LRRC3B

The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

Description

Leucine rich repeat containing 3B

Tissue specificity

Tissue enhanced (brain, choroid plexus, skeletal muscle)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (26622806 - 26717537)

Ensembl ID

ENSG00000179796  (ver. 103.38)

Orthologs

Mouse Lrrc3b: ENSMUSG00000045201

UniProt

Q96PB8

neXtProt

NX_Q96PB8

Human splice variants
Mouse splice variants

Protein structure