TDP1

gene product
FLJ11090, SCAN1
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
311 antibodies from 26 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
129 antibodies
Novus Biologicals
38 antibodies
Bethyl Laboratories
3 antibodies
Abnova Corporation
8 antibodies
GeneTex
3 antibodies
Invitrogen Antibodies
6 antibodies
Proteintech Group
1 antibody
LifeSpan BioSciences, Inc.
40 antibodies
Acris Antibodies GmbH
3 antibodies
NovoPro Bioscience Inc.
1 antibody
OriGene
7 antibodies
Biorbyt
8 antibodies
Abgent
4 antibodies
Antibodies.com
1 antibody
Cell Signaling Technology, Inc
1 antibody
NSJ Bioreagents
1 antibody
Aviva Systems Biology
2 antibodies
ProSci
3 antibodies
Atlas Antibodies
1 antibody
St John's Laboratory
3 antibodies
Creative Biolabs
10 antibodies
MyBioSource
6 antibodies
RabMAbs
1 antibody
RayBiotech, Inc.
1 antibody
United States Biological
29 antibodies
Sigma-Aldrich
1 antibody