Tissue expression
Cell line expression
Protein structure
IREB2
Iron responsive element binding protein 2IRP2
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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Novus Biologicals | NB100-1798 | 6 references | Polyclonal |
WB
ICC
IHC
GS |
|
Proteintech Group | 23829-1-AP | 7 references | Polyclonal |
WB
EL
ICC
IHC |
|
antibodies-online | ABIN952944 | 5 references | Polyclonal |
WB
IHC
FC
|
|
Invitrogen Antibodies | PA1-16544 | 2 references | Polyclonal |
WB
IHC
GS
OA |
|
Abgent | AP12657c | Polyclonal |
WB
IHC
FC
|
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