HLA-A

gene product
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
1325 antibodies from 32 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Proteintech Group
5 antibodies
Novus Biologicals
205 antibodies
GeneTex
9 antibodies
NovoPro Bioscience Inc.
3 antibodies
antibodies-online
452 antibodies
BioLegend
73 antibodies
OriGene
4 antibodies
LifeSpan BioSciences, Inc.
116 antibodies
Abnova Corporation
12 antibodies
NSJ Bioreagents
7 antibodies
HUABIO Research
1 antibody
Invitrogen Antibodies
42 antibodies
R&D Systems
11 antibodies
Affinity Biosciences
1 antibody
Biorbyt
12 antibodies
Aviva Systems Biology
19 antibodies
Creative Biolabs
115 antibodies
Antibodies.com
2 antibodies
St John's Laboratory
1 antibody
Creative Diagnostics
56 antibodies
Abgent
2 antibodies
International Blood Group Reference Laboratory
2 antibodies
Miltenyi Biotec
84 antibodies
Arigo
7 antibodies
GenWay
19 antibodies
MyBioSource
8 antibodies
Abbexa
13 antibodies
United States Biological
18 antibodies
eBioscience, An Affymetrix Company
15 antibodies
MilliporeSigma / Merck KGaA
8 antibodies
Leading Biology
2 antibodies
CPTAC
1 antibody