Tissue expression
Cell line expression
Protein structure

IREB2

Iron responsive element binding protein 2
IRP2 
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
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385 antibodies from 35 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
29 antibodies
Proteintech Group
1 antibody
Invitrogen Antibodies
13 antibodies
antibodies-online
89 antibodies
Biorbyt
48 antibodies
Acris Antibodies GmbH
3 antibodies
Abgent
3 antibodies
Abnova Corporation
12 antibodies
OriGene
4 antibodies
HUABIO Research
1 antibody
Everest Biotech
1 antibody
Aviva Systems Biology
3 antibodies
St John's Laboratory
3 antibodies
Cusabio Biotech Co., Ltd
4 antibodies
Antibodies.com
1 antibody
Bioworld Technology, Inc
1 antibody
FineTest Biotech
1 antibody
NovoPro Bioscience Inc.
1 antibody
NSJ Bioreagents
1 antibody
GeneTex
2 antibodies
Arigo
1 antibody
ProSci
3 antibodies
MyBioSource
6 antibodies
Creative Biolabs
8 antibodies
Atlas Antibodies
2 antibodies
United States Biological
39 antibodies
Abiocode, Inc.
3 antibodies
Creative Diagnostics
8 antibodies
Abbexa
7 antibodies
EMD Millipore
2 antibodies
Cell Signaling Technology, Inc
1 antibody
RayBiotech, Inc.
1 antibody
Leading Biology
2 antibodies
MilliporeSigma / Merck KGaA
3 antibodies