SLC6A4

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]

Description

Solute carrier family 6 member 4

Tissue specificity

Tissue enhanced (brain, intestine, lung)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Membrane

Protein family

FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

17:q11.2 (30194319 - 30236002)

Ensembl ID

ENSG00000108576  (ver. 103.38)

Orthologs

Mouse Slc6a4: ENSMUSG00000020838

UniProt

P31645

neXtProt

NX_P31645

Human splice variants
Mouse splice variants