GSKIP

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Description

GSK3B interacting protein

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli, Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (96363452 - 96387288)

Ensembl ID

ENSG00000100744  (ver. 103.38)

Orthologs

Mouse Gskip: ENSMUSG00000044715

UniProt

Q9P0R6

neXtProt

NX_Q9P0R6

Human splice variants
Mouse splice variants

Protein structure