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LearnAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- H00055775-A01 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#H00055775-A01, RRID:AB_461513
- Product name
- TDP1 polyclonal antibody (A01)
- Antibody type
- Polyclonal
- Description
- Mouse polyclonal antibody raised against a full-length recombinant TDP1.
- Antigen sequence
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLC
ARQGAANEPRYTCSEAQKAAHKRKISPVKFSNTDS
VLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQA
EKVVIKKEKDISAPNDGTAQRTENHGAPACHRLKE
EEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVK
PKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDW
LVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPY
ENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIH
TSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGES
PTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSET
NVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASS
MPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYP
AGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNA
MPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGAL
EKNGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFF
AGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYV
KAPDTHGNMWVPS- Storage
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Submitted references Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.
PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.
In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.
Katyal S, Lee Y, Nitiss KC, Downing SM, Li Y, Shimada M, Zhao J, Russell HR, Petrini JH, Nitiss JL, McKinnon PJ
Nature neuroscience 2014 Jun;17(6):813-21
Nature neuroscience 2014 Jun;17(6):813-21
PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.
Das BB, Huang SY, Murai J, Rehman I, Amé JC, Sengupta S, Das SK, Majumdar P, Zhang H, Biard D, Majumder HK, Schreiber V, Pommier Y
Nucleic acids research 2014 Apr;42(7):4435-49
Nucleic acids research 2014 Apr;42(7):4435-49
In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.
Hawkins AJ, Subler MA, Akopiants K, Wiley JL, Taylor SM, Rice AC, Windle JJ, Valerie K, Povirk LF
DNA repair 2009 May 1;8(5):654-63
DNA repair 2009 May 1;8(5):654-63
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y
The EMBO journal 2009 Dec 2;28(23):3667-80
The EMBO journal 2009 Dec 2;28(23):3667-80
TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo.
Katyal S, el-Khamisy SF, Russell HR, Li Y, Ju L, Caldecott KW, McKinnon PJ
The EMBO journal 2007 Nov 14;26(22):4720-31
The EMBO journal 2007 Nov 14;26(22):4720-31
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