SRCAP

This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]

Description

Snf2 related CREBBP activator protein

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Golgi apparatus

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (30698209 - 30741409)

Ensembl ID

ENSG00000080603  (ver. 103.38)

Orthologs

-

UniProt

Q6ZRS2

neXtProt

NX_Q6ZRS2

Human splice variants

Protein structure