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antibody from Proteintech Group
Targeting: STING1
ERIS, FLJ38577, MITA, MPYS, NET23, STING, TMEM173
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- Antibody Data
- Antigen structure
- References [619]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- 19851-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19851-1-AP, RRID:AB_10665370
- Product name
- TMEM173/STING antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TMEM173/STING antibody (Cat. #19851-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting the LHX1-LDB1 Complex Restores STING-dependent Senescence Surveillance and Inhibits Head and Neck Cancer Progression.
Prognostic value of cGAS-STING-IRF3 signaling in cholangiocarcinoma patients.
Discovery of an orally bioavailable selenium-containing Polθ inhibitor with a dual mechanism of DNA damage and immune activation for HR-deficient cancers.
A biomimetic arsenic-based nanozyme enhances dual epigenetic regulation to improve the efficacy of immunotherapy for acute myeloid leukaemia.
Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation.
STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1.
Shenkangling alleviates renal fibrosis induced by renal ischemia-reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway.
STING-mediated metabolic reprogramming drives lipid peroxidation during Staphylococcus aureus infection.
Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment.
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development.
Promotion of hepatocellular carcinoma by small nuclear ribonucleoprotein polypeptide F through upregulation of transmembrane P24 trafficking protein 2 and triggering of the cGAS-STING pathway.
SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways.
TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses.
SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING.
Anti-Inflammatory Effects of Curcumin via the Nrf2-cGAS-STING-NF-κB Pathway in MH7A Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Fibroblast growth factor-inducible 14 accelerates pulmonary fibrosis by inducing fibroblast senescence in mice.
EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS-STING Pathway.
Disruption of sphingolipid metabolism triggers lung vascular inflammation and aging-like changes under hypoxia through VDAC1-mediated mitochondrial DNA release.
STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis.
STING Mediates Microglial Polarization to Promote Neuroinflammation in Epilepsy-Related Cognitive Dysfunction.
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
PTPN2 alleviates psoriasis by targeting the STING-STAT3 axis and restoring autophagy: in vitro and in vivo evidence.
Microneedle patches deliver targeted GLP-1RAs-loaded nanoparticles for the treatment of rheumatoid arthritis.
Resveratrol Mitigates Age-Associated Cognitive Decline via Inhibition of cGAS-STING-Mediated Microglial Senescence.
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
STING-ERO1 signaling exacerbates PARylation-mediated parthanatos in sepsis.
Ultrasmall Prussian blue-integrated cryogel for enhanced ROS scavenging and immunomodulation via cGAS-STING inhibition in wound healing.
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Babaodan suppresses inflammatory and vascular microenvironment in triple-negative breast cancer by inhibiting the cGAS-STING/NF-κB signaling pathway.
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Loss of cGAS facilitates angiogenesis in diabetic foot ulcer healing by suppressing the STING/ferroptosis pathway.
ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance.
Systemic LINE-1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS-STING Pathway in Aging.
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
SARS-CoV-2 spike protein induces depressive-like behaviors by disrupting astrocytic Cx43-mediated gap junction intercellular communication.
Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression.
Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.
Mitochondrial DAMPs produce inflammatory hyperalgesia via stimulator of interferon genes (STING) activation in DRG neurons.
Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway.
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Regulation of AP1 adaptor assembly by the bi-handed chaperone MEA1.
Migration and invasion inhibitory protein inhibits M2 macrophage polarization to suppress colorectal cancer progression through the STING-NFκB2-IL10 axis.
Loss of LXRβ Drives CD4(+) T Cell Senescence and Exacerbates the Progression of Colitis.
Maidong Dishao Decoction can inhibit the activation of the cGAS-STING signaling pathway of Sjögren's syndrome by reducing oxidative stress in salivary gland epithelial cells.
STING knockdown blocks disease progression and inflammation in mice with alcoholic liver disease by relieving pyroptosis via suppressing NLRP3.
Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway.
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Melatonin impedes NCOA4/ACSL4-dependent ferroptosis by targeting STING to ameliorate diabetic cognitive dysfunction.
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender.
Puerarin Attenuates White Matter Injury and Blood-Brain Barrier Disruption After Intracerebral Hemorrhagic Stroke via cGAS-STING Axis.
Electroacupuncture Attenuates Neuroinflammation and Postoperative Cognitive Dysfunction in Aged Rats by Suppressing the cGAS-STING Pathway.
Machine learning-guided Huanglian Jiedu decoction targets STING in periodontitis-induced Alzheimer's Disease.
Kynurenic Acid/GPR35 Signaling Protects the Infarcted Heart by Suppressing Macrophage mtDNA-Triggered cGAS-STING Activation.
Targeting FAM83D triggers tumor cell senescence via cGAS-STING signaling activation and reprograms TAMs to combat glioma.
Monocyte-macrophage SAMHD1 alleviates EAMG by modulating the cGAS-STING pathway.
Targeting the Pyroptosis-Mitochondrial Homeostasis Crosstalk: Astaxanthin Attenuates Alcohol-Induced Inflammatory Liver Injury via Inhibition of cGAS-STING Signaling.
Investigating the impact and mechanism of Licochalcone B derivative CTG12 on NLRP3 inflammasome.
Ultrasound-Responsive Cerasome Nanoparticle Improves STING-Driven Immunotherapy in Triple-Negative Breast Cancer.
LL37-induced mitochondrial stress activates the mtDNA/cGAS/STING pathway to promote mast cell-mediated rosacea inflammation.
Lactiplantibacillus plantarum GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation.
Mechanisms of topical Mahoniae Caulis against acute mastitis: Integrating SMR, network pharmacology, molecular docking, and experimental validation.
Identification of Pinostilbene as a natural STING agonist that triggers FTH1 degradation via K48-ubiquitination to induce ferroptosis in non-small cell lung cancer.
Ultrasound-triggered carrier-free nanoprodrugs activate cGAS-STING pathway to enhance tumor-targeting chemo-immunotherapy.
TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury.
Ophiopogon japonicus Polysaccharides Promote Microbial Production Of Chenodeoxycholic Acid To Alleviate Ulcerative Colitis in Mice by Inhibiting the STING1-Related NF-κB Pathway.
PIM1 Inhibition Alleviates Aspergillus fumigatus Keratitis by Regulating DDX41-Mediated STING Signaling Pathway.
Unlocking the Puzzle of Mammalian Transfection: The Role of the RNA-sensing-Mediated Interferon Response in the Cellular Defense Against Foreign DNA Intrusion.
Repetitive Trans-spinal Magnetic Stimulation Suppresses Microglia to Engulf Synapse and Promotes Nerve Repairment via cGAS-STING Signaling Pathway after Spinal Cord Injury.
RACK1 Associates With STING to Promote Type I Interferon Activation and Inhibit Pseudorabies Virus Infection.
Caveolin-1 knockout improves CFA-induced inflammatory pain in adult mice through modulating the cGAS STING pathway and autophagy.
Fumarate Hydratase Restrains mtDNA Attenuates LPS-Induced Acute Lung Injury Through cGAS-STING Pathways.
Lily polysaccharides alleviate colitis through the microbiota-N8-acetylspermidine-cGAS-STING signaling axis.
Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway.
Targeting the LPS-STING axis: neomycin restores STING-mediated anti-tumor immune suppression and inhibits tumor growth.
Sophora tonkinensis enhances activation of cGAS-STING pathway and restrains HBV replication.
Lamins regulate cancer cell plasticity and chemosensitivity.
High cGAS-STING expression associates with improved efficacy of neoadjuvant chemo-immunotherapy in head and neck squamous cell carcinoma.
High cyclic GMP-AMP synthase and stimulator of interferon genes in cholangiocarcinoma suggest their potential as targets for treatment.
Study on the Mechanism of QRICH1 Mediating PRMT1 to Regulate the Arginine Methylation Modification of cGAS to Promote Arsenics-Induced Pyroptosis in Hepatocellular Carcinoma Cells.
TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway.
STING inhibits LINE-1 retrotransposition through sorting ORF1p to lysosomes for degradation.
TFEB and TFE3 regulate STING1-dependent immune responses by controlling type I interferon signaling.
Thiamet-G ameliorates Parkinson's disease-associated cognitive impairment via increasing O-GlcNAcylation of STING in the microglia.
Dihydrotanshinone I, a main compound of Salvia miltiorrhiza, alleviates autoimmune and inflammatory diseases by directly targeting IRF3.
Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis.
Biomimetic Nanoregulators Mediated Tyrosine Hydroxylase mRNA and Stimulator of Interferon Genes Antagonist Codelivery for Synergistic Therapy on Parkinson's Disease.
Harnessing cGAS-STING signaling to counteract the genotoxic-immune nexus in tauopathy.
Extrachromosomal circular DNA drives ferroptosis and immunity in trophoblasts via the STING pathway in preeclampsia.
Salvianolic acid A ameliorates sepsis through inhibiting inflammation via binding STING and modulating TBK1/IRF3 signaling pathway.
RHBDF2 governs microglial neuroinflammation during cerebral ischemia-reperfusion injury and is positively regulated by the m6A reader YTHDF1.
cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models.
cGAS-STING-NFκB PATHWAY PLAYS A ROLE IN BURN INJURY-INDUCED MUSCLE WASTING.
Hepatocyte mitochondrial DNA activated store-operated Ca(2+) entry via Stim1/Orai1-induced podocyte injury in trichloroethylene sensitized mice: A new insight in liver and kidney crosstalk.
Specifically Breaking Through the Injured Blood-Brain Barrier With Tannic Acid-Based Nanomedicine for Ischemic Stroke Ischemia Reperfusion Treatment.
STING inhibits the progression of esophageal squamous cell carcinoma by suppressing CPT1A-mediated fatty acid β-oxidation.
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Mitochondrial DNA leakage and micronucleus formation activate the cGAS-STING pathway in aristolochic acid I-induced nephritis.
Gelatin enhances bacteria-phagocytosis via a ROS-mitochondria-STING axis in differentiated human macrophage-like U937 cells.
Salvia miltiorrhiza water extract ameliorated cGAS-STING-mediated acute liver injury by blocking interaction between STING and TBK1.
Activation of STING pathway by mitochondrial fission negatively regulates adipogenic differentiation of 3 T3-L1 cells.
GALNT6 dual regulates innate immunity STING signaling and PD-L1 expression to promote immune evasion in pancreatic ductal adenocarcinoma.
IRE1α translational suppression potentiates STING-dependent chemoresistance in pancreatic cancer.
TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy.
Improvement of the stability of ginsenoside Rg5 and its pharmacological efficacy in nonalcoholic steatohepatitis.
Polydopamine as a biocompatible and precise mitochondrial targeted therapeutic platform for reversing myocardial ischemia-reperfusion injury.
Role and mechanism of piR-0228 targeting RIPK1 to regulate vascular remodeling and aortic dissection.
Treadmill exercise alleviates STING-mediated microglia pyroptosis and polarization via activating mitophagy post-TBI.
AMPK impairment caused by gelatin disturbs mitochondrial dynamics leading to enhanced phagocytosis of bacteria in PMA-stimulated U937 cells.
Crosstalk between DNA damage and cGAS-STING immune pathway drives neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease.
Potential Therapeutic Effects of Astragaloside IV in Parkinson's Disease Models via Modulation of α-syn-γH2AX-STING-IFN-I Axis.
TFNAs induce autophagy via activation of the nonclassical cGAS-STING signalling pathway to attenuate acute lung injury in mice.
Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis.
Autonomous STING signaling in Purkinje cells drives neurodegeneration independent of type I interferon.
Qihuang Yishen formula attenuates renal tubular injury by modulating inflammation via the cGAS/STING pathway in diabetic kidney disease.
Butyrate ameliorates ulcerative colitis through targeting STING-dependent ER stress signaling and limiting CD4(+) TRM T cells accumulation.
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice.
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation.
Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing.
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery.
Decursin protects against DSS-induced experimental colitis in mice by inhibiting the cGAS-STING signaling pathway.
Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling.
Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy.
Mitigating Doxorubicin-Induced Cardiotoxicity and Enhancing Anti-Tumor Efficacy with a Metformin-Integrated Self-Assembled Nanomedicine.
Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release.
Astilbin Alleviates IL-17-Induced Hyperproliferation and Inflammation in HaCaT Cells via Inhibiting Ferroptosis Through the cGAS-STING Pathway.
A quantitative method to monitor STING degradation with dual-luciferase reporters.
Hyperandrogenism triggers mtDNA release to participate in ovarian inflammation via mPTP/cGAS/STING in PCOS.
Marine-derived STING inhibitors, excavatolide B promote wound repair in full-thickness-incision rats.
AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity.
Suppression of Sepsis Cytokine Storm by Escherichia Coli Cell Wall-Derived Carbon Dots.
DSTYK phosphorylates STING at late endosomes to promote STING signaling.
Pectin/caffeic acid nanoparticles in a poloxamer thermosensitive gel for the treatment of ulcerative colitis by inhibiting cGAS-STING pathway.
Dynamic STING repression orchestrates immune cell development and function.
cGAS-STING mediates neutrophil extracellular traps-induced EMT in myositis-associated interstitial lung disease: STING as a potential therapeutic target.
Prenatal amoxicillin exposure induces depressive-like behavior in offspring via gut microbiota and myristic acid-mediated modulation of the STING pathway.
cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy.
Dual-modality immune nano-activator harnessing Mn(2)⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy.
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway.
Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota.
Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis.
YAP/TAZ-mediated nuclear membrane rupture in promoting senescence of skeletal muscle associated with COPD.
Pectin-loaded ferulic acid nanoparticles: A potential therapeutic strategy for ulcerative colitis via modulation of the cGAS-STING pathway.
PINK1 Deficiency Facilitates Palmitic Acid-Induced Inflammation by Disrupting Mitochondrial Function to Activate mtDNA-cGAS-STING Signaling.
Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment.
STING-∆C, a novel splice isoform of STING, inhibits DNA virus-induced innate immunity and autophagy.
Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury.
Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis.
Leucine enhances the cGAS-STING-NLRP3 pathway in autoimmune thyroiditis.
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis.
African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis.
The activation of cGAS-STING pathway promotes the epithelial-mesenchymal transition and inflammation in intrauterine adhesion.
Inhibition of the ATP synthase c subunit ameliorates HDM/LPS-induced inflammatory responses in asthmatic bronchial epithelial cells by blocking the mPTP-mtDNA-cGAS-STING axis.
STING-ΔN, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infection.
IDH1/MDH1 deacetylation activates the cGAS-STING pathway by promoting NETosis in acute liver failure.
STING contributes to the inflammation and proliferation of Staphylococcus aureus via mitochondrial reactive oxygen species-hypoxic inducible factor 1α axis in epithelial cells.
Mitochondria-targeted manganese-based mesoporous silica nanoplatforms trigger cGAS-STING activation and sensitize anti PD-L1 therapy in triple-negative breast cancer.
CSDE1 enhances genotoxic drug resistance in cancer by modulating RPA2 through CSDE1-eIF3a regulatory complex.
Epithelial Atg5 Deficiency Intensifies Caspase-11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS-STING-NLRP3 Axis in Macrophages During Pseudomonas Infection.
Pharmacological inhibition of the cGAS-STING pathway suppresses microglia pyroptosis in sepsis-associated encephalopathy.
Nanodrug Modulates Premetastatic Niche and Suppresses Metastatic Lung Adenocarcinoma via Programmed Cell Death Ligand 1 Blockade and STING Pathway Activation.
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
Mitophagy-mtROS axis contributes to anti-tuberculosis-induced liver injury through activation of the cGAS-STING pathway in rat hepatocytes.
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects.
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
XBP1 promotes endometrial fibrosis through cGAS-STING signaling pathway in intrauterine adhesion.
Butyrate attenuates SA-AKI by inhibiting pyroptosis via the STING-GSDMD axis.
STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NF-κB signaling.
The role of mitochondrial reactive oxygen species in initiating mitochondrial damage and inflammation in wasp-venom-induced acute kidney injury.
Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage.
Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo.
Overexpression of FBP1 enhances dendritic cell activation and maturation by inhibiting glycolysis and promoting the secretion of IL33 in lung adenocarcinoma.
9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.
C9orf72 Alleviates DSS‑Induced Ulcerative Colitis via the cGAS-STING Pathway.
Electroacupuncture intervention relieves pain by stimulating the STING/IFN-I pathway in rat models of cancer-induced bone pain.
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD.
Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration.
MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling.
Decreased STING predicts adverse efficacy in bortezomib regimens and poor survival in multiple myeloma.
Semen Strychni Pulveratum and vomicine alleviate neuroinflammation in amyotrophic lateral sclerosis through cGAS-STING-TBK1 pathway.
Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome.
OPA3 inhibits the cGAS-STING pathway mediated by mtDNA stress to promote colorectal cancer progression.
Hesperidin enhanced anti-breast cancer effect and alleviated cisplatin induced nephrotoxicity through silk fibroin delivery system.
Prognostic Impact of Stimulator of Interferon Genes Expression in Triple Negative Breast Cancer.
Curcumol ameliorates alcohol and high-fat diet-induced fatty liver disease via modulation of the Ceruloplasmin/iron overload/mtDNA signaling pathway.
Mechanical Force-Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis.
Hierarchical Targeting Nanodrug with Holistic DNA Protection for Effective Treatment of Acute Kidney Injury.
Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways.
Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling.
Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling.
Diffuse Traumatic Brain Injury Induced Stimulator of Interferons (STING) Signaling in Microglia Drives Cortical Neuroinflammation, Neuronal Dysfunction, and Impaired Cognition.
The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance.
Aggregatin is a mitochondrial regulator of MAVS activation to drive innate immunity.
Wen-Shen-Tong-Luo-Zhi-Tong Decoction alleviates bone loss in aged mice by suppressing LONP1-mediated macrophage senescence.
Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction.
Long non-coding RNA NEAT1 mediated lupus nephritis induced podocytes pyroptosis through DNMT1-STING axis.
Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury.
Macrophage extracellular traps impair intestinal barrier function in DSS-induced colitis in mice by inducing intestinal epithelial cell apoptosis.
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage degeneration in obesity-associated osteoarthritis.
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Unveiling EXOC4/SEC8: a key player in enhancing antiviral immunity by inhibiting the FBXL19-STING1-SQSTM1 signaling axis.
PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation.
Porcine cGAS-STING signalling induced apoptosis negatively regulates STING downstream IFN response and autophagy via different mechanisms.
A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin.
VAPB is a negative regulator of STING-mediated innate immune signaling.
TAT-PBX1 fusion protein alleviates LPS-induced acute lung injury via AMPK-TFAM signaling activation.
KAT2A affects the inflammatory progression of lupus nephritis through multilevel regulation of cGAS.
The Role of STING-Mediated Activation of the Integrated Stress Response in Inflammation-Induced Depletion of Ovarian Reserve.
HIF-1α mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis.
IRF1 amplifies HSV-1-triggered antiviral innate immunity in a feed-forward manner.
Kurarinone Alleviates cGAS-STING-Triggered Inflammatory Diseases by Targeting STING.
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine.
IFI16 Induced by p53 Activates the NF-κB Pathway to Counteract Cisplatin-Induced Apoptosis in Cervical Cancer Cells.
TAX1BP1-dependent autophagic degradation of STING1 impairs anti-tumor immunity.
Inhibition of STING-induced mitochondrial Drp1/N-GSDMD-mediated MtDNA release alleviates Sepsis-induced lung injury.
Gene expression cluster differences and molecular correlation with the STING pathway in orbital MALT lymphoma and orbital IgG4-related eye disease.
Conditional knockout mouse model demonstrates that Copa expression is required for viability in development and adulthood.
Beneficial Effects of Different Types of Exercise on Diabetic Cardiomyopathy.
RPA1 protects DNA damage-induced PANoptosis in limb development.
Inhibition of CPT1A activates the cGAS/STING pathway to enhance neutrophil-mediated tumor abrogation in triple-negative breast cancer.
Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors.
hnRNPA2B1 recognizes RNA virus SFTSV infection through mitochondrial DNA.
Excision repair cross complementation group 1 gene exon 3 skipping isoform presents selective cGAS-STING activation in platinum-sensitive lung adenocarcinoma.
PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal.
Esketamine alleviated cardiomyocyte ferroptosis induced by oxygen-glucose deprivation/reoxygenation (OGD/R) via cyclic GMP-AMP synthase interactor.
TRIM35 Negatively Regulates the cGAS-STING-Mediated Signaling Pathway by Attenuating K63-Linked Ubiquitination of STING.
Eliminating Radioresistance With a Magnetic Ion-Generator by Simultaneously Augmenting DNA Damage and Diminishing Immunosuppression.
RNF144A inhibits autophagy by targeting BECN1 for degradation during L. monocytogenes infection.
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases.
Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis.
Diffuse traumatic brain injury induced stimulator of interferons (STING) signaling in microglia drives cortical neuroinflammation, neuronal dysfunction, and impaired cognition.
Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8(+) T cells.
STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders.
An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer.
Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling.
PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway.
An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death.
Identification of fibrosis-associated lncRNAs in diabetic cardiomyopathy patients.
Metformin promotes anti-tumor immunity in STK11 mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites.
Establishment of a STING-Deficient HepG2 Cell Line through CRISPR/Cas9 System and Evaluation of Its Effects on Salmonella Replication.
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway.
Astragalus Polysaccharide Mitigates Rhabdomyolysis-Induced Acute Kidney Injury via Inhibition of M1 Macrophage Polarization and the cGAS-STING Pathway.
Alteration of cGAS-STING signaling pathway components in the mouse cortex and hippocampus during healthy brain aging.
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
African swine fever virus structural protein p17 inhibits IRF3 activation by recruiting host protein PR65A and inducing apoptotic degradation of STING.
Pseudorabies virus tegument protein US2 antagonizes antiviral innate immunity by targeting cGAS-STING signaling pathway.
African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation.
Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity.
Quercetin ameliorates ulcerative colitis by restoring the balance of M2/M1 and repairing the intestinal barrier via downregulating cGAS‒STING pathway.
Environment-responsive dendrobium polysaccharide hydrogel embedding manganese microsphere as a post-operative adjuvant to boost cascaded immune cycle against melanoma.
A guide to selecting high-performing antibodies for STING1 (Uniprot ID: Q86WV6) for use in western blot, immunoprecipitation, and immunofluorescence.
The involvement of Sting in exacerbating acute lung injury in sepsis via the PARP-1/NLRP3 signaling pathway.
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol.
Lipo/TK-CDN/TPP/Y6 nanoparticles inhibit cutaneous melanoma formation.
Chlorogenic acid can improve spermatogenic dysfunction in rats with varicocele by regulating mitochondrial homeostasis and inhibiting the activation of NLRP3 inflammasomes by oxidative mitochondrial DNA and cGAS/STING pathway.
Geniposide dosage and administration time: Balancing therapeutic benefits and adverse reactions in liver disease treatment.
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
Mitochondrial dysfunction-associated alveolar epithelial senescence is involved in CdCl(2)-induced COPD-like lung injury.
GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline.
SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.
Pentagalloylglucose alleviates acetaminophen-induced acute liver injury by modulating inflammation via cGAS-STING pathway.
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
NSDHL promotes the degradation of sting in cholangiocarcinoma.
C-di-GMP@ZIF-8 nanocomposite injectable hydrogel based on modified chitosan and hyaluronic acid for infected wound healing by activating STING signaling.
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling.
tBHQ mitigates fatty liver ischemia-reperfusion injury by activating Nrf2 to attenuate hepatocyte mitochondrial damage and macrophage STING activation.
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis.
STING Agonist Delivered by Neutrophil Membrane-Coated Gold Nanoparticles Exerts Synergistic Tumor Inhibition with Radiotherapy.
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
ZC3HAV1 facilitates STING activation and enhances inflammation.
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells.
Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells.
Porphyromonas gingivalis OMVs promoting endothelial dysfunction via the STING pathway in periodontitis.
Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis.
TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry.
Morphine induces inflammatory responses via both TLR4 and cGAS-STING signaling pathways.
Chemerin alleviates the placental oxidative stress and improves fetal overgrowth of gestational diabetes mellitus mice induced by high fat diet.
Cadmium exposure triggers alveolar epithelial cell pyroptosis by inducing mitochondrial oxidative stress and activating the cGAS-STING pathway.
Uncovering the role of tumor cGAS expression in predicting response to PD-1/L1 inhibitors in non-small cell lung cancer.
PROTAC based STING degrader attenuates acute colitis by inhibiting macrophage M1 polarization and intestinal epithelial cells pyroptosis mediated by STING-NLRP3 axis.
STING orchestrates microglia polarization via interaction with LC3 in autophagy after ischemia.
NLRX1 and STING alleviate renal ischemia-reperfusion injury by regulating LC3 lipidation during mitophagy.
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration.
Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction.
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF-κB pathway.
RGD targeted magnetic ferrite nanoparticles enhance antitumor immunotherapeutic efficacy by activating STING signaling pathway.
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
NAD(+) supplementation prevents STING-induced senescence in CD8(+) T cells by improving mitochondrial homeostasis.
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro.
Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer.
Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways.
Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses.
The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases.
Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-κB signaling pathway.
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction.
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Identification of key mitochondria-related genes and their relevance to the immune system linking Parkinson's disease and primary Sjögren's syndrome through integrated bioinformatics analyses.
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry.
Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X.
The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice.
Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling.
Regulating NCOA4-Mediated Ferritinophagy for Therapeutic Intervention in Cerebral Ischemia-Reperfusion Injury.
Targeting STING in dendritic cells alleviates psoriatic inflammation by suppressing IL-17A production.
Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection.
Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair.
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling.
Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.
STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis.
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury.
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
CRIg+ macrophages deficiency enhanced inflammation damage in IBD due to gut extracellular vesicles containing microbial DNA.
Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity.
Antitumor Effect of Platinum-Modified STING Agonist MSA-2.
HIV-1 p17 matrix protein enhances type I interferon responses through the p17-OLA1-STING axis.
Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol.
Jujuboside B alleviates acetaminophen-induced hepatotoxicity in mice by regulating Nrf2-STING signaling pathway.
Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses.
Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders.
A conserved ion channel function of STING mediates noncanonical autophagy and cell death.
Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.
Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour-intrinsic innate sensing and immunogenicity.
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats.
Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway.
The cGAS-STING pathway promotes the development of preeclampsia by upregulating autophagy: Mechanisms and implications.
RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion.
STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation.
Double-filtration plasmapheresis reduces type I interferon bioavailability and inducing activity in systemic lupus erythematosus.
STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions.
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis.
Switchable ROS generator and scavenger to prevent the cisplatin induced acute kidney injury and improve efficacy via synergistic chemodynamic/immune therapy.
Gelsevirine ameliorates sepsis-associated encephalopathy by inhibiting the STING signalling-mediated pyroptosis pathway in microglia.
Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma.
AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male mice.
BAX pores facilitate mitochondrial DNA release in wasp sting-induced acute kidney injury.
Neutrophil extracellular traps induce barrier dysfunction in DSS-induced ulcerative colitis via the cGAS-STING pathway.
Click-chemistry-based protocol for detecting 4-octyl-itaconate-alkylated proteins in primary mouse macrophages.
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.
STING exerts antiviral innate immune response by activating pentose phosphate pathway.
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell death via a mitochondrial DNA/STING/IRF3 pathway.
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure.
β-Mangostin targets and suppresses glioma via STING activation and tumor-associated microglia polarization.
cGAS suppresses β-cell proliferation by a STING-independent but CEBPβ-dependent mechanism.
The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.
Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis.
STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding.
Activated STING-containing R-EVs from iPSC-derived MSCs promote antitumor immunity.
Human Stimulator of Interferon Genes Promotes Rhinovirus C Replication in Mouse Cells In Vitro and In Vivo.
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.
Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS-STING signaling pathway.
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke.
The activation of the AIM2 inflammasome after cigarette smoke exposure leads to an immunosuppressive lung microenvironment.
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway.
STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling.
Deletion of MGF505-2R Gene Activates the cGAS-STING Pathway Leading to Attenuation and Protection against Virulent African Swine Fever Virus.
cGAS Activation Accelerates the Progression of Autosomal Dominant Polycystic Kidney Disease.
Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.
Cytosolic DNA sensing protein pathway is activated in human hearts with dilated cardiomyopathy.
Autophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma.
Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity.
Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.
MAVI1, an endoplasmic reticulum-localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion.
Moderate Intensity of Treadmill Exercise Rescues TBI-Induced Ferroptosis, Neurodegeneration, and Cognitive Impairments via Suppressing STING Pathway.
Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells.
Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway.
DWL-4-140: A allene small molecule targeting STING that alleviates lupus-like phenotype in Trex1(-/-) mice.
STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury.
4-Octyl itaconate restricts STING activation by blocking its palmitoylation.
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells.
Porcine IKKε is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway.
A sequential scheme including PTT and 2'3'-cGAMP/CQ-LP reveals the antitumor immune function of PTT through the type I interferon pathway.
Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A.
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice.
PAR2 deficiency tunes inflammatory microenvironment to magnify STING signalling for mitigating cancer metastasis via anionic CRISPR/Cas9 nanoparticles.
The STING inhibitor C-176 attenuates MPTP-induced neuroinflammation and neurodegeneration in mouse parkinsonian models.
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
Regulation of STING activity in DNA sensing by ISG15 modification.
PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling.
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling.
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury.
STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion.
ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.
Induction of Inflammation Disrupts the Negative Interplay between STING and S1P Axis That Is Observed during Physiological Conditions in the Lung.
The mechanism of STING autoinhibition and activation.
STING mediates experimental osteoarthritis and mechanical allodynia in mouse.
C9ORF72 suppresses JAK-STAT mediated inflammation.
The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.
NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.
Flavonoid derivative DMXAA attenuates cisplatin-induced acute kidney injury independent of STING signaling.
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING.
Protocol using lentivirus to establish THP-1 suspension cell lines for immunostaining and confocal microscopy.
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Protocol for the identification and expression analysis of a cytoplasmic membrane-localized protein STING.
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS-STING Pathway.
STING deficiency protects against wasp venom-induced acute kidney injury.
Stimulator of interferon genes (STING) expression in the enteric nervous system and contributions of glial STING in disease.
Murine Coronavirus Disease 2019 Lethality Is Characterized by Lymphoid Depletion Associated with Suppressed Antigen-Presenting Cell Functionality.
Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.
RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis.
Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer.
Multiple Porcine Innate Immune Signaling Pathways Are Involved in the Anti-PEDV Response.
Effect of STING signaling on intestinal barrier damage in severe acute pancreatitis.
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
Yes-Associated Protein 1 Inhibition Induces Immunogenic Cell Death and Synergizes With Radiation and PD-1 Blockade.
Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway.
DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.
Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain.
cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS-STING Signaling Pathway.
Inhibition of cGAS ameliorates acute lung injury triggered by zinc oxide nanoparticles.
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.
African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation.
Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Proteomic analysis predicts anti-angiogenic resistance in recurred glioblastoma.
NF-κB regulates the expression of STING via alternative promoter usage.
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.
Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma.
RNF144A promotes antiviral responses by modulating STING ubiquitination.
STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats.
Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress.
Naringin protects against inflammation and apoptosis induced by intestinal ischemia-reperfusion injury through deactivation of cGAS-STING signaling pathway.
The innate immune sensor STING accelerates neointima formation via NF-κB signaling pathway.
Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway.
Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy.
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
A role of STING signaling in obesity-induced lung inflammation.
The cGAS-STING pathway promotes endometriosis by up-regulating autophagy.
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1.
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
STING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy.
Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells.
STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages.
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
African Swine Fever Virus Structural Protein p17 Inhibits cGAS-STING Signaling Pathway Through Interacting With STING.
The Absence of STING Ameliorates Non-Alcoholic Fatty Liver Disease and Reforms Gut Bacterial Community.
Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING.
Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis.
Deficient DNASE1L3 facilitates neutrophil extracellular traps-induced invasion via cyclic GMP-AMP synthase and the non-canonical NF-κB pathway in diabetic hepatocellular carcinoma.
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Human Atheromatous Plaques Expressed Sensing Adaptor STING, a Potential Role in Vascular Inflammation Pathogenesis.
Clathrin-associated AP-1 controls termination of STING signalling.
Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.
BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma.
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways.
STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal Cortex.
Baicalein-loaded silk fibroin peptide nanofibers protect against cisplatin-induced acute kidney injury: Fabrication, characterization and mechanism.
Pharmacological inhibition of the cGAS-STING signaling pathway suppresses microglial M1-polarization in the spinal cord and attenuates neuropathic pain.
SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy.
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.
Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment.
HIV-1-induced type I IFNs promote viral latency in macrophages.
UNC13D inhibits STING signaling by attenuating its oligomerization on the endoplasmic reticulum.
Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity.
The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages.
Interruption of post-Golgi STING trafficking activates tonic interferon signaling.
cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress.
Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity.
SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy.
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment.
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury.
STING activation promotes inflammatory response and delays skin wound healing in diabetic mice.
ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
1,25(OH)(2) D(3) blocks IFNβ production through regulating STING in epithelial layer of oral lichen planus.
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
STING expression is an independent prognostic factor in patients with mycosis fungoides.
The Porcine and Chicken Innate DNA Sensing cGAS-STING-IRF Signaling Axes Exhibit Differential Species Specificity.
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium.
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics.
CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T(H)1 and T(H)9 cells.
Helicobacter pylori actively suppresses innate immune nucleic acid receptors.
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
The cGAS-STING pathway connects mitochondrial damage to inflammation in burn-induced acute lung injury in rat.
STING-mediated inflammation contributes to Gao binge ethanol feeding model.
Molecular cloning and functional analysis of Macaca mulatta STING.
Sustained IL-4 priming of macrophages enhances the inflammatory response to TLR7/8 ligand R848.
Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP.
ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation.
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients.
Expression of STING Is Increased in Monocyte-Derived Macrophages and Contributes to Liver Inflammation in Hepatic Ischemia-Reperfusion Injury.
The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε.
Mitochondrial cristae architecture protects against mtDNA release and inflammation.
Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer.
The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy.
MPYS Modulates Fatty Acid Metabolism and Immune Tolerance at Homeostasis Independent of Type I IFNs.
Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction.
Irradiation combined with PD-L1(-/-) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation.
New mechanism of nephrotoxicity of triptolide: Oxidative stress promotes cGAS-STING signaling pathway.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer.
Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling.
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production.
STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis.
Activation of the cGAS-STING signaling pathway in adenomyosis patients.
Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma.
Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function.
Screening of Porcine Innate Immune Adaptor Signaling Revealed Several Anti-PRRSV Signaling Pathways.
eccDNAs are apoptotic products with high innate immunostimulatory activity.
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection.
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Pharmacological activation of STING blocks SARS-CoV-2 infection.
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine.
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells.
A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation.
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells.
ALG2 regulates type I interferon responses by inhibiting STING trafficking.
Chromosome aberrations induced by the non-mutagenic carcinogen acetamide involve in rat hepatocarcinogenesis through micronucleus formation in hepatocytes.
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease.
Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.
Transfected DNA is targeted by STING-mediated restriction.
Mutant p53 suppresses innate immune signaling to promote tumorigenesis.
The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction.
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.
Long non-coding RNA MALAT1 targeting STING transcription promotes bronchopulmonary dysplasia through regulation of CREB.
Reactive oxygen species oxidize STING and suppress interferon production.
Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells.
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C.
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.
RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
SPHK2-Generated S1P in CD11b(+) Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages.
Redox homeostasis maintained by GPX4 facilitates STING activation.
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo.
Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation.
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
TBC1D9 regulates TBK1 activation through Ca(2+) signaling in selective autophagy.
Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer.
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice.
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion.
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.
African Swine Fever Virus Armenia/07 Virulent Strain Controls Interferon Beta Production through the cGAS-STING Pathway.
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection.
Tandem Mass Tag Proteomic Analysis of in Vitro and in Vivo Models of Cutaneous Leishmaniasis Reveals Parasite-Specific and Nonspecific Modulation of Proteins in the Host.
USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes.
IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.
Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection.
A proteomics landscape of circadian clock in mouse liver.
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
TRIM29 promotes DNA virus infections by inhibiting innate immune response.
Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.
HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity.
MITA modulated autophagy flux promotes cell death in breast cancer cells.
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
Activation of STING requires palmitoylation at the Golgi.
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways.
NET23/STING promotes chromatin compaction from the nuclear envelope.
Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-κB induced cell death.
Long M, Chen Y, Du R, Yang J, Wang J, Sun Y, Tian X, Wang S, Zhong Y, Liang W, Zhang J, Shang Z
International journal of biological sciences 2026;22(3):1186-1206
International journal of biological sciences 2026;22(3):1186-1206
Prognostic value of cGAS-STING-IRF3 signaling in cholangiocarcinoma patients.
Artbua P, Kentachalee N, Sitthirak S, Sa-Ngiamwibool P, Wichian P, Deenonpoe R
PloS one 2026;21(2):e0342756
PloS one 2026;21(2):e0342756
Discovery of an orally bioavailable selenium-containing Polθ inhibitor with a dual mechanism of DNA damage and immune activation for HR-deficient cancers.
Ma L, Luo M, Liu X, Yang J, Li J, Zhong M, Liu X, Xiao M, Xiang H, Luo G
European journal of medicinal chemistry 2026 Sep 5;313:118887
European journal of medicinal chemistry 2026 Sep 5;313:118887
A biomimetic arsenic-based nanozyme enhances dual epigenetic regulation to improve the efficacy of immunotherapy for acute myeloid leukaemia.
Chang A, Peng H, Chen Y, Zhang H, Xu X, Zhang K, Yang J, Li W, Wang X, Dong X, Ni J
Biomaterials 2026 Oct;333:124215
Biomaterials 2026 Oct;333:124215
Spike RBD drives sustained Parkinson's disease progression via microglia-neuron crosstalk-mediated RTP801 upregulation.
Wang SS, Yuan RL, Wang WF, Peng Y, Hu KC, He WB, Zhao YX, Yan X, Zhang Z, Chu SF, Chen NH
Journal of advanced research 2026 May;83:315-332
Journal of advanced research 2026 May;83:315-332
STING1 exacerbates iodinated contrast-induced acute kidney injury by promoting ferroptosis through chaperone-mediated autophagic degradation of FTH1.
Wu T, Wu X, Cai J, Tang CY, Wang XF, Zeng MY, Liu YT, Tang Y, Liu ZW, Meng W, Duan SB
Autophagy 2026 May;22(5):1081-1096
Autophagy 2026 May;22(5):1081-1096
Shenkangling alleviates renal fibrosis induced by renal ischemia-reperfusion injury by mitigating mitochondrial damage through modulation of the STING signaling pathway.
Mao Y, Lin S, Wu M, Ma H, Ji J, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158020
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158020
STING-mediated metabolic reprogramming drives lipid peroxidation during Staphylococcus aureus infection.
Yu R, Sun N, Fu S, Fang Y, Feng S, Qiu Y, Wang H, Xu Y, Miao J
International immunopharmacology 2026 May 1;176:116497
International immunopharmacology 2026 May 1;176:116497
Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment.
Wen J, Xu Y, Qin S, Guo Y, Wang X, Liu L, Lu Z, Yan Y, Zhan X, Zhao J, Xiao X, Bai Z
International immunopharmacology 2026 May 1;176:116468
International immunopharmacology 2026 May 1;176:116468
Targeted knockdown of Piezo1 in synovial macrophages attenuates osteoarthritis development.
Yan Z, Wu D, Zhao H, Guan H, Chen J, Huang C, Chen X, Deng X, Hu J, Wang J, Zhang Y
Journal of orthopaedic translation 2026 Mar;57:101053
Journal of orthopaedic translation 2026 Mar;57:101053
Promotion of hepatocellular carcinoma by small nuclear ribonucleoprotein polypeptide F through upregulation of transmembrane P24 trafficking protein 2 and triggering of the cGAS-STING pathway.
Xie X, Pu L, Zeng J, Xu M, Yin X, Liu H, Yang J, Cao J, Song H
International journal of biological macromolecules 2026 Mar;352:151166
International journal of biological macromolecules 2026 Mar;352:151166
SIRT4 regulates antiviral and autoimmune responses by promoting cGAS-mediated signaling pathways.
Yang B, Zhang Y, Wang S, Wu Y, Diao Z, Zhang Q, Lu C, Shen M, Zhang X, Ma S, Yang C, Pei J, Xing H, Liang Y, Wang J
EMBO reports 2026 Mar;27(5):1228-1253
EMBO reports 2026 Mar;27(5):1228-1253
TRIM29 knockout pigs exhibit enhanced broad-spectrum disease resilience by amplifying type I interferon antiviral defenses.
Yang X, Zhong H, Cheng J, Jiang H, Tan J, Wang C, Song C, Cai G, Yang H, Wu Z
PLoS pathogens 2026 Mar;22(3):e1014023
PLoS pathogens 2026 Mar;22(3):e1014023
SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING.
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B
The Journal of general virology 2026 Mar;107(3)
The Journal of general virology 2026 Mar;107(3)
Anti-Inflammatory Effects of Curcumin via the Nrf2-cGAS-STING-NF-κB Pathway in MH7A Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Li L, Shen T, Li Z, Guo Q, Pang Q
Biomedicines 2026 Mar 9;14(3)
Biomedicines 2026 Mar 9;14(3)
Fibroblast growth factor-inducible 14 accelerates pulmonary fibrosis by inducing fibroblast senescence in mice.
Guan XX, Zhong WJ, Tang WF, Liu YB, Chen MR, Li JL, Zhang CY, Zhou Y, Guan CX, Wu JN, Ma L, Duan JX
Cellular and molecular life sciences : CMLS 2026 Mar 6;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 6;83(1)
EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS-STING Pathway.
Huo L, Wu C, Li X, Ma C, Huang J, Chen Z, He W, Tao T, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 30;:e22826
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 30;:e22826
Disruption of sphingolipid metabolism triggers lung vascular inflammation and aging-like changes under hypoxia through VDAC1-mediated mitochondrial DNA release.
Xu J, Ge Y, Zhang B, He S, Cao Q, Li P, Bu Y, Bai Y, Zhang L, Tan G, Ma J, Xie M
Apoptosis : an international journal on programmed cell death 2026 Mar 3;31(3)
Apoptosis : an international journal on programmed cell death 2026 Mar 3;31(3)
STING Drives Psoriatic Inflammation by Promoting Neutrophil Recruitment and Facilitating NETosis.
Luo H, Hu C, Tian T, Qian T, Jiang X, Dang Y, Chen B, Yang Z, Luo N, Zhang D, Hao F
Immunology 2026 Mar 3;
Immunology 2026 Mar 3;
STING Mediates Microglial Polarization to Promote Neuroinflammation in Epilepsy-Related Cognitive Dysfunction.
Yang H, Wang W, Liu X, Shi M, Wang H, Wu X, Liu Y, Yu Y
Neurochemical research 2026 Mar 25;51(2)
Neurochemical research 2026 Mar 25;51(2)
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Zhang Y, Zhu Z, Ji P, Ming J, Zhou Y
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
PTPN2 alleviates psoriasis by targeting the STING-STAT3 axis and restoring autophagy: in vitro and in vivo evidence.
Yang Y, Zhong Y, Liu F, Liu S, Chen Y
Immunobiology 2026 Mar 20;231(3):153174
Immunobiology 2026 Mar 20;231(3):153174
Microneedle patches deliver targeted GLP-1RAs-loaded nanoparticles for the treatment of rheumatoid arthritis.
Zhang H, Liu Y, Zhang S, Wang Z, Zhang X, Zhang Y, Zhang J, Liang S, Li C, Su M, Tian Z, Luo L
Journal of nanobiotechnology 2026 Mar 16;24(1)
Journal of nanobiotechnology 2026 Mar 16;24(1)
Resveratrol Mitigates Age-Associated Cognitive Decline via Inhibition of cGAS-STING-Mediated Microglial Senescence.
Duan X, Cheng J, Wang J, Chen W, Ruan Z
Cells 2026 Mar 16;15(6)
Cells 2026 Mar 16;15(6)
Fibroblast-derived exosomes induce macrophage pyroptosis to mediate orthodontic bone remodeling through the mtDNA/NLRP3 axis.
Yu Q, Guo K, Yang Y, Liu H, Han Y, Yu X, Wang J, Zhao Y, Su X, Zhu K, Zheng S, Wang S, Li W, Huang Y
Journal of nanobiotechnology 2026 Mar 14;24(1)
Journal of nanobiotechnology 2026 Mar 14;24(1)
STING-ERO1 signaling exacerbates PARylation-mediated parthanatos in sepsis.
Li X, Zhou Q, Zhang X, Li Y, Yang Y, Wu J, Liu Q, Liu P, Jiang H, Liu J, Deng L, Lin Z, Wu C, Wu L, Zhao Y, Ren J, Wu X
Cell communication and signaling : CCS 2026 Mar 12;24(1)
Cell communication and signaling : CCS 2026 Mar 12;24(1)
Ultrasmall Prussian blue-integrated cryogel for enhanced ROS scavenging and immunomodulation via cGAS-STING inhibition in wound healing.
Zhou X, Hu G, Huang C, Liu Y, Ma ZR, Lu Y, Xu Y, Qian W
Materials today. Bio 2026 Jun;38:103056
Materials today. Bio 2026 Jun;38:103056
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Wang D, Zhou Z, Zhao Z, Liu M, Li Y, Mu L, Zhou H, Li X, Zhang F, Tian S, Zhou X, Shi Y
Free radical biology & medicine 2026 Jun;249:246-259
Free radical biology & medicine 2026 Jun;249:246-259
Babaodan suppresses inflammatory and vascular microenvironment in triple-negative breast cancer by inhibiting the cGAS-STING/NF-κB signaling pathway.
Lai B, Zeng W, Zhou B, Liu R, Lai P, Ren J, Chen R, Che L, Chen X, Pei X, Qiu Y
Journal of ethnopharmacology 2026 Jun 12;364:121515
Journal of ethnopharmacology 2026 Jun 12;364:121515
ACOT8-mediated palmitate accumulation promotes M1 macrophage polarization in renal ischemia-reperfusion injury via activation of the cGAS-STING pathway.
Zhang H, Liu X, Ji X, Zhang G, Wang B, Xiong F, Sun D, Wang C
International immunopharmacology 2026 Jun 1;178:116558
International immunopharmacology 2026 Jun 1;178:116558
Loss of cGAS facilitates angiogenesis in diabetic foot ulcer healing by suppressing the STING/ferroptosis pathway.
Li W, Kang M, Zhang G, Hu H, Qin H
International immunopharmacology 2026 Jul 1;180:116684
International immunopharmacology 2026 Jul 1;180:116684
ABCC10-mediated cGAMP efflux drives cancer cell radiotherapy resistance.
Zhang Z, Gao J, Liao X, Zhang Z, Cao X, Gong Y, Chen W, Zhang L, Tsai HI, Wang D, Zhu H
Cell death and differentiation 2026 Jan;33(1):111-125
Cell death and differentiation 2026 Jan;33(1):111-125
Systemic LINE-1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS-STING Pathway in Aging.
Yu S, Cheng Q, Yu Q, Cui Z, Chen H, Wu S, Jin Y, Wang Y, Li M, Lu Z
Aging cell 2026 Jan;25(1):e70350
Aging cell 2026 Jan;25(1):e70350
Chlorogenic acid targets STING to alleviate pressure overload-induced heart failure and myocardial fibrosis.
Huang K, Xiao JL, Tang JY, Pu HY, Li FH, Gao K, Yu X, Guo SZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157625
SARS-CoV-2 spike protein induces depressive-like behaviors by disrupting astrocytic Cx43-mediated gap junction intercellular communication.
Yuan RL, Wang SS, Li PY, Ruan Y, He JQ, Zhou R, Wang WF, Jiang YT, Ye JR, Peng Y, He WB, Chu SF, Zhang Z, Chen NH
Brain, behavior, and immunity 2026 Jan;131:106176
Brain, behavior, and immunity 2026 Jan;131:106176
Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression.
Shi J, Li Z, Sun X, Yang Y, Luo Y, Song Z, Dong H, Jin L, Xie J, Shan Y, Zhao G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e05778
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(2):e05778
Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.
Li M, Li R, Xu B, Lian Y, Yang C, Li J, Liang J, Ding L, Zhang D, Guo J, Fu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e08753
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e08753
Mitochondrial DAMPs produce inflammatory hyperalgesia via stimulator of interferon genes (STING) activation in DRG neurons.
Amino H, Higashi A, Yamakita S, Horii Y, Amaya F
Molecular pain 2026 Jan-Dec;22:17448069261435322
Molecular pain 2026 Jan-Dec;22:17448069261435322
Selective antagonism of adenosine A2A receptor reduces hypobaric hypoxia-induced neuroinflammation by inhibiting cGAS-STING pathway.
Cheng H, Gao Y, Shang H, Han W, Zhang X, Gao R, Dang W, Ma Z, Liu X, Gao Y
Scientific reports 2026 Jan 5;16(1):1091
Scientific reports 2026 Jan 5;16(1):1091
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Zhang H, Chang A, Xu X, Peng H, Zhang K, Yang J, Li W, Wang X, Wang W, Yin X, Qu C, Dong X, Ni J
Current issues in molecular biology 2026 Jan 27;48(2)
Current issues in molecular biology 2026 Jan 27;48(2)
Regulation of AP1 adaptor assembly by the bi-handed chaperone MEA1.
Wan C, Wu J, Ouyang Y, Puscher H, Tian Y, Li S, Yin Q, Shen J
Nature communications 2026 Jan 20;17(1)
Nature communications 2026 Jan 20;17(1)
Migration and invasion inhibitory protein inhibits M2 macrophage polarization to suppress colorectal cancer progression through the STING-NFκB2-IL10 axis.
Chen S, Lu C, Li J, Shen X, Sun Y
Cancer biology & medicine 2026 Jan 14;23(1):86-106
Cancer biology & medicine 2026 Jan 14;23(1):86-106
Loss of LXRβ Drives CD4(+) T Cell Senescence and Exacerbates the Progression of Colitis.
Zhang Y, Xu Y, You P, Liu Y, Xu J
Biomedicines 2026 Jan 11;14(1)
Biomedicines 2026 Jan 11;14(1)
Maidong Dishao Decoction can inhibit the activation of the cGAS-STING signaling pathway of Sjögren's syndrome by reducing oxidative stress in salivary gland epithelial cells.
Zhu W, Chen L, Li Y, Gu R, Zhang Y, Lu Y, Wang Y
Journal of ethnopharmacology 2026 Jan 10;354:120470
Journal of ethnopharmacology 2026 Jan 10;354:120470
STING knockdown blocks disease progression and inflammation in mice with alcoholic liver disease by relieving pyroptosis via suppressing NLRP3.
Song Y, Liu M, Zhou M, Ren X, Feng B, Xie Y
International immunopharmacology 2026 Jan 1;168(Pt 2):115858
International immunopharmacology 2026 Jan 1;168(Pt 2):115858
Trillin attenuates liver ischemia-reperfusion injury by inhibiting autophagy through regulation of the cGAS-STING pathway.
Wu T, Yu Q, Wang Y, Tang H, Guo W
International immunopharmacology 2026 Jan 1;168(Pt 2):115790
International immunopharmacology 2026 Jan 1;168(Pt 2):115790
CDK10 suppresses nucleic acid sensors-mediated antitumor immunity.
Xu G, Guo F, He C, Wang X, Xiang B, Fan L, Chen B, Peng J, Sun Y, Shi J, Xing X, Yao Y, Dai P, Li H, Xiong W, Liu H, Xiao R, Qing G, Jiang C, Jiang B, Lei X, Zhang J
Nature cancer 2026 Feb;7(2):283-303
Nature cancer 2026 Feb;7(2):283-303
Melatonin impedes NCOA4/ACSL4-dependent ferroptosis by targeting STING to ameliorate diabetic cognitive dysfunction.
Xu T, Xie Z, Zhao Y, Ren Z, Wu M, Zhu Z, Meng H, Zhang Y, Wan M, Chen C, Han J, Che H
Bioorganic chemistry 2026 Feb;169:109357
Bioorganic chemistry 2026 Feb;169:109357
Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender.
Huang Y, Hu B, Liu Y, Xie LQ, Dai Y, An YZ, Peng XY, Cheng YL, Guo YF, Kuang WH, Xiao Y, Chen X, Zheng YJ, Xie GQ, Wang JP, Peng H, Luo XH
Cell metabolism 2026 Feb 3;38(2):281-297.e11
Cell metabolism 2026 Feb 3;38(2):281-297.e11
Puerarin Attenuates White Matter Injury and Blood-Brain Barrier Disruption After Intracerebral Hemorrhagic Stroke via cGAS-STING Axis.
Ouyang Y, Yu L, Shi Y, Chen Z, Tang X, Jin J, Huang Z, Tang X, Zhu B, Wang X
Biology 2026 Feb 3;15(3)
Biology 2026 Feb 3;15(3)
Electroacupuncture Attenuates Neuroinflammation and Postoperative Cognitive Dysfunction in Aged Rats by Suppressing the cGAS-STING Pathway.
Ma B, Fan S, Deng J, Wei K, Li Y, Yin J, Xie L
Experimental neurobiology 2026 Feb 28;35(1):42-55
Experimental neurobiology 2026 Feb 28;35(1):42-55
Machine learning-guided Huanglian Jiedu decoction targets STING in periodontitis-induced Alzheimer's Disease.
Li J, Chen M, Ren P, Sun G, Zhong F, Zhu Y, Li G, Fan Y, Chen J, Xu M, Qiao M, Zhao G, Xu Y, Wu W
NPJ digital medicine 2026 Feb 27;9(1)
NPJ digital medicine 2026 Feb 27;9(1)
Kynurenic Acid/GPR35 Signaling Protects the Infarcted Heart by Suppressing Macrophage mtDNA-Triggered cGAS-STING Activation.
Mao Y, Jiao J, Zhu X, Liu W, He S, Li N, Yang H, Li J, Tang T, Xia N, Cheng X
Antioxidants (Basel, Switzerland) 2026 Feb 27;15(3)
Antioxidants (Basel, Switzerland) 2026 Feb 27;15(3)
Targeting FAM83D triggers tumor cell senescence via cGAS-STING signaling activation and reprograms TAMs to combat glioma.
Liu H, Lin X, Dai L, Zhang W, Zhang Y, Liu N, Li Y, Peters JJ, Gu J, Peng K, Jiang N, Wanggou S, Li X
Journal of experimental & clinical cancer research : CR 2026 Feb 26;45(1)
Journal of experimental & clinical cancer research : CR 2026 Feb 26;45(1)
Monocyte-macrophage SAMHD1 alleviates EAMG by modulating the cGAS-STING pathway.
Que W, Fan R, Lu D, Liu L, Dong J, Ke P, Jing S, Gan Y, Xiao F
Journal of neuroinflammation 2026 Feb 19;23(1)
Journal of neuroinflammation 2026 Feb 19;23(1)
Targeting the Pyroptosis-Mitochondrial Homeostasis Crosstalk: Astaxanthin Attenuates Alcohol-Induced Inflammatory Liver Injury via Inhibition of cGAS-STING Signaling.
Liu S, Zhang H, Du R, Gao X, Wang T, Qin W, Sun D, Liang H, Wang P
Journal of agricultural and food chemistry 2026 Feb 18;74(6):5218-5236
Journal of agricultural and food chemistry 2026 Feb 18;74(6):5218-5236
Investigating the impact and mechanism of Licochalcone B derivative CTG12 on NLRP3 inflammasome.
Bian S, Fang ZE, Wang L, Wang J, Dong M, Yang N, Wang J, Li L, Xu G
Cell communication and signaling : CCS 2026 Feb 18;24(1)
Cell communication and signaling : CCS 2026 Feb 18;24(1)
Ultrasound-Responsive Cerasome Nanoparticle Improves STING-Driven Immunotherapy in Triple-Negative Breast Cancer.
Yang D, Sun C, He Y, Wu R, Li C, Gong X, Zhuang H, Wang Y, Qin H, Wang Y, Li Q, Paulmurugan R, Liang X, Wang Y
ACS applied materials & interfaces 2026 Feb 18;18(6):9379-9400
ACS applied materials & interfaces 2026 Feb 18;18(6):9379-9400
LL37-induced mitochondrial stress activates the mtDNA/cGAS/STING pathway to promote mast cell-mediated rosacea inflammation.
Sun R, Fan H, Ma Q, Li X, Liu J, Xu C, Liu C, Zhang D, Ma W
Free radical biology & medicine 2026 Feb 16;244:422-434
Free radical biology & medicine 2026 Feb 16;244:422-434
Lactiplantibacillus plantarum GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation.
Lu S, Yue K, He S, Mi J, Yang T, Yang Y, Ma H, Ren Z, Ren L, Xu J
Cellular and molecular life sciences : CMLS 2026 Feb 10;83(1):107
Cellular and molecular life sciences : CMLS 2026 Feb 10;83(1):107
Mechanisms of topical Mahoniae Caulis against acute mastitis: Integrating SMR, network pharmacology, molecular docking, and experimental validation.
Feng S, Zhou N, Wang T, Wang Y, Shu R, Liu Y, Lyu G
Tissue & cell 2026 Aug;101:103472
Tissue & cell 2026 Aug;101:103472
Identification of Pinostilbene as a natural STING agonist that triggers FTH1 degradation via K48-ubiquitination to induce ferroptosis in non-small cell lung cancer.
