EPC1

This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Description

Enhancer of polycomb homolog 1

Tissue specificity

Tissue enriched (bone marrow)

Subcell location

Nucleoplasm, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (32267751 - 32378798)

Ensembl ID

ENSG00000120616  (ver. 103.38)

Orthologs

Mouse Epc1: ENSMUSG00000024240

UniProt

Q9H2F5

neXtProt

NX_Q9H2F5

Human splice variants
Mouse splice variants

Protein structure