Tissue expression
Cell line expression
Protein structure
PHF8
PHD finger protein 8JHDM1F, KDM7B, KIAA1111, ZNF422
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Top validated antibodies |
|||||
Novus Biologicals | NB100-93313 | 1 references | Polyclonal |
WB
IP
IHC
ChIP |
|
Invitrogen Antibodies | A301-772A | Polyclonal |
WB
IP
IHC
ChIP
OA
|
||
antibodies-online | ABIN408592 | Polyclonal |
WB
ICC
IP
IHC |
||
Acris Antibodies GmbH | AP53285PU-N | Polyclonal |
WB
EL
IHC
FC |
||
Cell Signaling Technology, Inc | 37377 | Monoclonal |
WB
IP
FC
ChIP |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider