody has been validated for the following applications: ELISA, WB, IHC, IF, IP, FC analysis.
