Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-BL4297 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-CAMLG monoclonal antibody, clone 4G23
- Antibody type
- Monoclonal
- Description
- The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 _g
- Storage
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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