Song S, Hua S, Chen G, Yin X, Chen Z, Li C, Zhou D, Zhu B
Redox biology 2026 Apr;91:104099
Redox biology 2026 Apr;91:104099
Ultrasound-triggered carrier-free nanoprodrugs activate cGAS-STING pathway to enhance tumor-targeting chemo-immunotherapy.
Xu X, Jin P, Chen Y, Wu B, Fang X, Song Y, Luo J, Wang G, Huang P
Materials today. Bio 2026 Apr;37:102858
Materials today. Bio 2026 Apr;37:102858
TRIM25 triggers pyroptosis through mitochondrial DNA release in intestinal ischemia-reperfusion injury.
Song Y, Lu X, Ren X, Li M, Meng F, Miao Y, Ding D, Liu Y
Free radical biology & medicine 2026 Apr;247:333-347
Free radical biology & medicine 2026 Apr;247:333-347
Ophiopogon japonicus Polysaccharides Promote Microbial Production Of Chenodeoxycholic Acid To Alleviate Ulcerative Colitis in Mice by Inhibiting the STING1-Related NF-κB Pathway.
Gao X, Zhang C, Zhao Z, Chen Y, Lei H, Cao Z, Yu W, Lin W, He Y, Li X, Xiang Q, Zhang Z, Zhang L, Chen G
Journal of agricultural and food chemistry 2026 Apr 22;74(15):12087-12101
Journal of agricultural and food chemistry 2026 Apr 22;74(15):12087-12101
PIM1 Inhibition Alleviates Aspergillus fumigatus Keratitis by Regulating DDX41-Mediated STING Signaling Pathway.
Han F, Wang L, Wu J, Ma H, Luo X, Li J
Investigative ophthalmology & visual science 2026 Apr 1;67(4):2
Investigative ophthalmology & visual science 2026 Apr 1;67(4):2
Unlocking the Puzzle of Mammalian Transfection: The Role of the RNA-sensing-Mediated Interferon Response in the Cellular Defense Against Foreign DNA Intrusion.
Li X, Zhou Y, Wei J, Sun W, Fan L, Yan J
International journal of biological sciences 2025;21(9):3886-3900
International journal of biological sciences 2025;21(9):3886-3900
Repetitive Trans-spinal Magnetic Stimulation Suppresses Microglia to Engulf Synapse and Promotes Nerve Repairment via cGAS-STING Signaling Pathway after Spinal Cord Injury.
Huang M, Di J, Li N, Xiao L, Tian Z, He T, Pang M, Liu B, He L, Rong L
International journal of biological sciences 2025;21(14):6132-6155
International journal of biological sciences 2025;21(14):6132-6155
RACK1 Associates With STING to Promote Type I Interferon Activation and Inhibit Pseudorabies Virus Infection.
Li Y, Liu Y, Dai Y, Niu J, Li G, Yu X, Wan C, Fang R, Ye C
Transboundary and emerging diseases 2025;2025:9584967
Transboundary and emerging diseases 2025;2025:9584967
Caveolin-1 knockout improves CFA-induced inflammatory pain in adult mice through modulating the cGAS STING pathway and autophagy.
Chang H, Cheng C, Zheng N, Zhu H, Yang H, Zhu X, Zhang F
PloS one 2025;20(10):e0333646
PloS one 2025;20(10):e0333646
Fumarate Hydratase Restrains mtDNA Attenuates LPS-Induced Acute Lung Injury Through cGAS-STING Pathways.
Jiang Z, He R, Zhong Y, Liu B, He Z
Journal of inflammation research 2025;18:5399-5413
Journal of inflammation research 2025;18:5399-5413
Lily polysaccharides alleviate colitis through the microbiota-N8-acetylspermidine-cGAS-STING signaling axis.
Wu Y, Wan X, Hou L, Zhang H, Wang J, Wu K, Shao J, Song Z
Frontiers in microbiology 2025;16:1686902
Frontiers in microbiology 2025;16:1686902
Epimedium brevicornu Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway.
Liu L, Zhan X, Wang X, Wen J, He C, Chen X, Guo Y, Wang X, Li L, Cheng H, Bai Z, Xiao X
Frontiers in pharmacology 2025;16:1681650
Frontiers in pharmacology 2025;16:1681650
Targeting the LPS-STING axis: neomycin restores STING-mediated anti-tumor immune suppression and inhibits tumor growth.
Fan H, Fu D, Tian M, Li Z, Liu S, Ye C, Wu K, Zhu C
Frontiers in immunology 2025;16:1637667
Frontiers in immunology 2025;16:1637667
Sophora tonkinensis enhances activation of cGAS-STING pathway and restrains HBV replication.
Guo Y, Wen J, Wang X, Wang X, Xu Y, Huang S, Lu Z, Chen X, Huang A, Ma Z, Cao J, Zhan X, Bai Z
Frontiers in pharmacology 2025;16:1630460
Frontiers in pharmacology 2025;16:1630460
Lamins regulate cancer cell plasticity and chemosensitivity.
Chen G, Wei T, Huang A, Shen J, Ju F, Huang S, Li H
Frontiers in oncology 2025;15:1599175
Frontiers in oncology 2025;15:1599175
High cGAS-STING expression associates with improved efficacy of neoadjuvant chemo-immunotherapy in head and neck squamous cell carcinoma.
Wang M, Shi M, Ding Y, Zhang Z, Ge Y, Li Z, Jing Y, Hu H, Chen X
Frontiers in oncology 2025;15:1584061
Frontiers in oncology 2025;15:1584061
High cyclic GMP-AMP synthase and stimulator of interferon genes in cholangiocarcinoma suggest their potential as targets for treatment.
Zin Myint HN, Saranaruk P, Paungpan N, Waraasawapati S, Pairojkul C, Saisomboon S, Settha N, Pattanachot J, Okada S, Seubwai W, Kitkhuandee A, Sawanyawisuth K, Vaeteewoottacharn K
PeerJ 2025;13:e19800
PeerJ 2025;13:e19800
Study on the Mechanism of QRICH1 Mediating PRMT1 to Regulate the Arginine Methylation Modification of cGAS to Promote Arsenics-Induced Pyroptosis in Hepatocellular Carcinoma Cells.
Zhang J, Tian T, Tian S, Yao J, Zhang Y, Xie R, Yang T, Han B
Journal of hepatocellular carcinoma 2025;12:597-614
Journal of hepatocellular carcinoma 2025;12:597-614
TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway.
Sun K, Zhang X, Hou L, Lu F, Liu H, Zheng Z, Guo Z, Xu J, Ruan Z, Hou Y, He J, Guo F, Yang K
Journal of advanced research 2025 Sep;75:213-227
Journal of advanced research 2025 Sep;75:213-227
STING inhibits LINE-1 retrotransposition through sorting ORF1p to lysosomes for degradation.
Huang Y, Xu F, Wang L, Mei S, Zhao F, Wang L, Xie Y, Wei L, Hu Y, Gao Z, Xue T, Fang J, Guo F
EMBO reports 2025 Sep;26(18):4607-4630
EMBO reports 2025 Sep;26(18):4607-4630
TFEB and TFE3 regulate STING1-dependent immune responses by controlling type I interferon signaling.
Tapia PJ, Martina JA, Contreras PS, Prashar A, Jeong E, De Nardo D, Puertollano R
Autophagy 2025 Sep;21(9):2028-2045
Autophagy 2025 Sep;21(9):2028-2045
Thiamet-G ameliorates Parkinson's disease-associated cognitive impairment via increasing O-GlcNAcylation of STING in the microglia.
Zhu S, Wang N, Chen S, Zou J, Tan S
Neurochemistry international 2025 Sep;188:106014
Neurochemistry international 2025 Sep;188:106014
Dihydrotanshinone I, a main compound of Salvia miltiorrhiza, alleviates autoimmune and inflammatory diseases by directly targeting IRF3.
Shi W, Wen J, Gao Y, Liu T, Li H, Yang H, Zhao J, Wei Z, Li C, Yao Q, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157005
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157005
Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis.
Lu J, Wang H, Zhang H, Li J, Li H, Chen Q, Han D, Liu J, Lv L, Xiong J, Yuan K, Wei X, Sheng S, Liu F, Shi Y, Dong Z, Li Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e01070
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e01070
Biomimetic Nanoregulators Mediated Tyrosine Hydroxylase mRNA and Stimulator of Interferon Genes Antagonist Codelivery for Synergistic Therapy on Parkinson's Disease.
Yang L, Li S, Hou C, Zhang Y, Cheng L, Wang Z, He W, Zhang W
ACS nano 2025 Sep 30;19(38):33734-33748
ACS nano 2025 Sep 30;19(38):33734-33748
Harnessing cGAS-STING signaling to counteract the genotoxic-immune nexus in tauopathy.
Singh H, Khan S, Xiao J, Nguyen N, Das A, Johnson D, Fang-Liao F, Frautschy SA, McDonald MP, Pourmotabbed T, Khan MM
bioRxiv : the preprint server for biology 2025 Sep 28;
bioRxiv : the preprint server for biology 2025 Sep 28;
Extrachromosomal circular DNA drives ferroptosis and immunity in trophoblasts via the STING pathway in preeclampsia.
Wang X, Bian W, Huang M, Li T, Xiong H, Xiang S, Li H, Yang H, Yang H
Biochemical and biophysical research communications 2025 Sep 25;781:152522
Biochemical and biophysical research communications 2025 Sep 25;781:152522
Salvianolic acid A ameliorates sepsis through inhibiting inflammation via binding STING and modulating TBK1/IRF3 signaling pathway.
Qin X, Zhang L, Tang J, Zhang F, Zhang L, Yue M, Yu S, Gong S, Li F, Yu B, Kou J, Zhang Y
International immunopharmacology 2025 Sep 23;162:115104
International immunopharmacology 2025 Sep 23;162:115104
RHBDF2 governs microglial neuroinflammation during cerebral ischemia-reperfusion injury and is positively regulated by the m6A reader YTHDF1.
Xu L, Zhang R, Zhang X, Liu B, Shang X, Huang D
Molecular medicine (Cambridge, Mass.) 2025 Sep 2;31(1):284
Molecular medicine (Cambridge, Mass.) 2025 Sep 2;31(1):284
cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models.
Xiao L, Ai YL, Mi XY, Liang H, Zhi X, Wu LZ, Chen QT, Gou T, Chen C, Zhou B, Hong WB, Yao LM, Chen JJ, Deng X, Li FN, Wu Q, Chen HZ
The Journal of clinical investigation 2025 Sep 16;135(18)
The Journal of clinical investigation 2025 Sep 16;135(18)
cGAS-STING-NFκB PATHWAY PLAYS A ROLE IN BURN INJURY-INDUCED MUSCLE WASTING.
Xie F, You Z, Yan B, Dai J, Yang J, Wang S, Ogata H, Yasuhara S, Martyn JJ
Shock (Augusta, Ga.) 2025 Sep 1;64(3):338-348
Shock (Augusta, Ga.) 2025 Sep 1;64(3):338-348
Hepatocyte mitochondrial DNA activated store-operated Ca(2+) entry via Stim1/Orai1-induced podocyte injury in trichloroethylene sensitized mice: A new insight in liver and kidney crosstalk.
Dong LL, Jia XQ, Xie HB, Zhu LF, Zhou PC, Cheng RX, Cao CL, Zhu QX, Zhang JX
Toxicology and applied pharmacology 2025 Oct;503:117465
Toxicology and applied pharmacology 2025 Oct;503:117465
Specifically Breaking Through the Injured Blood-Brain Barrier With Tannic Acid-Based Nanomedicine for Ischemic Stroke Ischemia Reperfusion Treatment.
Shi X, Wang S, Xiong T, Li R, Zheng W, Chen W, Zhao T, Yang Y, Ying X, Qi W, Xia Y, Wang J, Zhang Y, Huang Q, Nan Y, Ai K
Exploration (Beijing, China) 2025 Oct;5(5):20240388
Exploration (Beijing, China) 2025 Oct;5(5):20240388
STING inhibits the progression of esophageal squamous cell carcinoma by suppressing CPT1A-mediated fatty acid β-oxidation.
Zhang L, Zhu LJ, Zhao Y, Lei XY, Wu DH, He KY, Liu MJ, Yang JY, Guo JR, Jiang ZH, Yan ZH, Xu ZX, Jian YP
Acta pharmacologica Sinica 2025 Oct;46(10):2793-2807
Acta pharmacologica Sinica 2025 Oct;46(10):2793-2807
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Li M, Dong W, Cui Y, Li J, Yang C, Zhang D, Fu X
Materials today. Bio 2025 Oct;34:102233
Materials today. Bio 2025 Oct;34:102233
Mitochondrial DNA leakage and micronucleus formation activate the cGAS-STING pathway in aristolochic acid I-induced nephritis.
Lei YY, Hu YS, Cao YY, Xi J, Ma YN, Zhang XH, Gao QW, Fu JA, Zhang XY, Su L, Luan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115648
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115648
Gelatin enhances bacteria-phagocytosis via a ROS-mitochondria-STING axis in differentiated human macrophage-like U937 cells.
Sun X, Li M, Ma Y, Chen K, Jiang S, Hayashi T, Itoh K, Mizuno K, Hattori S, Fujisaki H, Liu W, Ikejima T
Molecular immunology 2025 Oct;186:48-62
Molecular immunology 2025 Oct;186:48-62
Salvia miltiorrhiza water extract ameliorated cGAS-STING-mediated acute liver injury by blocking interaction between STING and TBK1.
Li C, Xu R, Zhang M, Chen S, Yao Q, Zheng C, Wang X, Wen X, Xiao X, Wang Y, Bai Z
Chinese herbal medicines 2025 Oct;17(4):768-778
Chinese herbal medicines 2025 Oct;17(4):768-778
Activation of STING pathway by mitochondrial fission negatively regulates adipogenic differentiation of 3 T3-L1 cells.
Ma K, Sun H, Wu X, Quan J, Tang R, Liu W, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Ikejima T
Cellular signalling 2025 Oct;134:111948
Cellular signalling 2025 Oct;134:111948
GALNT6 dual regulates innate immunity STING signaling and PD-L1 expression to promote immune evasion in pancreatic ductal adenocarcinoma.
Chong S, Liu Y, Bian Z, Hu D, Guo S, Dong C, Zeng J, Fan S, Chen X
Cellular signalling 2025 Oct;134:111942
Cellular signalling 2025 Oct;134:111942
IRE1α translational suppression potentiates STING-dependent chemoresistance in pancreatic cancer.
Luo Y, Sun M, Chang L, He Z, Zhou X, Yuan Y, Sun H, Luo S, Huang J, Wu H, Liu W, Zhou Z, Mao Y, Ji Y, Liang T
Cell death & disease 2025 Oct 6;16(1):680
Cell death & disease 2025 Oct 6;16(1):680
TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy.
Levi-D'Ancona E, Walker EM, Zhu J, Deng Y, Sidarala V, Stendahl AM, Reck EC, Henry-Kanarek BA, Lietzke AC, Chai B, Pasmooij MB, Hubers DL, Basrur V, Ghosh S, Stiles L, Nesvizhskii AI, Shirihai OS, Soleimanpour SA
Science advances 2025 Oct 10;11(41):eadw4153
Science advances 2025 Oct 10;11(41):eadw4153
Improvement of the stability of ginsenoside Rg5 and its pharmacological efficacy in nonalcoholic steatohepatitis.
Ma J, Bai X, Duan Z, Fu R, Zeng W, Li Y, Guan Z, Zhu C
Life sciences 2025 Oct 1;378:123818
Life sciences 2025 Oct 1;378:123818
Polydopamine as a biocompatible and precise mitochondrial targeted therapeutic platform for reversing myocardial ischemia-reperfusion injury.
Zhao T, Huang Y, Chen W, Qi W, Wang J, Xia Y, Zhou J, Long X, Nan Y, Huang Q, Ai K
Bioactive materials 2025 Nov;53:908-931
Bioactive materials 2025 Nov;53:908-931
Role and mechanism of piR-0228 targeting RIPK1 to regulate vascular remodeling and aortic dissection.
Li X, Wang W, Wang S, Li X, Zhang B, Stephen BE, Yu T, Wang J, Yang Y
Atherosclerosis 2025 Nov;410:120459
Atherosclerosis 2025 Nov;410:120459
Treadmill exercise alleviates STING-mediated microglia pyroptosis and polarization via activating mitophagy post-TBI.
Chen J, Zhu T, Yang X, Yang Z, Shen M, Gu B, Wang D, Zhang Y, Zhang M, Sun S, Yu J, Yan C
Free radical biology & medicine 2025 Nov;239:155-176
Free radical biology & medicine 2025 Nov;239:155-176
AMPK impairment caused by gelatin disturbs mitochondrial dynamics leading to enhanced phagocytosis of bacteria in PMA-stimulated U937 cells.
Chen K, Sun X, Feng Y, Jiang S, Hayashi T, Itoh K, Mizuno K, Hattori S, Fujisaki H, Liu W, Ikejima T
Cellular signalling 2025 Nov;135:111985
Cellular signalling 2025 Nov;135:111985
Crosstalk between DNA damage and cGAS-STING immune pathway drives neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease.
Khan S, Delotterie DF, Xiao J, Thangavel R, Hori R, Koprich J, Alway SE, McDonald MP, Khan MM
Brain, behavior, and immunity 2025 Nov;130:106065
Brain, behavior, and immunity 2025 Nov;130:106065
Potential Therapeutic Effects of Astragaloside IV in Parkinson's Disease Models via Modulation of α-syn-γH2AX-STING-IFN-I Axis.
Wang R, Sun F, Wang N, Chen F, Wang X, Li C, Wang H
Molecular neurobiology 2025 Nov 7;63(1):11
Molecular neurobiology 2025 Nov 7;63(1):11
TFNAs induce autophagy via activation of the nonclassical cGAS-STING signalling pathway to attenuate acute lung injury in mice.
Wei C, Liu Y, Pan B, Zhang J, Chen J, Ling P, Xiang Y, Zhu S, Sun Y
BMC pulmonary medicine 2025 Nov 7;25(1):514
BMC pulmonary medicine 2025 Nov 7;25(1):514
Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis.
Fan K, Zhou S, Ren Y, Xiong J, Wang H, Fu Y, Chen Y, Wang B, Fan K, Gao M, Guo T, Wei X, Jiao L, Shi J, Ding C, Zhang Y
Cell death and differentiation 2025 Nov 27;
Cell death and differentiation 2025 Nov 27;
Autonomous STING signaling in Purkinje cells drives neurodegeneration independent of type I interferon.
Yang K, Dunn M, Torres-Ramirez G, Dobbs N, Shakkottai VG, Yan N
Cell reports 2025 Nov 25;44(11):116480
Cell reports 2025 Nov 25;44(11):116480
Qihuang Yishen formula attenuates renal tubular injury by modulating inflammation via the cGAS/STING pathway in diabetic kidney disease.
Guo Y, Xue T, Meng X, Yan P, Zhang M, Zhang Q, Li T, Shi K, Zhang N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157399
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157399
Butyrate ameliorates ulcerative colitis through targeting STING-dependent ER stress signaling and limiting CD4(+) TRM T cells accumulation.
Xiao T, Kang J, Zhao C, Zhu R, Sun M, Wang Y
Journal of inflammation (London, England) 2025 Nov 24;22(1):50
Journal of inflammation (London, England) 2025 Nov 24;22(1):50
Hyperosmolarity-Induced Oxidative Stress Leads to Senescence in Human Corneal Epithelial Cells (HCEPC) via DNA Damage, Metabolic Disturbance and Mitophagy Decline.
Zhang Y, Fan T
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Antioxidants (Basel, Switzerland) 2025 Nov 19;14(11)
Palmitoylation of TBK1 enhances the type I interferon signaling and strengthens anti-malarial immunity in mice.
Han Z, Xiong S, Zeng K, Xiao Z, Zhang L, Zhang Y, Guo J, Peng W, Xie Y, Liu W, Yu X
Nature communications 2025 Nov 18;16(1):10109
Nature communications 2025 Nov 18;16(1):10109
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation.
Wang Z, Hou Y, Liu P, Wu R, Yang J, Fan S, Peng Z, Han X, Su B, Zhang C
Immunity 2025 Nov 11;58(11):2670-2684.e10
Immunity 2025 Nov 11;58(11):2670-2684.e10
Application of Dental Pulp Stem Cell-Derived Intracellular Vesicles for Diabetic Wound Healing.
Pang P, Liu Y, Song H, Ye Z, Zhou H, Zhang R, Kumeria T, She W, Xu C, Mei PL, He Y, Ye Q
Diabetes 2025 Nov 1;74(11):2060-2074
Diabetes 2025 Nov 1;74(11):2060-2074
Targeting and reprogramming microglial phagocytosis of neutrophils by ginsenoside Rg1 nanovesicles promotes stroke recovery.
Hu K, Ye J, Fan P, Zheng R, Wang S, Peng Y, Ruan Y, Yan X, Zhang Z, Chu S, Chen N
Bioactive materials 2025 May;47:181-197
Bioactive materials 2025 May;47:181-197
Decursin protects against DSS-induced experimental colitis in mice by inhibiting the cGAS-STING signaling pathway.
Wang J, Wang Y, Huang C, Chen Y, Li X, Jiang Z
Naunyn-Schmiedeberg's archives of pharmacology 2025 May;398(5):5119-5127
Naunyn-Schmiedeberg's archives of pharmacology 2025 May;398(5):5119-5127
Distinct pathogenic mutations in ARF1 allow dissection of its dual role in cGAS-STING signalling.
Lang J, Bergner T, Zinngrebe J, Lepelley A, Vill K, Leiz S, Wlaschek M, Wagner M, Scharffetter-Kochanek K, Fischer-Posovszky P, Read C, Crow YJ, Hirschenberger M, Sparrer KMJ
EMBO reports 2025 May;26(9):2232-2261
EMBO reports 2025 May;26(9):2232-2261
Targeting KMT5C Suppresses Lung Cancer Progression and Enhances the Efficacy of Immunotherapy.
Yuan Y, Li Q, Yan G, Qian Y, Guo W, Li S, Wang F, Shang W, Zhu Z, Ge D, Wang Y, Liu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2407575
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2407575
Mitigating Doxorubicin-Induced Cardiotoxicity and Enhancing Anti-Tumor Efficacy with a Metformin-Integrated Self-Assembled Nanomedicine.
Huang J, Yang J, Yang Y, Lu X, Xu J, Lu S, Pan H, Zhou W, Li W, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2415227
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2415227
Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release.
Peng Y, Xu J, Wei L, Luo M, Chen S, Wei X, Luo S, Su Z, Wang Z
Molecular medicine (Cambridge, Mass.) 2025 May 7;31(1):176
Molecular medicine (Cambridge, Mass.) 2025 May 7;31(1):176
Astilbin Alleviates IL-17-Induced Hyperproliferation and Inflammation in HaCaT Cells via Inhibiting Ferroptosis Through the cGAS-STING Pathway.
Xu X, Zhang H, Chang A, Peng H, Li S, Zhang K, Wang W, Yin X, Qu C, Dong X, Ni J
International journal of molecular sciences 2025 May 24;26(11)
International journal of molecular sciences 2025 May 24;26(11)
A quantitative method to monitor STING degradation with dual-luciferase reporters.
Shoji T, Sato K, Shinojima A, Koide S, Shindo R, Hongo K, Mukai K, Kuchitsu Y, Taguchi T
Cell structure and function 2025 May 20;50(1):115-124
Cell structure and function 2025 May 20;50(1):115-124
Hyperandrogenism triggers mtDNA release to participate in ovarian inflammation via mPTP/cGAS/STING in PCOS.
Cai J, Zhu Q, Xiang Y, Weng L, Liang N, Hong X, Xue M, Ge H
iScience 2025 May 16;28(5):112391
iScience 2025 May 16;28(5):112391
Marine-derived STING inhibitors, excavatolide B promote wound repair in full-thickness-incision rats.
Chang CK, Wu ZS, Niu GH, Chou YY, Tang SH, Zhang MM, Sung CS, Tung HT, Tsou LK, Tang CC, Sung PJ, Lo YH, Wen ZH
International immunopharmacology 2025 May 16;155:114593
International immunopharmacology 2025 May 16;155:114593
AUP1 and UBE2G2 complex targets STING signaling and regulates virus-induced innate immunity.
Wang X-T, Zhu X, Lian Z-H, Liu Q, Yan H-H, Qiu Y, Ge X-Y
mBio 2025 May 14;16(5):e0060225
mBio 2025 May 14;16(5):e0060225
Suppression of Sepsis Cytokine Storm by Escherichia Coli Cell Wall-Derived Carbon Dots.
Li Y, Huang X, Qiao Q, Li Y, Han X, Chen C, Chen Y, Guo S, Zhang Y, Gao W, Liu H, Sun T
Advanced materials (Deerfield Beach, Fla.) 2025 Mar;37(12):e2414237
Advanced materials (Deerfield Beach, Fla.) 2025 Mar;37(12):e2414237
DSTYK phosphorylates STING at late endosomes to promote STING signaling.
Dong H, Zhang H, Song P, Hu Y, Chen D
EMBO reports 2025 Mar;26(6):1620-1646
EMBO reports 2025 Mar;26(6):1620-1646
Pectin/caffeic acid nanoparticles in a poloxamer thermosensitive gel for the treatment of ulcerative colitis by inhibiting cGAS-STING pathway.
Zhou S, Yu Z, Yao W, Wang M, Yang Y, Qin J, Wu X, Guo C
Colloids and surfaces. B, Biointerfaces 2025 Mar;247:114419
Colloids and surfaces. B, Biointerfaces 2025 Mar;247:114419
Dynamic STING repression orchestrates immune cell development and function.
Knox K, Jeltema D, Dobbs N, Yang K, Xing C, Song K, Tang Z, Torres-Ramirez G, Wang J, Gao S, Wu T, Yao C, Wang J, Yan N
Science immunology 2025 Mar 7;10(105):eado9933
Science immunology 2025 Mar 7;10(105):eado9933
cGAS-STING mediates neutrophil extracellular traps-induced EMT in myositis-associated interstitial lung disease: STING as a potential therapeutic target.
Feng Y, Su Q, Zhu J, Cui X, Guo J, Yang J, Zhang S
International immunopharmacology 2025 Mar 6;149:114144
International immunopharmacology 2025 Mar 6;149:114144
Prenatal amoxicillin exposure induces depressive-like behavior in offspring via gut microbiota and myristic acid-mediated modulation of the STING pathway.
Wei L, Qi C, Wang T, Jin X, Zhou X, Luo M, Lu M, Chen H, Guo J, Wang H, Xu D
Journal of hazardous materials 2025 Mar 5;485:136750
Journal of hazardous materials 2025 Mar 5;485:136750
cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy.
Li H, Wang X, Luo X, Shi H, Li J
Frontiers in bioscience (Landmark edition) 2025 Mar 5;30(3):26084
Frontiers in bioscience (Landmark edition) 2025 Mar 5;30(3):26084
Dual-modality immune nano-activator harnessing Mn(2)⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy.
Ma S, Zhang X, Zhu X, Yan K, Wang Q, Lei L, Li J, Guo J, Tang W, Liu J, Cao J, Wang D, Luo T
Journal of nanobiotechnology 2025 Mar 25;23(1):248
Journal of nanobiotechnology 2025 Mar 25;23(1):248
Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway.
Wang J, Niu S, Hu X, Li T, Liu S, Tu Y, Shang Z, Zhao L, Xu P, Lin J, Chen L, Billadeau DD, Jia D
Cell discovery 2025 Mar 18;11(1):23
Cell discovery 2025 Mar 18;11(1):23
Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota.
Yang F, Gao Y, Xie S, Yang W, Wang Q, Ye W, Sun L, Zhou J, Feng X
Food & function 2025 Mar 17;16(6):2316-2334
Food & function 2025 Mar 17;16(6):2316-2334
Discovery of a Novel CRBN-Recruiting cGAS PROTAC Degrader for the Treatment of Ulcerative Colitis.
He P, Wen C, Zhang X, Yin H
Journal of medicinal chemistry 2025 Mar 13;68(5):5551-5572
Journal of medicinal chemistry 2025 Mar 13;68(5):5551-5572
YAP/TAZ-mediated nuclear membrane rupture in promoting senescence of skeletal muscle associated with COPD.
Gong G, Shen S, Shen S, Wang R, Zheng T, Xu W, Wu J
Respiratory research 2025 Mar 12;26(1):98
Respiratory research 2025 Mar 12;26(1):98
Pectin-loaded ferulic acid nanoparticles: A potential therapeutic strategy for ulcerative colitis via modulation of the cGAS-STING pathway.
Xiao J, Zhou S, Fei F, Long L, Guo C
Toxicology and applied pharmacology 2025 Jun;499:117317
Toxicology and applied pharmacology 2025 Jun;499:117317
PINK1 Deficiency Facilitates Palmitic Acid-Induced Inflammation by Disrupting Mitochondrial Function to Activate mtDNA-cGAS-STING Signaling.
Ye B, Pei Y, Li H, Jiang Y, Jin W, Gao Y, Liu W, Guan X, Qiao Y, Gao X, Zhang Y, Ma N, Chang H
Cell biochemistry and function 2025 Jun;43(6):e70092
Cell biochemistry and function 2025 Jun;43(6):e70092
Membrane biomimetic nanoenzyme-incorporated hybrid glycyrrhizic acid hydrogel for precise mitochondrial ROS scavenging for osteoarthritis treatment.
Fan Y, Niu Z, Yin L, Yao L, Ding S, Tong Y, Wang J, Hong Z, Chen J, Zhang Q, Ji L, Chen J, Xia C, Bi Q
Materials today. Bio 2025 Jun;32:101778
Materials today. Bio 2025 Jun;32:101778
STING-∆C, a novel splice isoform of STING, inhibits DNA virus-induced innate immunity and autophagy.
Zheng SN, Zhang J, Li T, Li CH, Deng J, Li JX, Wang PH
International journal of biological macromolecules 2025 Jun;311(Pt 3):143894
International journal of biological macromolecules 2025 Jun;311(Pt 3):143894
Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury.
Li L, Yuan H, Li H, Cheng R, Zhou Z, Hu F, Xu L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jun;200:115428
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jun;200:115428
Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis.
Huang L, Chen X, Shao Y, Deng S, Wang C, Chen J, Xie Y, Yuan S, Tang L
Clinical and translational medicine 2025 Jun;15(6):e70337
Clinical and translational medicine 2025 Jun;15(6):e70337
Leucine enhances the cGAS-STING-NLRP3 pathway in autoimmune thyroiditis.
Shen X, Feng T, Li S, Wang X, Zhang W, Wang S, Zhang X, Yang J, Liu Y
Journal of translational autoimmunity 2025 Jun;10:100284
Journal of translational autoimmunity 2025 Jun;10:100284
STING-mediated mitochondrial DNA release exacerbates PANoptosis in liver ischemia reperfusion injury.
Wu C, Miao H, Yi Z, Jia H, Huang A, Zhang H, Liu Z, Sun X, Zheng Y, Gao L, Ma S
International immunopharmacology 2025 Jun 5;157:114778
International immunopharmacology 2025 Jun 5;157:114778
TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis.
Shi Y, Huang M, Zhou W, Zhao Y, Zhao J, Zhong B, French SW, Tang X, Liu H
Journal of translational medicine 2025 Jun 3;23(1):621
Journal of translational medicine 2025 Jun 3;23(1):621
African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis.
Chen Y, Wang J, Zhou Y, Liu M, Li W, Deng Y, Yang Y, Fang C, Niu S, Dai J, Dai H
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):263
Cellular and molecular life sciences : CMLS 2025 Jun 28;82(1):263
The activation of cGAS-STING pathway promotes the epithelial-mesenchymal transition and inflammation in intrauterine adhesion.
Wu X, He L, Lin Y, Zheng Y, Mao R, Hu J, Yuan R, Ge H
International immunopharmacology 2025 Jun 26;159:114840
International immunopharmacology 2025 Jun 26;159:114840
Inhibition of the ATP synthase c subunit ameliorates HDM/LPS-induced inflammatory responses in asthmatic bronchial epithelial cells by blocking the mPTP-mtDNA-cGAS-STING axis.
Wang D, Liu C, Bao C, Hu J, Li Z, Ma X, Zhu Y, Xu S
Respiratory research 2025 Jun 21;26(1):219
Respiratory research 2025 Jun 21;26(1):219
STING-ΔN, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infection.
Deng J, Zheng SN, Zhang J, Li CH, Li T, Wang PH
Cell communication and signaling : CCS 2025 Jun 21;23(1):299
Cell communication and signaling : CCS 2025 Jun 21;23(1):299
IDH1/MDH1 deacetylation activates the cGAS-STING pathway by promoting NETosis in acute liver failure.
Wang Y, Guo J, Zhang D, Zhang X, Luo K, Gong Z
International immunopharmacology 2025 Jun 17;158:114884
International immunopharmacology 2025 Jun 17;158:114884
STING contributes to the inflammation and proliferation of Staphylococcus aureus via mitochondrial reactive oxygen species-hypoxic inducible factor 1α axis in epithelial cells.
Gao X, Wu B, Qiu Y, Feng S, Zhang J, Miao J
Infection and immunity 2025 Jun 10;93(6):e0013825
Infection and immunity 2025 Jun 10;93(6):e0013825
Mitochondria-targeted manganese-based mesoporous silica nanoplatforms trigger cGAS-STING activation and sensitize anti PD-L1 therapy in triple-negative breast cancer.
Zhong N, Zu Z, Lu Y, Sha X, Li Y, Liu Y, Lu S, Luo X, Zhou Y, Tao J, Wu F, Teng Z, Tang Y, Wang S
Acta biomaterialia 2025 Jun 1;199:374-386
Acta biomaterialia 2025 Jun 1;199:374-386
CSDE1 enhances genotoxic drug resistance in cancer by modulating RPA2 through CSDE1-eIF3a regulatory complex.
Cui JJ, Guo CX, Li J, Guo AX, Zhang Z, Li SY, Wang LY, Jia XB, Guo H, Xia K, Hu ZM, Ouyang QY, Wang Y, Xie YT, Liu ZQ, Zhang JT, Wu W, Chen YH, Yin JY
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jul;81:101249
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jul;81:101249
Epithelial Atg5 Deficiency Intensifies Caspase-11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS-STING-NLRP3 Axis in Macrophages During Pseudomonas Infection.
Wang J, Zhang L, Liu Y, Liu Y, Xiong A, Ran Q, He X, Wong VKW, Combs C, Li G, Wu M
MedComm 2025 Jul;6(7):e70239
MedComm 2025 Jul;6(7):e70239
Pharmacological inhibition of the cGAS-STING pathway suppresses microglia pyroptosis in sepsis-associated encephalopathy.
Zeng QQ, Qi Y, Yu H, Xu Y, Chen JX, Zheng YW, Zhang GF, Zhang QL, Zheng YH, Guo J, Zhao ZH, Wang FS, Jin GL
Journal of neuroinflammation 2025 Jul 9;22(1):176
Journal of neuroinflammation 2025 Jul 9;22(1):176
Nanodrug Modulates Premetastatic Niche and Suppresses Metastatic Lung Adenocarcinoma via Programmed Cell Death Ligand 1 Blockade and STING Pathway Activation.
Wu X, Li B, Liao H, Chen X, Yu X, Hu J, Lin Q, Cao T, Xu K, Zhou Q, Zhu L
ACS nano 2025 Jul 8;19(26):23893-23907
ACS nano 2025 Jul 8;19(26):23893-23907
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
Yao M, Li P, Li X, Li W, Qian P
Veterinary research 2025 Jul 5;56(1):137
Veterinary research 2025 Jul 5;56(1):137
Mitophagy-mtROS axis contributes to anti-tuberculosis-induced liver injury through activation of the cGAS-STING pathway in rat hepatocytes.
Chen W, Luo C, Zhou H, Liu Z, Huang J, Liu Y, You M, Yang G
International immunopharmacology 2025 Jul 28;160:114984
International immunopharmacology 2025 Jul 28;160:114984
Disruption of cholesterol homeostasis triggers NLRP3-cGAS-STING axis-dependent hepatic fibrosis and honokiol intervention effects.
Wang Z, Liu J, Mou Y, Zhou X, Liao W, Li Y, Liu Y, Tang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156904
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156904
Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice.
Wu Y, Zhang Y, Yu Y, Wang X, Zhen Z, Yuan Y, Xie B, Han M, Wang M, Zhang X, Sun X, Wen X, Hashimoto K, Shang Y, Yuan S, Zhang J
Nature communications 2025 Jul 23;16(1):6779
Nature communications 2025 Jul 23;16(1):6779
XBP1 promotes endometrial fibrosis through cGAS-STING signaling pathway in intrauterine adhesion.
Wu X, He L, Lin Y, Zheng Y, Jiang P, Tian C, Mao R, Yang B, Shi Y, Ge H, Hu J, Yuan R
Scientific reports 2025 Jul 2;15(1):23299
Scientific reports 2025 Jul 2;15(1):23299
Butyrate attenuates SA-AKI by inhibiting pyroptosis via the STING-GSDMD axis.
Tian X, Yuan L, Zeng Y
Biochemical and biophysical research communications 2025 Jan;743:151143
Biochemical and biophysical research communications 2025 Jan;743:151143
STING induces HOIP-mediated synthesis of M1 ubiquitin chains to stimulate NF-κB signaling.
Fischer TD, Bunker EN, Zhu PP, Le Guerroué F, Hadjian M, Dominguez-Martin E, Scavone F, Cohen R, Yao T, Wang Y, Werner A, Youle RJ
The EMBO journal 2025 Jan;44(1):141-165
The EMBO journal 2025 Jan;44(1):141-165
The role of mitochondrial reactive oxygen species in initiating mitochondrial damage and inflammation in wasp-venom-induced acute kidney injury.
Xia L, Yuan H, Gao Z, Lv Y, Xu L, Hu F
Journal of toxicologic pathology 2025 Jan;38(1):17-26
Journal of toxicologic pathology 2025 Jan;38(1):17-26
Inhibiting UGCG prevents PRV infection by decreasing lysosome-associated autophage.
Fan W, Yao C, Ma Y, Wang H, Liu P, Zhang Z, Chu B, Yang G, Wang M
International journal of biological macromolecules 2025 Jan;285:138303
International journal of biological macromolecules 2025 Jan;285:138303
Naringenin loaded fucoidan/polyvinylpyrrolidone nanoparticles protect against folic acid induced acute kidney injury in vitro and in vivo.
Jiang T, Zhu F, Gao X, Wu X, Zhu W, Guo C
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114343
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114343
Overexpression of FBP1 enhances dendritic cell activation and maturation by inhibiting glycolysis and promoting the secretion of IL33 in lung adenocarcinoma.
Li C, Zhu L, Yang Y, Zhang T, Chen C, Zhang Y, Ji W, Duan X, Xue W, Li L, Zhao J
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167559
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167559
9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.
Liu W, Hu J, Wang Y, Gan T, Ding Y, Wang X, Xu Q, Xiong J, Xiong N, Lu S, Wang Y, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156241
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156241
C9orf72 Alleviates DSS‑Induced Ulcerative Colitis via the cGAS-STING Pathway.
Wang Y, Xu T, Wang W
Immunity, inflammation and disease 2025 Jan;13(1):e70139
Immunity, inflammation and disease 2025 Jan;13(1):e70139
Electroacupuncture intervention relieves pain by stimulating the STING/IFN-I pathway in rat models of cancer-induced bone pain.
Gu YM, Meng X, Liang JY, Xia Y, Huang JW, Wang K, Ju ZY
Molecular pain 2025 Jan-Dec;21:17448069251342240
Molecular pain 2025 Jan-Dec;21:17448069251342240
TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD.
Liu Z, Bai Y, Xu B, Wen H, Chen K, Lin J, Wang Y, Xu J, Wang H, Shi F, Wang J, Wang H
Journal of neuroinflammation 2025 Jan 22;22(1):14
Journal of neuroinflammation 2025 Jan 22;22(1):14
Hydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration.
Gong Z, Chen Z, Li D, Lu X, Wu J, Sun H, Wang X, Liu S, Xia X, Lu F, Jiang J, Sun C, Wang H, Zeng F, Ma X
Journal of nanobiotechnology 2025 Jan 20;23(1):29
Journal of nanobiotechnology 2025 Jan 20;23(1):29
MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling.
Wang H, Cui Z, Sun W, Yi M, Cheng Y, Zhang Y, Du Y, Pan T, Gao R, Feng L, Zeng B, Huang G, Li Y, Wang Y, Zhang CJ, He R, Wang C
Molecular cell 2025 Jan 2;85(1):150-165.e7
Molecular cell 2025 Jan 2;85(1):150-165.e7
Decreased STING predicts adverse efficacy in bortezomib regimens and poor survival in multiple myeloma.
Liu Y, Zhao Y, Li B, Chen X, Xiong H, Huang C
Clinical and experimental medicine 2025 Jan 14;25(1):37
Clinical and experimental medicine 2025 Jan 14;25(1):37
Semen Strychni Pulveratum and vomicine alleviate neuroinflammation in amyotrophic lateral sclerosis through cGAS-STING-TBK1 pathway.
Zhan Y, Huang J, Tang X, Du B, Yang B
Journal of ethnopharmacology 2025 Jan 10;336:118741
Journal of ethnopharmacology 2025 Jan 10;336:118741
Shuangdan Jiedu Decoction improved LPS-induced acute lung injury by regulating both cGAS-STING pathway and inflammasome.
Yao Q, Wen J, Chen S, Wang Y, Wen X, Wang X, Li C, Zheng C, Li J, Ma Z, Zhan X, Xiao X, Bai Z
Journal of ethnopharmacology 2025 Jan 10;336:118661
Journal of ethnopharmacology 2025 Jan 10;336:118661
OPA3 inhibits the cGAS-STING pathway mediated by mtDNA stress to promote colorectal cancer progression.
Yin Y, Ma Z, Yuan S, Xu K, Wang X
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):165-177
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):165-177
Hesperidin enhanced anti-breast cancer effect and alleviated cisplatin induced nephrotoxicity through silk fibroin delivery system.
Jin Y, Dong N, Shimizu S, Li Y, Yao Y, Qiao H, Liu X, Liu S, Guo C, Wang L
Toxicology and applied pharmacology 2025 Feb;495:117234
Toxicology and applied pharmacology 2025 Feb;495:117234
Prognostic Impact of Stimulator of Interferon Genes Expression in Triple Negative Breast Cancer.
Maeda T, Ono M, Osako T, Chiba T, Baba S, Iesato A, Ozaki Y, Inoue Y, Uehiro N, Takahashi Y, Kobayashi T, Kogawa T, Ohta T, Kitano S, Ueno T, Ohno S
Cancer medicine 2025 Feb;14(4):e70666
Cancer medicine 2025 Feb;14(4):e70666
Curcumol ameliorates alcohol and high-fat diet-induced fatty liver disease via modulation of the Ceruloplasmin/iron overload/mtDNA signaling pathway.
Ding T, Shen W, Tao W, Peng J, Pan M, Qi X, Feng W, Wei N, Zheng S, Jin H
The Journal of nutritional biochemistry 2025 Feb;136:109807
The Journal of nutritional biochemistry 2025 Feb;136:109807
Mechanical Force-Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis.
Zhang X, Huang N, Mu Y, Chen H, Zhu M, Zhang S, Liu P, Zhang H, Deng H, Feng K, Shang Q, Liu X, Zhang C, Shi M, Yang L, Sun J, Kong G, Geng J, Lu S, Li Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2401127
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2401127
Hierarchical Targeting Nanodrug with Holistic DNA Protection for Effective Treatment of Acute Kidney Injury.
Chen Q, Yang Y, Ying X, Huang C, Chen J, Wang J, Wu Z, Zeng W, Miao C, Shi X, Nan Y, Huang Q, Ai K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2411254
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2411254
Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways.
Han F, Wang L, Wu J, Shen L, Li Y, Guo H, Li J
Investigative ophthalmology & visual science 2025 Feb 3;66(2):13
Investigative ophthalmology & visual science 2025 Feb 3;66(2):13
Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling.
Xu ZY, Gao JS, He Y, Xiao XQ, Gong GZ, Zhang M
World journal of hepatology 2025 Feb 27;17(2):99292
World journal of hepatology 2025 Feb 27;17(2):99292
Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling.
Chen M, Li Y, Zhu JY, Mu WJ, Luo HY, Yan LJ, Li S, Li RY, Yin MT, Li X, Chen HM, Guo L
Cell reports 2025 Feb 25;44(2):115251
Cell reports 2025 Feb 25;44(2):115251
Diffuse Traumatic Brain Injury Induced Stimulator of Interferons (STING) Signaling in Microglia Drives Cortical Neuroinflammation, Neuronal Dysfunction, and Impaired Cognition.
Packer JM, Giammo SG, Wangler LM, Davis AC, Bray CE, Godbout JP
Research square 2025 Feb 17;
Research square 2025 Feb 17;
The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance.
Xu Y, Wang Q, Wang J, Qian C, Wang Y, Lu S, Song L, He Z, Liu W, Wan W
Immunity 2025 Feb 11;58(2):309-325.e6
Immunity 2025 Feb 11;58(2):309-325.e6
Aggregatin is a mitochondrial regulator of MAVS activation to drive innate immunity.
Gao J, Ding M, Xiyang Y, Qin S, Shukla D, Xu J, Miyagi M, Fujioka H, Liang J, Wang X
Journal of immunology (Baltimore, Md. : 1950) 2025 Feb 1;214(2):238-252
Journal of immunology (Baltimore, Md. : 1950) 2025 Feb 1;214(2):238-252
Wen-Shen-Tong-Luo-Zhi-Tong Decoction alleviates bone loss in aged mice by suppressing LONP1-mediated macrophage senescence.
Zhou Q, Wang K, Wang C, Sun X, Wang L, Sun J, Pan Y, Li M, Zhao Z, Zhou S, Wang Q, Zhang Y, Ma Y, Guo Y
Pharmaceutical biology 2025 Dec;63(1):524-548
Pharmaceutical biology 2025 Dec;63(1):524-548
Molybdenum-bridged endo-exogenous antioxidant synergy reverses acute kidney injury via mitochondrial homeostasis reconstruction.
Chen Q, Xiao Z, Ying X, Yang Y, Chen J, Wu Z, Zeng W, Miao C, Nan Y, Huang Q, Ai K
Bioactive materials 2025 Dec;54:777-796
Bioactive materials 2025 Dec;54:777-796
Long non-coding RNA NEAT1 mediated lupus nephritis induced podocytes pyroptosis through DNMT1-STING axis.
Zeng Y, He ZK, Liao YJ, Ma A, Li C, Fu P
Renal failure 2025 Dec;47(1):2595372
Renal failure 2025 Dec;47(1):2595372
Fatty acid synthesis promotes mtDNA release via ETS1-mediated oligomerization of VDAC1 facilitating endothelial dysfunction in sepsis-induced lung injury.
He S, Pan T, Tian R, He Q, Cheng D, Qu H, Li R, Tan R
Cell death and differentiation 2025 Dec;32(12):2177-2192
Cell death and differentiation 2025 Dec;32(12):2177-2192
Macrophage extracellular traps impair intestinal barrier function in DSS-induced colitis in mice by inducing intestinal epithelial cell apoptosis.
Zhou Z, Miao X, Shen Y, Wang P, Shi R, Fan H, Yang Y, Guo M, Wu J
Biochemical pharmacology 2025 Dec;242(Pt 3):117406
Biochemical pharmacology 2025 Dec;242(Pt 3):117406
Bavachinin exerts anti-tumor effects by activating TLR4/STING axis-dependent PANoptosis and synergistically enhances chemosensitivity in endometrial cancer.
Shu W, Chen G, Zhang J, Dong K, Zhou T, Cheng S, Zhang T, Zhang J, Li H, Yao Y, Yu S, Liu Y, Zhou X, Shen X, Wang H
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
Biochemical pharmacology 2025 Dec;242(Pt 2):117321
Dysfunctional autophagy triggers STING1 activation to exacerbate cartilage degeneration in obesity-associated osteoarthritis.
Kang X, Liu W, Ma X, Feng D, Sun H, Wu S
Autophagy 2025 Dec;21(12):3344-3360
Autophagy 2025 Dec;21(12):3344-3360
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Cai T, Liang Z, Chen Z, Li Y, Xiao W, Liang W, Xie H, Liu H, Zeng Z, Yang X, Luo S, Zheng X, Zhong K, Huang L, Xiong L, Kang L
Autophagy 2025 Dec;21(12):2982-3003
Autophagy 2025 Dec;21(12):2982-3003
Unveiling EXOC4/SEC8: a key player in enhancing antiviral immunity by inhibiting the FBXL19-STING1-SQSTM1 signaling axis.
Wang L, Hou P, Ma W, Jin R, Wei X, Li X, He H, Wang H
Autophagy 2025 Dec;21(12):2578-2596
Autophagy 2025 Dec;21(12):2578-2596
PRRSV evades innate immune cGAS-STING antiviral function via its Nsp5 to deter STING translocation and activation.
Xu Y, Chi C, Xin Q, Yu J, Zhang Y, Zhang P, Zheng W, Jiang S, Zheng W, Chen N, Wu J, Zhu J
Virulence 2025 Dec;16(1):2548625
Virulence 2025 Dec;16(1):2548625
Porcine cGAS-STING signalling induced apoptosis negatively regulates STING downstream IFN response and autophagy via different mechanisms.
Xia N, Liu A, Han H, Jiang S, Cao Q, Luo J, Zhang J, Hao W, Sun Z, Chen N, Zhang H, Zheng W, Zhu J
Virulence 2025 Dec;16(1):2496436
Virulence 2025 Dec;16(1):2496436
A novel nanomicelle based on Rebaudioside A: An oral nanoplatform with enhanced nephroprotective effect of myricetin.
Wang T, Gao Z, Guo C, Zhu W
International journal of pharmaceutics: X 2025 Dec;10:100389
International journal of pharmaceutics: X 2025 Dec;10:100389
VAPB is a negative regulator of STING-mediated innate immune signaling.
Ji W, Zhang Y, Zhang L, Liu Q, Niu S, Feng Y, Chen F, Liu X, Li X
Science advances 2025 Dec 5;11(49):eaea3996
Science advances 2025 Dec 5;11(49):eaea3996
TAT-PBX1 fusion protein alleviates LPS-induced acute lung injury via AMPK-TFAM signaling activation.
Chen Z, Liu X, Zuo K, Xin Y, Liu J
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Dec 3;33(12):6537-6553
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Dec 3;33(12):6537-6553
KAT2A affects the inflammatory progression of lupus nephritis through multilevel regulation of cGAS.
Tang Y, Zhang Y, Cao Q, Liu J, Zhuang Q
Journal of molecular medicine (Berlin, Germany) 2025 Dec 22;104(1):11
Journal of molecular medicine (Berlin, Germany) 2025 Dec 22;104(1):11
The Role of STING-Mediated Activation of the Integrated Stress Response in Inflammation-Induced Depletion of Ovarian Reserve.
Wang Q, Wu Y, Dong X, Wu Y, Dai Y, Cao Y, Du Y, Lv H, Wei K, Cao L, Yan L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71286
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71286
HIF-1α mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis.
Wang H, Zhao YC, Xu L, Zhang TJ, Liu LH, Zhou MQ, Zhang H, Yang YN, Pan P, Jin L, Zhang ZW, Zhang XZ, Zhang LL
Acta pharmacologica Sinica 2025 Aug;46(8):2225-2236
Acta pharmacologica Sinica 2025 Aug;46(8):2225-2236
IRF1 amplifies HSV-1-triggered antiviral innate immunity in a feed-forward manner.
Gao M, Qi Y, Zhang J
Cell insight 2025 Aug;4(4):100255
Cell insight 2025 Aug;4(4):100255
Kurarinone Alleviates cGAS-STING-Triggered Inflammatory Diseases by Targeting STING.
Liu L, Wang Z, Qi Y, Huang A, He C, Zhan X, Xiao X, Bai Z
Phytotherapy research : PTR 2025 Aug;39(8):3450-3465
Phytotherapy research : PTR 2025 Aug;39(8):3450-3465
CKLF1 disrupts microglial efferocytosis following acute ischemic stroke by binding to phosphatidylserine.
Fan PL, Lai HQ, Wang HY, Hu KC, Ruan Y, Ye JR, Wang SS, Peng Y, He WB, Li G, Yan X, Chu SF, Zhang Z, Chen NH
Cell death and differentiation 2025 Aug;32(8):1499-1517
Cell death and differentiation 2025 Aug;32(8):1499-1517
IFI16 Induced by p53 Activates the NF-κB Pathway to Counteract Cisplatin-Induced Apoptosis in Cervical Cancer Cells.
Zhong L, Li J, Zhong J, Zhang Y, Qi H, Yu H, Li X
Journal of cellular and molecular medicine 2025 Aug;29(15):e70728
Journal of cellular and molecular medicine 2025 Aug;29(15):e70728
TAX1BP1-dependent autophagic degradation of STING1 impairs anti-tumor immunity.
Zhang R, Yu C, Zeh HJ, Kroemer G, Klionsky DJ, Tang D, Kang R
Autophagy 2025 Aug;21(8):1802-1823
Autophagy 2025 Aug;21(8):1802-1823
Inhibition of STING-induced mitochondrial Drp1/N-GSDMD-mediated MtDNA release alleviates Sepsis-induced lung injury.
Zou S, Zuo Y, Chen Y, Zhang T, Fu T, Li G, Xiong R, Liu B, Hu Y, Hu Z, Miao C, Wu X, Li N, Geng Q
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):305
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):305
Gene expression cluster differences and molecular correlation with the STING pathway in orbital MALT lymphoma and orbital IgG4-related eye disease.
Tagami M, Isayama K, Nishio M, Yoshikawa A, Misawa N, Sakai A, Haruna Y, Tomita M, Mizukami Y, Azumi A, Honda S
Discover oncology 2025 Aug 4;16(1):1466
Discover oncology 2025 Aug 4;16(1):1466
Conditional knockout mouse model demonstrates that Copa expression is required for viability in development and adulthood.
Gilson T, Astroski JW, Qun W, Turner MJ, Androphy EJ, Custer SK
Biochemical and biophysical research communications 2025 Aug 30;776:152201
Biochemical and biophysical research communications 2025 Aug 30;776:152201
Beneficial Effects of Different Types of Exercise on Diabetic Cardiomyopathy.
Ma X, Gao H, Wang Z, Zhu D, Dai W, Wu M, Guo Y, Zhao L, Xiao W
Biomolecules 2025 Aug 25;15(9)
Biomolecules 2025 Aug 25;15(9)
RPA1 protects DNA damage-induced PANoptosis in limb development.
Yin Q, Peng S, Zhang Z, Jiang S, Li X, Huang D, Li Y, Zhou J, Xiao J, Ye L, Yin Y, Yuan Q
Science advances 2025 Aug 22;11(34):eadw2756
Science advances 2025 Aug 22;11(34):eadw2756
Inhibition of CPT1A activates the cGAS/STING pathway to enhance neutrophil-mediated tumor abrogation in triple-negative breast cancer.
Li C, Gao T, Zhao Q, Li Z, Wang Z, Ding S, Zhang M, Qin Y, Xue X, Zhang X, Tian G, Bian XW, Yang Y
Cancer letters 2025 Aug 16;633:217991
Cancer letters 2025 Aug 16;633:217991
Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors.
Shan JL, Zhang KM, Zhong WQ, Yang XY, Li ZL, Huang Y, Du T, Yang D, Tang JH, Chen YH, Zhang HL, Zhu XF, Deng R
Cancer research 2025 Aug 15;85(16):3015-3031
Cancer research 2025 Aug 15;85(16):3015-3031
hnRNPA2B1 recognizes RNA virus SFTSV infection through mitochondrial DNA.
Huang X-b, Zhang Y, Fan J-w, Yu X-y, Fang Y-l, Ren J-x, Liu B-y
mBio 2025 Aug 13;16(8):e0166825
mBio 2025 Aug 13;16(8):e0166825
Excision repair cross complementation group 1 gene exon 3 skipping isoform presents selective cGAS-STING activation in platinum-sensitive lung adenocarcinoma.
Li L, Xiao M, Zhang L, Zhao S, Zhang G, Wu S, Jin C, Yang J, Lu X
Free radical biology & medicine 2025 Aug 1;235:73-85
Free radical biology & medicine 2025 Aug 1;235:73-85
PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal.
Su T, Si Y
Tissue & cell 2025 Apr;93:102739
Tissue & cell 2025 Apr;93:102739
Esketamine alleviated cardiomyocyte ferroptosis induced by oxygen-glucose deprivation/reoxygenation (OGD/R) via cyclic GMP-AMP synthase interactor.
Ouyang J, Xiao W, Wu D, Bai M, Zhao Q, Li Y
Cytotechnology 2025 Apr;77(2):57
Cytotechnology 2025 Apr;77(2):57
TRIM35 Negatively Regulates the cGAS-STING-Mediated Signaling Pathway by Attenuating K63-Linked Ubiquitination of STING.
Zhang J, Wu Y, Wang Y, Wang J, Ye Y, Yin H, Sun N, Qin B, Sun N
Inflammation 2025 Apr;48(2):855-869
Inflammation 2025 Apr;48(2):855-869
Eliminating Radioresistance With a Magnetic Ion-Generator by Simultaneously Augmenting DNA Damage and Diminishing Immunosuppression.
Zhang R, Chen M, Zhou H, Liu Y, Wang Y, Chen C, Li Y, Zeng J, Cui J, Duan R, Gao M
Advanced materials (Deerfield Beach, Fla.) 2025 Apr;37(13):e2406378
Advanced materials (Deerfield Beach, Fla.) 2025 Apr;37(13):e2406378
RNF144A inhibits autophagy by targeting BECN1 for degradation during L. monocytogenes infection.
Yang B, Shen M, Lu C, Wang Y, Zhao X, Zhang Q, Qin X, Pei J, Wang H, Wang J
Autophagy 2025 Apr;21(4):789-806
Autophagy 2025 Apr;21(4):789-806
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Li X, Jin S, Wang D, Wu Y, Tang X, Liu Y, Yao T, Han S, Sun L, Wang Y, Hou SX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
3-D Sustained-Release Culture Carrier Alleviates Rat Intervertebral Disc Degeneration by Targeting STING in Transplanted Skeletal Stem Cells.
Luo L, Zhang S, Gong J, Zhang J, Xie P, Yin J, Zhang M, Zhang C, Chen H, Liu Y, Ni B, Li C, Tian Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2410151
Carnosic Acid Directly Targets STING C-Terminal Tail to Improve STING-Mediated Inflammatory Diseases.
Mu W, Xu G, Li L, Wen J, Xiu Y, Zhao J, Liu T, Wei Z, Luo W, Yang H, Wu Z, Zhan X, Xiao X, Bai Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2417686
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2417686
Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis.
Wang D, Wang S, Liu J, Shi X, Xiong T, Li R, Wei W, Ji L, Huang Q, Gong X, Ai K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413925
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413925
Diffuse traumatic brain injury induced stimulator of interferons (STING) signaling in microglia drives cortical neuroinflammation, neuronal dysfunction, and impaired cognition.
Packer JM, Giammo SG, Wangler LM, Davis AC, Bray CE, Godbout JP
Journal of neuroinflammation 2025 Apr 30;22(1):128
Journal of neuroinflammation 2025 Apr 30;22(1):128
Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8(+) T cells.
Herbst M, Köksal H, Brunn S, Zanetti D, Domocos I, De Stefani V, Gatti M, Vivalda F, Pereira P, Nater M, Cecconi V, Sartori AA, van den Broek M
Cell reports 2025 Apr 22;44(4):115510
Cell reports 2025 Apr 22;44(4):115510
STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders.
Tang Z, Xing C, Araszkiewicz A, Yang K, Huai W, Jeltema D, Dobbs N, Zhang Y, Sun LO, Yan N
Molecular cell 2025 Apr 17;85(8):1624-1639.e5
Molecular cell 2025 Apr 17;85(8):1624-1639.e5
An Immune Subtype Classification System Enables the Development of Strategies to Predict and Enhance Immunotherapy Responses in Colorectal Cancer.
Li D, Liu X, Gao W, Zhao W, Ji S, Wang S, Yang J, Li D, Chang Z, Chen Y, Sun X, Zhou J, Jiao Y, Du X, Dong G
Cancer research 2025 Apr 15;85(8):1441-1458
Cancer research 2025 Apr 15;85(8):1441-1458
Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling.
Wei W, Li H, Tian S, Zhang C, Liu J, Tao W, Cai T, Dong Y, Wang C, Lu D, Ai Y, Zhang W, Wang H, Liu K, Fan Y, Gao Y, Huang Q, Ma X, Wang B, Zhang X, Huang Y
The Journal of clinical investigation 2025 Apr 15;135(8)
The Journal of clinical investigation 2025 Apr 15;135(8)
PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway.
Zhou H, Wang X, Xu T, Gan D, Ma Z, Zhang H, Zhang J, Zeng Q, Xu D
Cardiovascular research 2025 Apr 15;121(1):128-142
Cardiovascular research 2025 Apr 15;121(1):128-142
An unconventional autophagic pathway that inhibits ATP secretion during apoptotic cell death.
Terraza-Silvestre E, Villamuera R, Bandera-Linero J, Letek M, Oña-Sánchez D, Ramón-Barros C, Moyano-Jimeno C, Pimentel-Muiños FX
Nature communications 2025 Apr 10;16(1):3409
Nature communications 2025 Apr 10;16(1):3409
Identification of fibrosis-associated lncRNAs in diabetic cardiomyopathy patients.
Dai X, Chen D, Yang F, Dong Z, Yang L, He J, Xiao J
Endokrynologia Polska 2024;75(5):525-538
Endokrynologia Polska 2024;75(5):525-538
Metformin promotes anti-tumor immunity in STK11 mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites.
Wang Z, Li K, Lu C, Feng M, Lin C, Yin G, Luo D, Liu W, Jin K, Dou Y, Wu DI, Zheng J, Zhang K, Li LI, Fan X
Oncology research 2024;32(10):1637-1648
Oncology research 2024;32(10):1637-1648
Establishment of a STING-Deficient HepG2 Cell Line through CRISPR/Cas9 System and Evaluation of Its Effects on Salmonella Replication.
Sun L, Huang K, Huang X
Journal of pathogens 2024;2024:9615181
Journal of pathogens 2024;2024:9615181
mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
Yang NS, Zhong WJ, Sha HX, Zhang CY, Jin L, Duan JX, Xiong JB, You ZJ, Zhou Y, Guan CX
International journal of biological sciences 2024;20(5):1927-1946
International journal of biological sciences 2024;20(5):1927-1946
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
Sha HX, Liu YB, Qiu YL, Zhong WJ, Yang NS, Zhang CY, Duan JX, Xiong JB, Guan CX, Zhou Y
International journal of biological sciences 2024;20(12):4713-4730
International journal of biological sciences 2024;20(12):4713-4730
Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway.
Yang G, Kantapan J, Mazhar M, Hu Q, Bai X, Zou Y, Wang H, Yang S, Wang L, Dechsupa N
Journal of inflammation research 2024;17:1643-1658
Journal of inflammation research 2024;17:1643-1658
Astragalus Polysaccharide Mitigates Rhabdomyolysis-Induced Acute Kidney Injury via Inhibition of M1 Macrophage Polarization and the cGAS-STING Pathway.
Sun C, Zhao X, Wang X, Yu Y, Shi H, Tang J, Sun S, Zhu S
Journal of inflammation research 2024;17:11505-11527
Journal of inflammation research 2024;17:11505-11527
Alteration of cGAS-STING signaling pathway components in the mouse cortex and hippocampus during healthy brain aging.
Passarella S, Kethiswaran S, Brandes K, Tsai IC, Cebulski K, Kröger A, Dieterich DC, Landgraf P
Frontiers in aging neuroscience 2024;16:1429005
Frontiers in aging neuroscience 2024;16:1429005
KAE ameliorates LPS-mediated acute lung injury by inhibiting PANoptosis through the intracellular DNA-cGAS-STING axis.
Chen Y, Wu X, Jiang Z, Li X
Frontiers in pharmacology 2024;15:1461931
Frontiers in pharmacology 2024;15:1461931
African swine fever virus structural protein p17 inhibits IRF3 activation by recruiting host protein PR65A and inducing apoptotic degradation of STING.
Wang S, Xiang Z, Gao P, Zhang Y, Zhou L, Ge X, Guo X, Han J, Yang H
Frontiers in microbiology 2024;15:1428233
Frontiers in microbiology 2024;15:1428233
Pseudorabies virus tegument protein US2 antagonizes antiviral innate immunity by targeting cGAS-STING signaling pathway.
Kong Z, Chen X, Gong L, Wang L, Zhang Y, Guan K, Yao W, Kang Y, Lu X, Zhang Y, Du Y, Sun A, Zhuang G, Zhao J, Wan B, Zhang G
Frontiers in immunology 2024;15:1403070
Frontiers in immunology 2024;15:1403070
African swine fever virus MGF505-6R attenuates type I interferon production by targeting STING for degradation.
Yao M, Cao H, Li W, Hu Z, Rong Z, Yin M, Tian L, Hu D, Li X, Qian P
Frontiers in immunology 2024;15:1380220
Frontiers in immunology 2024;15:1380220
Schisandrin C enhances type I IFN response activation to reduce tumor growth and sensitize chemotherapy through antitumor immunity.
Yang H, Zhan X, Zhao J, Shi W, Liu T, Wei Z, Li H, Hou X, Mu W, Chen Y, Zheng C, Wang Z, Wei S, Xiao X, Bai Z
Frontiers in pharmacology 2024;15:1369563
Frontiers in pharmacology 2024;15:1369563
Quercetin ameliorates ulcerative colitis by restoring the balance of M2/M1 and repairing the intestinal barrier via downregulating cGAS‒STING pathway.
Gao F, Zhu F, Shuai B, Wu M, Wei C, Yuan Y, Gui Y, Tian Y, Fan H, Wu H
Frontiers in pharmacology 2024;15:1351538
Frontiers in pharmacology 2024;15:1351538
Environment-responsive dendrobium polysaccharide hydrogel embedding manganese microsphere as a post-operative adjuvant to boost cascaded immune cycle against melanoma.
Gao N, Huang Y, Jing S, Zhang M, Liu E, Qiu L, Huang J, Muhitdinov B, Huang Y
Theranostics 2024;14(10):3810-3826
Theranostics 2024;14(10):3810-3826
A guide to selecting high-performing antibodies for STING1 (Uniprot ID: Q86WV6) for use in western blot, immunoprecipitation, and immunofluorescence.
Ruíz Moleón V, Alende C, Fotouhi M, Ayoubi R, Southern K, Laflamme C, NeuroSGC/YCharOS/EDDU collaborative group, ABIF consortium
F1000Research 2024;13:1049
F1000Research 2024;13:1049
The involvement of Sting in exacerbating acute lung injury in sepsis via the PARP-1/NLRP3 signaling pathway.
Ying T, Yu Y, Yu Q, Zhou G, Chen L, Gu Y, Zhu L, Ying H, Chen M
Pulmonary pharmacology & therapeutics 2024 Sep;86:102303
Pulmonary pharmacology & therapeutics 2024 Sep;86:102303
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol.
Zheng ZH, Wang JJ, Lin JG, Ye WL, Zou JM, Liang LY, Yang PL, Qiu WL, Li YY, Yang SJ, Zhao M, Zhou Q, Li CZ, Li M, Li ZM, Zhang DM, Liu PQ, Liu ZP
Acta pharmacologica Sinica 2024 Sep;45(9):1879-1897
Acta pharmacologica Sinica 2024 Sep;45(9):1879-1897
Lipo/TK-CDN/TPP/Y6 nanoparticles inhibit cutaneous melanoma formation.
Xiao A, Yin L, Chen T, Qian H
Journal of drug targeting 2024 Sep;32(8):931-940
Journal of drug targeting 2024 Sep;32(8):931-940
Chlorogenic acid can improve spermatogenic dysfunction in rats with varicocele by regulating mitochondrial homeostasis and inhibiting the activation of NLRP3 inflammasomes by oxidative mitochondrial DNA and cGAS/STING pathway.
Jia ZC, Liu SJ, Chen TF, Shi ZZ, Li XL, Gao ZW, Zhang Q, Zhong CF
Bioorganic chemistry 2024 Sep;150:107571
Bioorganic chemistry 2024 Sep;150:107571
Geniposide dosage and administration time: Balancing therapeutic benefits and adverse reactions in liver disease treatment.
Qiu J, Lin C, Ren G, Xu F, Hu T, Le Y, Fan X, Yu Z, Liu Q, Wang X, Dou X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155799
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155799
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
Puray-Chavez M, Eschbach JE, Xia M, LaPak KM, Zhou Q, Jasuja R, Pan J, Xu J, Zhou Z, Mohammed S, Wang Q, Lawson DQ, Djokic S, Hou G, Ding S, Brody SL, Major MB, Goldfarb D, Kutluay SB
bioRxiv : the preprint server for biology 2024 Sep 6;
bioRxiv : the preprint server for biology 2024 Sep 6;
Mitochondrial dysfunction-associated alveolar epithelial senescence is involved in CdCl(2)-induced COPD-like lung injury.
Peng K, Yao YX, Lu X, Wang WJ, Zhang YH, Zhao H, Wang H, Xu DX, Tan ZX
Journal of hazardous materials 2024 Sep 5;476:135103
Journal of hazardous materials 2024 Sep 5;476:135103
GRP78/IRE1 and cGAS/STING pathway crosstalk through CHOP facilitates iodoacetic acid-mediated testosterone decline.
Mou L, Sun D, Qu J, Tan X, Wang S, Zeng Q, Liu C
Journal of hazardous materials 2024 Sep 5;476:135101
Journal of hazardous materials 2024 Sep 5;476:135101
SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B
bioRxiv : the preprint server for biology 2024 Sep 5;
bioRxiv : the preprint server for biology 2024 Sep 5;
Pentagalloylglucose alleviates acetaminophen-induced acute liver injury by modulating inflammation via cGAS-STING pathway.
Zheng C, Chen Y, He T, Xiu Y, Dong X, Wang X, Wen X, Li C, Yao Q, Chen S, Zhan X, Gao L, Bai Z
Molecular medicine (Cambridge, Mass.) 2024 Sep 27;30(1):160
Molecular medicine (Cambridge, Mass.) 2024 Sep 27;30(1):160
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
Puray-Chavez M, Eschbach JE, Xia M, LaPak KM, Zhou Q, Jasuja R, Pan J, Xu J, Zhou Z, Mohammed S, Wang Q, Lawson DQ, Djokic S, Hou G, Ding S, Brody SL, Major MB, Goldfarb D, Kutluay SB
Nature communications 2024 Sep 27;15(1):8394
Nature communications 2024 Sep 27;15(1):8394
The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Aybar-Torres AA, Saldarriaga LA, Pham AT, Emtiazjoo AM, Sharma AK, Bryant AJ, Jin L
eLife 2024 Sep 18;13
eLife 2024 Sep 18;13
NSDHL promotes the degradation of sting in cholangiocarcinoma.
Yu W, Chen J, Tong Y, Zhu L, Deng Y, He J, Zhong C, Cai X
Heliyon 2024 Sep 15;10(17):e37592
Heliyon 2024 Sep 15;10(17):e37592
C-di-GMP@ZIF-8 nanocomposite injectable hydrogel based on modified chitosan and hyaluronic acid for infected wound healing by activating STING signaling.
Ren H, Zhang J, Jiang Y, Hao S, You J, Yin Z
International journal of biological macromolecules 2024 Sep 14;280(Pt 1):135660
International journal of biological macromolecules 2024 Sep 14;280(Pt 1):135660
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling.
Shi Y, Wu Z, Liu S, Zuo D, Niu Y, Qiu Y, Qiao L, He W, Qiu J, Yuan Y, Wang G, Li B
Nature communications 2024 Sep 10;15(1):7930
Nature communications 2024 Sep 10;15(1):7930
tBHQ mitigates fatty liver ischemia-reperfusion injury by activating Nrf2 to attenuate hepatocyte mitochondrial damage and macrophage STING activation.
Wu D, Xu J, Zhang Y, Wang Y, Bai Y, Zhan X, Gao Y, Zhou H, Hu H, Wang P, Rao Z
International immunopharmacology 2024 Sep 10;138:112515
International immunopharmacology 2024 Sep 10;138:112515
CuO Nanozymes Catalyze Cysteine and Glutathione Depletion Induced Ferroptosis and Cuproptosis for Synergistic Tumor Therapy.
Bai J, Zhang X, Zhao Z, Sun S, Cheng W, Yu H, Chang X, Wang B
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400326
Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis.
Zhu J, Zhao H, Aierken A, Zhou T, Menggen M, Gao H, He R, Aimulajiang K, Wen H
PLoS neglected tropical diseases 2024 Oct;18(10):e0012587
PLoS neglected tropical diseases 2024 Oct;18(10):e0012587
STING Agonist Delivered by Neutrophil Membrane-Coated Gold Nanoparticles Exerts Synergistic Tumor Inhibition with Radiotherapy.
Lu D, Li W, Tan J, Li Y, Mao W, Zheng Y, Yang M, Wang J, Wang W, Wang S, Gao J, Liu Y
ACS applied materials & interfaces 2024 Oct 9;16(40):53474-53488
ACS applied materials & interfaces 2024 Oct 9;16(40):53474-53488
Homoplantaginin alleviates high glucose-induced vascular endothelial senescence by inhibiting mtDNA-cGAS-STING pathway via blunting DRP1-mitochondrial fission-VDAC1 axis.
Wang L, Zhang X, Huang X, Sha X, Li X, Zheng J, Li S, Wei Z, Wu F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 31;38(20):e70127
ZC3HAV1 facilitates STING activation and enhances inflammation.
Qin D, Song H, Wang C, Ma X, Fu Y, Zhao C, Zhao W, Zhang L, Zhang W
Communications biology 2024 Oct 30;7(1):1418
Communications biology 2024 Oct 30;7(1):1418
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells.
Lazarchuk P, Nguyen MM, Curca CM, Pavlova MN, Oshima J, Sidorova JM
Aging 2024 Oct 17;16(20):12977-13011
Aging 2024 Oct 17;16(20):12977-13011
Copper induced cytosolic escape of mitochondrial DNA and activation of cGAS-STING-NLRP3 pathway-dependent pyroptosis in C8-D1A cells.
Shi W, Zhou Q, Lu L, Zhang Y, Zhang H, Pu Y, Yin L
Ecotoxicology and environmental safety 2024 Oct 15;285:117085
Ecotoxicology and environmental safety 2024 Oct 15;285:117085
Porphyromonas gingivalis OMVs promoting endothelial dysfunction via the STING pathway in periodontitis.
Chen Z, Cao Y, Jiang W, Yan Z, Cai G, Ye J, Wang H, Liu L
Oral diseases 2024 Nov;30(8):5461-5474
Oral diseases 2024 Nov;30(8):5461-5474
Vericiguat attenuates doxorubicin-induced cardiotoxicity through the PRKG1/PINK1/STING axis.
Zeng X, Zhang H, Xu T, Mei X, Wang X, Yang Q, Luo Z, Zeng Q, Xu D, Ren H
Translational research : the journal of laboratory and clinical medicine 2024 Nov;273:90-103
Translational research : the journal of laboratory and clinical medicine 2024 Nov;273:90-103
TRIM32 inhibits Venezuelan equine encephalitis virus infection by targeting a late step in viral entry.
Xie Y, Cao J, Gan S, Xu L, Zhang D, Qian S, Xu F, Ding Q, Schoggins JW, Fan W
PLoS pathogens 2024 Nov;20(11):e1012312
PLoS pathogens 2024 Nov;20(11):e1012312
Morphine induces inflammatory responses via both TLR4 and cGAS-STING signaling pathways.
Xie F, Kitagawa Y, Ogata H, Yasuhara S, You Z, Jeevendra Martyn JA
Cytokine 2024 Nov;183:156737
Cytokine 2024 Nov;183:156737
Chemerin alleviates the placental oxidative stress and improves fetal overgrowth of gestational diabetes mellitus mice induced by high fat diet.
Zhou X, Jiang Y, Wang Z, Wei L, Zhang H, Fang C, Zhu S, Du Y, Su R, Li W, He Z, Zhang L, Tan W, He M, Yu J, Wang S, Ding W, Feng L
Molecular medicine (Cambridge, Mass.) 2024 Nov 30;30(1):239
Molecular medicine (Cambridge, Mass.) 2024 Nov 30;30(1):239
Cadmium exposure triggers alveolar epithelial cell pyroptosis by inducing mitochondrial oxidative stress and activating the cGAS-STING pathway.
Zhang CY, Ou AJ, Jin L, Yang NS, Deng P, Guan CX, Huang XT, Duan JX, Zhou Y
Cell communication and signaling : CCS 2024 Nov 26;22(1):566
Cell communication and signaling : CCS 2024 Nov 26;22(1):566
Uncovering the role of tumor cGAS expression in predicting response to PD-1/L1 inhibitors in non-small cell lung cancer.
Ozawa Y, Koh Y, Shibaki R, Harutani Y, Akamatsu H, Hayata A, Sugimoto T, Kitamura Y, Fukuoka J, Nakanishi M, Yamamoto N
Cancer immunology, immunotherapy : CII 2024 Nov 2;74(1):7
Cancer immunology, immunotherapy : CII 2024 Nov 2;74(1):7
PROTAC based STING degrader attenuates acute colitis by inhibiting macrophage M1 polarization and intestinal epithelial cells pyroptosis mediated by STING-NLRP3 axis.
Xu S, Peng Y, Yang K, Liu S, He Z, Huang J, Xiao R, Liu J, Yan Z, Lian Z, Pan H, Chen J, Shi J, Yao X, Deng H
International immunopharmacology 2024 Nov 15;141:112990
International immunopharmacology 2024 Nov 15;141:112990
STING orchestrates microglia polarization via interaction with LC3 in autophagy after ischemia.
Kong L, Xu P, Shen N, Li W, Li R, Tao C, Wang G, Zhang Y, Sun W, Hu W, Liu X
Cell death & disease 2024 Nov 13;15(11):824
Cell death & disease 2024 Nov 13;15(11):824
NLRX1 and STING alleviate renal ischemia-reperfusion injury by regulating LC3 lipidation during mitophagy.
Liao Y, Li P, Hang Q, Chong Y, Long W, Wei X, Sun D, Liu Y
Experimental cell research 2024 Nov 1;443(1):114323
Experimental cell research 2024 Nov 1;443(1):114323
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration.
Jing X, Wang W, He X, Liu X, Yang X, Su C, Shao Y, Ge Z, Wang H, Cui X
Journal of orthopaedic translation 2024 May;46:65-78
Journal of orthopaedic translation 2024 May;46:65-78
Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction.
Xiu Y, Wang S, Zhang P, Li C, Wu Z, Wen J, Xu Y, Lv G, Zhao X, Dong X, Chen Y, Li J, Wang Y, Zou L, Xiao X, Bai Z
Chinese journal of natural medicines 2024 May;22(5):402-415
Chinese journal of natural medicines 2024 May;22(5):402-415
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF-κB pathway.
Wu X, Zhou L, Li Z, Rong K, Gao S, Chen Y, Zuo J, Tang W
Bioorganic chemistry 2024 May;146:107303
Bioorganic chemistry 2024 May;146:107303
RGD targeted magnetic ferrite nanoparticles enhance antitumor immunotherapeutic efficacy by activating STING signaling pathway.
Shi G, Liu X, Du Y, Tian J
iScience 2024 May 17;27(5):109062
iScience 2024 May 17;27(5):109062
Inactivation of Myostatin Delays Senescence via TREX1-SASP in Bovine Skeletal Muscle Cells.
Yang M, Gao L, Gao Y, Hao Z, Zhou X, Su G, Bai C, Wei Z, Liu X, Yang L, Li G
International journal of molecular sciences 2024 May 12;25(10)
International journal of molecular sciences 2024 May 12;25(10)
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S, Zhang Z, Chen N
Autophagy 2024 Mar;20(3):590-613
Autophagy 2024 Mar;20(3):590-613
NAD(+) supplementation prevents STING-induced senescence in CD8(+) T cells by improving mitochondrial homeostasis.
Ye B, Pei Y, Wang L, Meng D, Zhang Y, Zou S, Li H, Liu J, Xie Z, Tian C, Jiang Y, Qiao Y, Gao X, Zhang Y, Ma N
Journal of cellular biochemistry 2024 Mar;125(3):e30522
Journal of cellular biochemistry 2024 Mar;125(3):e30522
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro.
Duan QQ, Wang H, Su WM, Gu XJ, Shen XF, Jiang Z, Ren YL, Cao B, Li GB, Wang Y, Chen YP
BMC medicine 2024 Mar 5;22(1):96
BMC medicine 2024 Mar 5;22(1):96
Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer.
Sales Conniff A, Singh J, Heller R, Heller LC
Pharmaceutics 2024 Mar 5;16(3)
Pharmaceutics 2024 Mar 5;16(3)
Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways.
He Y, Yue J, Teng Y, Fan Z, Jia M, Teng H, Zhuge L
International immunopharmacology 2024 Mar 30;130:111687
International immunopharmacology 2024 Mar 30;130:111687
Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses.
Liu L, Manley JL
Cell reports 2024 Mar 26;43(3):113886
Cell reports 2024 Mar 26;43(3):113886
The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases.
Sanz MÁ, Polo M, Rodríguez-Pulido M, Huildore Bommanna R, Sáiz M
Cellular and molecular life sciences : CMLS 2024 Mar 20;81(1):148
Cellular and molecular life sciences : CMLS 2024 Mar 20;81(1):148
Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-κB signaling pathway.
Jia Y, Li F, Liu Z, Liu S, Huang M, Gao X, Su X, Wang Z, Wang T
Journal of virology 2024 Mar 19;98(3):e0181523
Journal of virology 2024 Mar 19;98(3):e0181523
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
Wu Z, Zhao X, Li R, Wen X, Xiu Y, Long M, Li J, Huang X, Wen J, Dong X, Xu Y, Bai Z, Zhan X, Xiao X
Chinese medicine 2024 Mar 18;19(1):48
Chinese medicine 2024 Mar 18;19(1):48
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Wang W, Ma Z, Feng X, Ren J, Sun S, Shao Y, Zhang W, Yang X, Zhang J, Jing X
Arthritis research & therapy 2024 Mar 16;26(1):71
Arthritis research & therapy 2024 Mar 16;26(1):71
Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction.
Kong W, Chen J, Ruan X, Xu X, Li X, Bao M, Shao Y, Bian X, Li R, Jiang Q, Zhang Y, Li Z, Yan F, Ye J
Life sciences 2024 Mar 15;341:122474
Life sciences 2024 Mar 15;341:122474
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.
Marques C, Held A, Dorfman K, Sung J, Song C, Kavuturu AS, Aguilar C, Russo T, Oakley DH, Albers MW, Hyman BT, Petrucelli L, Lagier-Tourenne C, Wainger BJ
Acta neuropathologica 2024 Mar 13;147(1):56
Acta neuropathologica 2024 Mar 13;147(1):56
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413
Virologica Sinica 2024 Jun;39(3):403-413
Identification of key mitochondria-related genes and their relevance to the immune system linking Parkinson's disease and primary Sjögren's syndrome through integrated bioinformatics analyses.
Zong Y, Yang Y, Zhao J, Li L, Luo D, Hu J, Gao Y, Xie X, Shen L, Chen S, Ning L, Jiang L
Computers in biology and medicine 2024 Jun;175:108511
Computers in biology and medicine 2024 Jun;175:108511
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Wang Y, Xu G, Wen J, Zhao X, Zhao H, Lv G, Xu Y, Xiu Y, Li J, Chen S, Yao Q, Chen Y, Ma L, Xiao X, Cao J, Bai Z
Immunology 2024 Jun;172(2):295-312
Immunology 2024 Jun;172(2):295-312
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
Shi W, Xu G, Gao Y, Yang H, Liu T, Zhao J, Li H, Wei Z, Hou X, Chen Y, Wen J, Li C, Zhao J, Zhang P, Wang Z, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry.
Xie Y, Cao J, Gan S, Xu L, Zhang D, Qian S, Xu F, Ding Q, Schoggins JW, Fan W
bioRxiv : the preprint server for biology 2024 Jun 4;
bioRxiv : the preprint server for biology 2024 Jun 4;
Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X.
Zhang X, Han L, Hou J, Yang H, Xu H, Li G, Shu Q, Zhu D, Zheng Y, Gao C
Cell reports 2024 Jun 25;43(6):114248
Cell reports 2024 Jun 25;43(6):114248
The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Aybar-Torres A, Saldarriaga LA, Pham AT, Emtiazjoo AM, Sharma AK, Bryant AJ, Jin L
bioRxiv : the preprint server for biology 2024 Jun 17;
bioRxiv : the preprint server for biology 2024 Jun 17;
cGAS/STING signaling pathway-mediated microglial activation in the PFC underlies chronic ethanol exposure-induced anxiety-like behaviors in mice.
Zhao W, Zhao S, Wei R, Wang Z, Zhang F, Zong F, Zhang HT
International immunopharmacology 2024 Jun 15;134:112185
International immunopharmacology 2024 Jun 15;134:112185
Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling.
Zhang J, Du J, Liu D, Zhuo J, Chu L, Li Y, Gao L, Xu M, Chen W, Huang W, Xie L, Chen J, Meng X, Zou F, Cai S, Dong H
Ecotoxicology and environmental safety 2024 Jun 1;277:116357
Ecotoxicology and environmental safety 2024 Jun 1;277:116357
Regulating NCOA4-Mediated Ferritinophagy for Therapeutic Intervention in Cerebral Ischemia-Reperfusion Injury.
Zhao L, Li Y, Wang W, Qi X, Wang S, Song W, Li T, Gao W
Neurochemical research 2024 Jul;49(7):1806-1822
Neurochemical research 2024 Jul;49(7):1806-1822
Targeting STING in dendritic cells alleviates psoriatic inflammation by suppressing IL-17A production.
Sun X, Liu L, Wang J, Luo X, Wang M, Wang C, Chen J, Zhou Y, Yin H, Song Y, Xiong Y, Li H, Zhang M, Zhu B, Li X
Cellular & molecular immunology 2024 Jul;21(7):738-751
Cellular & molecular immunology 2024 Jul;21(7):738-751
Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection.
Wang R, Senay TE, Luo TT, Liu W, Regan JM, Salisbury NJH, Galloway DA, You J
PLoS pathogens 2024 Jul;20(7):e1012170
PLoS pathogens 2024 Jul;20(7):e1012170
Amplifying protection against acute lung injury: Targeting both inflammasome and cGAS-STING pathway by Lonicerae Japonicae Flos-Forsythiae Fructus drug pair.
Li J, Dong M, Yao Q, Dong X, Chen Y, Wen J, Xu Y, Wu Z, Zhao X, Xiu Y, Zhan X, Bai Z, Xiao X
Chinese herbal medicines 2024 Jul;16(3):422-434
Chinese herbal medicines 2024 Jul;16(3):422-434
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Ming S, Zhang S, Xing J, Yang G, Zeng L, Wang J, Chu B
iScience 2024 Jul 19;27(7):110144
iScience 2024 Jul 19;27(7):110144
USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling.
Tang Y, Wang T, Gu L, Xu Y, Yang Z, Zhu W, Zhang Q, Luo J, Cao J, Jiao Y
International journal of radiation oncology, biology, physics 2024 Jul 15;119(4):1261-1274
International journal of radiation oncology, biology, physics 2024 Jul 15;119(4):1261-1274
Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.
Dong K, Sun Y, Gao X, Wang J, Wu X, Guo C
Colloids and surfaces. B, Biointerfaces 2024 Jan;233:113656
Colloids and surfaces. B, Biointerfaces 2024 Jan;233:113656
STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis.
Zhao J, Yi Z, Deng G, Li Y, Li J, Qin M, Wu C, Luo P, Ma S, Gao L
Free radical biology & medicine 2024 Jan;210:367-377
Free radical biology & medicine 2024 Jan;210:367-377
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Wang Y, She S, Li W, Zhu J, Li X, Yang F, Dai K
Molecular immunology 2024 Jan;165:42-54
Molecular immunology 2024 Jan;165:42-54
Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury.
Wei FL, Wang TF, Wang CL, Zhang ZP, Zhao JW, Heng W, Tang Z, Du MR, Yan XD, Li XX, Guo Z, Qian JX, Zhou CP
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(4):e2305442
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(4):e2305442
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
Liu Y, Duan R, Li P, Zhang B, Liu Y
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
CRIg+ macrophages deficiency enhanced inflammation damage in IBD due to gut extracellular vesicles containing microbial DNA.
Nie S, Zhang Z, Ji Y, Ding Q, Gong J, Xiao F, Chen L, Tian D, Liu M, Luo Z
Gut microbes 2024 Jan-Dec;16(1):2379633
Gut microbes 2024 Jan-Dec;16(1):2379633
Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity.
Zhu L, Jin J, Wang T, Hu Y, Liu H, Gao T, Dong Q, Jin Y, Li P, Liu Z, Huang Y, Liu X, Cao C
eLife 2024 Jan 29;12
eLife 2024 Jan 29;12
Antitumor Effect of Platinum-Modified STING Agonist MSA-2.
Wang M, Cai Y, He T, Zhang Y, Yi L, Li W, Zhou P
ACS omega 2024 Jan 16;9(2):2650-2656
ACS omega 2024 Jan 16;9(2):2650-2656
HIV-1 p17 matrix protein enhances type I interferon responses through the p17-OLA1-STING axis.
Zhang L, Li S, Xu X, Ma C, Zhang P, Ji W, Liu X
Journal of cell science 2024 Jan 15;137(2)
Journal of cell science 2024 Jan 15;137(2)
Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol.
Kemmoku H, Takahashi K, Mukai K, Mori T, Hirosawa KM, Kiku F, Uchida Y, Kuchitsu Y, Nishioka Y, Sawa M, Kishimoto T, Tanaka K, Yokota Y, Arai H, Suzuki KGN, Taguchi T
Nature communications 2024 Jan 11;15(1):220
Nature communications 2024 Jan 11;15(1):220
Jujuboside B alleviates acetaminophen-induced hepatotoxicity in mice by regulating Nrf2-STING signaling pathway.
Wang HF, Xu JS, Zong K, Liang ZW, Li RF, Xue JF, Ding J, Zhao LS
Ecotoxicology and environmental safety 2024 Jan 1;269:115810
Ecotoxicology and environmental safety 2024 Jan 1;269:115810
Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses.
Packer JM, Bray CE, Beckman NB, Wangler LM, Davis AC, Goodman EJ, Klingele NE, Godbout JP
Glia 2024 Feb;72(2):300-321
Glia 2024 Feb;72(2):300-321
Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders.
Wang A, Chen C, Mei C, Liu S, Xiang C, Fang W, Zhang F, Xu Y, Chen S, Zhang Q, Bai X, Lin A, Neculai D, Xia B, Ye C, Zou J, Liang T, Feng XH, Li X, Shen C, Xu P
Nature cell biology 2024 Feb;26(2):219-234
Nature cell biology 2024 Feb;26(2):219-234
A conserved ion channel function of STING mediates noncanonical autophagy and cell death.
Xun J, Zhang Z, Lv B, Lu D, Yang H, Shang G, Tan JX
EMBO reports 2024 Feb;25(2):544-569
EMBO reports 2024 Feb;25(2):544-569
Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.
Zhou S, Sun Y, Wang K, Gao X, Dong K, Wang J, Wu X, Guo C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114427
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114427
Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour-intrinsic innate sensing and immunogenicity.
Sun M, Han X, Li J, Zheng J, Li J, Wang H, Li X
Clinical and translational medicine 2024 Feb;14(2):e1598
Clinical and translational medicine 2024 Feb;14(2):e1598
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Peng D, Huang Z, Yang H, Luo Y, Wu Z
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats.
Takimoto N, Ishii Y, Mitsumoto T, Takasu S, Namiki M, Shibutani M, Ogawa K
Toxicological sciences : an official journal of the Society of Toxicology 2024 Feb 28;198(1):40-49
Toxicological sciences : an official journal of the Society of Toxicology 2024 Feb 28;198(1):40-49
Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway.
Yang T, Ma H, Lai H, Lu Y, Ni K, Hu X, Zhou Y, Zhou Z, Li W, Fang J, Zhang Y, Chen Z, He D
European journal of pharmacology 2024 Feb 15;965:176326
European journal of pharmacology 2024 Feb 15;965:176326
The cGAS-STING pathway promotes the development of preeclampsia by upregulating autophagy: Mechanisms and implications.
Sun J, Yu M, Du W, Zhu S, Chen Z, Tao J, Zhou Y, Chen Q, Zhao Y, Zhang Q
International immunopharmacology 2024 Feb 15;128:111531
International immunopharmacology 2024 Feb 15;128:111531
RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion.
Zhuang Q, Dai Z, Xu X, Bai S, Zhang Y, Zheng Y, Xing X, Hu E, Wang Y, Guo W, Zhao B, Zeng Y, Liu X
Cancer research 2024 Feb 1;84(3):405-418
Cancer research 2024 Feb 1;84(3):405-418
STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation.
Wang Y, Niu W, Zhu S, Sun J, Lv J, Wang N, Zhang H, Zhang Z, Wang M, Cao L, Li S, Zhai Q, Ma L
Inflammation 2024 Dec;47(6):2129-2144
Inflammation 2024 Dec;47(6):2129-2144
Double-filtration plasmapheresis reduces type I interferon bioavailability and inducing activity in systemic lupus erythematosus.
Saito T, Takatsuji R, Murayama G, Yamaji Y, Hagiwara Y, Nishioka Y, Kuga T, Miyashita T, Kusaoi M, Tamura N, Yamaji K
Immunological medicine 2024 Dec;47(4):264-274
Immunological medicine 2024 Dec;47(4):264-274
STING Activation in Macrophages and Microglia Drives Poststroke Inflammation: Implications for Neuroinflammatory Mechanisms and Therapeutic Interventions.
Liu Z, Qin Q, Wang S, Kang X, Liu Y, Wei L, Lu Z, Cai W, Hu M
CNS neuroscience & therapeutics 2024 Dec;30(12):e70106
CNS neuroscience & therapeutics 2024 Dec;30(12):e70106
TBK1 is involved in M-CSF-induced macrophage polarization through mediating the IRF5/IRF4 axis.
Li Y, Ji L, Liu C, Li J, Wen D, Li Z, Yu L, Guo M, Zhang S, Duan W, Yi L, Bi Y, Bu H, Li C, Liu Y
The FEBS journal 2024 Dec;291(23):5214-5235
The FEBS journal 2024 Dec;291(23):5214-5235
Switchable ROS generator and scavenger to prevent the cisplatin induced acute kidney injury and improve efficacy via synergistic chemodynamic/immune therapy.
Ren Y, Wu F, Huo L, Wang X, Zhang Y, Fan M, Tan M, Zhao J, Cheng J, Zhao Z, Bao J
Materials today. Bio 2024 Dec;29:101328
Materials today. Bio 2024 Dec;29:101328
Gelsevirine ameliorates sepsis-associated encephalopathy by inhibiting the STING signalling-mediated pyroptosis pathway in microglia.
Zeng QQ, Wang J, Yue RC, Wang FS, Xu Y, Su YP, Zhang QL, Zheng YW, Zhang GF, Li B, Yu CX, Jin GL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156071
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156071
Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma.
Nishimura S, Linares JF, L'Hermitte A, Duran A, Cid-Diaz T, Martinez-Ordoñez A, Ruiz-Martinez M, Kudo Y, Marzio A, Heikenwalder M, Roberts LR, Diaz-Meco MT, Moscat J
Molecular cell 2024 Dec 5;84(23):4660-4676.e10
Molecular cell 2024 Dec 5;84(23):4660-4676.e10
AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male mice.
Wang L, Xu X, Su S, Li B, Zhang K, Yu X, Xiao Y, Lu S, Lu Z, Wu Y, Ke C
Scientific reports 2024 Dec 30;14(1):31851
Scientific reports 2024 Dec 30;14(1):31851
BAX pores facilitate mitochondrial DNA release in wasp sting-induced acute kidney injury.
Zhou Z, Xu L, Lv Y, Li L, Yuan H, Hu F
International immunopharmacology 2024 Dec 25;143(Pt 2):113424
International immunopharmacology 2024 Dec 25;143(Pt 2):113424
Neutrophil extracellular traps induce barrier dysfunction in DSS-induced ulcerative colitis via the cGAS-STING pathway.
Sun T, Wang P, Zhai X, Wang Z, Miao X, Yang Y, Wu J
International immunopharmacology 2024 Dec 25;143(Pt 1):113358
International immunopharmacology 2024 Dec 25;143(Pt 1):113358
Click-chemistry-based protocol for detecting 4-octyl-itaconate-alkylated proteins in primary mouse macrophages.
Su C, Cheng T, Zhang H, Yin H
STAR protocols 2024 Dec 20;5(4):103314
STAR protocols 2024 Dec 20;5(4):103314
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.
Wen C, Wang L, Piffkó A, Chen D, Yu X, Zawieracz K, Bugno J, Yang K, Naccasha EZ, Ji F, Wang J, Huang X, Luo SY, Tan L, Shen B, Luo C, McNerney ME, Chmura SJ, Arina A, Pitroda S, He C, Liang HL, Weichselbaum RR
The Journal of clinical investigation 2024 Dec 2;134(23)
The Journal of clinical investigation 2024 Dec 2;134(23)
STING exerts antiviral innate immune response by activating pentose phosphate pathway.
Wu DH, Zhao ZL, Yin WT, Liu H, Xiang XY, Zhu LJ, Li JQ, Yan ZH, Li YJ, Jian YP, Xu ZX
Cell communication and signaling : CCS 2024 Dec 18;22(1):599
Cell communication and signaling : CCS 2024 Dec 18;22(1):599
Disturbance of mitochondrial dynamics led to spermatogenesis disorder in mice exposed to polystyrene micro- and nanoplastics.
Zhao M, Xie J, Zhang J, Zhao B, Zhang Y, Xue J, Zhang R, Zhang R, Wang H, Li Y, Ge W, Zhou X
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Environmental pollution (Barking, Essex : 1987) 2024 Dec 1;362:124935
Autophagy deficiency exacerbated hypoxia-reoxygenation induced inflammation and cell death via a mitochondrial DNA/STING/IRF3 pathway.
Tam E, Song E, Noskovicova N, Hinz B, Xu A, Sweeney G
Life sciences 2024 Dec 1;358:123173
Life sciences 2024 Dec 1;358:123173
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Li LG, Hu J, Han N, Chen NN, Yu TT, Ren T, Xu HZ, Peng XC, Li XY, Ma TQ, Chen H, Zhang L, Chen X, Wang MF, Li TF
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
Liang L, Zeng J, Liu R, Zheng Z, Lyu D, Zhang X, Wen M, Li M, Xiao H, Sun X, Li M, Huang H
Biochemical pharmacology 2024 Aug;226:116373
Biochemical pharmacology 2024 Aug;226:116373
SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure.
Li H, Wan L, Liu M, Ma E, Huang L, Yang Y, Li Q, Fang Y, Li J, Han B, Zhang C, Sun L, Hou X, Li H, Sun M, Qian S, Duan X, Zhao R, Yang X, Chen Y, Wu S, Zhang X, Zhang Y, Cheng G, Chen G, Gao Q, Xu J, Hou L, Wei C, Zhong H
PLoS pathogens 2024 Aug;20(8):e1012291
PLoS pathogens 2024 Aug;20(8):e1012291
β-Mangostin targets and suppresses glioma via STING activation and tumor-associated microglia polarization.
Yang Y, Luo X, Wang Y, Xu A, Peng L, Zhang X, Wang Z, Ying Y, Li K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117074
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117074
cGAS suppresses β-cell proliferation by a STING-independent but CEBPβ-dependent mechanism.
Cai Z, Yang Y, Zhong J, Ji Y, Li T, Luo J, Hu S, Luo H, Wu Y, Liu F, Zhang J
Metabolism: clinical and experimental 2024 Aug;157:155933
Metabolism: clinical and experimental 2024 Aug;157:155933
The WDR11 complex is a receptor for acidic-cluster-containing cargo proteins.
Deng H, Jia G, Li P, Tang Y, Zhao L, Yang Q, Zhao J, Wang J, Tu Y, Yong X, Zhang S, Mo X, Billadeau DD, Su Z, Jia D
Cell 2024 Aug 8;187(16):4272-4288.e20
Cell 2024 Aug 8;187(16):4272-4288.e20
Inhibition of cGAS attenuates neonatal hypoxic-ischemic encephalopathy via regulating microglia polarization and pyroptosis.
Shen H, Lu H, Mao L, Song L
Translational pediatrics 2024 Aug 31;13(8):1378-1394
Translational pediatrics 2024 Aug 31;13(8):1378-1394
STRAP upregulates antiviral innate immunity against PRV by targeting TBK1.
He W, Chang H, Li C, Wang C, Li L, Yang G, Chen J, Liu H
Virology journal 2024 Aug 24;21(1):197
Virology journal 2024 Aug 24;21(1):197
CDK4/6 Alters TBK1 Phosphorylation to Inhibit the STING Signaling Pathway in Prostate Cancer.
Li W, Guo F, Zeng R, Liang H, Wang Y, Xiong W, Wu H, Yang C, Jin X
Cancer research 2024 Aug 15;84(16):2588-2606
Cancer research 2024 Aug 15;84(16):2588-2606
Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding.
Li C, Wen J, Zhan X, Shi W, Ye X, Yao Q, Chen S, Zheng C, Wang X, Wen X, Xiao X, Wang Y, Bai Z
Chinese medicine 2024 Aug 15;19(1):107
Chinese medicine 2024 Aug 15;19(1):107
Activated STING-containing R-EVs from iPSC-derived MSCs promote antitumor immunity.
Qian L, Zhang Z, Zhang R, Zheng X, Xiao B, Zhang X, Wu Y, Chen Y, Zhang X, Zhou P, Fu Q, Kang T, Gao Y
Cancer letters 2024 Aug 10;597:217081
Cancer letters 2024 Aug 10;597:217081
Human Stimulator of Interferon Genes Promotes Rhinovirus C Replication in Mouse Cells In Vitro and In Vivo.
Goldstein ME, Ignacio MA, Loube JM, Whorton MR, Scull MA
Viruses 2024 Aug 10;16(8)
Viruses 2024 Aug 10;16(8)
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Apr;73(4):641-654
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Apr;73(4):641-654
Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS-STING signaling pathway.
Zhu W, Wang Y, Guan Y, Lu Y, Li Y, Sun L, Wang Y
Inflammopharmacology 2024 Apr;32(2):1113-1131
Inflammopharmacology 2024 Apr;32(2):1113-1131
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
Zhao QX, Yan SB, Wang F, Li XX, Shang GK, Zheng ZJ, Xiao J, Lin ZW, Li CB, Ji XP
Biochemical pharmacology 2024 Apr;222:116102
Biochemical pharmacology 2024 Apr;222:116102
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
Wang K, Wen Y, Fu X, Wei S, Liu S, Chen M
Free radical biology & medicine 2024 Apr;216:80-88
Free radical biology & medicine 2024 Apr;216:80-88
STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke.
Wu C, Zhang S, Sun H, Li A, Hou F, Qi L, Liao H
Journal of neuroinflammation 2024 Apr 8;21(1):86
Journal of neuroinflammation 2024 Apr 8;21(1):86
The activation of the AIM2 inflammasome after cigarette smoke exposure leads to an immunosuppressive lung microenvironment.
Colarusso C, Falanga A, Di Caprio S, Terlizzi M, Pinto A, Maiolino P, Sorrentino R
International immunopharmacology 2024 Apr 20;131:111832
International immunopharmacology 2024 Apr 20;131:111832
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway.
Li B, Xu L, Wang Z, Shi Q, Cui Y, Fan W, Wu Q, Tong X, Yan H
Cellular and molecular neurobiology 2024 Apr 18;44(1):36
Cellular and molecular neurobiology 2024 Apr 18;44(1):36
STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling.
Liu ZZ, Zhou CK, Lin XQ, Gao Y, Luo XY, Zhang JB, Yin Q, Zhang L, Zhang JG, An X, Chen W, Yang YJ
Veterinary research 2024 Apr 15;55(1):52
Veterinary research 2024 Apr 15;55(1):52
Deletion of MGF505-2R Gene Activates the cGAS-STING Pathway Leading to Attenuation and Protection against Virulent African Swine Fever Virus.
Sunwoo SY, García-Belmonte R, Walczak M, Vigara-Astillero G, Kim DM, Szymankiewicz K, Kochanowski M, Liu L, Tark D, Podgórska K, Revilla Y, Pérez-Núñez D
Vaccines 2024 Apr 11;12(4)
Vaccines 2024 Apr 11;12(4)
cGAS Activation Accelerates the Progression of Autosomal Dominant Polycystic Kidney Disease.
Yoo M, Haydak JC, Azeloglu EU, Lee K, Gusella GL
Journal of the American Society of Nephrology : JASN 2024 Apr 1;35(4):466-482
Journal of the American Society of Nephrology : JASN 2024 Apr 1;35(4):466-482
Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.
Peng M, Li X, Zhang X, Peng L
Experimental lung research 2023;49(1):86-100
Experimental lung research 2023;49(1):86-100
Cytosolic DNA sensing protein pathway is activated in human hearts with dilated cardiomyopathy.
Rouhi L, Cheedipudi SM, Cathcart B, Gurha P, Marian AJ
The journal of cardiovascular aging 2023;3(3)
The journal of cardiovascular aging 2023;3(3)
Autophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma.
Zheng R, Weng S, Xu J, Li Z, Wang Y, Aizimuaji Z, Ma S, Zheng L, Li H, Ying W, Rong W, Xiao T
Computational and structural biotechnology journal 2023;21:3564-3574
Computational and structural biotechnology journal 2023;21:3564-3574
Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity.
Sun X, Wang WJ, Lang J, Yang R, Shen WJ, Sun L, Hsu JM, Chan LC, Li CW, Xia W, Ke B, Yao G, Huang K, Lee PC, Koller PB, Hung MC
International journal of biological sciences 2023;19(14):4644-4656
International journal of biological sciences 2023;19(14):4644-4656
Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis.
Luo W, Xu G, Song Z, Mu W, Wen J, Hui S, Zhao J, Zhan X, Bai Z, Xiao X
Frontiers in pharmacology 2023;14:1160445
Frontiers in pharmacology 2023;14:1160445
MAVI1, an endoplasmic reticulum-localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion.
Shi TT, Huang Y, Li Y, Dai XL, He YH, Ding JC, Ran T, Shi Y, Yuan Q, Li WJ, Liu W
Science advances 2023 Sep;9(35):eadg7053
Science advances 2023 Sep;9(35):eadg7053
Moderate Intensity of Treadmill Exercise Rescues TBI-Induced Ferroptosis, Neurodegeneration, and Cognitive Impairments via Suppressing STING Pathway.
Chen J, Zhu T, Yu D, Yan B, Zhang Y, Jin J, Yang Z, Zhang B, Hao X, Chen Z, Yan C, Yu J
Molecular neurobiology 2023 Sep;60(9):4872-4896
Molecular neurobiology 2023 Sep;60(9):4872-4896
Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells.
Wu Z, Tang W, Ibrahim FEEM, Chen X, Yan H, Tao C, Wang Z, Guo Y, Fu Y, Wang Q, Ge Y
Neurochemical research 2023 Sep;48(9):2881-2894
Neurochemical research 2023 Sep;48(9):2881-2894
Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway.
Ding YY, Xu F, Wang YF, Han LL, Huang SQ, Zhao S, Ma LL, Zhang TH, Zhao WJ, Chen XD
Journal of integrative medicine 2023 Sep;21(5):496-508
Journal of integrative medicine 2023 Sep;21(5):496-508
DWL-4-140: A allene small molecule targeting STING that alleviates lupus-like phenotype in Trex1(-/-) mice.
Du H, Kou M, Deng W, Zhou X, Zhang X, Huang Z, Ren B, Cai X, Xu S, Chen Y, Chen L, Chen C, Bao H, Chen Q, Li D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115188
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115188
STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury.
Ni J, Guo T, Zhou Y, Jiang S, Zhang L, Zhu Z
Journal of translational medicine 2023 Sep 4;21(1):590
Journal of translational medicine 2023 Sep 4;21(1):590
4-Octyl itaconate restricts STING activation by blocking its palmitoylation.
Su C, Cheng T, Huang J, Zhang T, Yin H
Cell reports 2023 Sep 26;42(9):113040
Cell reports 2023 Sep 26;42(9):113040
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
Ouyang W, Wang S, Yan D, Wu J, Zhang Y, Li W, Hu J, Liu Z
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells.
Yang M, Delcroix V, Lennikov A, Wang N, Makarenkova HP, Dartt DA
The ocular surface 2023 Oct;30:263-275
The ocular surface 2023 Oct;30:263-275
Porcine IKKε is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway.
Luo J, Cao Q, Zhang J, Jiang S, Xia N, Sun S, Zheng W, Chen N, Meurens F, Zhu J
The Journal of biological chemistry 2023 Oct;299(10):105213
The Journal of biological chemistry 2023 Oct;299(10):105213
A sequential scheme including PTT and 2'3'-cGAMP/CQ-LP reveals the antitumor immune function of PTT through the type I interferon pathway.
Song X, Wang M, Liu S, Liu H, Jiang A, Zou Y, Deng Y, Qin Q, Song Y, Zheng Y
Pharmacological research 2023 Oct;196:106939
Pharmacological research 2023 Oct;196:106939
Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A.
Zhao X, Stein KR, Chen V, Griffin ME, Lairson LL, Hang HC
Nature chemical biology 2023 Oct;19(10):1205-1214
Nature chemical biology 2023 Oct;19(10):1205-1214
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Zhao C, Liang F, Ye M, Wu S, Qin Y, Zhao L, Zhang L, He J, Cen L, Lin F
Cell death discovery 2023 Oct 4;9(1):368
Cell death discovery 2023 Oct 4;9(1):368
Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice.
Yang L, Lu P, Qi X, Yang Q, Liu L, Dou T, Guan Q, Yu C
iScience 2023 Oct 20;26(10):108082
iScience 2023 Oct 20;26(10):108082
PAR2 deficiency tunes inflammatory microenvironment to magnify STING signalling for mitigating cancer metastasis via anionic CRISPR/Cas9 nanoparticles.
Fu X, Li J, Wu Y, Mao C, Jiang Y
Journal of controlled release : official journal of the Controlled Release Society 2023 Nov;363:733-746
Journal of controlled release : official journal of the Controlled Release Society 2023 Nov;363:733-746
The STING inhibitor C-176 attenuates MPTP-induced neuroinflammation and neurodegeneration in mouse parkinsonian models.
Wang B, Wang Y, Qiu J, Gao S, Yu S, Sun D, Lou H
International immunopharmacology 2023 Nov;124(Pt A):110827
International immunopharmacology 2023 Nov;124(Pt A):110827
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
Li LG, Yang XX, Xu HZ, Yu TT, Li QR, Hu J, Peng XC, Han N, Xu X, Chen NN, Chen X, Tang JM, Li TF
Advanced healthcare materials 2023 Nov;12(28):e2301561
Advanced healthcare materials 2023 Nov;12(28):e2301561
Regulation of STING activity in DNA sensing by ISG15 modification.
Lin C, Kuffour EO, Fuchs NV, Gertzen CGW, Kaiser J, Hirschenberger M, Tang X, Xu HC, Michel O, Tao R, Haase A, Martin U, Kurz T, Drexler I, Görg B, Lang PA, Luedde T, Sparrer KMJ, Gohlke H, König R, Münk C
Cell reports 2023 Nov 28;42(11):113277
Cell reports 2023 Nov 28;42(11):113277
PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling.
Lin Y, Yang J, Yang Q, Zeng S, Zhang J, Zhu Y, Tong Y, Li L, Tan W, Chen D, Sun Q
Nature communications 2023 Nov 21;14(1):7567
Nature communications 2023 Nov 21;14(1):7567
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
Jiang A, Liu J, Wang Y, Zhang C
Free radical biology & medicine 2023 Nov 1;208:516-529
Free radical biology & medicine 2023 Nov 1;208:516-529
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ
Nature communications 2023 Nov 1;14(1):6770
Nature communications 2023 Nov 1;14(1):6770
TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling.
Su W, Gao W, Zhang R, Wang Q, Li L, Bu Q, Xu Z, Liu Z, Wang M, Zhu Y, Wu G, Zhou H, Wang X, Lu L
JHEP reports : innovation in hepatology 2023 May;5(5):100695
JHEP reports : innovation in hepatology 2023 May;5(5):100695
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
Sun Z, Liu H, Hu Y, Luo G, Yuan Z, Tu B, Ruan H, Li J, Fan C
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
Ji Y, Luo Y, Wu Y, Sun Y, Zhao L, Xue Z, Sun M, Wei X, He Z, Wu SA, Lin LL, Lu Y, Chang L, Chen F, Chen S, Qian W, Xu X, Chen S, Pan D, Zhou Z, Xia S, Hu CA, Liang T, Qi L
Nature cell biology 2023 May;25(5):726-739
Nature cell biology 2023 May;25(5):726-739
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
Ma Z, Bai J, Jiang C, Zhu H, Liu D, Pan M, Wang X, Pi J, Jiang P, Liu X
Autophagy 2023 May;19(5):1512-1532
Autophagy 2023 May;19(5):1512-1532
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
Wen J, Qin S, Li Y, Zhang P, Zhan X, Fang M, Shi C, Mu W, Kan W, Zhao J, Hui S, Hou M, Li H, Xiao X, Xu G, Bai Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury.
Xu D, Yang F, Chen J, Zhu T, Wang F, Xiao Y, Liang Z, Bi L, Huang G, Jiang Z, Shan H, Li D
Acta pharmaceutica Sinica. B 2023 May;13(5):2124-2137
Acta pharmaceutica Sinica. B 2023 May;13(5):2124-2137
STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion.
Yang M, Jiang H, Ding C, Zhang L, Ding N, Li G, Zhang F, Wang J, Deng L, Liu J, Xu Y
Immunity 2023 May 9;56(5):1013-1026.e6
Immunity 2023 May 9;56(5):1013-1026.e6
ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.
Yi J, Wang L, Du J, Wang M, Shen H, Liu Z, Qin Y, Liu J, Hu G, Xiao R, Ding J, Chen X, Wang H, Huang H, Ouyang G, Liu W
Developmental cell 2023 May 8;58(9):760-778.e6
Developmental cell 2023 May 8;58(9):760-778.e6
Induction of Inflammation Disrupts the Negative Interplay between STING and S1P Axis That Is Observed during Physiological Conditions in the Lung.
