Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [1]
- ELISA [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN393275 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Tyrosyl-DNA Phosphodiesterase 1 (TDP1) (AA 1-609) antibody
- Antibody type
- Monoclonal
- Description
- This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Mouse
- Epitope
- AA 1-609
- Isotype
- IgG
- Antibody clone number
- 2A10-G2
- Vial size
- 100 μg
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Submitted references TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage.
The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.
Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.
Chiang SC, Carroll J, El-Khamisy SF
Cell cycle (Georgetown, Tex.) 2010 Feb 1;9(3):588-595
Cell cycle (Georgetown, Tex.) 2010 Feb 1;9(3):588-595
The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.
Dexheimer TS, Stephen AG, Fivash MJ, Fisher RJ, Pommier Y
Nucleic acids research 2010 Apr;38(7):2444-52
Nucleic acids research 2010 Apr;38(7):2444-52
Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
Hoskins JM, Rosner GL, Ratain MJ, McLeod HL, Innocenti F
Pharmacogenomics 2009 Jul;10(7):1139-46
Pharmacogenomics 2009 Jul;10(7):1139-46
Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y
The EMBO journal 2009 Dec 2;28(23):3667-80
The EMBO journal 2009 Dec 2;28(23):3667-80
Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.
Zhou T, Akopiants K, Mohapatra S, Lin PS, Valerie K, Ramsden DA, Lees-Miller SP, Povirk LF
DNA repair 2009 Aug 6;8(8):901-11
DNA repair 2009 Aug 6;8(8):901-11
No comments: Submit comment
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- ELISA