60242-1-Ig

antibody from Proteintech Group

Targeting: POU5F1 MGC22487, OCT3, Oct4, OTF3

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

60242-1-Ig

Provider

Proteintech Group

Product name

OCT4 antibody

Antibody type

Monoclonal

Description

OCT4 antibody (Cat. #60242-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1C4B6

Vial size

20ul, 150ul

References

Submitted references

CNOT3 resists ovarian aging by accelerating oocyte maturation and promoting ESCs differentiation.

Li N, Huang E, Wang R, Li J, Yuan X
Stem cell research & therapy 2026 Jan 17;17(1):83

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Precise excision of expanded GGC repeats in NOTCH2NLC via CRISPR/Cas9 for treating neuronal intranuclear inclusion disease.

Xie N, Pan Y, Tong H, Lin Y, Jiang Y, Wang Z, Wan J, Zhang W, Wang X, Sun X, Yan S, Yin P, Sun Q, Qi C, Tian Y, Shen L, Jiang H, Liang D, Tang B, Li S, Li XJ, Liu Q
Nature communications 2026 Jan 13;17(1):1683

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Primordial germ cell-like cells residing in the pituitary may serve as the origin of intracranial germ cell tumors.

Zhang Y, Zhang L, Shen Z, Liu J, Ye Z, Deng K, Yao Y, Han D
Scientific reports 2026 Feb 3;16(1):7086

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HPV16 E7 Enhances Cell Stemness via RTKN2-Mediated Activation of the NF-κB Pathway in Cervical Cancer.

Yang M, Ma Y, Cao Z, Zhan H, Jin Y, Huang X, Yang S
Biochemical genetics 2026 Apr;64(2):2582-2604

---

eNAMPT/Ac-STAT3/DIRAS2 Axis Promotes Development and Cancer Stemness in Triple-Negative Breast Cancer by Enhancing Cytokine Crosstalk Between Tumor-Associated Macrophages and Cancer Cells.

Zhang L, Wang L, Xu Z, Zhang X, Guan S, Liu Z, Gu S, Zhao L, Bai W, Li T, Zhao X
International journal of biological sciences 2025;21(5):2027-2047

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Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi011-A) from a patient with autosomal dominant spastic paraplegia 9A due to ALDH18A1 mutation.

Shan D, Wang H, Li J, Wang Y, Liu F
Stem cell research 2025 Sep;87:103807

---

NCAPH-YAP1 interaction promotes breast cancer stemness and tumor progression.

Qiu C, Wei Y, Li J
Stem cell research & therapy 2025 Sep 25;16(1):494

---

Notch3 mediated TGF‑β1 activation enhances epithelial‑mesenchymal transition and cancer stemness in non‑small lung cancer.

Wang F, Hu S, Bian J, Gao Q, Cao L, Sang L, Yang J, Xu X
International journal of oncology 2025 Oct;67(4)

---

OAC1 improves mitofusin 2 expression to alleviate neuronal injury following experimental ischemic stroke.

Wang Y, Chen K, Xu B, Wang H, Wang H, Lü T
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Nov 1;29(6):741-753

---

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi009-A) from a patient with amyotrophic lateral sclerosis due to SOD1 mutation.

Li B, Mu H, Shan D, Yang Y, Wang Y, Li J, Wang H, Sun X, Ji X, Zhan Z, Jiao Y, Tang Y, Kong B, Gao B, Wang Y, Sun P, Liu F
Stem cell research 2025 Jun;85:103704

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POLR1F promotes proliferation and stemness of anaplastic thyroid cancer by activating F2R/p38 MAPK signaling.

Gong Y, Wang S, Fang Z, Hu X, Li Y, Che Y, Tan Z, Su B, Ge M, Pan Z
Biochimica et biophysica acta. Molecular cell research 2025 Jun;1872(5):119963

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Dual-Action Tocilizumab-Conjugated Cisplatin Nanoparticles Overcome Chemoresistance and Metastasis in Non-Small-Cell Lung Cancer.

Wang Y, Wu F, Yang T, Li B, Wang H, Ye P, Li W
Pharmaceutics 2025 Jul 21;17(7)

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ERCC6L-mediated stabilization of HIF-1α enhances glycolysis and stemness properties of lung adenocarcinoma cells.

Lu Z, Yao X, Jiang J, Hou G
Cell death & disease 2025 Jul 21;16(1):541

---

TC2N maintains stem cell-like characteristics to accelerate lung carcinogenesis by blockade of dual specificity protein phosphatase 3.

