RA0470

antibody from Oursmab

Targeting: LTA LT, TNFB, TNFSF1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0470

Provider

Oursmab

Product name

Pateclizumab (Biosimilar Reference Antibody) (LTA)

Antibody type

Monoclonal

Description

Pateclizumab (also known as MLTA-3698A or RG-7418) is an investigational, humanized monoclonal antibody that targets lymphotoxin-alpha (LT¦Á, also known as TNF-¦Â), a cytokine belonging to the tumor necrosis factor (TNF) superfamily. LT¦Á exists both as a soluble homotrimer and as a membrane-bound heterotrimer with lymphotoxin-beta (LT¦Â), which signals through the LT¦Â receptor. By binding to LT¦Á, pateclizumab neutralizes its activity, thereby inhibiting signaling through both TNF receptors and the LT¦Â receptor. This blockade aims to disrupt the formation and maintenance of lymphoid-like structures in inflamed tissues, which are thought to drive chronic inflammation in autoimmune diseases. It has been clinically evaluated for the treatment of rheumatoid arthritis (RA).

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.