19559-1-AP

antibody from Proteintech Group

Targeting: SLC6A4 5-HTT, HTT, OCD1, SERT1

Provider product page for 19559-1-AP

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [27]
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Product number: 19559-1-AP - Provider product page
Provider: Proteintech Group
Product name: Serotonin transporter antibody
Antibody type: Polyclonal
Description: KD/KO validated Serotonin transporter antibody (Cat. #19559-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC6A4 protein structure - 19559-1-AP shown in red.

Submitted references An antibody-mediated versatile SERS sandwich biosensor for ultrasensitive detection of functional proteins in cells and tissues.

Ou Y, Yuan Y, Shu P, Chen W, Li J, Zhao Y, Xing Y, Peng N, Li Q, Wang J
Talanta 2026 Sep 1;307:129787

Alterations in the jejunal 5-hydroxytryptamine synthesis and turnover in septic mice induced by cecal ligation and puncture.

Kuroda A, Machida T, Hiraide S, Yamamoto T, Abe Y, Kumagai H, Tsuda S, Hamaue N, Iizuka K, Hattori Y, Matsuda N
Toxicology and applied pharmacology 2026 May;510:117764

Citalopram exhibits immune-dependent anti-tumor effects by modulating C5aR1(+) TAMs.

Dong F, Zhang S, Song K, Jiang L, Hu LP, Li Q, Zhang XL, Li J, Feng M, Cai ZW, Yao HF, Li RK, Li H, Chen J, Hu X, Wang J, Jiang C, Zhu HH, Wang C, Da LT, Zhang ZG, Bao Z, Wang X, Jiang SH
eLife 2026 Feb 9;14

Sleep disturbance triggers aberrant activation of vagus circuitry and induces intestinal stem cell dysfunction.

Zhang M, Wu X, Liu D, Li H, Li X, Yang W, Ye J, Hou L, Wang S, Ning N, Zhang H, Tian Y, Yu L, Wu K, Wang L, Plikus MV, Lv C, Wang F, Yu Z
Cell stem cell 2026 Feb 5;33(2):306-324.e8

Investigating the Relationship between Ulcerative Colitis and Circadian Rhythm Genes Using Bioinformatics Analysis and Machine Learning.

Wang J, You M, Li J, Wang X, Liu Y, Chen S, Wang P
International journal of general medicine 2025;18:3239-3251

From network prediction to experimental validation: Multi-Target mechanisms of Artemisia absinthium L. Essential Oil (AAEO) against depression.

Liu Z, Wang Q, Li X, Zhao Y, Liu W, Guo Q, Yuan Y
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120308

A Novel CHRM3-Driven Preclinical Model of Irritable Bowel Syndrome.

Yang J, Li X, Wang C, Yang X, Zheng P, Liang J, Zhang L, Xia L, Wan J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e71015

5-HT regulates resistance to aumolertinib by attenuating ferroptosis in lung adenocarcinoma.

Feng Y, He Y, Zuo R, Gong W, Gao Y, Wang Y, Wang Y, Chen W, Chen L, Luo Y, Yuan D, Chen P, Guo H
EMBO molecular medicine 2025 Oct;17(10):2586-2611

Diosgenin activates ERα-dependent PI3K/AKT/GSK3β signaling to enhance brain-derived serotonin and alleviate postmenopausal bone loss.

Chen X, Zhang M, Qian L, Guo Y, Zhu Y, Taxi W, Liu M, Wang K, Song L, Zhang C, Zhang Y, Wang L, Ma Y, Hu Y
Journal of advanced research 2025 Nov 24;

α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice.

Xu W, Wang M, Li X, He R, Ding RB, Bao J, Zhangsun D, Luo S
Marine drugs 2025 Mar 4;23(3)

Deficiency of Rab26 causes behavioral defects in mice through impaired trafficking of serotonin (5-HT) transporter.

Ren Y, Wang Z, Wei Z, Zhuang R, Zhang Y, Liu X, Jiang C, Liu X, Yun Y, Li Y, Hong W, Wang T
iScience 2025 Jul 18;28(7):112931

Piezo knockdown reduces 5‑hydroxytryptamine release from enterochromaffin cells and exacerbates intestinal dyskinesia in mice with functional constipation.

Yan X, Ma P, Wang W, Zeng W, Li Y, Hou Y, Ye J, Zheng Q, Zhang W, Yao J, Li Y
International journal of molecular medicine 2025 Dec;56(6)

AMP1-1 alleviates bone loss in weightless rats by reducing peripheral 5-HT content via the microbiota-gut-bone axis.

Yang F, Yan Q, Wang Y, Li Q, Wang J, Zeng X, Pi Y, Zhang M, Wei L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156447

Restraint Stress Disrupted Intestinal Homeostasis via 5-HT/HTR7/Wnt/β-Catenin/NF-kB Signaling.

Yu J, Wang Z, Chen Y, Dong Y
International journal of molecular sciences 2025 Apr 24;26(9)

Chronic Stress-induced Serotonin Impairs Intestinal Epithelial Cell Mitochondrial Biogenesis via the AMPK-PGC-1α Axis.

Yang D, Sun Y, Wen P, Chen Y, Cao J, Sun X, Dong Y
International journal of biological sciences 2024;20(11):4476-4495

The Impact of Depression on Detrimental Changes in Bone Microstructure in Female Mice.

Xu H, Sun Z, Wang G, Li R
Neuropsychiatric disease and treatment 2024;20:1421-1433

SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1.

Dong F, He K, Zhang S, Song K, Jiang L, Hu LP, Li Q, Zhang XL, Zhang N, Li BT, Zhu LL, Li J, Feng M, Gao Y, Chen J, Hu X, Wang J, Jiang C, Wang C, Zhu HH, Da LT, Ji J, Zhang ZG, Bao Z, Jiang SH
Cell reports 2024 Oct 22;43(10):114818

Impaired Response to Mismatch Novelty in the Li(2+)-Pilocarpine Rat Model of TLE: Correlation with Hippocampal Monoaminergic Inputs.

Nascimento C, Guerreiro-Pinto V, Pawlak S, Caulino-Rocha A, Amat-Garcia L, Cunha-Reis D
Biomedicines 2024 Mar 12;12(3)

The alteration of serotonergic markers in the amygdala and raphe nuclei of oestrogen receptor β knock-out female mice.

Kalinowski D, Bogus-Nowakowska K
The European journal of neuroscience 2024 Dec;60(11):6750-6764

Computational biology-based study of the molecular mechanism of spermidine amelioration of acute pancreatitis.

Shen Y, Duan H, Yuan L, Asikaer A, Liu Y, Zhang R, Liu Y, Wang Y, Lin Z
Molecular diversity 2024 Aug;28(4):2583-2601

Comparison of CUMS at different pregnancy stages, maternal separation, and their effects on offspring in postpartum depression mouse models.

Fei F, Chen Z, Tao Y, Jiang X, Xu X, Ma Y, Feng P, Wang P
Heliyon 2024 Aug 15;10(15):e35363

Prophylactic effect of Tongxieyaofang polysaccharide on depressive behavior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis.

Chen H, Kan Q, Zhao L, Ye G, He X, Tang H, Shi F, Zou Y, Liang X, Song X, Liu R, Luo J, Li Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114525

Identification of potential prognostic markers for lung adenocarcinoma using comprehensive analysis.

Huang L, Zhang A, Tang C, Wei J, Li M, Yuan S, Zhang H, Zhang X
Molecular medicine reports 2023 Aug;28(2)

Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress.

Tarry-Adkins JL, Robinson IG, Reynolds RM, Aye ILMH, Charnock-Jones DS, Jenkins B, Koulmann A, Ozanne SE, Aiken CE
Frontiers in cell and developmental biology 2022;10:935403

Detection of the role of intestinal flora and tryptophan metabolism involved in antidepressant-like actions of crocetin based on a multi-omics approach.

Lin S, Li Q, Xu Z, Chen Z, Tao Y, Tong Y, Wang T, Chen S, Wang P
Psychopharmacology 2022 Nov;239(11):3657-3677

Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.

Hadden C, Fahmi T, Cooper A, Savenka AV, Lupashin VV, Roberts DJ, Maroteaux L, Hauguel-de Mouzon S, Kilic F
Journal of cellular physiology 2017 Dec;232(12):3520-3529

Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability.

Li Y, Hadden C, Cooper A, Ahmed A, Wu H, Lupashin VV, Mayeux PR, Kilic F
Scientific reports 2016 Mar 9;6:22747

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