Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 10-3014 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-TLR5 Antibody
- Antibody type
- Monoclonal
- Description
- Toll-like receptor 5 (TLR5) plays a fundamental role in pathogen recognition and downstream signaling to induce effective immunity. It is well expressed in major old tissues including lung, skin, intestine, and spleen. TLR5 is present in synovial of patients with rheumatoid arthritis (RA), act as novel mediator of innate immunity-induced osteoclastogenesis and bone loss. TLR5 is a receptor for flagellin and is present on the basolateral surface of intestinal epithelial cells. It is involved in the migration of intestinal epithelial cells through activation of the p38 MAPK pathway. TLR5-mediated signaling specifically enhanced the maturation of lung dendritic cells. TLR5 influences the progression and outcome of ovarian, sarcoma, and luminal breast tumors. Mutations in TLR5 have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
A partial length recombinant TLR5 p
rotein was used as the immunogen fo
r this antibody.- Isotype
- IgG
- Antibody clone number
- ABM22C2
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Cell surface flowcytometry analysis of hTLR5 on human PBMC (Monocytes) using 0.5 µg/10^6 Cells of Anti-TLR5 antibody (Clone: ABM22C2). Green represent isotype control and red represent Anti human TLR5 antibody (Abeomics 10-3014). Goat anti mouse PE conjugated was used as the secondary antibody.
- Protocol
- Protocol