Gu J, Lv YF, Xia JY, Bai FH, Gong J, Pan GQ, Liu B, Huang L, Guo QN, Hao XL
Cell & bioscience 2025 Jan 23;15(1):8

---

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi007-A) from a patient with Kennedy disease.

Li B, Yang Y, Wang Y, Shan D, Li J, Wang H, Sun X, Tang Y, Jiao Y, Ji X, Zhan Z, Kong B, Gao B, Wang Y, Sun P, Liu F
Stem cell research 2025 Feb;82:103638

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NONHSAT141192.2 Facilitates the Stemness and Radioresistance of Glioma Stem Cells via the Regulation of PIK3R3 and SOX2.

Wang S, Ming H, Wang Z, Zhai X, Zhang X, Wu D, Bo Y, Wang H, Luo Y, Han Z, Hao L, Xiang Y, Han X, Wang Z, Wang Y
CNS neuroscience & therapeutics 2025 Feb;31(2):e70279

---

Dandelion extract suppresses the stem-like properties of triple-negative breast cancer cells by regulating CUEDC2/β-catenin/OCT4 signaling axis.

Deng X, Jiao Y, Hao H, Guo Z, An G, Zhang W, Xue D, Han S
Journal of ethnopharmacology 2025 Feb 27;342:119408

---

CCL8 suppresses ovarian cancer progression via M1 macrophage polarization and NF-κB-mediated apoptosis.

Fang J, Zhao X, Wang J, Yang Y, Xiao Y
Scientific reports 2025 Dec 17;16(1):2960

---

Zika virus capsid protein impairs neural differentiation.

Wang Y, Ma ZH, Hassaan NA, Hao G, Wang PH, Yao M, Wu C, Chen M, Xing L
International journal of biological macromolecules 2025 Aug;319(Pt 2):145479

---

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi008-A) from a patient with Spinocerebellar Ataxia Type 3.

Li B, Wang Y, Yang Y, Shan D, Li J, Wang H, Sun X, Zhan Z, Ji X, Tang Y, Jiao Y, Kong B, Gao B, Sun P, Liu F, Wang Y
Stem cell research 2025 Apr;84:103675

---

Hypoxic Cancer Cells-Derived Exosomes Strengthen the Development of Cancer Stem Cell-Like Properties Through Delivering LINC00665 in Thyroid Cancer Cells.

Zhou M, Peng C, Zhang Q, Tong Y
Cell biology international 2025 Apr;49(4):384-396

---

ΔNp63α promotes cigarette smoke-induced renal cancer stem cell activity via the Sonic Hedgehog pathway.

Zhao Y, Ma N, Wu W, Wu Y, Zhang W, Qian W, Sun X, Zhang T
Genetics and molecular biology 2024;47(2):e20230347

---

Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi004-A) from a patient with Congenital Nemaline Myopathy.

Wang Y, Liu W, Yang Y, Wang Y, Tang Y, Zhan Z, Sun X, Jiao Y, Shan D, Zhang R, Wang D, Sun P, Sun X, Yan C, Liu F
Stem cell research 2024 Jun;77:103435

---

Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi005-A) from a healthy female Chinese Han.

Liu W, Wang Y, Yang Y, Wang Y, Tang Y, Jiao Y, Shan D, Zhan Z, Zhang R, Wang D, Sun X, Sun P, Sun X, Yan C, Liu F
Stem cell research 2024 Jun;77:103386

---

The small nucleolar RNA SNORA51 enhances breast cancer stem cell-like properties via the RPL3/NPM1/c-MYC pathway.

Li S, Jin Z, Song X, Ma J, Peng Z, Yu H, Song J, Zhang Y, Sun X, He M, Yu X, Jin F, Zheng A
Molecular carcinogenesis 2024 Jun;63(6):1117-1132

---

Epigenetic inhibition of CTCF by HN1 promotes dedifferentiation and stemness of anaplastic thyroid cancer.

Pan Z, Lu X, Xu T, Chen J, Bao L, Li Y, Gong Y, Che Y, Zou X, Tan Z, Huang P, Ge M
Cancer letters 2024 Jan 1;580:216496

---

Biological characteristics of Muse cells derived from MenSCs and their application in acute liver injury and intracerebral hemorrhage diseases.

Li H, Wei J, Li M, Li Y, Zhang T, Tian J, Liu X, Li K, Lin J
Regenerative therapy 2024 Dec;27:48-62

---

Loss of Claudin-1 incurred by DNMT aberration promotes pancreatic cancer progression.

Zhu L, Tang N, Hang H, Zhou Y, Dong J, Yang Y, Mao L, Qiu Y, Fu X, Cao W
Cancer letters 2024 Apr 1;586:216611

---

Rab11-FIP4 interacts with ARF5 to promote cancer stemness in hepatocellular carcinoma.

