66680-1-Ig

antibody from Proteintech Group

Targeting: STING1 ERIS, FLJ38577, MITA, MPYS, NET23, STING, TMEM173

Provider product page for 66680-1-Ig

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [27]
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Product number: 66680-1-Ig - Provider product page
Provider: Proteintech Group
Product name: TMEM173/STING antibody
Antibody type: Monoclonal
Description: KD/KO validated TMEM173/STING antibody (Cat. #66680-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1F1E1
Vial size: 20ul, 150ul

STING1 protein structure - 66680-1-Ig shown in red.

Submitted references IGF2 promotes alveolar bone regeneration in murine periodontitis via inhibiting cGAS/STING-mediated M1 macrophage polarization.

Wang T, Tang Y, Xia Y, Zhang Q, Cao S, Bie M, Kang F
International immunopharmacology 2024 May 10;132:111984

Non-Canonical STING-PERK Pathway Modulation of Cellular Senescence and Therapeutic Response in Sepsis-Associated Acute Kidney Injury.

Dong Y, Liu G, Situ X, Xia L, Zhang T, Zhu X, Jin H, Liu Y, Shou S
Inflammation 2024 Jun 24;

Neuritin promotes autophagic flux by inhibiting the cGAS-STING pathway to alleviate brain injury after subarachnoid haemorrhage.

Zhang H, Ren K, Hu Y, Liu B, He Y, Xu H, Ma K, Tian W, Dai L, Zhao D
Brain research 2024 Aug 1;1836:148909

Aβ Induces Neuroinflammation and Microglial M1 Polarization via cGAS-STING-IFITM3 Signaling Pathway in BV-2 Cells.

Wu Z, Tang W, Ibrahim FEEM, Chen X, Yan H, Tao C, Wang Z, Guo Y, Fu Y, Wang Q, Ge Y
Neurochemical research 2023 Sep;48(9):2881-2894

FEN1 inhibitor SC13 promotes CAR-T cells infiltration into solid tumours through cGAS-STING signalling pathway.

Dong Y, Wang Y, Yin X, Zhu H, Liu L, Zhang M, Chen J, Wang A, Huang T, Hu J, Liang J, Guo Z, He L
Immunology 2023 Nov;170(3):388-400

STING promotes ferroptosis through NCOA4-dependent ferritinophagy in acute kidney injury.

Jin L, Yu B, Wang H, Shi L, Yang J, Wu L, Gao C, Pan H, Han F, Lin W, Lai EY, Wang YF, Yang Y
Free radical biology & medicine 2023 Nov 1;208:348-360

Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING.

Qian G, Zhang Y, Liu Y, Li M, Xin B, Jiang W, Han W, Wang Y, Tang X, Li L, Zhu L, Sun T, Yan B, Zheng Y, Xu J, Ge B, Zhang Z, Yan D
Cell reports 2023 May 30;42(5):112442

The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage.

Zhu X, Liu W, Tang X, Chen Y, Ge X, Ke Q, Liang X, Gan Y, Zheng Y, Zou M, Deng M, Liu Y, Li DW, Gong L
Journal of neuroinflammation 2023 May 22;20(1):119

NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury.

Zhao J, Zhen N, Zhou Q, Lou J, Cui W, Zhang G, Tian B
International journal of molecular sciences 2023 Mar 7;24(6)

Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis.

Zhang SY, Xu QP, Shi LN, Li SW, Wang WH, Wang QQ, Lu LX, Xiao H, Wang JH, Li FY, Liang YM, Gong ST, Peng HR, Zhang Z, Tang H
Signal transduction and targeted therapy 2023 Jun 19;8(1):236

STING/TBK1 Regulates Inflammation in Macrophages and Titanium Particles-Induced Osteolysis.

Ouyang Z, Xu J, Liu T, Lin S, Sun Y, Huang Y, Zheng Z, Zeng G, Li C, Li S, Ding Y
ACS biomaterials science & engineering 2023 Jun 12;9(6):3273-3284

Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway.

Bai L, Dai J, Xia Y, He K, Xue H, Guo Q, Tian D, Xiao L, Zhang X, Teng X, Wu Y, Jin S
Oxidative medicine and cellular longevity 2022;2022:1392896

LPS-Induced Activation of the cGAS-STING Pathway is Regulated by Mitochondrial Dysfunction and Mitochondrial DNA Leakage in Endometritis.

Li MZ, Wen XY, Liu XQ, Wang YQ, Yan L
Journal of inflammation research 2022;15:5707-5720

Human STING Is Regulated by an Autoinhibitory Mechanism for Type I Interferon Production.

Qi S, Wang C, Zhang R, Zhu J, Hou X, Jiang Y, Li J, Ren M, Li M, Hou F
Journal of innate immunity 2022;14(5):518-531

Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway.

Huang X, Yao Y, Hou X, Wei L, Rao Y, Su Y, Zheng G, Ruan XZ, Li D, Chen Y
Cellular and molecular gastroenterology and hepatology 2022;14(1):1-26

Curcumol Suppresses CCF-Mediated Hepatocyte Senescence Through Blocking LC3B-Lamin B1 Interaction in Alcoholic Fatty Liver Disease.

Qi X, Zheng S, Ma M, Lian N, Wang H, Chen L, Song A, Lu C, Zheng S, Jin H
Frontiers in pharmacology 2022;13:912825

Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration.

Zou M, Ke Q, Nie Q, Qi R, Zhu X, Liu W, Hu X, Sun Q, Fu JL, Tang X, Liu Y, Li DW, Gong L
Cell death and differentiation 2022 Sep;29(9):1816-1833

AMICA1 is a diagnostic and prognostic biomarker and induces immune cells infiltration by activating cGAS-STING signaling in lung adenocarcinoma.

Feng Z, Zhang Y, He M, Han Y, Cai C, Liu S, Liu P, Chen Y, Shen H, Zeng S
Cancer cell international 2022 Mar 5;22(1):111

GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.

Xu H, Jin J, Chen Y, Wu G, Zhu H, Wang Q, Wang J, Li S, Grigore FN, Ma J, Chen CC, Lan Q, Li M
Oncogene 2022 Jul;41(31):3876-3885

Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis.

Duan N, Zhang Y, Tan S, Sun J, Ye M, Gao H, Pu K, Wu M, Wang Q, Zhai Q
Neurobiology of disease 2022 Jul;169:105739

Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium.

Gagliardi TB, Goldstein ME, Song D, Gray KM, Jung JW, Ignacio MA, Stroka KM, Duncan GA, Scull MA
PLoS pathogens 2022 Jan;18(1):e1010159

Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy.

Liu K, Qiu D, Liang X, Huang Y, Wang Y, Jia X, Li K, Zhao J, Du C, Qiu X, Cui J, Xiao Z, Qin Y, Zhang Q
Autophagy 2022 Apr;18(4):860-876

Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING.

Fang R, Jiang Q, Guan Y, Gao P, Zhang R, Zhao Z, Jiang Z
Immunity 2021 May 11;54(5):962-975.e8

Staphylococcus aureus Induces IFN-β Production via a CARMA3-Independent Mechanism.

Zhou Y, Zhao S, Gao X, Jiang S, Ma J, Wang R, Li Q, Qin L, Tong Z, Wu J, Zhao J
Pathogens (Basel, Switzerland) 2021 Mar 4;10(3)

STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer.

Shi J, Liu C, Luo S, Cao T, Lin B, Zhou M, Zhang X, Wang S, Zheng T, Li X
Cellular immunology 2021 Aug;366:104384

The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson's disease.

Zhao M, Wang B, Zhang C, Su Z, Guo B, Zhao Y, Zheng R
Cell death and differentiation 2021 Aug;28(8):2517-2535

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections.

Yum S, Li M, Fang Y, Chen ZJ
Proceedings of the National Academy of Sciences of the United States of America 2021 Apr 6;118(14)

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