Explore
Validate
Learn19851-1-AP
antibody from Proteintech Group
Targeting: STING1
ERIS, FLJ38577, MITA, MPYS, NET23, STING, TMEM173
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [290]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 19851-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19851-1-AP, RRID:AB_10665370
- Product name
- TMEM173/STING antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TMEM173/STING antibody (Cat. #19851-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice.
Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway.
The involvement of Sting in exacerbating acute lung injury in sepsis via the PARP-1/NLRP3 signaling pathway.
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol.
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
tBHQ mitigates fatty liver ischemia-reperfusion injury by activating Nrf2 to attenuate hepatocyte mitochondrial damage and macrophage STING activation.
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF-κB pathway.
Porphyromonas gingivalis OMVs promoting endothelial dysfunction via the STING pathway in periodontitis.
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
NAD(+) supplementation prevents STING-induced senescence in CD8(+) T cells by improving mitochondrial homeostasis.
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro.
Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer.
Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways.
Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses.
The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases.
Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-κB signaling pathway.
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction.
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Identification of key mitochondria-related genes and their relevance to the immune system linking Parkinson's disease and primary Sjögren's syndrome through integrated bioinformatics analyses.
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling.
Regulating NCOA4-Mediated Ferritinophagy for Therapeutic Intervention in Cerebral Ischemia-Reperfusion Injury.
USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling.
Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.
STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis.
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury.
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity.
Antitumor Effect of Platinum-Modified STING Agonist MSA-2.
Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol.
Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses.
A conserved ion channel function of STING mediates noncanonical autophagy and cell death.
Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.
Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour-intrinsic innate sensing and immunogenicity.
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats.
Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway.
The cGAS-STING pathway promotes the development of preeclampsia by upregulating autophagy: Mechanisms and implications.
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
cGAS suppresses β-cell proliferation by a STING-independent but CEBPβ-dependent mechanism.
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.
Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS-STING signaling pathway.
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke.
STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation.
The activation of the AIM2 inflammasome after cigarette smoke exposure leads to an immunosuppressive lung microenvironment.
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway.
STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling.
Deletion of MGF505-2R Gene Activates the cGAS-STING Pathway Leading to Attenuation and Protection against Virulent African Swine Fever Virus.
Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.
Autophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma.
Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity.
MAVI1, an endoplasmic reticulum-localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion.
Moderate Intensity of Treadmill Exercise Rescues TBI-Induced Ferroptosis, Neurodegeneration, and Cognitive Impairments via Suppressing STING Pathway.
Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells.
Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway.
DWL-4-140: A allene small molecule targeting STING that alleviates lupus-like phenotype in Trex1(-/-) mice.
STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury.
4-Octyl itaconate restricts STING activation by blocking its palmitoylation.
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells.
Porcine IKKε is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway.
A sequential scheme including PTT and 2'3'-cGAMP/CQ-LP reveals the antitumor immune function of PTT through the type I interferon pathway.
Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A.
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice.
PAR2 deficiency tunes inflammatory microenvironment to magnify STING signalling for mitigating cancer metastasis via anionic CRISPR/Cas9 nanoparticles.
The STING inhibitor C-176 attenuates MPTP-induced neuroinflammation and neurodegeneration in mouse parkinsonian models.
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
Regulation of STING activity in DNA sensing by ISG15 modification.
PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling.
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling.
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury.
STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion.
ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.
Induction of Inflammation Disrupts the Negative Interplay between STING and S1P Axis That Is Observed during Physiological Conditions in the Lung.
The mechanism of STING autoinhibition and activation.
STING mediates experimental osteoarthritis and mechanical allodynia in mouse.
C9ORF72 suppresses JAK-STAT mediated inflammation.
The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.
NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.
Flavonoid derivative DMXAA attenuates cisplatin-induced acute kidney injury independent of STING signaling.
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING.
Protocol for the identification and expression analysis of a cytoplasmic membrane-localized protein STING.
Protocol using lentivirus to establish THP-1 suspension cell lines for immunostaining and confocal microscopy.
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS-STING Pathway.
STING deficiency protects against wasp venom-induced acute kidney injury.
Stimulator of interferon genes (STING) expression in the enteric nervous system and contributions of glial STING in disease.
Murine Coronavirus Disease 2019 Lethality Is Characterized by Lymphoid Depletion Associated with Suppressed Antigen-Presenting Cell Functionality.
Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.
RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis.
Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer.
Multiple Porcine Innate Immune Signaling Pathways Are Involved in the Anti-PEDV Response.
Effect of STING signaling on intestinal barrier damage in severe acute pancreatitis.
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
Yes-Associated Protein 1 Inhibition Induces Immunogenic Cell Death and Synergizes With Radiation and PD-1 Blockade.
DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.
Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain.
cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS-STING Signaling Pathway.
Inhibition of cGAS ameliorates acute lung injury triggered by zinc oxide nanoparticles.
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.
African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation.
Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner.
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Proteomic analysis predicts anti-angiogenic resistance in recurred glioblastoma.
NF-κB regulates the expression of STING via alternative promoter usage.
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.
Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma.
RNF144A promotes antiviral responses by modulating STING ubiquitination.
STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats.
Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress.
Naringin protects against inflammation and apoptosis induced by intestinal ischemia-reperfusion injury through deactivation of cGAS-STING signaling pathway.
The innate immune sensor STING accelerates neointima formation via NF-κB signaling pathway.
Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway.
Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy.
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
A role of STING signaling in obesity-induced lung inflammation.
The cGAS-STING pathway promotes endometriosis by up-regulating autophagy.
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1.
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
STING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy.
Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells.
STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages.
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
African Swine Fever Virus Structural Protein p17 Inhibits cGAS-STING Signaling Pathway Through Interacting With STING.
The Absence of STING Ameliorates Non-Alcoholic Fatty Liver Disease and Reforms Gut Bacterial Community.
Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING.
Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis.
Deficient DNASE1L3 facilitates neutrophil extracellular traps-induced invasion via cyclic GMP-AMP synthase and the non-canonical NF-κB pathway in diabetic hepatocellular carcinoma.
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Human Atheromatous Plaques Expressed Sensing Adaptor STING, a Potential Role in Vascular Inflammation Pathogenesis.
Clathrin-associated AP-1 controls termination of STING signalling.
Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.
BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma.
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways.
STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal Cortex.
Baicalein-loaded silk fibroin peptide nanofibers protect against cisplatin-induced acute kidney injury: Fabrication, characterization and mechanism.
Pharmacological inhibition of the cGAS-STING signaling pathway suppresses microglial M1-polarization in the spinal cord and attenuates neuropathic pain.
SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy.
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.
Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment.
HIV-1-induced type I IFNs promote viral latency in macrophages.
UNC13D inhibits STING signaling by attenuating its oligomerization on the endoplasmic reticulum.
Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity.
The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages.
Interruption of post-Golgi STING trafficking activates tonic interferon signaling.
cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress.
Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity.
SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy.
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment.
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury.
STING activation promotes inflammatory response and delays skin wound healing in diabetic mice.
ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
1,25(OH)(2) D(3) blocks IFNβ production through regulating STING in epithelial layer of oral lichen planus.
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
STING expression is an independent prognostic factor in patients with mycosis fungoides.
The Porcine and Chicken Innate DNA Sensing cGAS-STING-IRF Signaling Axes Exhibit Differential Species Specificity.
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium.
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics.
CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T(H)1 and T(H)9 cells.
Helicobacter pylori actively suppresses innate immune nucleic acid receptors.
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
The cGAS-STING pathway connects mitochondrial damage to inflammation in burn-induced acute lung injury in rat.
STING-mediated inflammation contributes to Gao binge ethanol feeding model.
Molecular cloning and functional analysis of Macaca mulatta STING.
Sustained IL-4 priming of macrophages enhances the inflammatory response to TLR7/8 ligand R848.
Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP.
ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation.
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients.
Expression of STING Is Increased in Monocyte-Derived Macrophages and Contributes to Liver Inflammation in Hepatic Ischemia-Reperfusion Injury.
The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε.
Mitochondrial cristae architecture protects against mtDNA release and inflammation.
Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer.
The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy.
MPYS Modulates Fatty Acid Metabolism and Immune Tolerance at Homeostasis Independent of Type I IFNs.
Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction.
Irradiation combined with PD-L1(-/-) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation.
New mechanism of nephrotoxicity of triptolide: Oxidative stress promotes cGAS-STING signaling pathway.
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer.
Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling.
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production.
STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis.
Activation of the cGAS-STING signaling pathway in adenomyosis patients.
Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma.
Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function.
Screening of Porcine Innate Immune Adaptor Signaling Revealed Several Anti-PRRSV Signaling Pathways.
eccDNAs are apoptotic products with high innate immunostimulatory activity.
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection.
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Pharmacological activation of STING blocks SARS-CoV-2 infection.
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine.
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells.
A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation.
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells.
Chromosome aberrations induced by the non-mutagenic carcinogen acetamide involve in rat hepatocarcinogenesis through micronucleus formation in hepatocytes.
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease.
Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.
Transfected DNA is targeted by STING-mediated restriction.
Mutant p53 suppresses innate immune signaling to promote tumorigenesis.
The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction.
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.
Long non-coding RNA MALAT1 targeting STING transcription promotes bronchopulmonary dysplasia through regulation of CREB.
Reactive oxygen species oxidize STING and suppress interferon production.
Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells.
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C.
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.
RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
SPHK2-Generated S1P in CD11b(+) Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages.
Redox homeostasis maintained by GPX4 facilitates STING activation.
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo.
Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation.
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
TBC1D9 regulates TBK1 activation through Ca(2+) signaling in selective autophagy.
Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer.
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice.
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion.
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.
African Swine Fever Virus Armenia/07 Virulent Strain Controls Interferon Beta Production through the cGAS-STING Pathway.
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection.
Tandem Mass Tag Proteomic Analysis of in Vitro and in Vivo Models of Cutaneous Leishmaniasis Reveals Parasite-Specific and Nonspecific Modulation of Proteins in the Host.
USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes.
IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.
Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection.
A proteomics landscape of circadian clock in mouse liver.
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
TRIM29 promotes DNA virus infections by inhibiting innate immune response.
Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.
HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity.
MITA modulated autophagy flux promotes cell death in breast cancer cells.
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
Activation of STING requires palmitoylation at the Golgi.
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways.
NET23/STING promotes chromatin compaction from the nuclear envelope.
Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-κB induced cell death.
Yang NS, Zhong WJ, Sha HX, Zhang CY, Jin L, Duan JX, Xiong JB, You ZJ, Zhou Y, Guan CX
International journal of biological sciences 2024;20(5):1927-1946
International journal of biological sciences 2024;20(5):1927-1946
Pretreated MSCs with IronQ Transplantation Attenuate Microglia Neuroinflammation via the cGAS-STING Signaling Pathway.
Yang G, Kantapan J, Mazhar M, Hu Q, Bai X, Zou Y, Wang H, Yang S, Wang L, Dechsupa N
Journal of inflammation research 2024;17:1643-1658
Journal of inflammation research 2024;17:1643-1658
The involvement of Sting in exacerbating acute lung injury in sepsis via the PARP-1/NLRP3 signaling pathway.
Ying T, Yu Y, Yu Q, Zhou G, Chen L, Gu Y, Zhu L, Ying H, Chen M
Pulmonary pharmacology & therapeutics 2024 Sep;86:102303
Pulmonary pharmacology & therapeutics 2024 Sep;86:102303
Cytosolic DNA initiates a vicious circle of aging-related endothelial inflammation and mitochondrial dysfunction via STING: the inhibitory effect of Cilostazol.
Zheng ZH, Wang JJ, Lin JG, Ye WL, Zou JM, Liang LY, Yang PL, Qiu WL, Li YY, Yang SJ, Zhao M, Zhou Q, Li CZ, Li M, Li ZM, Zhang DM, Liu PQ, Liu ZP
Acta pharmacologica Sinica 2024 Sep;45(9):1879-1897
Acta pharmacologica Sinica 2024 Sep;45(9):1879-1897
A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models.
Puray-Chavez M, Eschbach JE, Xia M, LaPak KM, Zhou Q, Jasuja R, Pan J, Xu J, Zhou Z, Mohammed S, Wang Q, Lawson DQ, Djokic S, Hou G, Ding S, Brody SL, Major MB, Goldfarb D, Kutluay SB
bioRxiv : the preprint server for biology 2024 Sep 6;
bioRxiv : the preprint server for biology 2024 Sep 6;
tBHQ mitigates fatty liver ischemia-reperfusion injury by activating Nrf2 to attenuate hepatocyte mitochondrial damage and macrophage STING activation.
Wu D, Xu J, Zhang Y, Wang Y, Bai Y, Zhan X, Gao Y, Zhou H, Hu H, Wang P, Rao Z
International immunopharmacology 2024 Sep 10;138:112515
International immunopharmacology 2024 Sep 10;138:112515
Arylacryl amides: Design, synthesis and the protection against cisplatin-induced acute kidney injury via TLR4/STING/NF-κB pathway.
Wu X, Zhou L, Li Z, Rong K, Gao S, Chen Y, Zuo J, Tang W
Bioorganic chemistry 2024 May;146:107303
Bioorganic chemistry 2024 May;146:107303
Porphyromonas gingivalis OMVs promoting endothelial dysfunction via the STING pathway in periodontitis.
Chen Z, Cao Y, Jiang W, Yan Z, Cai G, Ye J, Wang H, Liu L
Oral diseases 2024 May 2;
Oral diseases 2024 May 2;
CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction.
Wang H, Ye J, Peng Y, Ma W, Chen H, Sun H, Feng Z, He W, Li G, Chu S, Zhang Z, Chen N
Autophagy 2024 Mar;20(3):590-613
Autophagy 2024 Mar;20(3):590-613
NAD(+) supplementation prevents STING-induced senescence in CD8(+) T cells by improving mitochondrial homeostasis.
Ye B, Pei Y, Wang L, Meng D, Zhang Y, Zou S, Li H, Liu J, Xie Z, Tian C, Jiang Y, Qiao Y, Gao X, Zhang Y, Ma N
Journal of cellular biochemistry 2024 Mar;125(3):e30522
Journal of cellular biochemistry 2024 Mar;125(3):e30522
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro.
Duan QQ, Wang H, Su WM, Gu XJ, Shen XF, Jiang Z, Ren YL, Cao B, Li GB, Wang Y, Chen YP
BMC medicine 2024 Mar 5;22(1):96
BMC medicine 2024 Mar 5;22(1):96
Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer.
Sales Conniff A, Singh J, Heller R, Heller LC
Pharmaceutics 2024 Mar 5;16(3)
Pharmaceutics 2024 Mar 5;16(3)
Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways.
He Y, Yue J, Teng Y, Fan Z, Jia M, Teng H, Zhuge L
International immunopharmacology 2024 Mar 30;130:111687
International immunopharmacology 2024 Mar 30;130:111687
Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses.
Liu L, Manley JL
Cell reports 2024 Mar 26;43(3):113886
Cell reports 2024 Mar 26;43(3):113886
The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases.
Sanz MÁ, Polo M, Rodríguez-Pulido M, Huildore Bommanna R, Sáiz M
Cellular and molecular life sciences : CMLS 2024 Mar 20;81(1):148
Cellular and molecular life sciences : CMLS 2024 Mar 20;81(1):148
Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-κB signaling pathway.
Jia Y, Li F, Liu Z, Liu S, Huang M, Gao X, Su X, Wang Z, Wang T
Journal of virology 2024 Mar 19;98(3):e0181523
Journal of virology 2024 Mar 19;98(3):e0181523
The combination of Schisandrin C and Luteolin synergistically attenuates hepatitis B virus infection via repressing HBV replication and promoting cGAS-STING pathway activation in macrophages.
Wu Z, Zhao X, Li R, Wen X, Xiu Y, Long M, Li J, Huang X, Wen J, Dong X, Xu Y, Bai Z, Zhan X, Xiao X
Chinese medicine 2024 Mar 18;19(1):48
Chinese medicine 2024 Mar 18;19(1):48
TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis.
Wang W, Ma Z, Feng X, Ren J, Sun S, Shao Y, Zhang W, Yang X, Zhang J, Jing X
Arthritis research & therapy 2024 Mar 16;26(1):71
Arthritis research & therapy 2024 Mar 16;26(1):71
Cardiac injury activates STING signaling via upregulating SIRT6 in macrophages after myocardial infarction.
Kong W, Chen J, Ruan X, Xu X, Li X, Bao M, Shao Y, Bian X, Li R, Jiang Q, Zhang Y, Li Z, Yan F, Ye J
Life sciences 2024 Mar 15;341:122474
Life sciences 2024 Mar 15;341:122474
Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.
Marques C, Held A, Dorfman K, Sung J, Song C, Kavuturu AS, Aguilar C, Russo T, Oakley DH, Albers MW, Hyman BT, Petrucelli L, Lagier-Tourenne C, Wainger BJ
Acta neuropathologica 2024 Mar 13;147(1):56
Acta neuropathologica 2024 Mar 13;147(1):56
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413
Virologica Sinica 2024 Jun;39(3):403-413
Identification of key mitochondria-related genes and their relevance to the immune system linking Parkinson's disease and primary Sjögren's syndrome through integrated bioinformatics analyses.
Zong Y, Yang Y, Zhao J, Li L, Luo D, Hu J, Gao Y, Xie X, Shen L, Chen S, Ning L, Jiang L
Computers in biology and medicine 2024 Jun;175:108511
Computers in biology and medicine 2024 Jun;175:108511
Flavonoid extracted from Epimedium attenuate cGAS-STING-mediated diseases by targeting the formation of functional STING signalosome.
Wang Y, Xu G, Wen J, Zhao X, Zhao H, Lv G, Xu Y, Xiu Y, Li J, Chen S, Yao Q, Chen Y, Ma L, Xiao X, Cao J, Bai Z
Immunology 2024 Jun;172(2):295-312
Immunology 2024 Jun;172(2):295-312
Compound Danshen Dripping Pill effectively alleviates cGAS-STING-triggered diseases by disrupting STING-TBK1 interaction.
Shi W, Xu G, Gao Y, Yang H, Liu T, Zhao J, Li H, Wei Z, Hou X, Chen Y, Wen J, Li C, Zhao J, Zhang P, Wang Z, Xiao X, Bai Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155404
The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice.
Aybar-Torres A, Saldarriaga LA, Pham AT, Emtiazjoo AM, Sharma AK, Bryant AJ, Jin L
bioRxiv : the preprint server for biology 2024 Jun 17;
bioRxiv : the preprint server for biology 2024 Jun 17;
Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling.
Zhang J, Du J, Liu D, Zhuo J, Chu L, Li Y, Gao L, Xu M, Chen W, Huang W, Xie L, Chen J, Meng X, Zou F, Cai S, Dong H
Ecotoxicology and environmental safety 2024 Jun 1;277:116357
Ecotoxicology and environmental safety 2024 Jun 1;277:116357
Regulating NCOA4-Mediated Ferritinophagy for Therapeutic Intervention in Cerebral Ischemia-Reperfusion Injury.
Zhao L, Li Y, Wang W, Qi X, Wang S, Song W, Li T, Gao W
Neurochemical research 2024 Jul;49(7):1806-1822
Neurochemical research 2024 Jul;49(7):1806-1822
USP11 Exacerbates Radiation-Induced Pneumonitis by Activating Endothelial Cell Inflammatory Response via OTUD5-STING Signaling.
Tang Y, Wang T, Gu L, Xu Y, Yang Z, Zhu W, Zhang Q, Luo J, Cao J, Jiao Y
International journal of radiation oncology, biology, physics 2024 Jul 15;119(4):1261-1274
International journal of radiation oncology, biology, physics 2024 Jul 15;119(4):1261-1274
Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway.
Dong K, Sun Y, Gao X, Wang J, Wu X, Guo C
Colloids and surfaces. B, Biointerfaces 2024 Jan;233:113656
Colloids and surfaces. B, Biointerfaces 2024 Jan;233:113656
STING modulates iron metabolism to promote liver injury and inflammation in acute immune hepatitis.
Zhao J, Yi Z, Deng G, Li Y, Li J, Qin M, Wu C, Luo P, Ma S, Gao L
Free radical biology & medicine 2024 Jan;210:367-377
Free radical biology & medicine 2024 Jan;210:367-377
Inhibition of cGAS-STING pathway by stress granules after activation of M2 macrophages by human mesenchymal stem cells against drug induced liver injury.
Wang Y, She S, Li W, Zhu J, Li X, Yang F, Dai K
Molecular immunology 2024 Jan;165:42-54
Molecular immunology 2024 Jan;165:42-54
Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury.
Wei FL, Wang TF, Wang CL, Zhang ZP, Zhao JW, Heng W, Tang Z, Du MR, Yan XD, Li XX, Guo Z, Qian JX, Zhou CP
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(4):e2305442
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jan;11(4):e2305442
3-N-butylphthalide attenuates neuroinflammation in rotenone-induced Parkinson's disease models via the cGAS-STING pathway.
Liu Y, Duan R, Li P, Zhang B, Liu Y
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241229041
Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity.
Zhu L, Jin J, Wang T, Hu Y, Liu H, Gao T, Dong Q, Jin Y, Li P, Liu Z, Huang Y, Liu X, Cao C
eLife 2024 Jan 29;12
eLife 2024 Jan 29;12
Antitumor Effect of Platinum-Modified STING Agonist MSA-2.
Wang M, Cai Y, He T, Zhang Y, Yi L, Li W, Zhou P
ACS omega 2024 Jan 16;9(2):2650-2656
ACS omega 2024 Jan 16;9(2):2650-2656
Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol.
Kemmoku H, Takahashi K, Mukai K, Mori T, Hirosawa KM, Kiku F, Uchida Y, Kuchitsu Y, Nishioka Y, Sawa M, Kishimoto T, Tanaka K, Yokota Y, Arai H, Suzuki KGN, Taguchi T
Nature communications 2024 Jan 11;15(1):220
Nature communications 2024 Jan 11;15(1):220
Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses.
Packer JM, Bray CE, Beckman NB, Wangler LM, Davis AC, Goodman EJ, Klingele NE, Godbout JP
Glia 2024 Feb;72(2):300-321
Glia 2024 Feb;72(2):300-321
A conserved ion channel function of STING mediates noncanonical autophagy and cell death.
Xun J, Zhang Z, Lv B, Lu D, Yang H, Shang G, Tan JX
EMBO reports 2024 Feb;25(2):544-569
EMBO reports 2024 Feb;25(2):544-569
Polyvinylpyrrolidone-Polydatin nanoparticles protect against oxaliplatin induced intestinal toxicity in vitro and in vivo.
Zhou S, Sun Y, Wang K, Gao X, Dong K, Wang J, Wu X, Guo C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114427
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114427
Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour-intrinsic innate sensing and immunogenicity.
Sun M, Han X, Li J, Zheng J, Li J, Wang H, Li X
Clinical and translational medicine 2024 Feb;14(2):e1598
Clinical and translational medicine 2024 Feb;14(2):e1598
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Peng D, Huang Z, Yang H, Luo Y, Wu Z
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats.
Takimoto N, Ishii Y, Mitsumoto T, Takasu S, Namiki M, Shibutani M, Ogawa K
Toxicological sciences : an official journal of the Society of Toxicology 2024 Feb 28;198(1):40-49
Toxicological sciences : an official journal of the Society of Toxicology 2024 Feb 28;198(1):40-49
Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway.
Yang T, Ma H, Lai H, Lu Y, Ni K, Hu X, Zhou Y, Zhou Z, Li W, Fang J, Zhang Y, Chen Z, He D
European journal of pharmacology 2024 Feb 15;965:176326
European journal of pharmacology 2024 Feb 15;965:176326
The cGAS-STING pathway promotes the development of preeclampsia by upregulating autophagy: Mechanisms and implications.
Sun J, Yu M, Du W, Zhu S, Chen Z, Tao J, Zhou Y, Chen Q, Zhao Y, Zhang Q
International immunopharmacology 2024 Feb 15;128:111531
International immunopharmacology 2024 Feb 15;128:111531
Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer.
Li LG, Hu J, Han N, Chen NN, Yu TT, Ren T, Xu HZ, Peng XC, Li XY, Ma TQ, Chen H, Zhang L, Chen X, Wang MF, Li TF
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
Phytotherapy research : PTR 2024 Aug;38(8):3856-3876
cGAS suppresses β-cell proliferation by a STING-independent but CEBPβ-dependent mechanism.
Cai Z, Yang Y, Zhong J, Ji Y, Li T, Luo J, Hu S, Luo H, Wu Y, Liu F, Zhang J
Metabolism: clinical and experimental 2024 Aug;157:155933
Metabolism: clinical and experimental 2024 Aug;157:155933
SS-31 inhibits mtDNA-cGAS-STING signaling to improve POCD by activating mitophagy in aged mice.
Ji Y, Ma Y, Ma Y, Wang Y, Zhao X, Jin D, Xu L, Ge S
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Apr;73(4):641-654
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Apr;73(4):641-654
Rapamycin can alleviate the submandibular gland pathology of Sjögren's syndrome by limiting the activation of cGAS-STING signaling pathway.
Zhu W, Wang Y, Guan Y, Lu Y, Li Y, Sun L, Wang Y
Inflammopharmacology 2024 Apr;32(2):1113-1131
Inflammopharmacology 2024 Apr;32(2):1113-1131
STING deficiency alleviates ferroptosis through FPN1 stabilization in diabetic kidney disease.
Zhao QX, Yan SB, Wang F, Li XX, Shang GK, Zheng ZJ, Xiao J, Lin ZW, Li CB, Ji XP
Biochemical pharmacology 2024 Apr;222:116102
Biochemical pharmacology 2024 Apr;222:116102
mtDNA regulates cGAS-STING signaling pathway in adenomyosis.
Wang K, Wen Y, Fu X, Wei S, Liu S, Chen M
Free radical biology & medicine 2024 Apr;216:80-88
Free radical biology & medicine 2024 Apr;216:80-88
STING inhibition suppresses microglia-mediated synapses engulfment and alleviates motor functional deficits after stroke.
Wu C, Zhang S, Sun H, Li A, Hou F, Qi L, Liao H
Journal of neuroinflammation 2024 Apr 8;21(1):86
Journal of neuroinflammation 2024 Apr 8;21(1):86
STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation.
Wang Y, Niu W, Zhu S, Sun J, Lv J, Wang N, Zhang H, Zhang Z, Wang M, Cao L, Li S, Zhai Q, Ma L
Inflammation 2024 Apr 26;
Inflammation 2024 Apr 26;
The activation of the AIM2 inflammasome after cigarette smoke exposure leads to an immunosuppressive lung microenvironment.
Colarusso C, Falanga A, Di Caprio S, Terlizzi M, Pinto A, Maiolino P, Sorrentino R
International immunopharmacology 2024 Apr 20;131:111832
International immunopharmacology 2024 Apr 20;131:111832
Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway.
Li B, Xu L, Wang Z, Shi Q, Cui Y, Fan W, Wu Q, Tong X, Yan H
Cellular and molecular neurobiology 2024 Apr 18;44(1):36
Cellular and molecular neurobiology 2024 Apr 18;44(1):36
STING-dependent trained immunity contributes to host defense against Clostridium perfringens infection via mTOR signaling.
Liu ZZ, Zhou CK, Lin XQ, Gao Y, Luo XY, Zhang JB, Yin Q, Zhang L, Zhang JG, An X, Chen W, Yang YJ
Veterinary research 2024 Apr 15;55(1):52
Veterinary research 2024 Apr 15;55(1):52
Deletion of MGF505-2R Gene Activates the cGAS-STING Pathway Leading to Attenuation and Protection against Virulent African Swine Fever Virus.
Sunwoo SY, García-Belmonte R, Walczak M, Vigara-Astillero G, Kim DM, Szymankiewicz K, Kochanowski M, Liu L, Tark D, Podgórska K, Revilla Y, Pérez-Núñez D
Vaccines 2024 Apr 11;12(4)
Vaccines 2024 Apr 11;12(4)
Inhibition of cGAS aggravated the host inflammatory response to Aspergillus fumigatus.
Peng M, Li X, Zhang X, Peng L
Experimental lung research 2023;49(1):86-100
Experimental lung research 2023;49(1):86-100
Autophagy and biotransformation affect sorafenib resistance in hepatocellular carcinoma.
Zheng R, Weng S, Xu J, Li Z, Wang Y, Aizimuaji Z, Ma S, Zheng L, Li H, Ying W, Rong W, Xiao T
Computational and structural biotechnology journal 2023;21:3564-3574
Computational and structural biotechnology journal 2023;21:3564-3574
Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity.
Sun X, Wang WJ, Lang J, Yang R, Shen WJ, Sun L, Hsu JM, Chan LC, Li CW, Xia W, Ke B, Yao G, Huang K, Lee PC, Koller PB, Hung MC
International journal of biological sciences 2023;19(14):4644-4656
International journal of biological sciences 2023;19(14):4644-4656
MAVI1, an endoplasmic reticulum-localized microprotein, suppresses antiviral innate immune response by targeting MAVS on mitochondrion.
Shi TT, Huang Y, Li Y, Dai XL, He YH, Ding JC, Ran T, Shi Y, Yuan Q, Li WJ, Liu W
Science advances 2023 Sep;9(35):eadg7053
Science advances 2023 Sep;9(35):eadg7053
Moderate Intensity of Treadmill Exercise Rescues TBI-Induced Ferroptosis, Neurodegeneration, and Cognitive Impairments via Suppressing STING Pathway.
Chen J, Zhu T, Yu D, Yan B, Zhang Y, Jin J, Yang Z, Zhang B, Hao X, Chen Z, Yan C, Yu J
Molecular neurobiology 2023 Sep;60(9):4872-4896
Molecular neurobiology 2023 Sep;60(9):4872-4896
Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells.
Wu Z, Tang W, Ibrahim FEEM, Chen X, Yan H, Tao C, Wang Z, Guo Y, Fu Y, Wang Q, Ge Y
Neurochemical research 2023 Sep;48(9):2881-2894
Neurochemical research 2023 Sep;48(9):2881-2894
Electroacupuncture alleviates postoperative pain through inhibiting neuroinflammation via stimulator of interferon genes/type-1 interferon pathway.
Ding YY, Xu F, Wang YF, Han LL, Huang SQ, Zhao S, Ma LL, Zhang TH, Zhao WJ, Chen XD
Journal of integrative medicine 2023 Sep;21(5):496-508
Journal of integrative medicine 2023 Sep;21(5):496-508
DWL-4-140: A allene small molecule targeting STING that alleviates lupus-like phenotype in Trex1(-/-) mice.
Du H, Kou M, Deng W, Zhou X, Zhang X, Huang Z, Ren B, Cai X, Xu S, Chen Y, Chen L, Chen C, Bao H, Chen Q, Li D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115188
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115188
STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury.
Ni J, Guo T, Zhou Y, Jiang S, Zhang L, Zhu Z
Journal of translational medicine 2023 Sep 4;21(1):590
Journal of translational medicine 2023 Sep 4;21(1):590
4-Octyl itaconate restricts STING activation by blocking its palmitoylation.
Su C, Cheng T, Huang J, Zhang T, Yin H
Cell reports 2023 Sep 26;42(9):113040
Cell reports 2023 Sep 26;42(9):113040
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation.
Ouyang W, Wang S, Yan D, Wu J, Zhang Y, Li W, Hu J, Liu Z
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
Signal transduction and targeted therapy 2023 Sep 21;8(1):371
Genomic DNA activates the AIM2 inflammasome and STING pathways to induce inflammation in lacrimal gland myoepithelial cells.
Yang M, Delcroix V, Lennikov A, Wang N, Makarenkova HP, Dartt DA
The ocular surface 2023 Oct;30:263-275
The ocular surface 2023 Oct;30:263-275
Porcine IKKε is involved in the STING-induced type I IFN antiviral response of the cytosolic DNA signaling pathway.
Luo J, Cao Q, Zhang J, Jiang S, Xia N, Sun S, Zheng W, Chen N, Meurens F, Zhu J
The Journal of biological chemistry 2023 Oct;299(10):105213
The Journal of biological chemistry 2023 Oct;299(10):105213
A sequential scheme including PTT and 2'3'-cGAMP/CQ-LP reveals the antitumor immune function of PTT through the type I interferon pathway.
Song X, Wang M, Liu S, Liu H, Jiang A, Zou Y, Deng Y, Qin Q, Song Y, Zheng Y
Pharmacological research 2023 Oct;196:106939
Pharmacological research 2023 Oct;196:106939
Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A.
Zhao X, Stein KR, Chen V, Griffin ME, Lairson LL, Hang HC
Nature chemical biology 2023 Oct;19(10):1205-1214
Nature chemical biology 2023 Oct;19(10):1205-1214
GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion.
Zhao C, Liang F, Ye M, Wu S, Qin Y, Zhao L, Zhang L, He J, Cen L, Lin F
Cell death discovery 2023 Oct 4;9(1):368
Cell death discovery 2023 Oct 4;9(1):368
Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice.
Yang L, Lu P, Qi X, Yang Q, Liu L, Dou T, Guan Q, Yu C
iScience 2023 Oct 20;26(10):108082
iScience 2023 Oct 20;26(10):108082
PAR2 deficiency tunes inflammatory microenvironment to magnify STING signalling for mitigating cancer metastasis via anionic CRISPR/Cas9 nanoparticles.
Fu X, Li J, Wu Y, Mao C, Jiang Y
Journal of controlled release : official journal of the Controlled Release Society 2023 Nov;363:733-746
Journal of controlled release : official journal of the Controlled Release Society 2023 Nov;363:733-746
The STING inhibitor C-176 attenuates MPTP-induced neuroinflammation and neurodegeneration in mouse parkinsonian models.
Wang B, Wang Y, Qiu J, Gao S, Yu S, Sun D, Lou H
International immunopharmacology 2023 Nov;124(Pt A):110827
International immunopharmacology 2023 Nov;124(Pt A):110827
A Dihydroartemisinin-Loaded Nanoreactor Motivates Anti-Cancer Immunotherapy by Synergy-Induced Ferroptosis to Activate Cgas/STING for Reprogramming of Macrophage.
Li LG, Yang XX, Xu HZ, Yu TT, Li QR, Hu J, Peng XC, Han N, Xu X, Chen NN, Chen X, Tang JM, Li TF
Advanced healthcare materials 2023 Nov;12(28):e2301561
Advanced healthcare materials 2023 Nov;12(28):e2301561
Regulation of STING activity in DNA sensing by ISG15 modification.
Lin C, Kuffour EO, Fuchs NV, Gertzen CGW, Kaiser J, Hirschenberger M, Tang X, Xu HC, Michel O, Tao R, Haase A, Martin U, Kurz T, Drexler I, Görg B, Lang PA, Luedde T, Sparrer KMJ, Gohlke H, König R, Münk C
Cell reports 2023 Nov 28;42(11):113277
Cell reports 2023 Nov 28;42(11):113277
PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling.
Lin Y, Yang J, Yang Q, Zeng S, Zhang J, Zhu Y, Tong Y, Li L, Tan W, Chen D, Sun Q
Nature communications 2023 Nov 21;14(1):7567
Nature communications 2023 Nov 21;14(1):7567
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
Jiang A, Liu J, Wang Y, Zhang C
Free radical biology & medicine 2023 Nov 1;208:516-529
Free radical biology & medicine 2023 Nov 1;208:516-529
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch SA, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ
Nature communications 2023 Nov 1;14(1):6770
Nature communications 2023 Nov 1;14(1):6770
TAK1 deficiency promotes liver injury and tumorigenesis via ferroptosis and macrophage cGAS-STING signalling.
Su W, Gao W, Zhang R, Wang Q, Li L, Bu Q, Xu Z, Liu Z, Wang M, Zhu Y, Wu G, Zhou H, Wang X, Lu L
JHEP reports : innovation in hepatology 2023 May;5(5):100695
JHEP reports : innovation in hepatology 2023 May;5(5):100695
STING contributes to trauma-induced heterotopic ossification through NLRP3-dependent macrophage pyroptosis.
Sun Z, Liu H, Hu Y, Luo G, Yuan Z, Tu B, Ruan H, Li J, Fan C
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
Clinical immunology (Orlando, Fla.) 2023 May;250:109300
SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.
Ji Y, Luo Y, Wu Y, Sun Y, Zhao L, Xue Z, Sun M, Wei X, He Z, Wu SA, Lin LL, Lu Y, Chang L, Chen F, Chen S, Qian W, Xu X, Chen S, Pan D, Zhou Z, Xia S, Hu CA, Liang T, Qi L
Nature cell biology 2023 May;25(5):726-739
Nature cell biology 2023 May;25(5):726-739
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy.
Ma Z, Bai J, Jiang C, Zhu H, Liu D, Pan M, Wang X, Pi J, Jiang P, Liu X
Autophagy 2023 May;19(5):1512-1532
Autophagy 2023 May;19(5):1512-1532
Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway.
Wen J, Qin S, Li Y, Zhang P, Zhan X, Fang M, Shi C, Mu W, Kan W, Zhao J, Hui S, Hou M, Li H, Xiao X, Xu G, Bai Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113732
Novel STING-targeted PET radiotracer for alert and therapeutic evaluation of acute lung injury.
Xu D, Yang F, Chen J, Zhu T, Wang F, Xiao Y, Liang Z, Bi L, Huang G, Jiang Z, Shan H, Li D
Acta pharmaceutica Sinica. B 2023 May;13(5):2124-2137
Acta pharmaceutica Sinica. B 2023 May;13(5):2124-2137
STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion.
Yang M, Jiang H, Ding C, Zhang L, Ding N, Li G, Zhang F, Wang J, Deng L, Liu J, Xu Y
Immunity 2023 May 9;56(5):1013-1026.e6
Immunity 2023 May 9;56(5):1013-1026.e6
ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer.
Yi J, Wang L, Du J, Wang M, Shen H, Liu Z, Qin Y, Liu J, Hu G, Xiao R, Ding J, Chen X, Wang H, Huang H, Ouyang G, Liu W
Developmental cell 2023 May 8;58(9):760-778.e6
Developmental cell 2023 May 8;58(9):760-778.e6
Induction of Inflammation Disrupts the Negative Interplay between STING and S1P Axis That Is Observed during Physiological Conditions in the Lung.
Terlizzi M, Colarusso C, Falanga A, Somma P, De Rosa I, Panico L, Pinto A, Maiolino P, Sorrentino R
International journal of molecular sciences 2023 May 5;24(9)
International journal of molecular sciences 2023 May 5;24(9)
The mechanism of STING autoinhibition and activation.
Liu S, Yang B, Hou Y, Cui K, Yang X, Li X, Chen L, Liu S, Zhang Z, Jia Y, Xie Y, Xue Y, Li X, Yan B, Wu C, Deng W, Qi J, Lu D, Gao GF, Wang P, Shang G
Molecular cell 2023 May 4;83(9):1502-1518.e10
Molecular cell 2023 May 4;83(9):1502-1518.e10
STING mediates experimental osteoarthritis and mechanical allodynia in mouse.
Shin Y, Cho D, Kim SK, Chun JS
Arthritis research & therapy 2023 May 31;25(1):90
Arthritis research & therapy 2023 May 31;25(1):90
C9ORF72 suppresses JAK-STAT mediated inflammation.
Pang W, Hu F
iScience 2023 May 19;26(5):106579
iScience 2023 May 19;26(5):106579
The role of chemerin in the regulation of cGAS-STING pathway in gestational diabetes mellitus placenta.
Zhou X, Zhang H, Jiang Y, Wei L, Chen Y, Zhang J, Gao P, Zhu S, Fang C, Du Y, Su R, He M, Yu J, Wang S, Ding W, Feng L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22806
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22806
NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.
Zhao J, Zhen N, Zhou Q, Lou J, Cui W, Zhang G, Tian B
International journal of molecular sciences 2023 Mar 7;24(6)
International journal of molecular sciences 2023 Mar 7;24(6)
Flavonoid derivative DMXAA attenuates cisplatin-induced acute kidney injury independent of STING signaling.
Lu L, Liu W, Li S, Bai M, Zhou Y, Jiang Z, Jia Z, Huang S, Zhang A, Gong W
Clinical science (London, England : 1979) 2023 Mar 31;137(6):435-452
Clinical science (London, England : 1979) 2023 Mar 31;137(6):435-452
4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING.
Li W, Li Y, Kang J, Jiang H, Gong W, Chen L, Wu C, Liu M, Wu X, Zhao Y, Ren J
Cell reports 2023 Mar 28;42(3):112145
Cell reports 2023 Mar 28;42(3):112145
Protocol for the identification and expression analysis of a cytoplasmic membrane-localized protein STING.
Shi J, Liu C, Luo S, Zhang Y, Li M, Zhou M, Weng M, Li X, Zheng T
STAR protocols 2023 Mar 20;4(2):102172
STAR protocols 2023 Mar 20;4(2):102172
Protocol using lentivirus to establish THP-1 suspension cell lines for immunostaining and confocal microscopy.
Ji W, Zhang L, Liu X
STAR protocols 2023 Mar 17;4(1):102032
STAR protocols 2023 Mar 17;4(1):102032
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING.
Fang R, Jiang Q, Jia X, Jiang Z
Immunity 2023 Mar 14;56(3):500-515.e6
Immunity 2023 Mar 14;56(3):500-515.e6
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity.
Tang M, Chen G, Tu B, Hu Z, Huang Y, DuFort CC, Wan X, Mao Z, Liu Y, Zhu WG, Lu W
Science advances 2023 Jun 16;9(24):eade6624
Science advances 2023 Jun 16;9(24):eade6624
Yi-Shen-Xie-Zhuo formula alleviates cisplatin-induced AKI by regulating inflammation and apoptosis via the cGAS/STING pathway.
Qi J, Luo Q, Zhang Q, Wu M, Zhang L, Qin L, Xue Q, Nie X
Journal of ethnopharmacology 2023 Jun 12;309:116327
Journal of ethnopharmacology 2023 Jun 12;309:116327
Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS-STING Pathway.
Farris LC, Torres-Odio S, Adams LG, West AP, Hyde JA
Journal of immunology (Baltimore, Md. : 1950) 2023 Jun 1;210(11):1761-1770
Journal of immunology (Baltimore, Md. : 1950) 2023 Jun 1;210(11):1761-1770
STING deficiency protects against wasp venom-induced acute kidney injury.
Lv Y, Lu L, Yu F, Gao Z, Yuan H, Hu F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1427-1440
Stimulator of interferon genes (STING) expression in the enteric nervous system and contributions of glial STING in disease.
Dharshika C, Gonzales J, Chow A, Morales-Soto W, Gulbransen BD
Neurogastroenterology and motility 2023 Jul;35(7):e14553
Neurogastroenterology and motility 2023 Jul;35(7):e14553
Murine Coronavirus Disease 2019 Lethality Is Characterized by Lymphoid Depletion Associated with Suppressed Antigen-Presenting Cell Functionality.
Lee YJ, Seok SH, Lee NY, Choi HJ, Lee YW, Chang HJ, Hwang JY, On DI, Noh HA, Lee SB, Kwon HK, Yun JW, Shin JS, Seo JY, Nam KT, Lee H, Lee HY, Park JW, Seong JK
The American journal of pathology 2023 Jul;193(7):866-882
The American journal of pathology 2023 Jul;193(7):866-882
Silk fibroin peptide self-assembled nanofibers delivered naringenin to alleviate cisplatin-induced acute kidney injury by inhibiting mtDNA-cGAS-STING pathway.
Liu S, Gao X, Yin Y, Wang J, Dong K, Shi D, Wu X, Guo C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113844
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113844
RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis.
Zhang X, Wu J, Liu Q, Li X, Yang Y, Wu L, Wu X, Zhao Y, Ren J
Clinical and translational medicine 2023 Jul;13(7):e1334
Clinical and translational medicine 2023 Jul;13(7):e1334
Elevated Tumor Cell-Intrinsic STING Expression in Advanced Laryngeal Cancer.
Viculin J, Degoricija M, Vilović K, Gabela I, Franković L, Vrdoljak E, Korac-Prlic J
Cancers 2023 Jul 5;15(13)
Cancers 2023 Jul 5;15(13)
Multiple Porcine Innate Immune Signaling Pathways Are Involved in the Anti-PEDV Response.
Zhang Y, Xu Y, Jiang S, Sun S, Zhang J, Luo J, Cao Q, Zheng W, Meurens F, Chen N, Zhu J
Viruses 2023 Jul 26;15(8)
Viruses 2023 Jul 26;15(8)
Effect of STING signaling on intestinal barrier damage in severe acute pancreatitis.
Zhang Y, Jiang Y, Li H, Wang J, Li C, Zhang D
Experimental cell research 2023 Jul 15;428(2):113630
Experimental cell research 2023 Jul 15;428(2):113630
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication.
Zhao J, Xu G, Hou X, Mu W, Yang H, Shi W, Wen J, Liu T, Wu Z, Bai J, Zhang P, Wang Z, Xiao X, Zou W, Bai Z, Zhan X
Journal of ethnopharmacology 2023 Jul 15;311:116427
Journal of ethnopharmacology 2023 Jul 15;311:116427
Yes-Associated Protein 1 Inhibition Induces Immunogenic Cell Death and Synergizes With Radiation and PD-1 Blockade.
Zhuang Y, Wang Y, Liu C, Li S, Du S, Li G
International journal of radiation oncology, biology, physics 2023 Jul 15;116(4):894-905
International journal of radiation oncology, biology, physics 2023 Jul 15;116(4):894-905
DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.
Lou M, Huang D, Zhou Z, Shi X, Wu M, Rui Y, Su J, Zheng W, Yu XF
Journal of medical virology 2023 Jan;95(1):e28310
Journal of medical virology 2023 Jan;95(1):e28310
Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain.
Zhang Y, Wang W, Gong Z, Peng Y, Li X, Zhang Z, Zhang X, You X, Wu J
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):117-132
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jan;72(1):117-132
cGAS-STING pathway aggravates early cerebral ischemia-reperfusion injury in mice by activating NCOA4-mediated ferritinophagy.
Li B, Wang W, Li Y, Wang S, Liu H, Xia Z, Gao W, Zhao B
Experimental neurology 2023 Jan;359:114269
Experimental neurology 2023 Jan;359:114269
Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics.
Zheng M, Hu Z, Wang Y, Wang C, Zhong C, Cui W, You J, Gao B, Sun X, La L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154495
Myricetin-Loaded Nanomicelles Protect against Cisplatin-Induced Acute Kidney Injury by Inhibiting the DNA Damage-cGAS-STING Signaling Pathway.
Qi X, Wang J, Fei F, Gao X, Wu X, Shi D, Guo C
Molecular pharmaceutics 2023 Jan 2;20(1):136-146
Molecular pharmaceutics 2023 Jan 2;20(1):136-146
Inhibition of cGAS ameliorates acute lung injury triggered by zinc oxide nanoparticles.
Jiang Z, Jiang Y, Fan J, Zhang J, Xu G, Fan Y, Zhang L, Qin X, Jiang X, Mao L, Liu G, Chen C, Zou Z
Toxicology letters 2023 Jan 15;373:62-75
Toxicology letters 2023 Jan 15;373:62-75
Human kidney organoids model of Esculentoside A nephrotoxicity to investigate the role of epithelial-mesenchymal transition via STING signaling.
Gu S, Wu G, Lu D, Wang Y, Tang L, Zhang W
Toxicology letters 2023 Jan 15;373:172-183
Toxicology letters 2023 Jan 15;373:172-183
Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.
Wang J, Qin X, Huang Y, Zhang G, Liu Y, Cui Y, Wang Y, Pei J, Ma S, Song Z, Zhu X, Wang H, Yang B
Journal of virology 2023 Feb 28;97(2):e0197522
Journal of virology 2023 Feb 28;97(2):e0197522
African Swine Fever Virus L83L Negatively Regulates the cGAS-STING-Mediated IFN-I Pathway by Recruiting Tollip To Promote STING Autophagic Degradation.
Cheng M, Kanyema MM, Sun Y, Zhao W, Lu Y, Wang J, Li X, Shi C, Wang J, Wang N, Yang W, Jiang Y, Huang H, Yang G, Zeng Y, Wang C, Cao X
Journal of virology 2023 Feb 28;97(2):e0192322
Journal of virology 2023 Feb 28;97(2):e0192322
Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner.
Sun S, Xu Y, Qiu M, Jiang S, Cao Q, Luo J, Zhang T, Chen N, Zheng W, Meurens F, Liu Z, Zhu J
Viruses 2023 Feb 28;15(3)
Viruses 2023 Feb 28;15(3)
TRAF3 activates STING-mediated suppression of EV-A71 and target of viral evasion.
Zheng W, Zhou Z, Rui Y, Ye R, Xia F, Guo F, Liu X, Su J, Lou M, Yu XF
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Signal transduction and targeted therapy 2023 Feb 24;8(1):79
Proteomic analysis predicts anti-angiogenic resistance in recurred glioblastoma.
Jeon H, Byun J, Kang H, Kim K, Lee E, Kim JH, Hong CK, Song SW, Kim YH, Chong S, Kim JH, Nam SJ, Park JE, Lee S
Journal of translational medicine 2023 Feb 2;21(1):69
Journal of translational medicine 2023 Feb 2;21(1):69
NF-κB regulates the expression of STING via alternative promoter usage.
Chen LY, Pang XY, Chen C, Xu HG
Life sciences 2023 Feb 1;314:121336
Life sciences 2023 Feb 1;314:121336
Stimulator of interferon genes promotes diabetic sarcopenia by targeting peroxisome proliferator activated receptors γ degradation and inhibiting fatty acid oxidation.
Yan SB, Liang H, Zhan P, Zheng H, Zhao QX, Zheng ZJ, Lu HX, Shang GK, Ji XP
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Journal of cachexia, sarcopenia and muscle 2023 Dec;14(6):2623-2641
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production.
Wen J, Mu W, Li H, Yan Y, Zhan X, Luo W, Wang Z, Kan W, Zhao J, Hui S, He P, Qin S, Xu Y, Zhang P, Xiao X, Xu G, Bai Z
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
Molecular medicine (Cambridge, Mass.) 2023 Dec 8;29(1):167
CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.
Zhang G, Jiang P, Tang W, Wang Y, Qiu F, An J, Zheng Y, Wu D, Zhou J, Neculai D, Shi Y, Sheng W
Molecular cell 2023 Dec 7;83(23):4370-4385.e9
Molecular cell 2023 Dec 7;83(23):4370-4385.e9
Tumor endothelial cell autophagy is a key vascular-immune checkpoint in melanoma.
Verhoeven J, Jacobs KA, Rizzollo F, Lodi F, Hua Y, Poźniak J, Narayanan Srinivasan A, Houbaert D, Shankar G, More S, Schaaf MB, Dubroja Lakic N, Ganne M, Lamote J, Van Weyenbergh J, Boon L, Bechter O, Bosisio F, Uchiyama Y, Bertrand MJ, Marine JC, Lambrechts D, Bergers G, Agrawal M, Agostinis P
EMBO molecular medicine 2023 Dec 7;15(12):e18028
EMBO molecular medicine 2023 Dec 7;15(12):e18028
RNF144A promotes antiviral responses by modulating STING ubiquitination.
Yang B, Pei J, Lu C, Wang Y, Shen M, Qin X, Huang Y, Yang X, Zhao X, Ma S, Song Z, Liang Y, Wang H, Wang J
EMBO reports 2023 Dec 6;24(12):e57528
EMBO reports 2023 Dec 6;24(12):e57528
STING-IFN-I pathway relieves incision induced acute postoperative pain via inhibiting the neuroinflammation in dorsal root ganglion of rats.
Ma L, Deng D, Zhang T, Zhao W, Liu C, Huang S, Xu F, Wang Y, Zhao S, Ding Y, Huang Y, Wang K, Zhang Y, Yang X, Cao S, Chen X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Aug;72(8):1551-1565
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Aug;72(8):1551-1565
Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress.
Chen X, Yu Z, Nong C, Xue R, Zhang M, Zhang Y, Sun L, Zhang L, Wang X
Cell biology and toxicology 2023 Aug;39(4):1753-1772
Cell biology and toxicology 2023 Aug;39(4):1753-1772
Naringin protects against inflammation and apoptosis induced by intestinal ischemia-reperfusion injury through deactivation of cGAS-STING signaling pathway.
Gu L, Wang F, Wang Y, Sun D, Sun Y, Tian T, Meng Q, Yin L, Xu L, Lu X, Peng J, Lin Y, Sun P
Phytotherapy research : PTR 2023 Aug;37(8):3495-3507
Phytotherapy research : PTR 2023 Aug;37(8):3495-3507
The innate immune sensor STING accelerates neointima formation via NF-κB signaling pathway.
He L, Liu D, Zhou W, Han Y, Ju Y, Liu H, Chen Y, Yu J, Wang L, Wang J, He C
International immunopharmacology 2023 Aug;121:110412
International immunopharmacology 2023 Aug;121:110412
Ficolin B secreted by alveolar macrophage exosomes exacerbates bleomycin-induced lung injury via ferroptosis through the cGAS-STING signaling pathway.
Wu X, Jiang Y, Li R, Xia Y, Li F, Zhao M, Li G, Tan X
Cell death & disease 2023 Aug 30;14(8):577
Cell death & disease 2023 Aug 30;14(8):577
Small cytosolic double-stranded DNA represses cyclic GMP-AMP synthase activation and induces autophagy.
Liu Y, Chen X, Zhao Y, Wang XY, Luo YW, Chen L, Wang W, Zhong S, Hu M, Dai Z, Jiang J, Wang X, Ji H, Cheng XX, Zheng A, Zuo J, Liu H, Ma D, Luo Z, Cao F, Hu S, Huang AL, Tang KF
Cell reports 2023 Aug 29;42(8):112852
Cell reports 2023 Aug 29;42(8):112852
STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages.
Liu Y, Sun Q, Zhang C, Ding M, Wang C, Zheng Q, Ma Z, Xu H, Zhou G, Wang X, Cheng Z, Xia H
iScience 2023 Aug 18;26(8):107376
iScience 2023 Aug 18;26(8):107376
A role of STING signaling in obesity-induced lung inflammation.
Qi Y, Wu Z, Chen D, Zhu L, Yang Y
International journal of obesity (2005) 2023 Apr;47(4):325-334
International journal of obesity (2005) 2023 Apr;47(4):325-334
The cGAS-STING pathway promotes endometriosis by up-regulating autophagy.
Zhu S, Chen Q, Sun J, Du W, Chen Z, Yu M, Tao J, Zhou Y, Zhao Y, Zhang Q
International immunopharmacology 2023 Apr;117:109644
International immunopharmacology 2023 Apr;117:109644
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Li J, Sun Y, Zhao X, Ma Y, Xie Y, Liu S, Hui B, Shi X, Sun X, Zhang X
Cell death & disease 2023 Apr 8;14(4):259
Cell death & disease 2023 Apr 8;14(4):259
The Papain-Like Protease of Porcine Reproductive and Respiratory Syndrome Virus Impedes STING Translocation from the Endoplasmic Reticulum to the Golgi Apparatus by Deubiquitinating STIM1.
Diao F, Bai J, Jiang C, Sun Y, Gao Y, Nauwynck H, Jiang P, Liu X
Journal of virology 2023 Apr 27;97(4):e0018823
Journal of virology 2023 Apr 27;97(4):e0018823
Newly synthesized AIFM1 determines the hypersensitivity of T lymphocytes to STING activation-induced cell apoptosis.
Ji W, Zhang L, Ma C, Xu X, Li S, Xia H, Zhou W, Liu X
Cell reports 2023 Apr 25;42(4):112327
Cell reports 2023 Apr 25;42(4):112327
STING directly recruits WIPI2 for autophagosome formation during STING-induced autophagy.
Wan W, Qian C, Wang Q, Li J, Zhang H, Wang L, Pu M, Huang Y, He Z, Zhou T, Shen HM, Liu W
The EMBO journal 2023 Apr 17;42(8):e112387
The EMBO journal 2023 Apr 17;42(8):e112387
Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells.
Lazarchuk P, Nguyen VN, Brunon S, Pavlova MN, Sidorova JM
Frontiers in molecular biosciences 2022;9:1048726
Frontiers in molecular biosciences 2022;9:1048726
STING Induces Liver Ischemia-Reperfusion Injury by Promoting Calcium-Dependent Caspase 1-GSDMD Processing in Macrophages.
Wu XY, Chen YJ, Liu CA, Gong JH, Xu XS
Oxidative medicine and cellular longevity 2022;2022:8123157
Oxidative medicine and cellular longevity 2022;2022:8123157
Predicting the Immune Microenvironment and Prognosis with a NETosis-Related lncRNA Signature in Head and Neck Squamous Cell Carcinoma.
He X, Xiao Y, Liu S, Deng R, Li Z, Zhu X
BioMed research international 2022;2022:3191474
BioMed research international 2022;2022:3191474
Resveratrol reduces inflammatory response and detrimental effects in chronic cerebral hypoperfusion by down-regulating stimulator of interferon genes/TANK-binding kinase 1/interferon regulatory factor 3 signaling.
Kang N, Shi Y, Song J, Gao F, Fan M, Jin W, Gao Y, Lv P
Frontiers in aging neuroscience 2022;14:868484
Frontiers in aging neuroscience 2022;14:868484
African Swine Fever Virus Structural Protein p17 Inhibits cGAS-STING Signaling Pathway Through Interacting With STING.
Zheng W, Xia N, Zhang J, Cao Q, Jiang S, Luo J, Wang H, Chen N, Zhang Q, Meurens F, Zhu J
Frontiers in immunology 2022;13:941579
Frontiers in immunology 2022;13:941579
The Absence of STING Ameliorates Non-Alcoholic Fatty Liver Disease and Reforms Gut Bacterial Community.
Zhang Q, Chen Q, Yan C, Niu C, Zhou J, Liu J, Song Y, Zhou F, Fan Y, Ren J, Xu H, Zhang B
Frontiers in immunology 2022;13:931176
Frontiers in immunology 2022;13:931176
Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING.
Yu TT, Han N, Li LG, Peng XC, Li QR, Xu HZ, Wang XY, Yang ZY, Chen X, Wang MF, Li TF
Frontiers in pharmacology 2022;13:837784
Frontiers in pharmacology 2022;13:837784
Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis.
Xia N, Zheng W, Jiang S, Cao Q, Luo J, Zhang J, Xu Y, Sun S, Zhang K, Chen N, Meurens F, Zhu J
Frontiers in immunology 2022;13:1021384
Frontiers in immunology 2022;13:1021384
Deficient DNASE1L3 facilitates neutrophil extracellular traps-induced invasion via cyclic GMP-AMP synthase and the non-canonical NF-κB pathway in diabetic hepatocellular carcinoma.
Li N, Zheng X, Chen M, Huang L, Chen L, Huo R, Li X, Huang Y, Sun M, Mai S, Wu Z, Zhang H, Liu J, Yang CT
Clinical & translational immunology 2022;11(4):e1386
Clinical & translational immunology 2022;11(4):e1386
Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases.
Zhao X, Yu M, Zhao Y, Zheng Y, Meng L, Du K, Xie Z, Lv H, Zhang W, Liu J, Wang Q, Yuan Y, Wang Z, Deng J
Journal of neurology 2022 Sep;269(9):4985-4996
Journal of neurology 2022 Sep;269(9):4985-4996
Human Atheromatous Plaques Expressed Sensing Adaptor STING, a Potential Role in Vascular Inflammation Pathogenesis.
Pallarés J, Torreguitart N, Arqué G, Portero-Otin M, Purroy F
Thrombosis and haemostasis 2022 Sep;122(9):1621-1624
Thrombosis and haemostasis 2022 Sep;122(9):1621-1624
Clathrin-associated AP-1 controls termination of STING signalling.
Liu Y, Xu P, Rivara S, Liu C, Ricci J, Ren X, Hurley JH, Ablasser A
Nature 2022 Oct;610(7933):761-767
Nature 2022 Oct;610(7933):761-767
Activation of cGAS-STING pathway - A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy.
Zhou M, Cheng X, Zhu W, Jiang J, Zhu S, Wu X, Liu M, Fang Q
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631
Journal of clinical laboratory analysis 2022 Oct;36(10):e24631
BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma.
Langbein LE, El Hajjar R, He S, Sementino E, Zhong Z, Jiang W, Leiby BE, Li L, Uzzo RG, Testa JR, Yang H
Cancer letters 2022 Oct 28;547:215885
Cancer letters 2022 Oct 28;547:215885
SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways.
Zhuang X, Ma J, Xu G, Sun Z
Molecular medicine (Cambridge, Mass.) 2022 Oct 22;28(1):125
Molecular medicine (Cambridge, Mass.) 2022 Oct 22;28(1):125
STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal Cortex.
Zhang X, Li X, Wang W, Zhang Y, Gong Z, Peng Y, Wu J, You X
Cancers 2022 Oct 22;14(21)
Cancers 2022 Oct 22;14(21)
Baicalein-loaded silk fibroin peptide nanofibers protect against cisplatin-induced acute kidney injury: Fabrication, characterization and mechanism.
Liu S, Gao X, Wang Y, Wang J, Qi X, Dong K, Shi D, Wu X, Guo C
International journal of pharmaceutics 2022 Oct 15;626:122161
International journal of pharmaceutics 2022 Oct 15;626:122161
Pharmacological inhibition of the cGAS-STING signaling pathway suppresses microglial M1-polarization in the spinal cord and attenuates neuropathic pain.
Wu W, Zhang X, Wang S, Li T, Hao Q, Li S, Yao W, Sun R
Neuropharmacology 2022 Oct 1;217:109206
Neuropharmacology 2022 Oct 1;217:109206
SARS-CoV-2 ORF10 antagonizes STING-dependent interferon activation and autophagy.
Han L, Zheng Y, Deng J, Nan ML, Xiao Y, Zhuang MW, Zhang J, Wang W, Gao C, Wang PH
Journal of medical virology 2022 Nov;94(11):5174-5188
Journal of medical virology 2022 Nov;94(11):5174-5188
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy.
Han C, Qian X, Ren X, Zhang S, Hu L, Li J, Huang Y, Huang R, Ooi K, Lin H, Xia C
Molecular neurobiology 2022 Nov;59(11):7006-7024
Molecular neurobiology 2022 Nov;59(11):7006-7024
Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment.
Xu A, Yang R, Zhang M, Wang X, Di Y, Jiang B, Di Y, Zhou Z, Zhou L
Journal of drug targeting 2022 Nov;30(9):961-972
Journal of drug targeting 2022 Nov;30(9):961-972
HIV-1-induced type I IFNs promote viral latency in macrophages.
Dickey LL, Martins LJ, Planelles V, Hanley TM
Journal of leukocyte biology 2022 Nov;112(5):1343-1356
Journal of leukocyte biology 2022 Nov;112(5):1343-1356
UNC13D inhibits STING signaling by attenuating its oligomerization on the endoplasmic reticulum.
Song P, Yang W, Lou KF, Dong H, Zhang H, Wang B, Chen D
EMBO reports 2022 Nov 7;23(11):e55099
EMBO reports 2022 Nov 7;23(11):e55099
Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity.
Liu W, Alameh MG, Yang JF, Xu JR, Lin PJC, Tam YK, Weissman D, You J
International journal of molecular sciences 2022 Nov 22;23(23)
International journal of molecular sciences 2022 Nov 22;23(23)
The Lack of STING Impairs the MHC-I Dependent Antigen Presentation and JAK/STAT Signaling in Murine Macrophages.
Caiazza C, Brusco T, D'Alessio F, D'Agostino M, Avagliano A, Arcucci A, Ambrosino C, Fiume G, Mallardo M
International journal of molecular sciences 2022 Nov 17;23(22)
International journal of molecular sciences 2022 Nov 17;23(22)
Interruption of post-Golgi STING trafficking activates tonic interferon signaling.
Tu X, Chu TT, Jeltema D, Abbott K, Yang K, Xing C, Han J, Dobbs N, Yan N
Nature communications 2022 Nov 15;13(1):6977
Nature communications 2022 Nov 15;13(1):6977
cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress.
Hu H, Zhao R, He Q, Cui C, Song J, Guo X, Zang N, Yang M, Zou Y, Yang J, Li J, Wang L, Xia L, Wang L, He F, Hou X, Yan F, Chen L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22266
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22266
Pseudorabies virus tegument protein UL13 recruits RNF5 to inhibit STING-mediated antiviral immunity.
Kong Z, Yin H, Wang F, Liu Z, Luan X, Sun L, Liu W, Shang Y
PLoS pathogens 2022 May;18(5):e1010544
PLoS pathogens 2022 May;18(5):e1010544
SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Song C, Liu D, Liu S, Li D, Horecny I, Zhang X, Li P, Chen L, Miller M, Chowdhury R, Issa M, Shen R, Yan Y, Zhang F, Zhang L, Zhang L, Bai C, Feng J, Zhuang L, Zhang R, Li J, Wilkinson H, Liu J, Tao W
Scientific reports 2022 May 20;12(1):8579
Scientific reports 2022 May 20;12(1):8579
Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy.
Liu J, Yuan L, Ruan Y, Deng B, Yang Z, Ren Y, Li L, Liu T, Zhao H, Mai R, Chen J
Journal of medicinal chemistry 2022 May 12;65(9):6593-6611
Journal of medicinal chemistry 2022 May 12;65(9):6593-6611
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Shen R, Yang K, Cheng X, Guo C, Xing X, Sun H, Liu D, Liu X, Wang D
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment.
Xiong H, Chen Z, Lin B, Chen W, Li Q, Li Y, Fang M, Wang Y, Zhang H, Lu Y, Bi A, Wu S, Jia Y, Wang X
Molecular therapy oncolytics 2022 Mar 17;24:371-384
Molecular therapy oncolytics 2022 Mar 17;24:371-384
XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury.
Liu Z, Wang M, Wang X, Bu Q, Wang Q, Su W, Li L, Zhou H, Lu L
Redox biology 2022 Jun;52:102305
Redox biology 2022 Jun;52:102305
STING activation promotes inflammatory response and delays skin wound healing in diabetic mice.
Feng Z, Zang C, Zhang L, Yin S, Zhuang Q, Wang X
Biochemical and biophysical research communications 2022 Jun 30;611:126-131
Biochemical and biophysical research communications 2022 Jun 30;611:126-131
ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
Shi C, Yang X, Liu Y, Li H, Chu H, Li G, Yin H
The EMBO journal 2022 Jun 1;41(11):e109272
The EMBO journal 2022 Jun 1;41(11):e109272
GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
Xu H, Jin J, Chen Y, Wu G, Zhu H, Wang Q, Wang J, Li S, Grigore FN, Ma J, Chen CC, Lan Q, Li M
Oncogene 2022 Jul;41(31):3876-3885
Oncogene 2022 Jul;41(31):3876-3885
1,25(OH)(2) D(3) blocks IFNβ production through regulating STING in epithelial layer of oral lichen planus.
Ge X, Wang Y, Xie H, Li R, Zhang F, Zhao B, Du J
Journal of cellular and molecular medicine 2022 Jul;26(13):3751-3759
Journal of cellular and molecular medicine 2022 Jul;26(13):3751-3759
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
Wu J, Liu Q, Zhang X, Tan M, Li X, Liu P, Wu L, Jiao F, Lin Z, Wu X, Wang X, Zhao Y, Ren J
Cell death & disease 2022 Jul 28;13(7):653
Cell death & disease 2022 Jul 28;13(7):653
STING expression is an independent prognostic factor in patients with mycosis fungoides.
Takayanagi-Hara R, Sawada Y, Sugino H, Minokawa Y, Kawahara-Nanamori H, Itamura M, Tashiro T, Kaneoka A, Saito-Sasaki N, Yamamoto K, Okada E
Scientific reports 2022 Jul 26;12(1):12739
Scientific reports 2022 Jul 26;12(1):12739
The Porcine and Chicken Innate DNA Sensing cGAS-STING-IRF Signaling Axes Exhibit Differential Species Specificity.
Jiang S, Luo J, Zhang Y, Cao Q, Wang Y, Xia N, Zheng W, Chen N, Meurens F, Wu H, Zhu J
Journal of immunology (Baltimore, Md. : 1950) 2022 Jul 15;209(2):412-426
Journal of immunology (Baltimore, Md. : 1950) 2022 Jul 15;209(2):412-426
Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer.
Lee KM, Lin CC, Servetto A, Bae J, Kandagatla V, Ye D, Kim G, Sudhan DR, Mendiratta S, González Ericsson PI, Balko JM, Lee J, Barnes S, Malladi VS, Tabrizi S, Reddy SM, Yum S, Chang CW, Hutchinson KE, Yost SE, Yuan Y, Chen ZJ, Fu YX, Hanker AB, Arteaga CL
Cancer immunology research 2022 Jul 1;10(7):829-843
Cancer immunology research 2022 Jul 1;10(7):829-843
Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium.
Gagliardi TB, Goldstein ME, Song D, Gray KM, Jung JW, Ignacio MA, Stroka KM, Duncan GA, Scull MA
PLoS pathogens 2022 Jan;18(1):e1010159
PLoS pathogens 2022 Jan;18(1):e1010159
Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics.
Gao J, Wu Z, Zhao M, Zhang R, Li M, Sun D, Cheng H, Qi X, Shen Y, Xu Q, Chen H, Chen D, Sun Y
Acta pharmaceutica Sinica. B 2022 Jan;12(1):149-166
Acta pharmaceutica Sinica. B 2022 Jan;12(1):149-166
CD4 T cell-intrinsic STING signaling controls the differentiation and effector functions of T(H)1 and T(H)9 cells.
Benoit-Lizon I, Jacquin E, Rivera Vargas T, Richard C, Roussey A, Dal Zuffo L, Martin T, Melis A, Vinokurova D, Shahoei SH, Baeza Garcia A, Pignol C, Giorgiutti S, Carapito R, Boidot R, Végran F, Flavell RA, Ryffel B, Nelson ER, Soulas-Sprauel P, Lawrence T, Apetoh L
Journal for immunotherapy of cancer 2022 Jan;10(1)
Journal for immunotherapy of cancer 2022 Jan;10(1)
Helicobacter pylori actively suppresses innate immune nucleic acid receptors.
Dooyema SDR, Noto JM, Wroblewski LE, Piazuelo MB, Krishna U, Suarez G, Romero-Gallo J, Delgado AG, Peek RM
Gut microbes 2022 Jan-Dec;14(1):2105102
Gut microbes 2022 Jan-Dec;14(1):2105102
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation.
Li S, Qian N, Jiang C, Zu W, Liang A, Li M, Elledge SJ, Tan X
Nature communications 2022 Jan 10;13(1):105
Nature communications 2022 Jan 10;13(1):105
The cGAS-STING pathway connects mitochondrial damage to inflammation in burn-induced acute lung injury in rat.
Comish PB, Liu MM, Huebinger R, Carlson D, Kang R, Tang D
Burns : journal of the International Society for Burn Injuries 2022 Feb;48(1):168-175
Burns : journal of the International Society for Burn Injuries 2022 Feb;48(1):168-175
STING-mediated inflammation contributes to Gao binge ethanol feeding model.
Wang L, You HM, Meng HW, Pan XY, Chen X, Bi YH, Zhang YF, Li JJ, Yin NN, Zhang ZW, Huang C, Li J
Journal of cellular physiology 2022 Feb;237(2):1471-1485
Journal of cellular physiology 2022 Feb;237(2):1471-1485
Molecular cloning and functional analysis of Macaca mulatta STING.
Zhao M, Zhang H, Sha H, Li H, Wang R
Developmental and comparative immunology 2022 Feb;127:104296
Developmental and comparative immunology 2022 Feb;127:104296
Sustained IL-4 priming of macrophages enhances the inflammatory response to TLR7/8 ligand R848.
Banete A, Gee K, Basta S
Journal of leukocyte biology 2022 Feb;111(2):401-413
Journal of leukocyte biology 2022 Feb;111(2):401-413
Targeting KDM4C enhances CD8(+) T cell mediated antitumor immunity by activating chemokine CXCL10 transcription in lung cancer.
Jie X, Chen Y, Zhao Y, Yang X, Xu Y, Wang J, Meng R, Zhang S, Dong X, Zhang T, Yang K, Xu S, Wu G
Journal for immunotherapy of cancer 2022 Feb;10(2)
Journal for immunotherapy of cancer 2022 Feb;10(2)
An alternatively spliced STING isoform localizes in the cytoplasmic membrane and directly senses extracellular cGAMP.
Li X, Zhu Y, Zhang X, An X, Weng M, Shi J, Wang S, Liu C, Luo S, Zheng T
The Journal of clinical investigation 2022 Feb 1;132(3)
The Journal of clinical investigation 2022 Feb 1;132(3)
ITGA2 induces STING expression in pancreatic cancer by inducing DNMT1 degradation.
Meng J, Cai H, Sun Y, Wen S, Wu H, Ren D
Cellular oncology (Dordrecht, Netherlands) 2022 Dec;45(6):1421-1434
Cellular oncology (Dordrecht, Netherlands) 2022 Dec;45(6):1421-1434
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity.
Gao Y, Zheng X, Chang B, Lin Y, Huang X, Wang W, Ding S, Zhan W, Wang S, Xiao B, Huo L, Yu Y, Chen Y, Gong R, Wu Y, Zhang R, Zhong L, Wang X, Chen Q, Gao S, Jiang Z, Wei D, Kang T
Cell research 2022 Dec;32(12):1086-1104
Cell research 2022 Dec;32(12):1086-1104
DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients.
Vasiyani H, Mane M, Rana K, Shinde A, Roy M, Singh J, Gohel D, Currim F, Srivastava R, Singh R
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):961-978
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):961-978
Expression of STING Is Increased in Monocyte-Derived Macrophages and Contributes to Liver Inflammation in Hepatic Ischemia-Reperfusion Injury.
Jiao J, Jiang Y, Qian Y, Liu G, Xu M, Wang F, Sun X, Gao Y, Su L, Shi Y, Kong X
The American journal of pathology 2022 Dec;192(12):1745-1762
The American journal of pathology 2022 Dec;192(12):1745-1762
The African swine fever virus protease pS273R inhibits DNA sensing cGAS-STING pathway by targeting IKKε.
Luo J, Zhang J, Ni J, Jiang S, Xia N, Guo Y, Shao Q, Cao Q, Zheng W, Chen N, Zhang Q, Chen H, Chen Q, Zhu H, Meurens F, Zhu J
Virulence 2022 Dec;13(1):740-756
Virulence 2022 Dec;13(1):740-756
Mitochondrial cristae architecture protects against mtDNA release and inflammation.
He B, Yu H, Liu S, Wan H, Fu S, Liu S, Yang J, Zhang Z, Huang H, Li Q, Wang F, Jiang Z, Liu Q, Jiang H
Cell reports 2022 Dec 6;41(10):111774
Cell reports 2022 Dec 6;41(10):111774
Activation of cGAS-STING Pathway Is Associated with MSI-H Stage IV Colorectal Cancer.
Kunac N, Degoricija M, Viculin J, Omerović J, Terzić J, Vilović K, Korac-Prlic J
Cancers 2022 Dec 30;15(1)
Cancers 2022 Dec 30;15(1)
The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy.
Jiang S, Xia N, Luo J, Zhang Y, Cao Q, Zhang J, Wang Y, Zhao Y, Zheng W, Chen N, Meurens F, Li X, Zhu J
Journal of virology 2022 Dec 14;96(23):e0147622
Journal of virology 2022 Dec 14;96(23):e0147622
MPYS Modulates Fatty Acid Metabolism and Immune Tolerance at Homeostasis Independent of Type I IFNs.
Mansouri S, Gogoi H, Patel S, Katikaneni DS, Singh A, Aybar-Torres A, de Lartigue G, Jin L
Journal of immunology (Baltimore, Md. : 1950) 2022 Dec 1;209(11):2114-2132
Journal of immunology (Baltimore, Md. : 1950) 2022 Dec 1;209(11):2114-2132
Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction.
Yu H, Liao K, Hu Y, Lv D, Luo M, Liu Q, Huang L, Luo S
Aging and disease 2022 Dec 1;13(6):1901-1918
Aging and disease 2022 Dec 1;13(6):1901-1918
Irradiation combined with PD-L1(-/-) and autophagy inhibition enhances the antitumor effect of lung cancer via cGAS-STING-mediated T cell activation.
Zhao X, Hu S, Zeng L, Liu X, Song Y, Zhang Y, Chen Q, Bai Y, Zhang J, Zhang H, Pan Y, Shao C
iScience 2022 Aug 19;25(8):104690
iScience 2022 Aug 19;25(8):104690
New mechanism of nephrotoxicity of triptolide: Oxidative stress promotes cGAS-STING signaling pathway.
Lu J, Zhang Y, Dong H, Sun J, Zhu L, Liu P, Wen F, Lin R
Free radical biology & medicine 2022 Aug 1;188:26-34
Free radical biology & medicine 2022 Aug 1;188:26-34
Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.
Ni L, Lin Z, Hu S, Shi Y, Jiang Z, Zhao J, Zhou Y, Wu Y, Tian N, Sun L, Wu A, Pan Z, Zhang X, Wang X
Biochemical pharmacology 2022 Apr;198:114935
Biochemical pharmacology 2022 Apr;198:114935
Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.
Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q
Autophagy 2022 Apr;18(4):860-876
Autophagy 2022 Apr;18(4):860-876
Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer.
Yu TT, Peng XC, Wang MF, Han N, Xu HZ, Li QR, Li LG, Xu X, Ma QL, Liu B, Wang J, Zhao L, Chen X, Li TF
Journal of cancer research and clinical oncology 2022 Apr;148(4):867-879
Journal of cancer research and clinical oncology 2022 Apr;148(4):867-879
Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling.
Liu K, Zhao X, Guo M, Zhu J, Li D, Ding J, Han X, Wu J
Toxicology letters 2022 Apr 1;358:6-16
Toxicology letters 2022 Apr 1;358:6-16
Negative Regulation of RNF90 on RNA Virus-Triggered Antiviral Immune Responses Targeting MAVS.
Yang B, Zhang G, Qin X, Huang Y, Ren X, Sun J, Ma S, Liu Y, Song D, Liu Y, Cui Y, Wang H, Wang J
Frontiers in immunology 2021;12:730483
Frontiers in immunology 2021;12:730483
Brucella spp. Omp25 Promotes Proteasome-Mediated cGAS Degradation to Attenuate IFN-β Production.
Li R, Liu W, Yin X, Zheng F, Wang Z, Wu X, Zhang X, Du Q, Huang Y, Tong D
Frontiers in microbiology 2021;12:702881
Frontiers in microbiology 2021;12:702881
STING Contributes to Host Defense Against Staphylococcus aureus Pneumonia Through Suppressing Necroptosis.
Liu ZZ, Yang YJ, Zhou CK, Yan SQ, Ma K, Gao Y, Chen W
Frontiers in immunology 2021;12:636861
Frontiers in immunology 2021;12:636861
Activation of the cGAS-STING signaling pathway in adenomyosis patients.
Lin Y, Wang L, Ye M, Yu KN, Sun X, Xue M, Deng X
Immunity, inflammation and disease 2021 Sep;9(3):932-942
Immunity, inflammation and disease 2021 Sep;9(3):932-942
Efficient Delivery of Chlorin e6 by Polyglycerol-Coated Iron Oxide Nanoparticles with Conjugated Doxorubicin for Enhanced Photodynamic Therapy of Melanoma.
Li TF, Xu HZ, Xu YH, Yu TT, Tang JM, Li K, Wang C, Peng XC, Li QR, Sang XY, Zheng MY, Liu Y, Zhao L, Chen X
Molecular pharmaceutics 2021 Sep 6;18(9):3601-3615
Molecular pharmaceutics 2021 Sep 6;18(9):3601-3615
Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.
Yuan SJ, Wang C, Xu HZ, Liu Y, Zheng MY, Li K, Sun SK, Komatsu N, Zhao L, Chen X
International journal of pharmaceutics 2021 Sep 5;606:120872
International journal of pharmaceutics 2021 Sep 5;606:120872
A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment.
Chen A, Yang F, Kuang J, Xiong Y, Mi BB, Zhou Y, Hu JJ, Song SJ, Wan T, Wan ZZ, Huang HY, Li XR, Song W, Qiu WX
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
ACS applied materials & interfaces 2021 Sep 29;13(38):45335-45345
The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function.
Xu Y, Zhang Y, Sun S, Luo J, Jiang S, Zhang J, Liu X, Shao Q, Cao Q, Zheng W, Chen N, Meurens F, Zhu J
Viruses 2021 Sep 14;13(9)
Viruses 2021 Sep 14;13(9)
Screening of Porcine Innate Immune Adaptor Signaling Revealed Several Anti-PRRSV Signaling Pathways.
Xu Y, Ye M, Zhang Y, Sun S, Luo J, Jiang S, Zhang J, Liu X, Shao Q, Cao Q, Zheng W, Meurens F, Chen N, Zhu J
Vaccines 2021 Oct 14;9(10)
Vaccines 2021 Oct 14;9(10)
eccDNAs are apoptotic products with high innate immunostimulatory activity.
Wang Y, Wang M, Djekidel MN, Chen H, Liu D, Alt FW, Zhang Y
Nature 2021 Nov;599(7884):308-314
Nature 2021 Nov;599(7884):308-314
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection.
Liu W, Reyes HM, Yang JF, Li Y, Stewart KM, Basil MC, Lin SM, Katzen J, Morrisey EE, Weiss SR, You J
Journal of virology 2021 May 24;95(12)
Journal of virology 2021 May 24;95(12)
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Hou J, Han L, Zhao Z, Liu H, Zhang L, Ma C, Yi F, Liu B, Zheng Y, Gao C
Nature communications 2021 May 20;12(1):2970
Nature communications 2021 May 20;12(1):2970
Pharmacological activation of STING blocks SARS-CoV-2 infection.
Li M, Ferretti M, Ying B, Descamps H, Lee E, Dittmar M, Lee JS, Whig K, Kamalia B, Dohnalová L, Uhr G, Zarkoob H, Chen YC, Ramage H, Ferrer M, Lynch K, Schultz DC, Thaiss CA, Diamond MS, Cherry S
Science immunology 2021 May 18;6(59)
Science immunology 2021 May 18;6(59)
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Ma D, Yang M, Wang Q, Sun C, Shi H, Jing W, Bi Y, Shen X, Ma X, Qin Z, Lin Y, Zhu L, Zhao Y, Cheng Y, Han L
Science advances 2021 Mar;7(13)
Science advances 2021 Mar;7(13)
Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.
Zhou Y, Zhao S, Gao X, Jiang S, Ma J, Wang R, Li Q, Qin L, Tong Z, Wu J, Zhao J
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)
Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine.
Mai J, Li Z, Xia X, Zhang J, Li J, Liu H, Shen J, Ramirez M, Li F, Li Z, Yokoi K, Liu X, Mittendorf EA, Ferrari M, Shen H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jun;8(12):2100166
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Jun;8(12):2100166
The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells.
Vasiyani H, Shinde A, Roy M, Mane M, Singh K, Singh J, Gohel D, Currim F, Vaidya K, Chhabria M, Singh R
Apoptosis : an international journal on programmed cell death 2021 Jun;26(5-6):293-306
Apoptosis : an international journal on programmed cell death 2021 Jun;26(5-6):293-306
A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation.
Takahashi K, Niki T, Ogawa E, Fumika K, Nishioka Y, Sawa M, Arai H, Mukai K, Taguchi T
Scientific reports 2021 Jun 7;11(1):11996
Scientific reports 2021 Jun 7;11(1):11996
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.
Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Friesen O, Wu W, Stuhldreier F, Sun Y, Berning L, Friedrich A, Mendiburo MJ, Peter C, Wiek C, Hanenberg H, Stefanski A, Stühler K, Stork B
Scientific reports 2021 Jul 5;11(1):13863
Scientific reports 2021 Jul 5;11(1):13863
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis.
Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Experimental eye research 2021 Jan;202:108366
Experimental eye research 2021 Jan;202:108366
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
Sun H, Huang Y, Mei S, Xu F, Liu X, Zhao F, Yin L, Zhang D, Wei L, Wu C, Ma S, Wang J, Cen S, Liang C, Hu S, Guo F
Cell reports 2021 Jan 5;34(1):108586
Cell reports 2021 Jan 5;34(1):108586
USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells.
Lu R, Wu G, Chen M, Ji D, Liu Y, Zhou GG, Fu W
Molecular therapy oncolytics 2021 Dec 17;23:477-487
Molecular therapy oncolytics 2021 Dec 17;23:477-487
Chromosome aberrations induced by the non-mutagenic carcinogen acetamide involve in rat hepatocarcinogenesis through micronucleus formation in hepatocytes.
Nakamura K, Ishii Y, Takasu S, Nohmi T, Shibutani M, Ogawa K
Archives of toxicology 2021 Aug;95(8):2851-2865
Archives of toxicology 2021 Aug;95(8):2851-2865
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Chu TT, Tu X, Yang K, Wu J, Repa JJ, Yan N
Nature 2021 Aug;596(7873):570-575
Nature 2021 Aug;596(7873):570-575
The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease.
Zhao M, Wang B, Zhang C, Su Z, Guo B, Zhao Y, Zheng R
Cell death and differentiation 2021 Aug;28(8):2517-2535
Cell death and differentiation 2021 Aug;28(8):2517-2535
Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.
Zhao F, Zheng T, Gong W, Wu J, Xie H, Li W, Zhang R, Liu P, Liu J, Wu X, Zhao Y, Ren J
Cell death & disease 2021 Aug 27;12(9):815
Cell death & disease 2021 Aug 27;12(9):815
Transfected DNA is targeted by STING-mediated restriction.
Gu C, Ming L, Tao S, Luo M, Guo H, Xie Y, Liu J, Shen Z
Biochemical and biophysical research communications 2021 Apr 16;549:207-213
Biochemical and biophysical research communications 2021 Apr 16;549:207-213
Mutant p53 suppresses innate immune signaling to promote tumorigenesis.
Ghosh M, Saha S, Bettke J, Nagar R, Parrales A, Iwakuma T, van der Velden AWM, Martinez LA
Cancer cell 2021 Apr 12;39(4):494-508.e5
Cancer cell 2021 Apr 12;39(4):494-508.e5
The novel STING antagonist H151 ameliorates cisplatin-induced acute kidney injury and mitochondrial dysfunction.
Gong W, Lu L, Zhou Y, Liu J, Ma H, Fu L, Huang S, Zhang Y, Zhang A, Jia Z
American journal of physiology. Renal physiology 2021 Apr 1;320(4):F608-F616
American journal of physiology. Renal physiology 2021 Apr 1;320(4):F608-F616
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
Ren D, Qin G, Zhao J, Sun Y, Zhang B, Li D, Wang B, Jin X, Wu H
American journal of cancer research 2020;10(9):2851-2864
American journal of cancer research 2020;10(9):2851-2864
Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.
Li W, Luo Z, Yan CY, Wang XH, He ZJ, Ouyang SH, Yan C, Liu LF, Zhou QQ, Mu HL, Gong HB, Duan WJ, Liang L, Kurihara H, Feng D, Li YF, He RR
Theranostics 2020;10(20):9032-9049
Theranostics 2020;10(20):9032-9049
Long non-coding RNA MALAT1 targeting STING transcription promotes bronchopulmonary dysplasia through regulation of CREB.
Chen JH, Feng DD, Chen YF, Yang CX, Juan CX, Cao Q, Chen X, Liu S, Zhou GP
Journal of cellular and molecular medicine 2020 Sep;24(18):10478-10492
Journal of cellular and molecular medicine 2020 Sep;24(18):10478-10492
Reactive oxygen species oxidize STING and suppress interferon production.
Tao L, Lemoff A, Wang G, Zarek C, Lowe A, Yan N, Reese TA
eLife 2020 Sep 4;9
eLife 2020 Sep 4;9
Mitochondrial DNA drives noncanonical inflammation activation via cGAS-STING signaling pathway in retinal microvascular endothelial cells.
Guo Y, Gu R, Gan D, Hu F, Li G, Xu G
Cell communication and signaling : CCS 2020 Oct 28;18(1):172
Cell communication and signaling : CCS 2020 Oct 28;18(1):172
Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C.
McKnight KL, Swanson KV, Austgen K, Richards C, Mitchell JK, McGivern DR, Fritch E, Johnson J, Remlinger K, Magid-Slav M, Kapustina M, You S, Lemon SM
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27598-27607
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27598-27607
Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.
Peng Y, Zhuang J, Ying G, Zeng H, Zhou H, Cao Y, Chen H, Xu C, Fu X, Xu H, Li J, Cao S, Chen J, Gu C, Yan F, Chen G
Journal of neuroinflammation 2020 May 25;17(1):165
Journal of neuroinflammation 2020 May 25;17(1):165
RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation.
Yang B, Liu Y, Cui Y, Song D, Zhang G, Ma S, Liu Y, Chen M, Chen F, Wang H, Wang J
PLoS pathogens 2020 Mar;16(3):e1008387
PLoS pathogens 2020 Mar;16(3):e1008387
SPHK2-Generated S1P in CD11b(+) Macrophages Blocks STING to Suppress the Inflammatory Function of Alveolar Macrophages.
Joshi JC, Joshi B, Rochford I, Rayees S, Akhter MZ, Baweja S, Chava KR, Tauseef M, Abdelkarim H, Natarajan V, Gaponenko V, Mehta D
Cell reports 2020 Mar 24;30(12):4096-4109.e5
Cell reports 2020 Mar 24;30(12):4096-4109.e5
Redox homeostasis maintained by GPX4 facilitates STING activation.
Jia M, Qin D, Zhao C, Chai L, Yu Z, Wang W, Tong L, Lv L, Wang Y, Rehwinkel J, Yu J, Zhao W
Nature immunology 2020 Jul;21(7):727-735
Nature immunology 2020 Jul;21(7):727-735
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo.
Yamashiro LH, Wilson SC, Morrison HM, Karalis V, Chung JJ, Chen KJ, Bateup HS, Szpara ML, Lee AY, Cox JS, Vance RE
Nature communications 2020 Jul 7;11(1):3382
Nature communications 2020 Jul 7;11(1):3382
Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation.
Zhang CX, Huang DJ, Baloche V, Zhang L, Xu JX, Li BW, Zhao XR, He J, Mai HQ, Chen QY, Zhang XS, Busson P, Cui J, Li J
Oncogenesis 2020 Jul 6;9(7):65
Oncogenesis 2020 Jul 6;9(7):65
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
Pokatayev V, Yang K, Tu X, Dobbs N, Wu J, Kalb RG, Yan N
Nature immunology 2020 Feb;21(2):158-167
Nature immunology 2020 Feb;21(2):158-167
TBC1D9 regulates TBK1 activation through Ca(2+) signaling in selective autophagy.
Nozawa T, Sano S, Minowa-Nozawa A, Toh H, Nakajima S, Murase K, Aikawa C, Nakagawa I
Nature communications 2020 Feb 7;11(1):770
Nature communications 2020 Feb 7;11(1):770
Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer.
Yu J, Deng H, Xu Z
Scientific reports 2020 Dec 7;10(1):21360
Scientific reports 2020 Dec 7;10(1):21360
mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion.
Zhang X, Wu J, Liu Q, Li X, Li S, Chen J, Hong Z, Wu X, Zhao Y, Ren J
Cell death & disease 2020 Dec 11;11(12):1050
Cell death & disease 2020 Dec 11;11(12):1050
DNA Sensor IFI204 Contributes to Host Defense Against Staphylococcus aureus Infection in Mice.
Chen W, Yu SX, Zhou FH, Zhang XJ, Gao WY, Li KY, Liu ZZ, Han WY, Yang YJ
Frontiers in immunology 2019;10:474
Frontiers in immunology 2019;10:474
Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury.
Maekawa H, Inoue T, Ouchi H, Jao TM, Inoue R, Nishi H, Fujii R, Ishidate F, Tanaka T, Tanaka Y, Hirokawa N, Nangaku M, Inagi R
Cell reports 2019 Oct 29;29(5):1261-1273.e6
Cell reports 2019 Oct 29;29(5):1261-1273.e6
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion.
Zhang CX, Ye SB, Ni JJ, Cai TT, Liu YN, Huang DJ, Mai HQ, Chen QY, He J, Zhang XS, Zeng YX, Li J, Cui J
Cell death and differentiation 2019 Nov;26(11):2314-2328
Cell death and differentiation 2019 Nov;26(11):2314-2328
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing.
Hu S, Sun H, Yin L, Li J, Mei S, Xu F, Wu C, Liu X, Zhao F, Zhang D, Huang Y, Ren L, Cen S, Wang J, Liang C, Guo F
Science signaling 2019 Nov 26;12(609)
Science signaling 2019 Nov 26;12(609)
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway.
Gui X, Yang H, Li T, Tan X, Shi P, Li M, Du F, Chen ZJ
Nature 2019 Mar;567(7747):262-266
Nature 2019 Mar;567(7747):262-266
Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity.
Li L, Yang L, Cheng S, Fan Z, Shen Z, Xue W, Zheng Y, Li F, Wang D, Zhang K, Lian J, Wang D, Zhu Z, Zhao J, Zhang Y
Molecular cancer 2019 Jun 20;18(1):108
Molecular cancer 2019 Jun 20;18(1):108
African Swine Fever Virus Armenia/07 Virulent Strain Controls Interferon Beta Production through the cGAS-STING Pathway.
García-Belmonte R, Pérez-Núñez D, Pittau M, Richt JA, Revilla Y
Journal of virology 2019 Jun 15;93(12)
Journal of virology 2019 Jun 15;93(12)
The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling.
Abdel-Nour M, Carneiro LAM, Downey J, Tsalikis J, Outlioua A, Prescott D, Da Costa LS, Hovingh ES, Farahvash A, Gaudet RG, Molinaro R, van Dalen R, Lau CCY, Azimi FC, Escalante NK, Trotman-Grant A, Lee JE, Gray-Owen SD, Divangahi M, Chen JJ, Philpott DJ, Arnoult D, Girardin SE
Science (New York, N.Y.) 2019 Jul 5;365(6448)
Science (New York, N.Y.) 2019 Jul 5;365(6448)
cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection.
Li Q, Liu C, Yue R, El-Ashram S, Wang J, He X, Zhao D, Zhou X, Xu L
International journal of molecular sciences 2019 Feb 19;20(4)
International journal of molecular sciences 2019 Feb 19;20(4)
Tandem Mass Tag Proteomic Analysis of in Vitro and in Vivo Models of Cutaneous Leishmaniasis Reveals Parasite-Specific and Nonspecific Modulation of Proteins in the Host.
Negrão F, Diedrich JK, Giorgio S, Eberlin MN, Yates JR 3rd
ACS infectious diseases 2019 Dec 13;5(12):2136-2147
ACS infectious diseases 2019 Dec 13;5(12):2136-2147
USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
Ye L, Zhang Q, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D, Zhong B
PLoS pathogens 2019 Apr;15(4):e1007680
PLoS pathogens 2019 Apr;15(4):e1007680
STING positively regulates human ORMDL3 expression through TBK1-IRF3-STAT6 complex mediation.
Cao Q, Juan CX, Zhang DQ, He J, Cao YZ, Pasha AB, Wang JY, Qi HX, Li S, Jin R, Zhou GP
Experimental cell research 2018 Sep 15;370(2):498-505
Experimental cell research 2018 Sep 15;370(2):498-505
Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes.
Verrier ER, Yim SA, Heydmann L, El Saghire H, Bach C, Turon-Lagot V, Mailly L, Durand SC, Lucifora J, Durantel D, Pessaux P, Manel N, Hirsch I, Zeisel MB, Pochet N, Schuster C, Baumert TF
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1695-1709
Hepatology (Baltimore, Md.) 2018 Nov;68(5):1695-1709
IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.
Yang B, Song D, Liu Y, Cui Y, Lu G, Di W, Xing H, Ma L, Guo Z, Guan Y, Wang H, Wang J
FEBS letters 2018 May;592(10):1693-1704
FEBS letters 2018 May;592(10):1693-1704
Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.
Motani K, Kosako H
The Journal of biological chemistry 2018 May 18;293(20):7717-7726
The Journal of biological chemistry 2018 May 18;293(20):7717-7726
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Torralba D, Baixauli F, Villarroya-Beltri C, Fernández-Delgado I, Latorre-Pellicer A, Acín-Pérez R, Martín-Cófreces NB, Jaso-Tamame ÁL, Iborra S, Jorge I, González-Aseguinolaza G, Garaude J, Vicente-Manzanares M, Enríquez JA, Mittelbrunn M, Sánchez-Madrid F
Nature communications 2018 Jul 9;9(1):2658
Nature communications 2018 Jul 9;9(1):2658
Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice.
Luo X, Li H, Ma L, Zhou J, Guo X, Woo SL, Pei Y, Knight LR, Deveau M, Chen Y, Qian X, Xiao X, Li Q, Chen X, Huo Y, McDaniel K, Francis H, Glaser S, Meng F, Alpini G, Wu C
Gastroenterology 2018 Dec;155(6):1971-1984.e4
Gastroenterology 2018 Dec;155(6):1971-1984.e4
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)
Journal of virology 2018 Aug 1;92(15)
Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection.
Liu Y, Liu Y, Wu J, Roizman B, Zhou GG
Proceedings of the National Academy of Sciences of the United States of America 2018 Apr 3;115(14):E3230-E3237
Proceedings of the National Academy of Sciences of the United States of America 2018 Apr 3;115(14):E3230-E3237
A proteomics landscape of circadian clock in mouse liver.
Wang Y, Song L, Liu M, Ge R, Zhou Q, Liu W, Li R, Qie J, Zhen B, Wang Y, He F, Qin J, Ding C
Nature communications 2018 Apr 19;9(1):1553
Nature communications 2018 Apr 19;9(1):1553
The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection.
Chunfa L, Xin S, Qiang L, Sreevatsan S, Yang L, Zhao D, Zhou X
Frontiers in cellular and infection microbiology 2017;7:169
Frontiers in cellular and infection microbiology 2017;7:169
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
Takahama M, Fukuda M, Ohbayashi N, Kozaki T, Misawa T, Okamoto T, Matsuura Y, Akira S, Saitoh T
Cell reports 2017 Sep 19;20(12):2944-2954
Cell reports 2017 Sep 19;20(12):2944-2954
TRIM29 promotes DNA virus infections by inhibiting innate immune response.
Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z
Nature communications 2017 Oct 16;8(1):945
Nature communications 2017 Oct 16;8(1):945
Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.
Wang J, Kang L, Song D, Liu L, Yang S, Ma L, Guo Z, Ding H, Wang H, Yang B
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 1;199(7):2475-2482
Journal of immunology (Baltimore, Md. : 1950) 2017 Oct 1;199(7):2475-2482
HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity.
Wang J, Yang S, Liu L, Wang H, Yang B
Virus research 2017 Mar 15;232:13-21
Virus research 2017 Mar 15;232:13-21
MITA modulated autophagy flux promotes cell death in breast cancer cells.
Bhatelia K, Singh K, Prajapati P, Sripada L, Roy M, Singh R
Cellular signalling 2017 Jul;35:73-83
Cellular signalling 2017 Jul;35:73-83
Decreased expression of STING predicts poor prognosis in patients with gastric cancer.
Song S, Peng P, Tang Z, Zhao J, Wu W, Li H, Shao M, Li L, Yang C, Duan F, Zhang M, Zhang J, Wu H, Li C, Wang X, Wang H, Ruan Y, Gu J
Scientific reports 2017 Feb 8;7:39858
Scientific reports 2017 Feb 8;7:39858
Indirubin, a bisindole alkaloid from Isatis indigotica, reduces H1N1 susceptibility in stressed mice by regulating MAVS signaling.
Jie C, Luo Z, Chen H, Wang M, Yan C, Mao ZF, Xiao GK, Kurihara H, Li YF, He RR
Oncotarget 2017 Dec 1;8(62):105615-105629
Oncotarget 2017 Dec 1;8(62):105615-105629
PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
Liu Y, Qu L, Liu Y, Roizman B, Zhou GG
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 15;114(33):E6902-E6911
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 15;114(33):E6902-E6911
Activation of STING requires palmitoylation at the Golgi.
Mukai K, Konno H, Akiba T, Uemura T, Waguri S, Kobayashi T, Barber GN, Arai H, Taguchi T
Nature communications 2016 Jun 21;7:11932
Nature communications 2016 Jun 21;7:11932
AIM2 inhibits autophagy and IFN-β production during M. bovis infection.
Liu C, Yue R, Yang Y, Cui Y, Yang L, Zhao D, Zhou X
Oncotarget 2016 Jul 26;7(30):46972-46987
Oncotarget 2016 Jul 26;7(30):46972-46987
Hepatitis B virus polymerase disrupts K63-linked ubiquitination of STING to block innate cytosolic DNA-sensing pathways.
Liu Y, Li J, Chen J, Li Y, Wang W, Du X, Song W, Zhang W, Lin L, Yuan Z
Journal of virology 2015 Feb;89(4):2287-300
Journal of virology 2015 Feb;89(4):2287-300
NET23/STING promotes chromatin compaction from the nuclear envelope.
Malik P, Zuleger N, de las Heras JI, Saiz-Ros N, Makarov AA, Lazou V, Meinke P, Waterfall M, Kelly DA, Schirmer EC
PloS one 2014;9(11):e111851
PloS one 2014;9(11):e111851
Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-κB induced cell death.
Bhatelia K, Singh A, Tomar D, Singh K, Sripada L, Chagtoo M, Prajapati P, Singh R, Godbole MM, Singh R
Biochimica et biophysica acta 2014 Feb;1842(2):144-53
Biochimica et biophysica acta 2014 Feb;1842(2):144-53
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse thymus tissue were subjected to SDS PAGE followed by western blot with 19851-1-AP(TMEM173 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 19851-1-AP(TMEM173 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 19851-1-AP(TMEM173 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TMEM173 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TMEM173. This antibody recognizes human, mouse, rat antigen. The TMEM173 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