Song F, Zhang Q, Lu X, Xu T, Hu Q, Hu X, Fan W, Zhang Y, Huang P
Journal of physiology and biochemistry 2023 Nov;79(4):757-770

---

CircNFIX stimulates the proliferation, invasion, and stemness properties of ovarian cancer cells by enhancing SH3RF3 mRNA stability via binding LIN28B.

Yu XZ, Yang BW, Ao MY, Wu YK, Ye H, Wang RY, Xi MR, Hou MM
The Kaohsiung journal of medical sciences 2023 Mar;39(3):234-243

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Integration of metabolomics and transcriptomics to reveal ferroptosis is involved in Tripterygium wilfordii polyglycoside tablet-induced testicular injury.

Qin Z, Zhang G, Jiang S, Ning F, Zhao Z, Huang M, Jin J
Journal of ethnopharmacology 2023 Mar 25;304:116055

---

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi002-A) from a patient with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency.

Zhang C, Wang D, Wang Y, Sun P, Zhao D, Zhao X, Zhao Y, Liu F, Xu J, Yan C
Stem cell research 2023 Jun;69:103067

---

MicroRNA26a Overexpression Hastens Osteoblast Differentiation Capacity in Dental Stem Cells.

Kaufman S, Chang P, Pendleton E, Chandar N
Cellular reprogramming 2023 Jun;25(3):109-120

---

Enhanced binding of β-catenin and β-TrCP mediates LMPt's anti-CSCs activity in colorectal cancer.

Wang M, Wang X, Zhao W, Li Y, Cai M, Wang K, Xi X, Zhao C, Zhou H, Shao R, Xia G, Zhang Y, Zhao W
Biochemical pharmacology 2023 Jun;212:115577

---

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246

---

Application of mPEG-CS-cRGD/Bmi-1RNAi-PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells.

Xu X, Zhou T, Wei X, Jiang X, Cao J
Drug delivery 2023 Dec;30(1):2180112

---

Effect of microserum environment stimulation on extraction and biological function of colorectal cancer stem cells.

Wang F, Zhao J, Zhang C, Yang B, Tian T, Tian M, Meng N, Xie W, Liu G, Zhu X, Su M, He Z, Liu Y, Tang D, Li Y
Discover oncology 2023 Aug 28;14(1):156

---

RNA-seq and ATAC-seq analyses of multilineage differentiating stress enduring cells: Comparison with dermal fibroblasts.

Mao XQ, Cheng Y, Zhang RZ, Liu YB, Li Y, Ge K, Jin HL
Cell biology international 2022 Sep;46(9):1480-1494

---

WTAP promotes oesophageal squamous cell carcinoma development by decreasing CPSF4 expression in an m(6)A-dependent manner.

Luo Q, Zhan X, Kuang Y, Sun M, Dong F, Sun E, Chen B
Medical oncology (Northwood, London, England) 2022 Sep 29;39(12):231

---

Induced retinal pigment epithelial cells with anti-epithelial-to-mesenchymal transition ability delay retinal degeneration.

Tian H, Chen Z, Zhu X, Ou Q, Wang Z, Wu B, Xu JY, Jin C, Gao F, Wang J, Zhang J, Zhang J, Lu L, Xu GT
iScience 2022 Oct 21;25(10):105050

---

Autism-associated protein POGZ controls ESCs and ESC neural induction by association with esBAF.

Sun X, Cheng L, Sun Y
Molecular autism 2022 Jun 1;13(1):24

---

Establishment of an induced pluripotent stem cell (iPSC) line (INNDSUi001-A) from a healthy female Chinese Han.

Wang D, Zhang R, Wang Y, Sun P, Ji X, Sun X, Xu J, Zhao D, Yan C, Liu F
Stem cell research 2022 Jul;62:102819

---

Generation of a human induced pluripotent stem cell line (INNDSUi003-A) derived from patient with Becker muscular dystrophy (BMD).

Ji X, Wang Y, Sun P, Wang D, Sun X, Zhang R, Xu J, Li W, Liu F, Yan C
Stem cell research 2022 Jul;62:102794

---

CRIP1 suppresses BBOX1-mediated carnitine metabolism to promote stemness in hepatocellular carcinoma.

Wang J, Zhou Y, Zhang D, Zhao W, Lu Y, Liu C, Lin W, Zhang Y, Chen K, Wang H, Zhao L
The EMBO journal 2022 Aug 1;41(15):e110218

---

PIWIL1 Drives Chemoresistance in Multiple Myeloma by Modulating Mitophagy and the Myeloma Stem Cell Population.

