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Protein structure
TLR5
Toll like receptor 5FLJ10052, MGC126430, MGC126431, SLEB1, TIL3
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease. [provided by RefSeq, Dec 2009]
Top validated antibodies |
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| Novus Biologicals |  NBP2-24787 |
36 references | Monoclonal |
WB
ICC
IP
IHC
FC
|
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| Proteintech Group | 19810-1-AP |
12 references | Polyclonal |
WB
EL
IP
IHC
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| Invitrogen Antibodies | PA1-41139 |
2 references | Polyclonal |
WB
IHC
FC
OA
|
|
| Enzo Life Sciences | ALX-804-598-C100 |
4 references | Monoclonal |
WB
ICC
IHC
FC
|
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| Abnova Corporation | MAB0109 |
5 references | Monoclonal |
WB
IHC
FC
|
|
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