Terlizzi M, Colarusso C, Falanga A, Somma P, De Rosa I, Panico L, Pinto A, Maiolino P, Sorrentino R
International journal of molecular sciences 2023 May 5;24(9)
International journal of molecular sciences 2023 May 5;24(9)
The mechanism of STING autoinhibition and activation.
Liu S, Yang B, Hou Y, Cui K, Yang X, Li X, Chen L, Liu S, Zhang Z, Jia Y, Xie Y, Xue Y, Li X, Yan B, Wu C, Deng W, Qi J, Lu D, Gao GF, Wang P, Shang G
Molecular cell 2023 May 4;83(9):1502-1518.e10
Molecular cell 2023 May 4;83(9):1502-1518.e10
STING mediates experimental osteoarthritis and mechanical allodynia in mouse.
Shin Y, Cho D, Kim SK, Chun JS
Arthritis research & therapy 2023 May 31;25(1):90
Arthritis research & therapy 2023 May 31;25(1):90
C9ORF72 suppresses JAK-STAT mediated inflammation.
Pang W, Hu F
iScience 2023 May 19;26(5):106579
iScience 2023 May 19;26(5):106579
The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.
Zhou X, Zhang H, Jiang Y, Wei L, Chen Y, Zhang J, Gao P, Zhu S, Fang C, Du Y, Su R, He M, Yu J, Wang S, Ding W, Feng L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22806
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22806
NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.
Zhao J, Zhen N, Zhou Q, Lou J, Cui W, Zhang G, Tian B
International journal of molecular sciences 2023 Mar 7;24(6)
International journal of molecular sciences 2023 Mar 7;24(6)
Flavonoid derivative DMXAA attenuates cisplatin-induced acute kidney injury independent of STING signaling.
Lu L, Liu W, Li S, Bai M, Zhou Y, Jiang Z, Jia Z, Huang S, Zhang A, Gong W
Clinical science (London, England : 1979) 2023 Mar 31;137(6):435-452
Clinical science (London, England : 1979) 2023 Mar 31;137(6):435-452
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING.
Li W, Li Y, Kang J, Jiang H, Gong W, Chen L, Wu C, Liu M, Wu X, Zhao Y, Ren J
Cell reports 2023 Mar 28;42(3):112145
Cell reports 2023 Mar 28;42(3):112145
Protocol using lentivirus to establish THP-1 suspension cell lines for immunostaining and confocal microscopy.
Ji W, Zhang L, Liu X
STAR protocols 2023 Mar 17;4(1):102032
STAR protocols 2023 Mar 17;4(1):102032
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
Fang R, Jiang Q, Jia X, Jiang Z
Immunity 2023 Mar 14;56(3):500-515.e6
Immunity 2023 Mar 14;56(3):500-515.e6
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Tang M, Chen G, Tu B, Hu Z, Huang Y, DuFort CC, Wan X, Mao Z, Liu Y, Zhu WG, Lu W
Science advances 2023 Jun 16;9(24):eade6624
Science advances 2023 Jun 16;9(24):eade6624
Protocol for the identification and expression analysis of a cytoplasmic membrane-localized protein STING.
Shi J, Liu C, Luo S, Zhang Y, Li M, Zhou M, Weng M, Li X, Zheng T
STAR protocols 2023 Jun 16;4(2):102172
STAR protocols 2023 Jun 16;4(2):102172
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
Qi J, Luo Q, Zhang Q, Wu M, Zhang L, Qin L, Xue Q, Nie X
Journal of ethnopharmacology 2023 Jun 12;309:116327
Journal of ethnopharmacology 2023 Jun 12;309:116327
Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS-STING Pathway.
Farris LC, Torres-Odio S, Adams LG, West AP, Hyde JA
Journal of immunology (Baltimore, Md. : 1950) 2023 Jun 1;210(11):1761-1770
Journal of immunology (Baltimore, Md. : 1950) 2023 Jun 1;210(11):1761-1770
STING deficiency protects against wasp venom-induced acute kidney injury.
Lv Y, Lu L, Yu F, Gao Z, Yuan H, Hu F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
Stimulator of interferon genes (STING) expression in the enteric nervous system and contributions of glial STING in disease.
Dharshika C, Gonzales J, Chow A, Morales-Soto W, Gulbransen BD
Neurogastroenterology and motility 2023 Jul;35(7):e14553
Neurogastroenterology and motility 2023 Jul;35(7):e14553
Murine Coronavirus Disease 2019 Lethality Is Characterized by Lymphoid Depletion Associated with Suppressed Antigen-Presenting Cell Functionality.
Lee YJ, Seok SH, Lee NY, Choi HJ, Lee YW, Chang HJ, Hwang JY, On DI, Noh HA, Lee SB, Kwon HK, Yun JW, Shin JS, Seo JY, Nam KT, Lee H, Lee HY, Park JW, Seong JK
The American journal of pathology 2023 Jul;193(7):866-882
The American journal of pathology 2023 Jul;193(7):866-882
Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.
Liu S, Gao X, Yin Y, Wang J, Dong K, Shi D, Wu X, Guo C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113844
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113844
RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis.
Zhang X, Wu J, Liu Q, Li X, Yang Y, Wu L, Wu X, Zhao Y, Ren J
Clinical and translational medicine 2023 Jul;13(7):e1334
Clinical and translational medicine 2023 Jul;13(7):e1334
Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer.
Viculin J, Degoricija M, Vilović K, Gabela I, Franković L, Vrdoljak E, Korac-Prlic J
Cancers 2023 Jul 5;15(13)
Cancers 2023 Jul 5;15(13)
Multiple Porcine Innate Immune Signaling Pathways Are Involved in the Anti-PEDV Response.
Zhang Y, Xu Y, Jiang S, Sun S, Zhang J, Luo J, Cao Q, Zheng W, Meurens F, Chen N, Zhu J
Viruses 2023 Jul 26;15(8)
Viruses 2023 Jul 26;15(8)
Effect of STING signaling on intestinal barrier damage in severe acute pancreatitis.
Zhang Y, Jiang Y, Li H, Wang J, Li C, Zhang D
Experimental cell research 2023 Jul 15;428(2):113630
Experimental cell research 2023 Jul 15;428(2):113630
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
Zhao J, Xu G, Hou X, Mu W, Yang H, Shi W, Wen J, Liu T, Wu Z, Bai J, Zhang P, Wang Z, Xiao X, Zou W, Bai Z, Zhan X
Journal of ethnopharmacology 2023 Jul 15;311:116427
Journal of ethnopharmacology 2023 Jul 15;311:116427
Yes-Associated Protein 1 Inhibition Induces Immunogenic Cell Death and Synergizes With Radiation and PD-1 Blockade.
Zhuang Y, Wang Y, Liu C, Li S, Du S, Li G
International journal of radiation oncology, biology, physics 2023 Jul 15;116(4):894-905
International journal of radiation oncology, biology, physics 2023 Jul 15;116(4):894-905
Regulation of Monocyte Activation by PPARα Through Interaction With the cGAS-STING Pathway.
Dong L, Cheng R, Ma X, Liang W, Hong Y, Li H, Zhou K, Du Y, Takahashi Y, Zhang X, Li XR, Ma JX
Diabetes 2023 Jul 1;72(7):958-972
Diabetes 2023 Jul 1;72(7):958-972
DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.
Lou M, Huang D, Zhou Z, Shi X, Wu M, Rui Y, Su J, Zheng W, Yu XF
Journal of medical virology 2023 Jan;95(1):e28310
Journal of medical virology 2023 Jan;95(1):e28310
Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain.
Zhang Y, Wang W, Gong Z, Peng Y, Li X, Zhang Z, Zhang X, You X, Wu J
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):117-132
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):117-132
cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
Li B, Wang W, Li Y, Wang S, Liu H, Xia Z, Gao W, Zhao B
Experimental neurology 2023 Jan;359:114269
Experimental neurology 2023 Jan;359:114269
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
Zheng M, Hu Z, Wang Y, Wang C, Zhong C, Cui W, You J, Gao B, Sun X, La L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS-STING Signaling Pathway.
Qi X, Wang J, Fei F, Gao X, Wu X, Shi D, Guo C
Molecular pharmaceutics 2023 Jan 2;20(1):136-146
Molecular pharmaceutics 2023 Jan 2;20(1):136-146
Inhibition of cGAS ameliorates acute lung injury triggered by zinc oxide nanoparticles.
Jiang Z, Jiang Y, Fan J, Zhang J, Xu G, Fan Y, Zhang L, Qin X, Jiang X, Mao L, Liu G, Chen C, Zou Z
Toxicology letters 2023 Jan 15;373:62-75
Toxicology letters 2023 Jan 15;373:62-75
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Gu S, Wu G, Lu D, Wang Y, Tang L, Zhang W
Toxicology letters 2023 Jan 15;373:172-183
Toxicology letters 2023 Jan 15;373:172-183
Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.
Wang J, Qin X, Huang Y, Zhang G, Liu Y, Cui Y, Wang Y, Pei J, Ma S, Song Z, Zhu X, Wang H, Yang B
Journal of virology 2023 Feb 28;97(2):e0197522
Journal of virology 2023 Feb 28;97(2):e0197522
African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation.
Cheng M, Kanyema MM, Sun Y, Zhao W, Lu Y, Wang J, Li X, Shi C, Wang J, Wang N, Yang W, Jiang Y, Huang H, Yang G, Zeng Y, Wang C, Cao X
Journal of virology 2023 Feb 28;97(2):e0192322
Journal of virology 2023 Feb 28;97(2):e0192322
Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner.
Sun S, Xu Y, Qiu M, Jiang S, Cao Q, Luo J, Zhang T, Chen N, Zheng W, Meurens F, Liu Z, Zhu J
Viruses 2023 Feb 28;15(3)
Viruses 2023 Feb 28;15(3)
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Proteomic analysis predicts anti-angiogenic resistance in recurred glioblastoma.
Jeon H, Byun J, Kang H, Kim K, Lee E, Kim JH, Hong CK, Song SW, Kim YH, Chong S, Kim JH, Nam SJ, Park JE, Lee S
Journal of translational medicine 2023 Feb 2;21(1):69
Journal of translational medicine 2023 Feb 2;21(1):69
NF-κB regulates the expression of STING via alternative promoter usage.
Chen LY, Pang XY, Chen C, Xu HG
Life sciences 2023 Feb 1;314:121336
Life sciences 2023 Feb 1;314:121336
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Yan SB, Liang H, Zhan P, Zheng H, Zhao QX, Zheng ZJ, Lu HX, Shang GK, Ji XP
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
Wen J, Mu W, Li H, Yan Y, Zhan X, Luo W, Wang Z, Kan W, Zhao J, Hui S, He P, Qin S, Xu Y, Zhang P, Xiao X, Xu G, Bai Z
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.
Zhang G, Jiang P, Tang W, Wang Y, Qiu F, An J, Zheng Y, Wu D, Zhou J, Neculai D, Shi Y, Sheng W
Molecular cell 2023 Dec 7;83(23):4370-4385.e9
Molecular cell 2023 Dec 7;83(23):4370-4385.e9
Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma.
Verhoeven J, Jacobs KA, Rizzollo F, Lodi F, Hua Y, Poźniak J, Narayanan Srinivasan A, Houbaert D, Shankar G, More S, Schaaf MB, Dubroja Lakic N, Ganne M, Lamote J, Van Weyenbergh J, Boon L, Bechter O, Bosisio F, Uchiyama Y, Bertrand MJ, Marine JC, Lambrechts D, Bergers G, Agrawal M, Agostinis P
EMBO molecular medicine 2023 Dec 7;15(12):e18028
EMBO molecular medicine 2023 Dec 7;15(12):e18028
RNF144A promotes antiviral responses by modulating STING ubiquitination.
Yang B, Pei J, Lu C, Wang Y, Shen M, Qin X, Huang Y, Yang X, Zhao X, Ma S, Song Z, Liang Y, Wang H, Wang J
EMBO reports 2023 Dec 6;24(12):e57528
EMBO reports 2023 Dec 6;24(12):e57528
STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats.
Ma L, Deng D, Zhang T, Zhao W, Liu C, Huang S, Xu F, Wang Y, Zhao S, Ding Y, Huang Y, Wang K, Zhang Y, Yang X, Cao S, Chen X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Aug;72(8):1551-1565
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Aug;72(8):1551-1565
Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress.
Chen X, Yu Z, Nong C, Xue R, Zhang M, Zhang Y, Sun L, Zhang L, Wang X
Cell biology and toxicology 2023 Aug;39(4):1753-1772
Cell biology and toxicology 2023 Aug;39(4):1753-1772
Naringin protects against inflammation and apoptosis induced by intestinal ischemia-reperfusion injury through deactivation of cGAS-STING signaling pathway.
Gu L, Wang F, Wang Y, Sun D, Sun Y, Tian T, Meng Q, Yin L, Xu L, Lu X, Peng J, Lin Y, Sun P
Phytotherapy research : PTR 2023 Aug;37(8):3495-3507
Phytotherapy research : PTR 2023 Aug;37(8):3495-3507
The innate immune sensor STING accelerates neointima formation via NF-κB signaling pathway.
He L, Liu D, Zhou W, Han Y, Ju Y, Liu H, Chen Y, Yu J, Wang L, Wang J, He C
International immunopharmacology 2023 Aug;121:110412
International immunopharmacology 2023 Aug;121:110412
Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway.
Wu X, Jiang Y, Li R, Xia Y, Li F, Zhao M, Li G, Tan X
Cell death & disease 2023 Aug 30;14(8):577
Cell death & disease 2023 Aug 30;14(8):577
Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy.
Liu Y, Chen X, Zhao Y, Wang XY, Luo YW, Chen L, Wang W, Zhong S, Hu M, Dai Z, Jiang J, Wang X, Ji H, Cheng XX, Zheng A, Zuo J, Liu H, Ma D, Luo Z, Cao F, Hu S, Huang AL, Tang KF
Cell reports 2023 Aug 29;42(8):112852
Cell reports 2023 Aug 29;42(8):112852
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
Liu Y, Sun Q, Zhang C, Ding M, Wang C, Zheng Q, Ma Z, Xu H, Zhou G, Wang X, Cheng Z, Xia H
iScience 2023 Aug 18;26(8):107376
iScience 2023 Aug 18;26(8):107376
A role of STING signaling in obesity-induced lung inflammation.
Qi Y, Wu Z, Chen D, Zhu L, Yang Y
International journal of obesity (2005) 2023 Apr;47(4):325-334
International journal of obesity (2005) 2023 Apr;47(4):325-334
The cGAS-STING pathway promotes endometriosis by up-regulating autophagy.
Zhu S, Chen Q, Sun J, Du W, Chen Z, Yu M, Tao J, Zhou Y, Zhao Y, Zhang Q
International immunopharmacology 2023 Apr;117:109644
International immunopharmacology 2023 Apr;117:109644
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Li J, Sun Y, Zhao X, Ma Y, Xie Y, Liu S, Hui B, Shi X, Sun X, Zhang X
Cell death & disease 2023 Apr 8;14(4):259
Cell death & disease 2023 Apr 8;14(4):259
The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1.
Diao F, Bai J, Jiang C, Sun Y, Gao Y, Nauwynck H, Jiang P, Liu X
Journal of virology 2023 Apr 27;97(4):e0018823
Journal of virology 2023 Apr 27;97(4):e0018823
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
Ji W, Zhang L, Ma C, Xu X, Li S, Xia H, Zhou W, Liu X
Cell reports 2023 Apr 25;42(4):112327
Cell reports 2023 Apr 25;42(4):112327
STING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy.
Wan W, Qian C, Wang Q, Li J, Zhang H, Wang L, Pu M, Huang Y, He Z, Zhou T, Shen HM, Liu W
The EMBO journal 2023 Apr 17;42(8):e112387
The EMBO journal 2023 Apr 17;42(8):e112387
Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells.
Lazarchuk P, Nguyen VN, Brunon S, Pavlova MN, Sidorova JM
Frontiers in molecular biosciences 2022;9:1048726
Frontiers in molecular biosciences 2022;9:1048726
STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages.
Wu XY, Chen YJ, Liu CA, Gong JH, Xu XS
Oxidative medicine and cellular longevity 2022;2022:8123157
Oxidative medicine and cellular longevity 2022;2022:8123157
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
He X, Xiao Y, Liu S, Deng R, Li Z, Zhu X
BioMed research international 2022;2022:3191474
BioMed research international 2022;2022:3191474
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
Kang N, Shi Y, Song J, Gao F, Fan M, Jin W, Gao Y, Lv P
Frontiers in aging neuroscience 2022;14:868484
Frontiers in aging neuroscience 2022;14:868484
African Swine Fever Virus Structural Protein p17 Inhibits cGAS-STING Signaling Pathway Through Interacting With STING.
Zheng W, Xia N, Zhang J, Cao Q, Jiang S, Luo J, Wang H, Chen N, Zhang Q, Meurens F, Zhu J
Frontiers in immunology 2022;13:941579
Frontiers in immunology 2022;13:941579
The Absence of STING Ameliorates Non-Alcoholic Fatty Liver Disease and Reforms Gut Bacterial Community.
Zhang Q, Chen Q, Yan C, Niu C, Zhou J, Liu J, Song Y, Zhou F, Fan Y, Ren J, Xu H, Zhang B
Frontiers in immunology 2022;13:931176
Frontiers in immunology 2022;13:931176
Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING.
Yu TT, Han N, Li LG, Peng XC, Li QR, Xu HZ, Wang XY, Yang ZY, Chen X, Wang MF, Li TF
Frontiers in pharmacology 2022;13:837784
Frontiers in pharmacology 2022;13:837784
Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis.
Xia N, Zheng W, Jiang S, Cao Q, Luo J, Zhang J, Xu Y, Sun S, Zhang K, Chen N, Meurens F, Zhu J
Frontiers in immunology 2022;13:1021384
Frontiers in immunology 2022;13:1021384
Deficient DNASE1L3 facilitates neutrophil extracellular traps-induced invasion via cyclic GMP-AMP synthase and the non-canonical NF-κB pathway in diabetic hepatocellular carcinoma.
Li N, Zheng X, Chen M, Huang L, Chen L, Huo R, Li X, Huang Y, Sun M, Mai S, Wu Z, Zhang H, Liu J, Yang CT
Clinical & translational immunology 2022;11(4):e1386
Clinical & translational immunology 2022;11(4):e1386
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Zhao X, Yu M, Zhao Y, Zheng Y, Meng L, Du K, Xie Z, Lv H, Zhang W, Liu J, Wang Q, Yuan Y, Wang Z, Deng J
Journal of neurology 2022 Sep;269(9):4985-4996
Journal of neurology 2022 Sep;269(9):4985-4996
Human Atheromatous Plaques Expressed Sensing Adaptor STING, a Potential Role in Vascular Inflammation Pathogenesis.
Pallarés J, Torreguitart N, Arqué G, Portero-Otin M, Purroy F
Thrombosis and haemostasis 2022 Sep;122(9):1621-1624
Thrombosis and haemostasis 2022 Sep;122(9):1621-1624
Clathrin-associated AP-1 controls termination of STING signalling.
Liu Y, Xu P, Rivara S, Liu C, Ricci J, Ren X, Hurley JH, Ablasser A
Nature 2022 Oct;610(7933):761-767
Nature 2022 Oct;610(7933):761-767
Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.
Zhou M, Cheng X, Zhu W, Jiang J, Zhu S, Wu X, Liu M, Fang Q
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631
BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma.
Langbein LE, El Hajjar R, He S, Sementino E, Zhong Z, Jiang W, Leiby BE, Li L, Uzzo RG, Testa JR, Yang H
Cancer letters 2022 Oct 28;547:215885
Cancer letters 2022 Oct 28;547:215885
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways.
Zhuang X, Ma J, Xu G, Sun Z
Molecular medicine (Cambridge, Mass.) 2022 Oct 22;28(1):125
Molecular medicine (Cambridge, Mass.) 2022 Oct 22;28(1):125
STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal Cortex.
Zhang X, Li X, Wang W, Zhang Y, Gong Z, Peng Y, Wu J, You X
Cancers 2022 Oct 22;14(21)
Cancers 2022 Oct 22;14(21)
Baicalein-loaded silk fibroin peptide nanofibers protect against cisplatin-induced acute kidney injury: Fabrication, characterization and mechanism.
Liu S, Gao X, Wang Y, Wang J, Qi X, Dong K, Shi D, Wu X, Guo C
International journal of pharmaceutics 2022 Oct 15;626:122161
International journal of pharmaceutics 2022 Oct 15;626:122161
Pharmacological inhibition of the cGAS-STING signaling pathway suppresses microglial M1-polarization in the spinal cord and attenuates neuropathic pain.
Wu W, Zhang X, Wang S, Li T, Hao Q, Li S, Yao W, Sun R
Neuropharmacology 2022 Oct 1;217:109206
Neuropharmacology 2022 Oct 1;217:109206
SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy.
Han L, Zheng Y, Deng J, Nan ML, Xiao Y, Zhuang MW, Zhang J, Wang W, Gao C, Wang PH
Journal of medical virology 2022 Nov;94(11):5174-5188
Journal of medical virology 2022 Nov;94(11):5174-5188
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.
Han C, Qian X, Ren X, Zhang S, Hu L, Li J, Huang Y, Huang R, Ooi K, Lin H, Xia C
Molecular neurobiology 2022 Nov;59(11):7006-7024
Molecular neurobiology 2022 Nov;59(11):7006-7024
Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment.
Xu A, Yang R, Zhang M, Wang X, Di Y, Jiang B, Di Y, Zhou Z, Zhou L
Journal of drug targeting 2022 Nov;30(9):961-972
Journal of drug targeting 2022 Nov;30(9):961-972
HIV-1-induced type I IFNs promote viral latency in macrophages.
Dickey LL, Martins LJ, Planelles V, Hanley TM
Journal of leukocyte biology 2022 Nov;112(5):1343-1356
Journal of leukocyte biology 2022 Nov;112(5):1343-1356
UNC13D inhibits STING signaling by attenuating its oligomerization on the endoplasmic reticulum.
Song P, Yang W, Lou KF, Dong H, Zhang H, Wang B, Chen D
EMBO reports 2022 Nov 7;23(11):e55099
EMBO reports 2022 Nov 7;23(11):e55099
Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity.
Liu W, Alameh MG, Yang JF, Xu JR, Lin PJC, Tam YK, Weissman D, You J
International journal of molecular sciences 2022 Nov 22;23(23)
International journal of molecular sciences 2022 Nov 22;23(23)
The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages.
Caiazza C, Brusco T, D'Alessio F, D'Agostino M, Avagliano A, Arcucci A, Ambrosino C, Fiume G, Mallardo M
International journal of molecular sciences 2022 Nov 17;23(22)
International journal of molecular sciences 2022 Nov 17;23(22)
Interruption of post-Golgi STING trafficking activates tonic interferon signaling.
Tu X, Chu TT, Jeltema D, Abbott K, Yang K, Xing C, Han J, Dobbs N, Yan N
Nature communications 2022 Nov 15;13(1):6977
Nature communications 2022 Nov 15;13(1):6977
cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress.
Hu H, Zhao R, He Q, Cui C, Song J, Guo X, Zang N, Yang M, Zou Y, Yang J, Li J, Wang L, Xia L, Wang L, He F, Hou X, Yan F, Chen L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22266
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22266
Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity.
Kong Z, Yin H, Wang F, Liu Z, Luan X, Sun L, Liu W, Shang Y
PLoS pathogens 2022 May;18(5):e1010544
PLoS pathogens 2022 May;18(5):e1010544
SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Song C, Liu D, Liu S, Li D, Horecny I, Zhang X, Li P, Chen L, Miller M, Chowdhury R, Issa M, Shen R, Yan Y, Zhang F, Zhang L, Zhang L, Bai C, Feng J, Zhuang L, Zhang R, Li J, Wilkinson H, Liu J, Tao W
Scientific reports 2022 May 20;12(1):8579
Scientific reports 2022 May 20;12(1):8579
Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy.
Liu J, Yuan L, Ruan Y, Deng B, Yang Z, Ren Y, Li L, Liu T, Zhao H, Mai R, Chen J
Journal of medicinal chemistry 2022 May 12;65(9):6593-6611
Journal of medicinal chemistry 2022 May 12;65(9):6593-6611
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Shen R, Yang K, Cheng X, Guo C, Xing X, Sun H, Liu D, Liu X, Wang D
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment.
Xiong H, Chen Z, Lin B, Chen W, Li Q, Li Y, Fang M, Wang Y, Zhang H, Lu Y, Bi A, Wu S, Jia Y, Wang X
Molecular therapy oncolytics 2022 Mar 17;24:371-384
Molecular therapy oncolytics 2022 Mar 17;24:371-384
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury.
Liu Z, Wang M, Wang X, Bu Q, Wang Q, Su W, Li L, Zhou H, Lu L
Redox biology 2022 Jun;52:102305
Redox biology 2022 Jun;52:102305
STING activation promotes inflammatory response and delays skin wound healing in diabetic mice.
Feng Z, Zang C, Zhang L, Yin S, Zhuang Q, Wang X
Biochemical and biophysical research communications 2022 Jun 30;611:126-131
Biochemical and biophysical research communications 2022 Jun 30;611:126-131
ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
Shi C, Yang X, Liu Y, Li H, Chu H, Li G, Yin H
The EMBO journal 2022 Jun 1;41(11):e109272
The EMBO journal 2022 Jun 1;41(11):e109272
GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
Xu H, Jin J, Chen Y, Wu G, Zhu H, Wang Q, Wang J, Li S, Grigore FN, Ma J, Chen CC, Lan Q, Li M
Oncogene 2022 Jul;41(31):3876-3885
Oncogene 2022 Jul;41(31):3876-3885
1,25(OH)(2) D(3) blocks IFNβ production through regulating STING in epithelial layer of oral lichen planus.
Ge X, Wang Y, Xie H, Li R, Zhang F, Zhao B, Du J
Journal of cellular and molecular medicine 2022 Jul;26(13):3751-3759
Journal of cellular and molecular medicine 2022 Jul;26(13):3751-3759
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
Wu J, Liu Q, Zhang X, Tan M, Li X, Liu P, Wu L, Jiao F, Lin Z, Wu X, Wang X, Zhao Y, Ren J
Cell death & disease 2022 Jul 28;13(7):653
Cell death & disease 2022 Jul 28;13(7):653
STING expression is an independent prognostic factor in patients with mycosis fungoides.
Takayanagi-Hara R, Sawada Y, Sugino H, Minokawa Y, Kawahara-Nanamori H, Itamura M, Tashiro T, Kaneoka A, Saito-Sasaki N, Yamamoto K, Okada E
Scientific reports 2022 Jul 26;12(1):12739
Scientific reports 2022 Jul 26;12(1):12739
The Porcine and Chicken Innate DNA Sensing cGAS-STING-IRF Signaling Axes Exhibit Differential Species Specificity.
Jiang S, Luo J, Zhang Y, Cao Q, Wang Y, Xia N, Zheng W, Chen N, Meurens F, Wu H, Zhu J
Journal of immunology (Baltimore, Md. : 1950) 2022 Jul 15;209(2):412-426
Journal of immunology (Baltimore, Md. : 1950) 2022 Jul 15;209(2):412-426
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.
Lee KM, Lin CC, Servetto A, Bae J, Kandagatla V, Ye D, Kim G, Sudhan DR, Mendiratta S, González Ericsson PI, Balko JM, Lee J, Barnes S, Malladi VS, Tabrizi S, Reddy SM, Yum S, Chang CW, Hutchinson KE, Yost SE, Yuan Y, Chen ZJ, Fu YX, Hanker AB, Arteaga CL
Cancer immunology research 2022 Jul 1;10(7):829-843
Cancer immunology research 2022 Jul 1;10(7):829-843
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium.
Gagliardi TB, Goldstein ME, Song D, Gray KM, Jung JW, Ignacio MA, Stroka KM, Duncan GA, Scull MA
PLoS pathogens 2022 Jan;18(1):e1010159
PLoS pathogens 2022 Jan;18(1):e1010159
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics.
Gao J, Wu Z, Zhao M, Zhang R, Li M, Sun D, Cheng H, Qi X, Shen Y, Xu Q, Chen H, Chen D, Sun Y
Acta pharmaceutica Sinica. B 2022 Jan;12(1):149-166
Acta pharmaceutica Sinica. B 2022 Jan;12(1):149-166
CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T(H)1 and T(H)9 cells.
Benoit-Lizon I, Jacquin E, Rivera Vargas T, Richard C, Roussey A, Dal Zuffo L, Martin T, Melis A, Vinokurova D, Shahoei SH, Baeza Garcia A, Pignol C, Giorgiutti S, Carapito R, Boidot R, Végran F, Flavell RA, Ryffel B, Nelson ER, Soulas-Sprauel P, Lawrence T, Apetoh L
Journal for immunotherapy of cancer 2022 Jan;10(1)
Journal for immunotherapy of cancer 2022 Jan;10(1)
Helicobacter pylori actively suppresses innate immune nucleic acid receptors.
Dooyema SDR, Noto JM, Wroblewski LE, Piazuelo MB, Krishna U, Suarez G, Romero-Gallo J, Delgado AG, Peek RM
Gut microbes 2022 Jan-Dec;14(1):2105102
Gut microbes 2022 Jan-Dec;14(1):2105102
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
Li S, Qian N, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan X
Nature communications 2022 Jan 10;13(1):105
Nature communications 2022 Jan 10;13(1):105
The cGAS-STING pathway connects mitochondrial damage to inflammation in burn-induced acute lung injury in rat.
Comish PB, Liu MM, Huebinger R, Carlson D, Kang R, Tang D
Burns : journal of the International Society for Burn Injuries 2022 Feb;48(1):168-175
Burns : journal of the International Society for Burn Injuries 2022 Feb;48(1):168-175
STING-mediated inflammation contributes to Gao binge ethanol feeding model.
Wang L, You HM, Meng HW, Pan XY, Chen X, Bi YH, Zhang YF, Li JJ, Yin NN, Zhang ZW, Huang C, Li J
Journal of cellular physiology 2022 Feb;237(2):1471-1485
Journal of cellular physiology 2022 Feb;237(2):1471-1485
Molecular cloning and functional analysis of Macaca mulatta STING.
Zhao M, Zhang H, Sha H, Li H, Wang R
Developmental and comparative immunology 2022 Feb;127:104296
Developmental and comparative immunology 2022 Feb;127:104296
Sustained IL-4 priming of macrophages enhances the inflammatory response to TLR7/8 ligand R848.
Banete A, Gee K, Basta S
Journal of leukocyte biology 2022 Feb;111(2):401-413
Journal of leukocyte biology 2022 Feb;111(2):401-413
Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
Jie X, Chen Y, Zhao Y, Yang X, Xu Y, Wang J, Meng R, Zhang S, Dong X, Zhang T, Yang K, Xu S, Wu G
Journal for immunotherapy of cancer 2022 Feb;10(2)
Journal for immunotherapy of cancer 2022 Feb;10(2)
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP.
Li X, Zhu Y, Zhang X, An X, Weng M, Shi J, Wang S, Liu C, Luo S, Zheng T
The Journal of clinical investigation 2022 Feb 1;132(3)
The Journal of clinical investigation 2022 Feb 1;132(3)
ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation.
Meng J, Cai H, Sun Y, Wen S, Wu H, Ren D
Cellular oncology (Dordrecht, Netherlands) 2022 Dec;45(6):1421-1434
Cellular oncology (Dordrecht, Netherlands) 2022 Dec;45(6):1421-1434
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
Gao Y, Zheng X, Chang B, Lin Y, Huang X, Wang W, Ding S, Zhan W, Wang S, Xiao B, Huo L, Yu Y, Chen Y, Gong R, Wu Y, Zhang R, Zhong L, Wang X, Chen Q, Gao S, Jiang Z, Wei D, Kang T
Cell research 2022 Dec;32(12):1086-1104
Cell research 2022 Dec;32(12):1086-1104
DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients.
Vasiyani H, Mane M, Rana K, Shinde A, Roy M, Singh J, Gohel D, Currim F, Srivastava R, Singh R
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):961-978
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):961-978
Expression of STING Is Increased in Monocyte-Derived Macrophages and Contributes to Liver Inflammation in Hepatic Ischemia-Reperfusion Injury.
Jiao J, Jiang Y, Qian Y, Liu G, Xu M, Wang F, Sun X, Gao Y, Su L, Shi Y, Kong X
The American journal of pathology 2022 Dec;192(12):1745-1762
The American journal of pathology 2022 Dec;192(12):1745-1762
The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε.
Luo J, Zhang J, Ni J, Jiang S, Xia N, Guo Y, Shao Q, Cao Q, Zheng W, Chen N, Zhang Q, Chen H, Chen Q, Zhu H, Meurens F, Zhu J
Virulence 2022 Dec;13(1):740-756
Virulence 2022 Dec;13(1):740-756
Mitochondrial cristae architecture protects against mtDNA release and inflammation.
He B, Yu H, Liu S, Wan H, Fu S, Liu S, Yang J, Zhang Z, Huang H, Li Q, Wang F, Jiang Z, Liu Q, Jiang H
Cell reports 2022 Dec 6;41(10):111774
Cell reports 2022 Dec 6;41(10):111774
Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer.
Kunac N, Degoricija M, Viculin J, Omerović J, Terzić J, Vilović K, Korac-Prlic J
Cancers 2022 Dec 30;15(1)
Cancers 2022 Dec 30;15(1)
The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy.
Jiang S, Xia N, Luo J, Zhang Y, Cao Q, Zhang J, Wang Y, Zhao Y, Zheng W, Chen N, Meurens F, Li X, Zhu J
Journal of virology 2022 Dec 14;96(23):e0147622
Journal of virology 2022 Dec 14;96(23):e0147622
MPYS Modulates Fatty Acid Metabolism and Immune Tolerance at Homeostasis Independent of Type I IFNs.
Mansouri S, Gogoi H, Patel S, Katikaneni DS, Singh A, Aybar-Torres A, de Lartigue G, Jin L
Journal of immunology (Baltimore, Md. : 1950) 2022 Dec 1;209(11):2114-2132
Journal of immunology (Baltimore, Md. : 1950) 2022 Dec 1;209(11):2114-2132
Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction.
Yu H, Liao K, Hu Y, Lv D, Luo M, Liu Q, Huang L, Luo S
Aging and disease 2022 Dec 1;13(6):1901-1918
Aging and disease 2022 Dec 1;13(6):1901-1918
Irradiation combined with PD-L1(-/-) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation.
Zhao X, Hu S, Zeng L, Liu X, Song Y, Zhang Y, Chen Q, Bai Y, Zhang J, Zhang H, Pan Y, Shao C
iScience 2022 Aug 19;25(8):104690
iScience 2022 Aug 19;25(8):104690
New mechanism of nephrotoxicity of triptolide: Oxidative stress promotes cGAS-STING signaling pathway.
Lu J, Zhang Y, Dong H, Sun J, Zhu L, Liu P, Wen F, Lin R
Free radical biology & medicine 2022 Aug 1;188:26-34
Free radical biology & medicine 2022 Aug 1;188:26-34
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q
Autophagy 2022 Apr;18(4):860-876
Autophagy 2022 Apr;18(4):860-876
Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer.
Yu TT, Peng XC, Wang MF, Han N, Xu HZ, Li QR, Li LG, Xu X, Ma QL, Liu B, Wang J, Zhao L, Chen X, Li TF
Journal of cancer research and clinical oncology 2022 Apr;148(4):867-879
Journal of cancer research and clinical oncology 2022 Apr;148(4):867-879
Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling.
Liu K, Zhao X, Guo M, Zhu J, Li D, Ding J, Han X, Wu J
Toxicology letters 2022 Apr 1;358:6-16
Toxicology letters 2022 Apr 1;358:6-16
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Yang B, Zhang G, Qin X, Huang Y, Ren X, Sun J, Ma S, Liu Y, Song D, Liu Y, Cui Y, Wang H, Wang J
Frontiers in immunology 2021;12:730483
Frontiers in immunology 2021;12:730483
Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production.
Li R, Liu W, Yin X, Zheng F, Wang Z, Wu X, Zhang X, Du Q, Huang Y, Tong D
Frontiers in microbiology 2021;12:702881
Frontiers in microbiology 2021;12:702881
STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis.
Liu ZZ, Yang YJ, Zhou CK, Yan SQ, Ma K, Gao Y, Chen W
Frontiers in immunology 2021;12:636861
Frontiers in immunology 2021;12:636861
Activation of the cGAS-STING signaling pathway in adenomyosis patients.
Lin Y, Wang L, Ye M, Yu KN, Sun X, Xue M, Deng X
Immunity, inflammation and disease 2021 Sep;9(3):932-942
Immunity, inflammation and disease 2021 Sep;9(3):932-942
Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma.
Li TF, Xu HZ, Xu YH, Yu TT, Tang JM, Li K, Wang C, Peng XC, Li QR, Sang XY, Zheng MY, Liu Y, Zhao L, Chen X
Molecular pharmaceutics 2021 Sep 6;18(9):3601-3615
Molecular pharmaceutics 2021 Sep 6;18(9):3601-3615
Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.
Yuan SJ, Wang C, Xu HZ, Liu Y, Zheng MY, Li K, Sun SK, Komatsu N, Zhao L, Chen X
International journal of pharmaceutics 2021 Sep 5;606:120872
International journal of pharmaceutics 2021 Sep 5;606:120872
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
Chen A, Yang F, Kuang J, Xiong Y, Mi BB, Zhou Y, Hu JJ, Song SJ, Wan T, Wan ZZ, Huang HY, Li XR, Song W, Qiu WX
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function.
Xu Y, Zhang Y, Sun S, Luo J, Jiang S, Zhang J, Liu X, Shao Q, Cao Q, Zheng W, Chen N, Meurens F, Zhu J
Viruses 2021 Sep 14;13(9)
Viruses 2021 Sep 14;13(9)
Screening of Porcine Innate Immune Adaptor Signaling Revealed Several Anti-PRRSV Signaling Pathways.
Xu Y, Ye M, Zhang Y, Sun S, Luo J, Jiang S, Zhang J, Liu X, Shao Q, Cao Q, Zheng W, Meurens F, Chen N, Zhu J
Vaccines 2021 Oct 14;9(10)
Vaccines 2021 Oct 14;9(10)
eccDNAs are apoptotic products with high innate immunostimulatory activity.
Wang Y, Wang M, Djekidel MN, Chen H, Liu D, Alt FW, Zhang Y
Nature 2021 Nov;599(7884):308-314
Nature 2021 Nov;599(7884):308-314
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection.
Liu W, Reyes HM, Yang JF, Li Y, Stewart KM, Basil MC, Lin SM, Katzen J, Morrisey EE, Weiss SR, You J
Journal of virology 2021 May 24;95(12)
Journal of virology 2021 May 24;95(12)
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Hou J, Han L, Zhao Z, Liu H, Zhang L, Ma C, Yi F, Liu B, Zheng Y, Gao C
Nature communications 2021 May 20;12(1):2970
Nature communications 2021 May 20;12(1):2970
Pharmacological activation of STING blocks SARS-CoV-2 infection.
Li M, Ferretti M, Ying B, Descamps H, Lee E, Dittmar M, Lee JS, Whig K, Kamalia B, Dohnalová L, Uhr G, Zarkoob H, Chen YC, Ramage H, Ferrer M, Lynch K, Schultz DC, Thaiss CA, Diamond MS, Cherry S
Science immunology 2021 May 18;6(59)
Science immunology 2021 May 18;6(59)
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Ma D, Yang M, Wang Q, Sun C, Shi H, Jing W, Bi Y, Shen X, Ma X, Qin Z, Lin Y, Zhu L, Zhao Y, Cheng Y, Han L
Science advances 2021 Mar;7(13)
Science advances 2021 Mar;7(13)
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Zhou Y, Zhao S, Gao X, Jiang S, Ma J, Wang R, Li Q, Qin L, Tong Z, Wu J, Zhao J
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine.
Mai J, Li Z, Xia X, Zhang J, Li J, Liu H, Shen J, Ramirez M, Li F, Li Z, Yokoi K, Liu X, Mittendorf EA, Ferrari M, Shen H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jun;8(12):2100166
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jun;8(12):2100166
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells.
Vasiyani H, Shinde A, Roy M, Mane M, Singh K, Singh J, Gohel D, Currim F, Vaidya K, Chhabria M, Singh R
Apoptosis : an international journal on programmed cell death 2021 Jun;26(5-6):293-306
Apoptosis : an international journal on programmed cell death 2021 Jun;26(5-6):293-306
A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation.
Takahashi K, Niki T, Ogawa E, Fumika K, Nishioka Y, Sawa M, Arai H, Mukai K, Taguchi T
Scientific reports 2021 Jun 7;11(1):11996
Scientific reports 2021 Jun 7;11(1):11996
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Friesen O, Wu W, Stuhldreier F, Sun Y, Berning L, Friedrich A, Mendiburo MJ, Peter C, Wiek C, Hanenberg H, Stefanski A, Stühler K, Stork B
Scientific reports 2021 Jul 5;11(1):13863
Scientific reports 2021 Jul 5;11(1):13863
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Experimental eye research 2021 Jan;202:108366
Experimental eye research 2021 Jan;202:108366
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Sun H, Huang Y, Mei S, Xu F, Liu X, Zhao F, Yin L, Zhang D, Wei L, Wu C, Ma S, Wang J, Cen S, Liang C, Hu S, Guo F
Cell reports 2021 Jan 5;34(1):108586
Cell reports 2021 Jan 5;34(1):108586
USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells.
Lu R, Wu G, Chen M, Ji D, Liu Y, Zhou GG, Fu W
Molecular therapy oncolytics 2021 Dec 17;23:477-487
Molecular therapy oncolytics 2021 Dec 17;23:477-487
ALG2 regulates type I interferon responses by inhibiting STING trafficking.
Ji W, Zhang L, Xu X, Liu X
Journal of cell science 2021 Dec 15;134(24)
Journal of cell science 2021 Dec 15;134(24)
Chromosome aberrations induced by the non-mutagenic carcinogen acetamide involve in rat hepatocarcinogenesis through micronucleus formation in hepatocytes.
Nakamura K, Ishii Y, Takasu S, Nohmi T, Shibutani M, Ogawa K
Archives of toxicology 2021 Aug;95(8):2851-2865
Archives of toxicology 2021 Aug;95(8):2851-2865
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N
Nature 2021 Aug;596(7873):570-575
Nature 2021 Aug;596(7873):570-575
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease.
Zhao M, Wang B, Zhang C, Su Z, Guo B, Zhao Y, Zheng R
Cell death and differentiation 2021 Aug;28(8):2517-2535
Cell death and differentiation 2021 Aug;28(8):2517-2535
Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.
Zhao F, Zheng T, Gong W, Wu J, Xie H, Li W, Zhang R, Liu P, Liu J, Wu X, Zhao Y, Ren J
Cell death & disease 2021 Aug 27;12(9):815
Cell death & disease 2021 Aug 27;12(9):815
Transfected DNA is targeted by STING-mediated restriction.
Gu C, Ming L, Tao S, Luo M, Guo H, Xie Y, Liu J, Shen Z
Biochemical and biophysical research communications 2021 Apr 16;549:207-213
Biochemical and biophysical research communications 2021 Apr 16;549:207-213
Mutant p53 suppresses innate immune signaling to promote tumorigenesis.
Ghosh M, Saha S, Bettke J, Nagar R, Parrales A, Iwakuma T, van der Velden AWM, Martinez LA
Cancer cell 2021 Apr 12;39(4):494-508.e5
Cancer cell 2021 Apr 12;39(4):494-508.e5
The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction.
Gong W, Lu L, Zhou Y, Liu J, Ma H, Fu L, Huang S, Zhang Y, Zhang A, Jia Z
American journal of physiology. Renal physiology 2021 Apr 1;320(4):F608-F616
American journal of physiology. Renal physiology 2021 Apr 1;320(4):F608-F616
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Ren D, Qin G, Zhao J, Sun Y, Zhang B, Li D, Wang B, Jin X, Wu H
American journal of cancer research 2020;10(9):2851-2864
American journal of cancer research 2020;10(9):2851-2864
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.
Li W, Luo Z, Yan CY, Wang XH, He ZJ, Ouyang SH, Yan C, Liu LF, Zhou QQ, Mu HL, Gong HB, Duan WJ, Liang L, Kurihara H, Feng D, Li YF, He RR
Theranostics 2020;10(20):9032-9049
Theranostics 2020;10(20):9032-9049
Long non-coding RNA MALAT1 targeting STING transcription promotes bronchopulmonary dysplasia through regulation of CREB.
Chen JH, Feng DD, Chen YF, Yang CX, Juan CX, Cao Q, Chen X, Liu S, Zhou GP
Journal of cellular and molecular medicine 2020 Sep;24(18):10478-10492
Journal of cellular and molecular medicine 2020 Sep;24(18):10478-10492
Reactive oxygen species oxidize STING and suppress interferon production.
Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, Reese TA
eLife 2020 Sep 4;9
eLife 2020 Sep 4;9
Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells.
Guo Y, Gu R, Gan D, Hu F, Li G, Xu G
Cell communication and signaling : CCS 2020 Oct 28;18(1):172
Cell communication and signaling : CCS 2020 Oct 28;18(1):172
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C.
McKnight KL, Swanson KV, Austgen K, Richards C, Mitchell JK, McGivern DR, Fritch E, Johnson J, Remlinger K, Magid-Slav M, Kapustina M, You S, Lemon SM
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27598-27607
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27598-27607
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.
Peng Y, Zhuang J, Ying G, Zeng H, Zhou H, Cao Y, Chen H, Xu C, Fu X, Xu H, Li J, Cao S, Chen J, Gu C, Yan F, Chen G
Journal of neuroinflammation 2020 May 25;17(1):165
Journal of neuroinflammation 2020 May 25;17(1):165
RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
Yang B, Liu Y, Cui Y, Song D, Zhang G, Ma S, Liu Y, Chen M, Chen F, Wang H, Wang J
PLoS pathogens 2020 Mar;16(3):e1008387
PLoS pathogens 2020 Mar;16(3):e1008387
SPHK2-Generated S1P in CD11b(+) Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages.
Joshi JC, Joshi B, Rochford I, Rayees S, Akhter MZ, Baweja S, Chava KR, Tauseef M, Abdelkarim H, Natarajan V, Gaponenko V, Mehta D
Cell reports 2020 Mar 24;30(12):4096-4109.e5
Cell reports 2020 Mar 24;30(12):4096-4109.e5
Redox homeostasis maintained by GPX4 facilitates STING activation.
Jia M, Qin D, Zhao C, Chai L, Yu Z, Wang W, Tong L, Lv L, Wang Y, Rehwinkel J, Yu J, Zhao W
Nature immunology 2020 Jul;21(7):727-735
Nature immunology 2020 Jul;21(7):727-735
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo.
Yamashiro LH, Wilson SC, Morrison HM, Karalis V, Chung JJ, Chen KJ, Bateup HS, Szpara ML, Lee AY, Cox JS, Vance RE
Nature communications 2020 Jul 7;11(1):3382
Nature communications 2020 Jul 7;11(1):3382
Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation.
Zhang CX, Huang DJ, Baloche V, Zhang L, Xu JX, Li BW, Zhao XR, He J, Mai HQ, Chen QY, Zhang XS, Busson P, Cui J, Li J
Oncogenesis 2020 Jul 6;9(7):65
Oncogenesis 2020 Jul 6;9(7):65
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N
Nature immunology 2020 Feb;21(2):158-167
Nature immunology 2020 Feb;21(2):158-167
TBC1D9 regulates TBK1 activation through Ca(2+) signaling in selective autophagy.
Nozawa T, Sano S, Minowa-Nozawa A, Toh H, Nakajima S, Murase K, Aikawa C, Nakagawa I
Nature communications 2020 Feb 7;11(1):770
Nature communications 2020 Feb 7;11(1):770
Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer.
Yu J, Deng H, Xu Z
Scientific reports 2020 Dec 7;10(1):21360
Scientific reports 2020 Dec 7;10(1):21360
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Zhang X, Wu J, Liu Q, Li X, Li S, Chen J, Hong Z, Wu X, Zhao Y, Ren J
Cell death & disease 2020 Dec 11;11(12):1050
Cell death & disease 2020 Dec 11;11(12):1050
DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice.
Chen W, Yu SX, Zhou FH, Zhang XJ, Gao WY, Li KY, Liu ZZ, Han WY, Yang YJ
Frontiers in immunology 2019;10:474
Frontiers in immunology 2019;10:474
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.
Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, Fujii R, Ishidate F, Tanaka T, Tanaka Y, Hirokawa N, Nangaku M, Inagi R
Cell reports 2019 Oct 29;29(5):1261-1273.e6
Cell reports 2019 Oct 29;29(5):1261-1273.e6
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion.
Zhang CX, Ye SB, Ni JJ, Cai TT, Liu YN, Huang DJ, Mai HQ, Chen QY, He J, Zhang XS, Zeng YX, Li J, Cui J
Cell death and differentiation 2019 Nov;26(11):2314-2328
Cell death and differentiation 2019 Nov;26(11):2314-2328
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Hu S, Sun H, Yin L, Li J, Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, Liang C, Guo F
Science signaling 2019 Nov 26;12(609)
Science signaling 2019 Nov 26;12(609)
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Gui X, Yang H, Li T, Tan X, Shi P, Li M, Du F, Chen ZJ
Nature 2019 Mar;567(7747):262-266
Nature 2019 Mar;567(7747):262-266
Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.
Li L, Yang L, Cheng S, Fan Z, Shen Z, Xue W, Zheng Y, Li F, Wang D, Zhang K, Lian J, Wang D, Zhu Z, Zhao J, Zhang Y
Molecular cancer 2019 Jun 20;18(1):108
Molecular cancer 2019 Jun 20;18(1):108
African Swine Fever Virus Armenia/07 Virulent Strain Controls Interferon Beta Production through the cGAS-STING Pathway.
García-Belmonte R, Pérez-Núñez D, Pittau M, Richt JA, Revilla Y
Journal of virology 2019 Jun 15;93(12)
Journal of virology 2019 Jun 15;93(12)
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE
Science (New York, N.Y.) 2019 Jul 5;365(6448)
Science (New York, N.Y.) 2019 Jul 5;365(6448)
cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection.
Li Q, Liu C, Yue R, El-Ashram S, Wang J, He X, Zhao D, Zhou X, Xu L
International journal of molecular sciences 2019 Feb 19;20(4)
International journal of molecular sciences 2019 Feb 19;20(4)
Tandem Mass Tag Proteomic Analysis of in Vitro and in Vivo Models of Cutaneous Leishmaniasis Reveals Parasite-Specific and Nonspecific Modulation of Proteins in the Host.
Negrão F, Diedrich JK, Giorgio S, Eberlin MN, Yates JR 3rd
ACS infectious diseases 2019 Dec 13;5(12):2136-2147
ACS infectious diseases 2019 Dec 13;5(12):2136-2147
USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
Ye L, Zhang Q, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D, Zhong B
PLoS pathogens 2019 Apr;15(4):e1007680
PLoS pathogens 2019 Apr;15(4):e1007680
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
Cao Q, Juan CX, Zhang DQ, He J, Cao YZ, Pasha AB, Wang JY, Qi HX, Li S, Jin R, Zhou GP
Experimental cell research 2018 Sep 15;370(2):498-505
Experimental cell research 2018 Sep 15;370(2):498-505
Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes.
Verrier ER, Yim SA, Heydmann L, El Saghire H, Bach C, Turon-Lagot V, Mailly L, Durand SC, Lucifora J, Durantel D, Pessaux P, Manel N, Hirsch I, Zeisel MB, Pochet N, Schuster C, Baumert TF
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1695-1709
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1695-1709
IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.
Yang B, Song D, Liu Y, Cui Y, Lu G, Di W, Xing H, Ma L, Guo Z, Guan Y, Wang H, Wang J
FEBS letters 2018 May;592(10):1693-1704
FEBS letters 2018 May;592(10):1693-1704
Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.
Motani K, Kosako H
The Journal of biological chemistry 2018 May 18;293(20):7717-7726
The Journal of biological chemistry 2018 May 18;293(20):7717-7726
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Torralba D, Baixauli F, Villarroya-Beltri C, Fernández-Delgado I, Latorre-Pellicer A, Acín-Pérez R, Martín-Cófreces NB, Jaso-Tamame ÁL, Iborra S, Jorge I, González-Aseguinolaza G, Garaude J, Vicente-Manzanares M, Enríquez JA, Mittelbrunn M, Sánchez-Madrid F
Nature communications 2018 Jul 9;9(1):2658
Nature communications 2018 Jul 9;9(1):2658
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice.
Luo X, Li H, Ma L, Zhou J, Guo X, Woo SL, Pei Y, Knight LR, Deveau M, Chen Y, Qian X, Xiao X, Li Q, Chen X, Huo Y, McDaniel K, Francis H, Glaser S, Meng F, Alpini G, Wu C
Gastroenterology 2018 Dec;155(6):1971-1984.e4
Gastroenterology 2018 Dec;155(6):1971-1984.e4
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)
Journal of virology 2018 Aug 1;92(15)
Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection.
Liu Y, Liu Y, Wu J, Roizman B, Zhou GG
Proceedings of the National Academy of Sciences of the United States of America 2018 Apr 3;115(14):E3230-E3237
Proceedings of the National Academy of Sciences of the United States of America 2018 Apr 3;115(14):E3230-E3237
A proteomics landscape of circadian clock in mouse liver.
Wang Y, Song L, Liu M, Ge R, Zhou Q, Liu W, Li R, Qie J, Zhen B, Wang Y, He F, Qin J, Ding C
Nature communications 2018 Apr 19;9(1):1553
Nature communications 2018 Apr 19;9(1):1553
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.
Chunfa L, Xin S, Qiang L, Sreevatsan S, Yang L, Zhao D, Zhou X
Frontiers in cellular and infection microbiology 2017;7:169
Frontiers in cellular and infection microbiology 2017;7:169
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
Takahama M, Fukuda M, Ohbayashi N, Kozaki T, Misawa T, Okamoto T, Matsuura Y, Akira S, Saitoh T
Cell reports 2017 Sep 19;20(12):2944-2954
Cell reports 2017 Sep 19;20(12):2944-2954
TRIM29 promotes DNA virus infections by inhibiting innate immune response.
Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z
Nature communications 2017 Oct 16;8(1):945
Nature communications 2017 Oct 16;8(1):945
Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.
Wang J, Kang L, Song D, Liu L, Yang S, Ma L, Guo Z, Ding H, Wang H, Yang B
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 1;199(7):2475-2482
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 1;199(7):2475-2482
HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity.
Wang J, Yang S, Liu L, Wang H, Yang B
Virus research 2017 Mar 15;232:13-21
Virus research 2017 Mar 15;232:13-21
MITA modulated autophagy flux promotes cell death in breast cancer cells.
Bhatelia K, Singh K, Prajapati P, Sripada L, Roy M, Singh R
Cellular signalling 2017 Jul;35:73-83
Cellular signalling 2017 Jul;35:73-83
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Song S, Peng P, Tang Z, Zhao J, Wu W, Li H, Shao M, Li L, Yang C, Duan F, Zhang M, Zhang J, Wu H, Li C, Wang X, Wang H, Ruan Y, Gu J
Scientific reports 2017 Feb 8;7:39858
Scientific reports 2017 Feb 8;7:39858
Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
Jie C, Luo Z, Chen H, Wang M, Yan C, Mao ZF, Xiao GK, Kurihara H, Li YF, He RR
Oncotarget 2017 Dec 1;8(62):105615-105629
Oncotarget 2017 Dec 1;8(62):105615-105629
PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
Liu Y, Qu L, Liu Y, Roizman B, Zhou GG
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 15;114(33):E6902-E6911
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 15;114(33):E6902-E6911
Activation of STING requires palmitoylation at the Golgi.
Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, Barber GN, Arai H, Taguchi T
Nature communications 2016 Jun 21;7:11932
Nature communications 2016 Jun 21;7:11932
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Liu C, Yue R, Yang Y, Cui Y, Yang L, Zhao D, Zhou X
Oncotarget 2016 Jul 26;7(30):46972-46987
Oncotarget 2016 Jul 26;7(30):46972-46987
Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways.
Liu Y, Li J, Chen J, Li Y, Wang W, Du X, Song W, Zhang W, Lin L, Yuan Z
Journal of virology 2015 Feb;89(4):2287-300
Journal of virology 2015 Feb;89(4):2287-300
NET23/STING promotes chromatin compaction from the nuclear envelope.
Malik P, Zuleger N, de las Heras JI, Saiz-Ros N, Makarov AA, Lazou V, Meinke P, Waterfall M, Kelly DA, Schirmer EC
PloS one 2014;9(11):e111851
PloS one 2014;9(11):e111851
Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-κB induced cell death.
Bhatelia K, Singh A, Tomar D, Singh K, Sripada L, Chagtoo M, Prajapati P, Singh R, Godbole MM, Singh R
Biochimica et biophysica acta 2014 Feb;1842(2):144-53
Biochimica et biophysica acta 2014 Feb;1842(2):144-53
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse thymus tissue were subjected to SDS PAGE followed by western blot with 19851-1-AP(TMEM173 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 19851-1-AP(TMEM173 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 19851-1-AP(TMEM173 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TMEM173 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TMEM173. This antibody recognizes human, mouse, rat antigen. The TMEM173 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
