Tissue expression
Cell line expression
Protein structure
CLEC4G
C-type lectin domain family 4 member GLSECtin, UNQ431
This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]
Top validated antibodies |
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Proteintech Group | 18173-1-AP | Polyclonal |
WB
EL
IHC
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Invitrogen Antibodies | 18173-1-AP | Polyclonal |
WB
IHC |
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Novus Biologicals | FAB2947A | 1 references | Monoclonal |
FC
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R&D Systems | FAB2947A | 1 references | Monoclonal |
FC
|
|
Atlas Antibodies | HPA014044 | Polyclonal |
IHC
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Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider