ADGRL3

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

Description

adhesion G protein-coupled receptor L3

Protein family

G-protein coupled receptors, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted membrane proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

4:q13.1 (61201258 - 62078335)

Ensembl ID

ENSG00000150471  (ver. 84.38)

Orthologs

Mouse Adgrl3: ENSMUSG00000037605

UniProt

Q9HAR2

neXtProt

NX_Q9HAR2

Human splice variants
Mouse splice variants