MTCH2

This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]

Description

Mitochondrial carrier 2

Tissue specificity

Low tissue specificity

Subcell location

Mitochondria

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

11 (47617315 - 47642607)

Ensembl ID

ENSG00000109919  (ver. 103.38)

Orthologs

Mouse Mtch2: ENSMUSG00000027282

UniProt

Q9Y6C9

neXtProt

NX_Q9Y6C9

Human splice variants
Mouse splice variants

Protein structure