675902

antibody from BioLegend

Targeting: STING1 ERIS, FLJ38577, MITA, MPYS, NET23, STING, TMEM173

Western blot (Supportive data in Antibodypedia)

Antibody Data

Product number

675902

Provider

BioLegend

Proper citation

BioLegend Cat#675902, RRID:AB_2565608

Product name

Purified anti-STING (TMEM173)

Antibody type

Monoclonal

Antigen

Full length recombinant STING (TMEM173) protein produced in 293T cells.

Description

STING (TMEM173), also called stimulator of interferon genes, is a transmembrane adaptor protein that plays an important role in the innate immune response against viral and bacterial infections. It has been shown that cyclic GMP-AMP synthase (cGAS) plays a key role in STING activation. Upon activation, STING triggers downstream transcription factors STAT6 and IRF3 through TBK1 and leads to production of IFN-β. IFN-β protects infected cells and nearby cells from local infection. It is clear that chronic STING activation is involved in chronic inflammatory diseases, such as autoimmune syndromes and cancer.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

O94E12

Vial size

100 µg

Concentration

0.5 mg/ml

Storage

2°C-8°C

Handling

Ambient RT

Western blot

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Western blot analysis of THP-1 (lane 1) and Raw264.7 (lane 2). Anti-STING (TMEM173) antibody (clone O94E12) was used, followed by HRP anti-mouse IgG antibody (Cat. No. 405306). β-actin antibody (Poly6221) was used as a loading control.

Conjugate

Unconjugated