Wang Y, Yao L, Teng Y, Yin H, Wu Q
Frontiers in oncology 2021;11:783583

---

KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.

Wei H, Ma W, Lu X, Liu H, Lin K, Wang Y, Ye Z, Sun L, Huang Z, Pan T, Zhou Z, Cheng EY, Zhang H, Gao P, Zhong X
Cancer communications (London, England) 2021 Sep;41(9):904-920

---

A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties.

Liu S, Sun Y, Hou Y, Yang L, Wan X, Qin Y, Liu Y, Wang R, Zhu P, Teng Y, Liu M
Journal of hematology & oncology 2021 Oct 29;14(1):178

---

Apatinib suppresses lung cancer stem-like cells by complex interplay between β-catenin signaling and mitochondrial ROS accumulation.

Zhu J, Li X, Liang C, Zhou X, Ge M, Chen Y, Jin J, Yin J, Xu H, Xie C, Zhong C
Cell death discovery 2021 May 12;7(1):102

---

Gankyrin activates the hedgehog signalling to drive metastasis in osteosarcoma.

Wang C, Jing J, Hu X, Yu S, Yao F, Li Z, Cheng L
Journal of cellular and molecular medicine 2021 Jul;25(13):6232-6241

---

Effect of the interference with DRP1 expression on the biological characteristics of glioma stem cells.

Zhang L, Cao H, Tao H, Yang J, Gong W, Hu Q
Experimental and therapeutic medicine 2021 Jul;22(1):696

---

Parthenolide inhibits the tumor characteristics of renal cell carcinoma.

Liu D, Han Y, Liu L, Ren X, Zhang H, Fan S, Qin T, Li L
International journal of oncology 2021 Jan;58(1):100-110

---

Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions.

Chen X, Zhang Y, Qian W, Han L, Li W, Duan W, Wu Z, Wang Z, Ma Q
iScience 2021 Dec 17;24(12):103400

---

Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis.

Xu X, Zhang X, Wei C, Zheng D, Lu X, Yang Y, Luo A, Zhang K, Duan X, Wang Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2020 Sep 1;152:105450

---

Chlorogenic acid inhibits esophageal squamous cell carcinoma growth in vitro and in vivo by downregulating the expression of BMI1 and SOX2.

Zhan Y, Li R, Feng C, Li X, Huang S, Wang L, Liu Z, Jiang J, Han Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109602

---

Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.

Liao X, Song G, Xu Z, Bu Y, Chang F, Jia F, Xiao X, Ren X, Zhang M, Jia Q
BMC cancer 2020 Jan 13;20(1):31

---

lncRNA TPTEP1 inhibits stemness and radioresistance of glioma through miR‑106a‑5p‑mediated P38 MAPK signaling.

Tang T, Wang LX, Yang ML, Zhang RM
Molecular medicine reports 2020 Dec;22(6):4857-4867

---

Sulforaphane Inhibits the Acquisition of Tobacco Smoke-Induced Lung Cancer Stem Cell-Like Properties via the IL-6/ΔNp63α/Notch Axis.

Xie C, Zhu J, Jiang Y, Chen J, Wang X, Geng S, Wu J, Zhong C, Li X, Meng Z
Theranostics 2019;9(16):4827-4840

---

Cinobufotalin powerfully reversed EBV-miR-BART22-induced cisplatin resistance via stimulating MAP2K4 to antagonize non-muscle myosin heavy chain IIA/glycogen synthase 3β/β-catenin signaling pathway.

Liu Y, Jiang Q, Liu X, Lin X, Tang Z, Liu C, Zhou J, Zhao M, Li X, Cheng Z, Li L, Xie Y, Liu Z, Fang W
EBioMedicine 2019 Oct;48:386-404

---

Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway.

Xie C, Zhu J, Wang X, Chen J, Geng S, Wu J, Zhong C, Li X
Journal of experimental & clinical cancer research : CR 2019 Jan 28;38(1):39

---

Differential expression of CD44 and CD24 markers discriminates the epitheliod from the fibroblastoid subset in a sarcomatoid renal carcinoma cell line: evidence suggesting the existence of cancer stem cells in both subsets as studied with sorted cells.

Hsieh CH, Hsiung SC, Yeh CT, Yen CF, Chou YW, Lei WY, Pang ST, Chuang CK, Liao SK
Oncotarget 2017 Feb 28;8(9):15593-15609

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human brain tissue were subjected to SDS PAGE followed by western blot with 60242-1-Ig(OCT4 antibody) at dilution of 1:1000

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The OCT4 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human OCT4. This antibody recognizes human,mouse antigen. The OCT4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

60242-1-Ig.pdf

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