CAMLG

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]

Description

Calcium modulating ligand

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Vesicles

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

5 (134738495 - 134752157)

Ensembl ID

ENSG00000164615  (ver. 103.38)

Orthologs

Mouse Caml: ENSMUSG00000021501

UniProt

P49069

neXtProt

NX_P49069

Human splice variants
Mouse splice variants

Protein structure