LPP

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Description

LIM domain containing preferred translocation partner in lipoma

Tissue specificity

Low tissue specificity

Subcell location

Focal adhesion sites, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (188153284 - 188890671)

Ensembl ID

ENSG00000145012  (ver. 103.38)

Orthologs

Mouse Lpp: ENSMUSG00000033306

UniProt

Q93052

neXtProt

NX_Q93052

Human splice variants
Mouse splice variants

Protein structure